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Neurotransmitter Release High voltage Low voltage Mechanism of Exocytosis synapsins anchor vesicle to cytoskeleton Ca2+ influx activates Ca2+/calmodulin dependent kinase (CaMK) phosporylaton of synapsin I release of vesicle from cytoskeleton move to active zone Rab3A binds to vesicle hydrolysis of Rab GTP to GDP + PO4 targeted to docking site at active zone interaction of v-SNARES and t-SNARES docking and membrane fusion exocytosis and release of Rab into cytoplasm t-SNARES = syntaxin and SNAP25 v-SNARE = synaptobrevin (VAMP) http://www.youtube.com /watch?v=eRslV6lrVxY http://www.youtube.com/ watch?v=K7yku3sa4Y8