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Part Two: Etiology & Pathophysiology of Chronic Kidney Disease By T. Parent Nurse Educator, PHC Community Hemodialysis Units 2015 Glomerular disorders Nephrotic & Nephritic syndromes Nephrotic syndrome the loss of a lot of protein Nephritic syndrome the loss of a lot of blood Associated Diseases Minimal change glomerulonep hritis Membranoprolif erative Glomerulonephri tis Membranous Glomerulonep hritis Post streptococcal glomerulonep hritis Focal Segmental glomeruloscl erosis Diabetic Nephropathy Goodpast ures Rapidly progressive glomerulone phritis HenochSchonlein purpura Vasculitis disorder Wegners granulomat osis IgA Nephropath y Microscop ic polyangiti s Churg Strauss disease Vascular Diseases Microscopic Polyangiitis Wegener’s BLOOD VESSEL SIZE Small to Medium Small to Medium BLOOD VESSEL TYPE Arterioles to venules, And sometimes Arteries and veins Arterioles to venules, And sometimes Arteries and veins GRANULOMATOUS INFLAMMATION NO YES LUNG SYMPTOMS YES1 YES1 GLOMERULONEPHRITIS YES YES RENAL HYPERTENSION NO NO MONONEURITIS MULTIPLEX COMMON OCCASIONA L SKIN LESIONS YES2 YES2 GI SYMPTOMS NO NO EYE SYMPTOMS YES4 YES4 ANCA-POSITIVITY 75% 65-90% CONSTITUTIONALSYMPT OMS YES5 YES5 NECROTIZING TISSUE YES YES MICROANEURYSMS RARELY RARELY Medullary sponge kidney Neoplasms Interstitial diseases allergic drug reactions infections Acute interstitial nephritis (AIN) immunologically mediated disorders infections Chronic tubulointerstitial nephritis (CTIN reflux or obstructive nephropath drugs