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Growth and Development ST 120 Objectives • Discuss the concept of development as a biological process • Discuss the major developmental changes characteristic of the prenatal stage • Discuss the three stages of labor Objectives • Identify the three primary germ layers and several derivatives in the adult body • List and discuss the major developmental changes of the four postnatal periods of life • Discuss the effects of aging on the organ systems Growth and Development • Prenatal period: begins at conception and ends at birth • Postnatal period: the period after birth Prenatal Period • Embryology: the science of the development of the individual before birth • Describes the means by which a new human life is started and the steps by which a single microscopic cell is transformed into a human being Fertilization to Implantation • Uterine tubes are divided into three segments / cornea, middle, fimbriae • Fertilization most often occurs in the outer one third of the oviduct • The zygote is genetically complete • The zygote almost immediately begins mitotic division and in about 3 days is a solid mass of cells called a morula Fertilization to Implantation • The cells of the morula continue to divide, and by the time the developing embryo reaches the uterus, it is a hollow ball of cells called a blastocyst Fertilization to Implantation • It takes about ten days from the time of fertilization to the time when the blastocyst is completely implanted in the uterine lining No nutrients are available from the mother during these 10 days Fertilization to Implantation • The blastocyst cosists of an outer layer of cell and an inner cell mass • As the blastocyst develops, it forms a structure with two cavities, the yolk sac and amniotic cavity Fertilization to Implantation • The yolk sac in humans does not provide nutrition, instead, it functions to produce blood cells • The amniotic cavity becomes a fluidfilled, shock absorbing sac in which the embryo floats during development Fertilization to Implantation • The chorion develops into the placenta • The chorionic villi connect the blood vessels of the chorion to the placenta Fertilization to Implantation • The placenta anchors the developing fetus to the uterus for the exchange of nutrients and waste products • This barrier may be penetrated by some toxic substances Periods of Development • Gestation is divided into three 3month segments called trimesters • During the 1st trimester, the zygote develops into the morula and then the blastocyst Periods of Development • The embryonic phase extends from the 3rd week after fertilization until the end of the 8th week of gestation • The fetal phase is used to describe the 9th week to week 39. During this period, the term embryo is replaced by fetus Periods of Development • By day 35, the heart is beating, and the eyes and limb buds are visible • The end of the third trimester results in the completion of the limbs, facial features are apparent, and gender can be identified Formation of the Primary Germ Layers • Three layers of specialized cells develop early in the first trimester called the primary germ layers – Endoderm – Mesoderm – Ectoderm Endoderm • • • • • • • • • • Lining of GI tract Lining of lungs Lining of hepatic and pancreatic ducts Kidney ducts and bladder Anterior pituitary Thymus gland Thyroid gland Parathyroid gland Tonsils Adrenal medulla Mesoderm • • • • • • • Dermis of skin Circulatory system Many glands Kidneys Gonads Muscle Bones (except facial) Ectoderm • • • • • • • • • Epidermis Tooth enamel Lens and cornea of eye Outer ear Nasal cavity Facial bones Skeletal muscles of head Brain and spinal cord Sensory neurons Histogenesis • The process of how the primary germ layers develop into many different kinds of tissues Organogenesis • The way the tissues arrange themselves into organs Birth Defects • Developmental problems present at birth • May be structural or functional • May be caused by genetic factors or exposure to environmental factors called teratogens. Ex: x-rays, chemicals, drugs, cigarettes, alcohol, and infections like herpes or rubella Birth Defects • The 1st trimester is a period when the tissues are beginning to differentiate and the organs are just starting to develop, so the effect of teratogens are most likely to cause damage Parturition • The point of transition between the prenatal and postnatal periods of life • Process usually begins when the fetus takes a head-down position against the cervix Stages of Labor • Three stages – Stage one: period from onset of uterine contractions until dilation of the cervix is complete – Stage two: period from the time of maximal cervical dilation until the baby exits through the vagina – Stage three: process of expulsion of the placenta End of Day 1 Questions??????? Postnatal Period • Begins at birth and lasts until death • Growth and development occur gradually throughout life The Human Head…. • The infant head is approximately ¼ the total height of the body • The adult head is about 1/8 the total height How Big is Your Face? • The infant face is 1/8 of the skull surface • The adult face is ½ of the skull surface Postnatal Periods • • • • Infancy Childhood Adolescence and adulthood Older adulthood Infancy • Lasts about 18 months • 1st 4 weeks are referred to as neonatal period • Newborn must become totally selfsupporting after being fully dependent on the mother • Rapid development of the nervous and muscular systems Childhood • The end of infancy to puberty • Overall, growth is rapid, but monthto-month gains are less consistent • Deciduous teeth, which appear at ~6 months, are lost at ~ 6 years Childhood • Becomes less chubby • Potbelly gets flatter • Development of numerous motor and coordination skills Adolescence • Generally considered to be the teenage years • Rapid and intense physical growth • Developmental changes are controlled by sex hormones and are classified as secondary sex characteristics Adulthood • Completion of developmental changes • Bone maturation, full closure of growth plates, changes in the size and placement of body components • Balding patterns may become apparent • Maintenance of existing body tissues Older Adulthood • Gradual, but certain decline in the functioning of every major organ system • Senescence: older adulthood Effects of Aging • Skeletal System – Bones undergo changes in texture, degree of calcification, and shape – Shaggy appearance called lipping – Cervical and thoracic vertebrae are frequent sites of fractures – Degenerative joint diseases such as osteoarthritis are common Effects of Aging • Skin – – – – – – Dry Thin Inelastic Increased wrinkles and skinfolds Pigmentation changes Thinning and loss of hair Effects of Aging • Urinary System – Nephron units decrease by almost 50% – Reduction in overall function and excretory capacity or the ability to produce urine – Diminished muscle tone of bladder Effects of Aging • Respiratory System – Costal cartilage becomes hardened or calcified – Chest movements become difficult – Loss of muscle cells decreases the strength of the muscles associated with inspiration and expiration Effects of Aging • Cardiovascular System – Degenerative heart and blood vessel disease – Atherosclerosis: fatty deposits build up in the walls of blood vessels – Arteriosclerosis: actual hardening of the arteries – Hypertension: high blood pressure Effects of Aging • Special Senses – All show a gradual decline in performance and capacity – Most are farsighted – Presbyopia: hardening of the lens so it cannot become curved to accommodate for near vision Effects of Aging • Special Senses – Cataract: lens becomes cloudy – Glaucoma: increased pressure in the eye – Loss of hair cells in the Organ of Corti cause a decline in the ability to hear certain frequencies – Eardrum and ossicles may become fixed – Sense of taste decreases – Taste buds replaced with connective tissue End of Day 2 Questions??????