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Medication Policies The Regence Group and its affiliated Plans use medication policies for coverage decisions within the member’s written benefits. Below are summaries of recent changes to The Regence Group’s medication policies. The detailed policies and complete Medication Policy Manual are available online at http://www.blue.regence.com/policy/medication/contents.html. We have included the policy number for your convenience. NEW POLICIES (PUBLISHED WITHIN THE LAST 6 MONTHS) Policy Name and Number Summary of Policy Approval Date New policy allowing coverage of Actonel-containing medications when a generic oral bisphosphonate, such as alendronate, was not tolerated or is contraindicated 7/18/2008 Policy effective December 1, 2008. New policy allowing coverage of IV Boniva when an oral bisphosphonate, such as alendronate, was not tolerated or is contraindicated. 7/18/2008 New policy allowing coverage of oral Boniva when a generic oral bisphosphonate, such as alendronate, and oral Actonel® has been ineffective or is contraindicated. 7/18/2008 Policy effective December 1, 2008. New policy allowing coverage of Reclast when an oral bisphosphonate, such as alendronate, was not tolerated or is contraindicated. 7/18/2008 New policy allowing coverage of Arcalyst for cryopyrin-associated periodic syndromes (CAPS) when there is laboratory evidence of mutation in the CIAS1 gene, and there is documentation that the patient is experiencing classic CAPS symptoms resulting in significant functional impairment. 7/18/2008 (Click on policy name for link to policy) Actonel®, risedronateContaining Medications (Actonel, Actonel with Calcium) Dru155 Boniva®, ibandronate injection Dru156 Boniva®, ibandronate oral Dru157 Reclast®, zoledronic acid Dru158 Arcalyst®, rilonacept Dru159 © 2008 The Regence Group. All rights reserved. Page 1 of 5 NEW POLICIES (PUBLISHED WITHIN THE LAST 6 MONTHS) - CONTINUED Policy Name and Number (Click on policy name for link to policy) Cimzia®, certolizumab pegol Dru160 Relistor®, methylnaltrexone Dru161 Nplate®, romiplostim Dru162 Approval Date Summary of Policy New policy allowing coverage of Cimzia for the treatment of Crohn’s disease following prior unsuccessful treatment with systemic corticosteroids or an oral immunomodulatory medication and either Humira® or Remicade®. 7/18/2008 New policy allowing coverage of Relistor for opioidinduced constipation in terminally ill patients when treatment with a standard bowel regimen has been ineffective. 9/12/2008 New policy allowing coverage of Nplate for idiopathic thrombocytopenia purpura (ITP) when other treatments have been inadequate. 11/14/2008 © 2008 The Regence Group. All rights reserved. Page 2 of 5 Policy Updates as of November 14, 2008 Policy Name Summary of Changes (Click on policy name for link to policy) Policy No. Actiq®, fentanyl citrate oral transmucosal lozenges Policy update – No Criteria Changes Amerge®, naratriptan Policy update – No Criteria Changes Dru052 Amevive®, alefacept Policy update – No Criteria Changes Dru088 Axert®, almotriptan Policy update – No Criteria Changes Dru053 Celebrex®, celecoxib Policy update – No Criteria Changes Dru041 No Criteria Changes Dru002 Policy archived Dru089 Cimzia®, certolizumab pegol Policy update – No Criteria Changes Dru160 Effexor XR®, venlafaxine extendedrelease capsules Policy update – No Criteria Changes Dru146 Emend®, aprepitant No Criteria Changes Dru091 Enbrel®, etanercept No Criteria Changes Dru035 Fentora®, fentanyl buccal tablet Policy update – No Criteria Changes Dru141 Frova®, frovatriptan No Criteria Changes Dru054 Gleevec®, imatinib mesylate No Criteria Changes Dru043 Humira®, adalimumab No Criteria Changes Dru081 Imitrex®, sumatriptan No Criteria Changes Dru055 Kineret®, anakinra No Criteria Changes Dru049 Cerezyme®, imiglucerase Chelation Therapy Dru073 Policy updated to state that quantities exceeding 96 lozenges per month are considered not medically necessary. © 2008 The Regence Group. All rights reserved. Page 3 of 5 Policy Updates as of November 14, 2008 - CONTINUED Policy Name Summary of Changes (Click on policy name for link to policy) Policy No. Kytril®, granisetron No Criteria Changes Dru068 Maxalt®/Maxalt MLT®, rizatriptan No Criteria Changes Dru056 Orencia®, abatacept No Criteria Changes Dru129 Opana ER®, oxymorphone extendedrelease Policy update – criteria changes Dru142 Opioids for Chronic Non-Cancer Pain Policy update – criteria changes OxyContin®, oxycodone, Controlled Release Policy update – criteria changes Raptiva®, efalizumab No Criteria Changes Dru104 Relpax®, eletriptan No Criteria Changes Dru092 Policy update – No Criteria Changes Dru036 Remicade®, infliximab Reauthorization criteria simplified by removing requirement that patient be evaluated by consulting physician specializing in area thought to be the source of the patient’s non-cancer pain. Dru084 Reauthorization criteria simplified by removing requirement that patient be evaluated by consulting physician specializing in area thought to be the source of the patient’s non-cancer pain. Dru042 Reauthorization criteria simplified by removing requirement that patient be evaluated by consulting physician specializing in area thought to be the source of the patient’s non-cancer pain. Position statement updated to include “Efficacy in Rheumatic Conditions,” Efficacy in Crohn’s Disease” and “Efficacy in Plaque Psoriasis” tables. Sprycel®, dasatinib No Criteria Changes © 2008 The Regence Group. All rights reserved. Dru137 Page 4 of 5 Policy Updates as of November 14, 2008 - CONTINUED Policy Name Summary of Changes (Click on policy name for link to policy) Stadol NS®, butorphanol Policy archived tartrate nasal spray Policy No. Dru063 Tasigna®, nilotinib No Criteria Changes Dru151 Zavesca®, miglustat No Criteria Changes Dru109 Zofran®, ondansetron No Criteria Changes Dru046 Zomig®/Zomig ZMT®, zolmitriptan No Criteria Changes Dru057 © 2008 The Regence Group. All rights reserved. Page 5 of 5