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Pharmaceutical Services Division Penang State Health Department 2014 Good Prescribing Guideline This is a general guide for good prescribing practice within MOH facilities in Penang State. Users are advised to refer to the policy currently used at the respective facilities and update accordingly. Pharmaceutical Services Division Penang State Health Department Ministry of Health Malaysia i Good Prescribing Guideline GOOD PRESCRIBING GUIDELINE First Edition 2014 This is a publication of the Pharmaceutical Services Division, Penang State Health Department. Enquiries are to be directed to the address below. Permission is hereby granted to reproduce information contained herein provided that such reproduction be given due acknowledgement and shall not modify the text. This guideline can be downloaded from JKNPP website at www.jknpenang.moh.gov.my Pharmaceutical Services Division, Penang State Health Department, Aras 8, Bangunan Persekutuan, Jalan Anson, 10400 Pulau Pinang, Malaysia. Tel: 04 - 2292319 Fax: 04 - 2280314 Website: www.jknpenang.moh.gov.my ii Good Prescribing Guideline TABLE OF CONTENTS PAGE 1. ACKNOWLEDGEMENT 1 2. FOREWORD BY THE DIRECTOR OF PENANG STATE HEALTH DEPARTMENT 3 3. FOREWORD BY DEPUTY DIRECTOR (PHARMACY) OF PENANG STATE HEALTH DEPARTMENT 4 4. INTRODUCTION 5 5. GOOD PRESCRIBING PRINCIPLES 6 A. Details Pertaining to Medicines 6 B. Details Pertaining to Patient’s Data 9 C. Details Pertaining to Prescriber 9 6. ERROR PRONE ABBREVIATIONS, SYMBOLS & DOSE DESIGNATION 10 7. ACCEPTABLE TERMS AND ABBREVIATIONS 13 A. Drug Name 13 B. Prescribing Term 13 8. REFERENCES 14 9. APPENDICES 15 Appendix 1 - List of Acceptable Brand Names 15 Appendix 2 - List of Acceptable Drug Name Abbreviations 19 Appendix 3 - List of Acceptable Terms or Abbreviations 20 (a) Frequency or Timing 20 (b) Route of Administration 21 (c) Units of Measure and Concentration 22 (d) Dosage Forms 23 iii Good Prescribing Guideline Acknowledgement This guideline is an initiative by the Medication Safety Committee of Pharmaceutical Services Division, Penang State Health Department. The committee would like to express our heartfelt gratitude to Dato’ Dr. Hj. Lailanor bin Hj. Ibrahim (former Director of Penang State Health Department), Puan Zainab Md Yusuf (former Deputy Director (Pharmacy) of Penang State Health Department), members of the reviewers, contributors and all those involved for their valuable and constructive comments in the completion of this guideline. Reviewers Dato’ Dr. Ong Loke Meng Head of Medical Department Hospital Pulau Pinang Dr. Revathy Nallusamy Head of Paediatric Department Hospital Pulau Pinang Dr. Anita Bhajan Manocha Head of Medical Department Hospital Seberang Jaya Dr. Siti Khamariah Ahmad Family Medicine Specialist Pejabat Kesihatan Daerah Timur Laut Pn Noraini Ab. Kadir Senior Principal Assistant Director Pharmacy Practice & Development Division (Penang State) Cik Nor Hasni Haron Pharmacist, Hospital Pulau Pinang Pn Nurazrina Yuzrin Pharmacist, Hospital Seberang Jaya Contributors Oiyammaal M. Chelliah Pharmacist, Hospital Pulau Pinang Hafizah Hamad Pharmacist, Hospital Seberang Jaya Maryam Omar Pharmacist, Hospital Bukit Mertajam Afida Amir Ismet Amir Mohd Idris Pharmacist, Hospital Kepala Batas Ong Chiou Ting Pharmacist, Hospital Sungai Bakap Chung Sook Meng Pharmacist, Hospital Balik Pulau Suraniza Suhaimi Pharmacist, PKD Seberang Perai Utara Lee Shi Mun Pharmacist, PKD Seberang Perai Utara Nurzawani Mat Yusoff Pharmacist, PKD Seberang Perai Tengah Tan Siew Chin Pharmacist, PKD Seberang Perai Selatan Kua Wen Chyi Pharmacist, PKD Timur Laut Ng Wei Min Pharmacist, PKD Barat Daya Tan Pei Ling Senior Assistant Director Pharmacy Practice and Development Division (Penang State) 1 Good Prescribing Guideline Editors 2 Afida Amir Ismet Amir Mohd Idris Pharmacist, Hospital Kepala Batas Chua Cheah Chin Pharmacist, Hospital Kepala Batas Chung Sook Meng Pharmacist, Hospital Balik Pulau Sherene Tan Su Ann Pharmacist, Hospital Pulau Pinang Siti Hajar Rosli Pharmacist, Hospital Balik Pulau Tan Shu Hwa Pharmacist, Hospital Kepala Batas Good Prescribing Guideline Foreword Director Penang State Health Department Patient safety has become a fundamental priority in healthcare organizations worldwide and increasing effort is being invested to ensure patient safety. In the year 1999, a landmark report entitled “To Err is Human” by Institute of Medicine (IOM) triggered healthcare organizations to give serious consideration in reducing and preventing medication errors. In response to that, studies