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Pediatric Resident Academic Half Day June 7, 2012 Ellie Vyver, MD, FRCPC Division of Adolescent Medicine Objectives To examine substance abuse in the larger context of social determinants of health To learn about adolescent susceptibility to the effects of substances To have an understanding of risk and protective factors as well as resiliency To be familiar with national, province and local rates of substance use To develop an approach to the adolescent using substances The Chief Public Health Officer’s Report on the State of Public Health in Canada, 2011: Youth and Young Adults – http://publichealth.gc.ca/CPHOreport The Chief Public Health Officer’s Report on the State of Public Health in Canada, 2011: Youth and Young Adults – http://publichealth.gc.ca/CPHOreport The Chief Public Health Officer’s Report on the State of Public Health in Canada, 2011: Youth and Young Adults – http://publichealth.gc.ca/CPHOreport The Chief Public Health Officer’s Report on the State of Public Health in Canada, 2011: Youth and Young Adults – http://publichealth.gc.ca/CPHOreport The Chief Public Health Officer’s Report on the State of Public Health in Canada, 2011: Youth and Young Adults – http://publichealth.gc.ca/CPHOreport The Chief Public Health Officer’s Report on the State of Public Health in Canada, 2011: Youth and Young Adults – http://publichealth.gc.ca/CPHOreport SUMMARY Canadian youth are leading healthy lives Subpopulations like aboriginal youth, street involved youth, or sexual minorities are more vulnerable to particular health or socio-economic issues Cost of Substance Abuse Results of the Costs of Substance Abuse in Canada 2002 study released in 2006 Abuse of tobacco, alcohol and illegal drugs cost Canadians about $40 billion ($18 billion in 1992) Cost to Alberta was $4.4 billion ($1.6 billion in 1992) Tobacco $1.8 billion for AB (Canada $17 billion) Alcohol $1.6 billion for AB (Canada $14.6 billion Illegal drugs $1 billion for AB (Canada $8.2 billion) Cost of Substance Abuse Costs by category for Alberta: Indirect costs (productivity losses): 63% Direct health care costs: 23% Direct law enforcement costs: 11% Other direct costs: 3% Developmental Tasks of Adolescence Development of self-esteem and a healthy identity Emancipation from parents to autonomous behaviors Formation of a sexual identity Meaningful social and peer relationships Seeking vocational goals Establishing moral and ethical values Adolescent Brain Development and Susceptibility Period of significant brain development Increase in white matter volume ○ M>F ○ Reflects increased myelination Increase in gray matter volume in preadolescence followed by decrease ○ Changes in frontal lobe involved in development of executive functioning Emotional regulation Planning and organizing Response inhibition Giedd et al., Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci 1999;2:861 Gogtay N., Giedd JN., Lusk L., et al. Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Science 2004;101(21):8172-8179 Dopamine Synthesis in Preadolescent < Adolescent < Adult Large increase in levels and activity during adolescence Large role in reward circuitry of the brain that fuels drug addiction Hippocampus Increases significantly in size during adolescence Levels of dopamine in the hippocampus show large increase Involved in new memory formation Risk and Protective Factors Terms used to identify aspects of individuals or their environments that make development of a given problem more or less likely Health Canada, 1999 Risk Factors Defined as either life events or experiences that are statistically associated with an increase in problematic behaviour such as substance use Protective Factors Defined as the life events or experiences that mitigate the effects of risk factors and reduce the likelihood of problematic behaviour Increase RESILIENCY Resiliancy The ability to overcome adversity Risk and Protective Factors Can be categorized into five different domains: 1. Individual 2. Family 3. Peers 4. Schools 5. Community Johnston LD, O'Malley PM, Bachman JG, Schulenberg JE: Monitoring the Future national survey results on drug use, 1975–2006. Volume I: Secondary school students. Bethesda, MD: National Institute on Drug Abuse; 699. (NIH Publication No. 