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Download The Cell Cycle
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The Cell Cycle Year 12 Biology C9 Draw a circle to the left hand side of the page Divide the circle into four sections Divide the righthand quarter into fourths. G2 Phase Label the quarters M P h a s e S Phase G1 Phase G2 Phase Label the phases of M-phase (Mitosis) M P h a s e S Phase G1 Phase Add details of each phase of mitosis. G2 Phase S Phase G1 Phase Add details of each phase of mitosis. G2 Phase S Phase G1 Phase Add details of each phase of mitosis. G2 Phase S Phase G1 Phase Add details of each phase of mitosis. G2 Phase S Phase G1 Phase Add details of each phase of the cell cycle G2 Phase S Phase G1 Phase Add details of each phase of the cell cycle G2 Phase S Phase Cell growth Energy Organelles G1 Phase Add details of each phase of the cell cycle G2 Phase S Phase DNA Synthesis Cell growth Energy Organelles G1 Phase Add details of each phase of the cell cycle G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles G1 Phase Add checkpoints G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles Check for DNA Damage Cell big enough? G1 Phase Add checkpoints G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles Check for DNA Damage Cell big enough? G1 Phase Check for DNA Synthesis Cell size Add checkpoints G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles Check for DNA Damage Cell big enough? G1 Phase Check for DNA Synthesis Cell size Add checkpoints G2 Phase Cell Growth Check for DNA Synthesis Cell size Energy S Phase Hold to break down cyclins DNA Synthesis Cell growth Energy Organelles Check for DNA Damage Cell big enough? G1 Phase Add checkpoints G2 Phase Cell Growth Check for DNA Synthesis Cell size Energy S Phase Pause to break down cyclins DNA Synthesis Cell growth Energy Organelles Check for DNA Damage Cell big enough? G1 Phase Add checkpoints G2 Phase Cell Growth Check for DNA Synthesis Cell size Energy S Phase Pause to break down cyclins DNA Synthesis Cell growth Energy Organelles Check for DNA Damage Cell big enough? G1 Phase Add external growth factors… G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles G1 Phase Nucleus Mitosis promoting factor (e.g. hormone) Nucleus makes internal regulators.. G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Mitosis promoting factor (e.g. hormone) Organelles Nucleus G1 Phase Kinase Cyclin Nucleus makes internal regulators.. G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles G1 Phase Nucleus CDK complex Mitosis promoting factor (e.g. hormone) CDKs build up… G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles G1 Phase CDK complex CDKs build up… G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles G1 Phase CDK complex CDKs build up… G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles G1 Phase CDK complex CDKs build up… G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles G1 Phase CDK complex CDKs build up… G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles G1 Phase CDK complex G2 Phase Cell Growth Energy S Phase CDKs start to break down… DNA Synthesis Cell growth Energy Organelles G1 Phase CDK complex G2 Phase Cell Growth Energy S Phase CDKs start to break down… DNA Synthesis Cell growth Energy Organelles G1 Phase CDK complex G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles G1 Phase Only when all CDK has broken down can the cell proceed to Metaphase… G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy Organelles G1 Phase Only when all CDK has broken down can the cell proceed to Metaphase… G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy At telophase the cell can go into G0 phase (and remain there) or continue on to the cell cycle… Organelles G0 phase G1 Phase G2 Phase Cell Growth Energy S Phase DNA Synthesis Cell growth Energy The cell may then become differentiated into any one of the 200 body cells in humans.. Organelles G0 phase G1 Phase Differentiation G2 Phase Cell Growth Energy S Phase Role of inhibitors… •p27blocks the build up of CDK complex during G1 and prevents movement to S phase DNA Synthesis Cell growth Energy Organelles G1 Phase p27 CDK complex p53 G2 Phase Cell Growth Energy p53 S Phase Role of inhibitors… •p27blocks the build up of CDK complex during G1 and prevents movement to S phase •p53 stops cell cycle at any point if DNA is damaged. DNA Synthesis Cell growth Energy Organelles G1 Phase p53 CDK complex G2 Phase Cell Growth Energy S Phase Role of inhibitors… If mutations occur to inhibitors – cancer may result i.e. uncontrolled cell cycle. DNA Synthesis Cell growth Energy Organelles G1 Phase CDK complex