were actively conducted at all stages of medication use from prescribing, ordering, dispensing, administering and monitoring of medications to determine causes and enforce the strategies to reduce the incidence of medication errors. The Joint Commission revealed that communication failure was one of the leading causes of sentinel events from the year 2004 till June 2013. In Malaysia, the incidence of medication errors due to abbreviations and non-standard nomenclature was the foremost reported error with a prevalence of 95.2% at non-specialist hospitals and 95.1% at specialist hospitals. Generally, this error occurred when healthcare providers responsible for reading, interpreting and processing medication orders misinterpret an abbreviation causing the final medicinal outcome to differ from the intended meaning. Education on good prescribing practice among healthcare providers is essential in reducing medication error and developing a safe environment in healthcare organizations. I hope this Good Prescribing Guideline will be a good guide to all healthcare providers who are involved in each level of medication use process. This will result in safe medication practice that ensures patients receive the best and safest treatment. Finally, I would like to thank the committee who have contributed their precious time and effort in establishing this guide to ensure a safe healthcare practice for Penang state. Thank you. With Best Regards, DATO’ DR. HJH. ZAILAN BINTI DATO’ HJ. ADNAN Director of Penang State Health Department 3 Good Prescribing Guideline Foreword Deputy Director (Pharmacy) Penang State Health Department Medication safety is well recognized as a very important element in patient care. It is important to ensure that medication errors are prevented at all stages of the medication use process which comprises of prescribing, documenting, dispensing, administering and monitoring. Ever since Pharmaceutical Services Division of the Ministry of Health introduced the Medication Error Reporting System, there was a paradigm shift in the healthcare team towards developing a non-punitive culture. Medication error reports were extensively reported allowing more preventive actions to be identified and acted upon in all healthcare facilities. Some of which include the use of Tallman lettering for sound alike medications and the labelling of High Alert Medications in red. Prescribing is the most initial stage where medication error can occur and it is crucial to establish safeguards to prevent its occurrence from this point. It has been estimated that 1% of hospitalized patients suffer adverse events as the result of medical mismanagement and that drug related complications are the most common type of adverse event. A guideline on safe prescribing practice is indeed beneficial in reducing prescribing errors. Pharmaceutical Services Division of Penang has proactively established a Good Prescribing Guide as a reference to all healthcare providers as a step in creating a safe prescribing practice. It is hoped that this guide will facilitate healthcare providers in treating patients and to help them in identifying problem-prone medication in their respective facilities. Monitoring and supervision must be continuous to ensure sustainability and on-going systems improvements. All drugs listed in this guideline are the most common drugs used in our healthcare facilities. This list may be edited at the individual health facility based on localized medication error reports. With that, I would like to express my appreciation to all members in the working committee and the reviewers who had taken great effort in establishing this Good Prescribing Guideline. I hope this guide will serve its purpose well in reducing medication errors and instilling safe medication practice in the state of Penang. Thank you. ZUBAIDAH CHE’ EMBEE Deputy Director (Pharmacy) of Penang State Health Department 4 Good Prescribing Guideline Introduction Patient safety has become a fundamental mission in healthcare organizations worldwide and increasing effort is being invested to ensure patient safety. In the year 1999, a landmark report “To Err is Human” by Institute of Medicine (IOM) triggered healthcare organizations in giving serious consideration to reducing and preventing medication errors1. As part of this response, studies were actively conducted at all stages of medication use processes, which included the prescribing, ordering, dispensing, administering and monitoring of medications to determine causes and strategies to reduce the incidence of medication