07-6205) Domain Protective Factors Risk Factors Individual High intelligence Achievement oriented Optimistic view of future Good coping skills Untreated mental health/behavior problems School problems Genetic vulnerability Early pubertal development Rebelliousness Perception that most peers use Undiagnosed/untreated ADHD Low religiosity Perception drug use as low risk After school employment Prosocial values Perception most peers don`t use Treated ADHD High religiosity Perception drug use has risks Family Clear messages about no use Parents model appropriate use Strong attachment Parental monitoring Supportive parents Unclear messages, expect use Substance abuse Alienated from family Permissive or coercive parenting Lots of conflict Domain Protective Factors Risk Factors Peers Do not use Prosocial values Peers use Peers alienated from community Schools Offer opportunities for success and involvement Feel connected to school Personnel seen as fair and caring Poor quality Adequate recreational activities Strong community institutions Media realistically portrays harms Counter marketing Lack or recreational activities Community institutions lacking Media portrays as normative and promotes positive expectancies Lack of community norms about use Substance abuse common Drugs easily available Socioeconomic deprivation Community Feel alienated from school Personnel seen as uncaring TRENDS Top 3 Substances ALCOHOL CANNABIS TOBACCO ALCOHOL National Alcohol Use Data CAS 04 15-24 N= CADUMS 08 15-24 CADUMS 09 15-24 CADUMS 10 15-24 2,085 1,443 955 3,989 Lifetime Use 90.0 [85.4-93.2] 83.5 [79.7-86.8] 81.8 [77.6-85.4] 79.0 [76.8-81.1] Past 12 month Use 82.9 [79.8-85.6] 78.4 [74.2-82.1] 75.5 [70.8-79.6] 71.5 [69.1-73.9] Age of initiation (years) 15.6 [15.4-15.7] 15.6 [15.4-15.8] 15.9 [15.7-16.2] 15.9 [15.8-16.0] Alcohol The Chief Public Health Officer’s Report on the State of Public Health in Canada, 2011: Youth and Young Adults – http://publichealth.gc.ca/CPHOreport Alberta Data for Alcohol Use CANNABIS National Cannabis Use Data CAS 04 15-24 N= CADUMS 08 15-24 CADUMS 09 15-24 CADUMS 10 15-24 2,085 1,443 955 3,989 37.0 [33.4-40.6] 32.7 [28.3-37.4] 26.3 [22.0-31.1] 25.1(*) [22.8-27.3] Cannabis lifetime 61.4 [57.7-65.0] 52.9 [48.1-57.6] 42.9 [37.9-48.0] 41.4(*) [39.6-43.2] Age of initiation (years) 15.6 [15.3-15.8] 15.5 [15.2-15.8] 15.6 [15.2-16.0] 15.7 [15.5-15.8] Cannabis use Cannabis – past year How do Alberta Youth Compare? The majority (83.7%) of students in Grades 7 to 12 report that they are not currently using cannabis 16.3% of students indicate that they have used cannabis in the past 12 months Males (16.7%) and females (16.0%) are equally likely to report using cannabis Older students are more likely to use cannabis. Highest use in Calgary compared to rest of province TOBACCO The Chief Public Health Officer’s Report on the State of Public Health in Canada, 2011: Youth and Young Adults – http://publichealth.gc.ca/CPHOreport Alberta Youth and Tobacco Overall, rates of smoking among students in Grades 7 to 12 are low Most students (95.3%) are not current smokers. Older students are more likely to smoke Among all students, 69.7% reported they had never tried smoking tobacco. Equal proportions of males and females are nonsmokers (95.4% and 95.2% respectively) The percentage of all students who had ever smoked a cigarette, even just a few puffs, increased from 10.0% among students in Grade 7 to 47.8% in Grade 12 Calgary has the lowest rate of current smokers (5.2%) Illicit Drugs The Chief Public Health Officer’s Report on the State of Public Health in Canada, 2011: Youth and Young Adults – http://publichealth.gc.ca/CPHOreport Illicit Drug Use in 15-24 y.o. Past-year use of at least one of cocaine or crack, speed, hallucinogens, ectasy, and heroin decreased from 11.3% in 2004 to 7.0% in 2010. The rate of past year use of any drug excluding cannabis is almost nine times higher than that of adults (7.9% vs. 0.8%) Alberta Youth and Illicit Drugs Majority of Alberta students (78.7%) have not used illicit drugs (excluding cannabis) Illicit drugs most frequently used are MDMA or ecstasy (3.7%) and hallucinogens (4.0%) Males (19.1%) and females (23.6%) have similar rates of illicit drug use (excluding cannabis) Increase in the proportion who use illicit drugs (excluding cannabis) as grade increases. 