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Cell Division and Mitosis The division of somatic cells Important Vocabulary • Mitosis: the division of somatic cells (all cells in your body other than the sperm and egg cells). • Cytokinesis: the division of the nucleus. Chromosomes • The genetic information is passed on from one generation to the next in chromosomes. • Chromosomes are made from DNA. • Humans have 46 chromosomes this is the diploid number. Chromosomes • Chromosomes are not normally visible, but before a cell starts to divide the chromosomes condense and become visible. • Before cell division starts, each chromosome is replicated, this creates two identical sister chromatids. • One chromatid goes to each new cell. Chromosomes • Chromosomes are connected at the center at the centromere. The Cell Cycle • The cell cycle starts with interphase • This is the normal part of the cell cycle that the cell grows and DNA replication takes place. Mitosis • Mitosis is the actual division of the cell broken down into four phases: – – – – Prophase Metaphase Anaphase Telophase Prophase • During prophase the chromosomes become visible • The centrioles move to the opposite sides of the nucleus • The chromosomes attach to spindle fibers near the centromere • The nuclear envelope dissappears. Metaphase • During metaphase the chromosomes line up in the middle of the cell. • Microtubules connect the spindle fibers to the ends of the cell and to the centromere of the chromosome. Anaphase • The centromeres split the sister chromatids and separate and become individual chromosomes. • The individual chromosomes move to the poles. Telophase • The chromosome begin to untangle. • The nuclear envelope reforms. • The spindle breaks down. • The nucleolus of each daughter cell becomes visible in the daughter cells. Cytokinesis • Each new daughter cell splits its cytoplasm. • The new cell membrane forms. • In plants the cell plate is formed and the cell wall begins to form.