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Mitosis Notes 8.2 Cell Growth and Reproduction Notes I. Limitations of Cell Size A. Diffusion—nutrients move slower and less efficient as distances increase. B. DNA-limit to how quickly instructions for protein synthesis can be copied. C. Surface Area-cell would starve or be poisoned from waste. II. Reasons for Cell Division A. to replace tissue B. repair cells III. Chromosomes: Coiled DNA A. Carry genetic material. B. Chromatin are chromosomal strands of DNA wrapped around protein molecules. (uncoiled DNA) Found in a non-dividing cell) C. Sketch and label a chromosome: DNA Centromere Sister Chromatids IV. Cell Cycle-sequence of: A. Growth (interphase) & B. Division (mitosis) V. Steps of the Cell Cycle A. Interphase – cell grows and carries on metablolism. 1. Chromosomes (DNA) are duplicated. 2. Cells make proteins 3. Cells repair themselves 4. Excrete wastes 5. Make ATP 6. Produce new organelles 7. Sketch and label interphase: centrioles B. Mitosis - period of nuclear cell division in which two daughter cells are formed and are identical to the parent cell; (they have the same number of chromosomes) increases the number of (body) somatic cells; helps an organism grow in size; guarantees genetic continuity; involves 4 phases: st Prophase--1 and longest phase a. Chromatin coils up into visible chromosomes. b. Nucleus, nucleolus, and nuclear membrane begin to disappear. c. Centrioles migrate to opposite poles of the cell. Only animal cells contain centrioles. d. Spindle fibers form. Function: help separate sister chromatids. (doubled chromosomes) centrioles Spindle fibers Metaphase--2nd phase a. chromosomes move to equator of the cell. Each sister chromatid is attached to a separate spindle fiber by its centromere. rd 3 Anaphase: phase a. Centromeres split. b. Sister chromatids are pulled apart to opposite poles of the cell. c. Each chromatid is a copy of one original chromosome. Sister chromatid Telophase: final phase a. Chromosomes begin to uncoil. b. Spindle fibers break down. c. Nucleus, nucleolus, and nuclear membrane reappears. d. Cytoplasm begins to divide— called cytokinesis 1. In animal cells, the plasma membrane pinches in to form a cell furrow. 2. In plant cells, a cell plate forms along the equator. **End result of cell cycle- 2 new daughter cells are produced that are identical to parent cell. VI. Control of the Cell Cycle A. Gene-segment of DNA that controls production of proteins. B. Cancer-uncontrolled cell division