8.9% in Grade 7 27.4% in Grade 12 Calgary has one of the highest rates of illicit drug use in the province SALVIA Salvia Salvia divinorum Herb found in Southern Mexico; leaves are very potent Atypical psychedelic "la pastora" / "the shepherdess", "the leaves of the shepherdess", "diviner's mint“, "diviner's sage“ Smoked or leaves chewed Often tried once and not again as can cause very dramatic and frightening hallucinations “BATH SALTS” Bath Salts 3,4-methylenedioxypyrovalerone (MDPV) Stimulant Effects comparable to amphetamines Most often taken by insufflation but reports of taken orally Liked for its euphoria and increased sense of mental alertness, productivity, sociability, creativity, and sexual arousal Associated with compulsive, repeated dosing: “FIENDING” With fiending or high doses more likely to cause hallucinations and psychotic behaviours Erowid.org A 15 year old female presents to the ER intoxicated. Ambulance was called by her friends after she was found passed out outside at a party. Her parents are not yet aware that she is in the hospital. What are the medical issues to consider? What tests do you plan to order? Are there any questions you’d like to ask before ordering these tests? Will you contact her parents? oWhat will you tell them? How will you tell them? o What assumptions might you make about her family? What is the legislation in Canada about calling parents? Approach Confidentiality HEEADSSS Screen for problematic use Disclose drug screening tests Give results without parents present Motivational interviewing Consent to Treatment Consent is a “process” by which patients and/or their parent or guardian are provided with a clear understanding of a proposed procedure or treatment and the options available. This is done in the context of the medical needs of the patient. The process results in a decision by the patient or parent/guardian to otherwise what would be assault. Age of Consent? For medical care Not in Canada; except Quebec The Legislation Basic premise: Any person of any age can request medical care. HCP responsible for: Providing information for informed consent Determining that the young person is capable to consent HEEADSSS H – Home Environment E – Education and Employment E – Eating A – Activities D – Drugs S – Sexuality S – Suicide/depression S – Safety from injury and violence Screening for Problematic Use CRAFFT C – Have you ever driven a CAR or driven with someone else while high or drunk? R – Do you ever use drugs to RELAX, feel better, or fit in? A – Do you ever drink or get high ALONE? F – Do you ever FORGET things while drinking or using drugs? F – Do your FAMILY or FRIENDS ever tell you to cut down on drinking or drug use? T – Has your alcohol or drug use ever gotten you in TROUBLE? Stages of Drug Use Stage 0: No drug use Stage 1: Experimentation Stage 2: Regular use Stage 3: Abuse (as defined in DSM-IV) Stage 4: Dependence (as defined in DSM-IV) Stages of Change Model (Prochaska and DiClemente) From the client’s perspective Maintenance Stage Action Stage “I am aware of what I need to do to prevent relapse” “I am doing what is needed In order to change” Preparation Stage “I am looking at what I need To do in order to change” Contemplation Stage “I may have something I would like to change” Pierre Leichner M.D. Relapse Stage “I need to review what I need for change to occur” Precontemplation Stage “ I do not need to change. I don’t have a Problem, they do” Stages of Change Model (Prochaska and DiClemente) From the helper’s perspective Action Stage -Active listening -Supporting change activities -Encouraging rewards for action -Supporting countering activities Preparation Stage -Active listening -Elaboration of plans and goals -Developing decisional balance -Identifying supports -Do not expect action Maintenance Stage -Active listening -Provide recognition and support -Be prepared for relapse -Monitor and revise plan Relapse Stage -Active listening -Reviewing progress -Maintaining positive attitude -Support learning from past events Contemplation Stage -Active listening -Giving feedback / information -Encouraging exploring issues -Weighing pro’s and con’s for change -Do not expect action Pierre Leichner M.D. Precontemplation Stage -Active listening -Looking for common