errors. The Joint Commission revealed that communication failure was one of the leading causes of sentinel events from 2004 to June 2013 2. In Malaysia, the incidence of medication errors due to abbreviations and non-standard nomenclature was the foremost reported error with a prevalence of 95.2% at non-specialist hospitals and 95.1% at specialist hospitals3. This error in general occurred when healthcare providers responsible for reading, interpreting and processing medication orders misinterpret an abbreviation causing the final medicinal outcome to differ from intended meaning. Educating all healthcare providers on good prescribing practice will hopefully reduce medication error and develop a safe culture in healthcare organizations3. Objectives 1. To create and promote awareness of good prescribing practice among healthcare providers. 2. To minimize medication error due to prescribing error in handwritten prescriptions. 3. To establish a guide and training module on good prescribing practice for handwritten prescriptions. Scope 1. All handwritten prescriptions or medication orders (including Chemotherapy Request Forms) from outpatient and inpatient settings. 2. All hospitals and health clinics under the care of Penang State Health Department. 5 Good Prescribing Guideline Good Prescribing Principles A. Details Pertaining to Medicines All prescriptions must be written CLEARLY, LEGIBLY and INDELIBLY and ATTRIBUTABLE. Write drug names in full. DO NOT use abbreviations. Exception may be made for approved drug name abbreviations. Refer to Appendix 2 - List of Acceptable Drug Name Abbreviations DO NOT use chemical names or symbols. e.g. HCl (hydrochloric acid or hydrochloride) may be mistaken for KCl (potassium chloride). Exception may be made for approved drug names abbreviations. Refer to Appendix 2 - List of Acceptable Drug Name Abbreviations Drug name4,5 Use generic drug names. Exception may be made for: a) Combination products and approved brand names. b) Drugs where significant bioavailability issues exist. e.g. Adalat® vs. Nifedipine, Plavix® vs. Clopidogrel c) Unless otherwise specified, an equivalent generic brand will be dispensed for any medication ordered by brand name. e.g. “Please supply Plavix® for stented patient “ Refer to Appendix 1 - List of Acceptable Brand Names Where different formulations/ strengths /devices of a medication are available, it is important that details are clearly stated on the prescription. e.g. Actrapid Penfill or Actrapid Vial MDI Budesonide or Turbuhaler Budesonide DO NOT use trailing zeroes. e.g. Use 5mg, NOT 5.0mg Dose4,5 Use a leading zero in front of a decimal point for a dose less than 1. e.g. Use 0.5mg, NOT .5mg 6 Good Prescribing Guideline A. Details Pertaining to Medicines Use words or Hindu-Arabic numbers. e.g. One, Two, Three or 1, 2, 3, etc. DO NOT use Roman numerals. e.g. Do not use ‘II’ for two, ‘III’ for three, ‘V’ for five, etc. Quantities of 1 gram or more should be written in grams e.g. 1g, 1.5g, etc. Quantities less than 1 gram should be written in milligrams e.g. 500mg, NOT 0.5g Quantities less than 1 miligram should be written in micrograms e.g. 100mcg, NOT 0.1mg Where fractions need to be used, circle the dose to denote clearly, e.g. ‘½ tab’ could be interpreted as ‘half’ or as ‘one to two’ tablets Therefore, write Dose4,5 ½ if the intended meaning is ‘half a tablet’. For figures above 100, a) Use words to express intent. e.g. One thousand, one million, six million, etc b) Use commas for dosing units at or above 1,000 e.g. Syr. Nystatin 100,000 units qid For insulin, prescribe as ‘units’ in full with a space in between numbers and dose, e.g. ‘12 units’ DO NOT abbreviate as this is often associated with ten-fold errors, e.g. ‘U’ or ‘ü’ can be mistaken for number ‘0’. For multiple dose insulin, written as: S/C Actrapid Penfill 12 units am 10 units noon 13 units pm For combination drugs, specify: a) Strength b) Quantity of tablets per dose e.g. Tab. Glucovance (500mg/5mg) 2 tabs BD 7 Good Prescribing Guideline A. Details Pertaining to Medicines Dose4,5 For inhalers, prescribe as number of doses NOT puffs (unless a combination inhaler is involved). e.g. MDI Budesonide 200mcg BD Accuhaler Seretide (50mcg/250mcg) 1 puff BD For psychotropic drugs, prescribe as number of doses NOT number of tablets. e.g. Tab. Clonazepam 1mg ON/ PRN x 7 doses Dose units4,5 Diagnosis4,5 The term millilitre is abbreviated as mL or ml, NOT cc or cm3. Avoid acronyms or abbreviations for medical terms (diagnosis) and procedure names on orders or prescriptions. Refer to Appendix 3 - List of Acceptable