ground -Providing information and feedback -Do not expect action The Real Stages of Change Model Action Stage Maintenance Stage Preparation Stage Relapse Stage Contemplation Stage Precontemplation Stage Motivational Interviewing What is it? Evolved from experience in the treatment of problem drinkers First described by William Miller in 1983 in an article published in Behavioral Psychotherapy Elaborated by Miller and Stephen Rollnick: Motivational Interviewing: Preparing People for Change (2nd edition) (Miller/Rollnick) (April 2002) (First edition in 1991) Meta-Analysis of Research on Motivational Interviewing Treatment Effectiveness (Marmite, 2005) reviewed 72 studies on MI and showed efficacy Annabelle Blanchet M.D. MIT - How to do it? Directive, client-centered counseling style for eliciting behavior change by helping patients to explore and resolve ambivalence Central purpose is the examination and resolution of ambivalence, and the counselor is intentionally directive in pursuing this goal. Annabelle Blanchet M.D. MIT – General Principles (DARES) Develop Discrepancy Avoid Arguments Roll with Resistance Express Empathy Support Self-efficacy Annabelle Blanchet M.D. Develop Discrepancy The patient rather than the listener should present the arguments for change Change is motivated by a perceived discrepancy between present behavior and important personal goals or values Annabelle Blanchet M.D. Roll with Resistance & Avoid Arguments Avoid arguing for change Resistance is not directly opposed New perspectives are invited but not imposed The patient is a primary resource in finding answers and solutions Resistance is a signal to respond differently Annabelle Blanchet M. Express Empathy Acceptance Skillful facilitates change reflective listening is fundamental Ambivalence is normal Annabelle Blanchet M.D. Support Self-efficacy A person's belief in the possibility of change is an important motivator The patient, not the counselor, is responsible for choosing and carrying out change The counselor's own belief in the person's ability to change becomes a self-fulfilling prophecy Annabelle Blanchet M.D. MIT & Youth High ambivalence Developmentally - questioning authority Cohersive approach likely unsuccessful The invulnerable teen The maturing brain and lack of experiences Annabelle Blanchet M Treatment - What works? Limited evidence related to efficacy of treatment approaches for adolescents Concurrent mental health problems need to be included as part of treatment Challenges: Retention/attrition: drop out rate as high as 50-67% Access Relevance Treatment Youth substance use programs should not use the same treatment approaches that are used for adults Treatment should encompass elements of family, school, peers, and community Consistent theme in the literature regarding the importance of addressing family issues Treatment plan that is flexible and responsive to the unique needs of the individual youth Treatment Research dose not indicate which treatment modalities are most effective Options include: Individual outpatient counselling Family-centered practice Experiential learning Wilderness-based Detoxification and stabilization Residential Treatment Harm Reduction Vs Abstinence-based Harm Reduction Focus shifted away from eliminating use Aims to reduce related risks by modifying the behaviour (which may include eliminating use) Accepts that youth may choose to use substances Acknowledges the potential health and psychosocial risks Addiction Services for Youth PChAD Act The Protection of Children Abusing Drugs Act Act came into effect in Alberta July 1, 2006. Purpose is to give parents and guardians an option to help their children (under age 18 years) whose substance use has caused Significant physical, psychological or social harm to themselves OR physical harm to others AND Refusing voluntary addiction treatment services What have we learned? Canadian youth are generally living healthy lives and transitional well into adulthood Many social determinants influence health Subpopulations like aboriginal youth, street involved youth, or sexual minorities are more vulnerable Alcohol, cannabis, and tobacco are the most commonly used substances and use of them has been decreasing over time Key approaches are motivational interviewing and harm reduction