Terms or Abbreviations Frequency MUST always be specified, even for ‘as required’ medications. Where appropriate, state the quantity of drug to be given. e.g. Tab. Paracetamol 1g tds / PRN x 10 tablets Frequency4,5 Express dosage frequency unambiguously. e.g. Use ‘two times a week’, NOT ‘biweekly’ as the latter could be confused as ‘every two weeks’ For drugs to be administered only on specific days of the week, then those days must always be written in full. e.g. S/C Erythropoietin Beta 2,000 units 3x/ week on Monday, Wednesday and Friday Duration should be written clearly on the prescription. Duration6 If possible, for long term prescriptions (chronic illnesses), the appointment date (TCA) for the patient to visit the facility again can be written on the TOP RIGHT of the prescription so that both patient and pharmacist are left with no ambiguity as to the quantity to be consumed/ dispensed. For short term / PRN usage, the number of tablets to be given should be written. e.g. Tab Paracetamol 1g tds / PRN x 10 tablets It can also deter patients from using more or less of the medicine. 8 Good Prescribing Guideline B. Details Pertaining to Patient’s Data One prescription for one patient. Patient’s data6 Patient's full name, full I.C. number (12 digits) or Hospital RN must be stated on all prescriptions for proper identification of a patient, their age and gender. (Age must be stated on all prescriptions) AGE and WEIGHT must be stated on all PAEDIATRIC prescriptions. e.g. Age: 2 years (14kg) The DATE when the prescription is written must be stated. C. Details Pertaining to Prescriber Prescriber’s information7 Prescriber’s signature & name stamp with MMC, department and hospital must be provided. 9 Good Prescribing Guideline Error Prone Abbreviations, Symbols and Dose Designation One of the major causes of medication errors is the ongoing use of potentially dangerous abbreviations and dose expressions8. The abbreviations, symbols and dose designations found in this table have been reported as being frequently misinterpreted and involved in harmful medication errors. They should never be used when communicating medical information. This includes internal communications, telephone or verbal prescriptions, computer-generated labels, labels for drug storage bins, medication administration records, as well as pharmacy and prescriber computer order entry screens. Abbreviations µg Intended Meaning Microgram Misinterpretation Mistaken as ‘mg’. Correction Use ‘mcg’ or ‘microgram’ cc Cubic centimeters Mistaken as ‘u’ (units). Use ‘mL or ml’ IJ Injection Mistaken as ‘IV’ or ‘intrajugular’. Use ‘Inj’ IU International unit Mistaken as ‘IV’ (intravenous) or ‘10’ (ten). Use ‘units’ q.d. or OD Once daily Mistaken as ‘BD’ or ‘QID’. Use ‘daily’ Mistaken as ‘q.i.d.’, especially if the period after the ‘q’ or the tail of the ‘q’ is misunderstood as an ‘i’. U or ü Unit Mistaken as the number ‘0’ or Use ‘units’ number ‘4’, causing a 10-fold overdose or greater. e.g. 4U seen as ‘40’ or 4ü seen as ‘44’. Mistaken as ‘cc’ causing the dose to be dispense in volume instead of units. e.g. 4u seen as 4cc ung 10 Ointment Latin abbreviation, not universally understood. Use ‘oint’ Good Prescribing Guideline Abbreviations SR Intended Meaning Slow Release Misinterpretation Mistaken as Syrup. e.g. SR Morphine mistaken as Syrup Morphine. Correction ‘SR’ to be written after a drug name. e.g. T. Morphine SR O oral biweekly Two possible meanings, i.e. ‘two times a week’ or ‘every two weeks’ X (10) Two possible meanings, i.e. ‘10 doses’ or ‘10 tablets’ 6/24 Every 6 hours 1/2 Half Mistaken as number ‘0’. - Use ‘T’ or ‘Tab’ for tablet, ‘C’ or ‘Cap’ for Capsule and ‘Syr’ for syrup Use ‘2x/ week’ or ‘every two weeks’ e.g. “T. Clonazepam 1mg ON x Prescribe as number of (10) “can be interpreted as ‘10 doses. tablets’ or ‘10 doses’. e.g. T. Clonazepam 1mg ON x (10 doses) Note: T. Clonazepam currently comes in 2mg strength. Mistaken as ‘six times a day’. Use ‘6 hrly’ or ‘QID’ Mistaken as ‘one or two’. Use ½ and circle it, i.e. I/I , II/II , III/III e.g. Cap. Cloxacillin II/II QID One, two, three Trailing zero after decimal point, e.g. 1.0mg 1 mg ½ Availability of drug dosage depends on product purchased. A capsule of Cloxacillin could be 250mg or 500mg. Use usual dose in numbers. e.g. Cap. Cloxacillin 250mg QID Mistaken as 10mg if the decimal point is not seen. DO NOT use trailing zeros for doses expressed in whole numbers. Write ‘1mg’ instead of ‘1.0mg’ “Naked” decimal point, e.g. .5mg 0.5 mg Mistaken as 5mg if the decimal point is not seen. Write ‘0.5 mg’ instead of ‘.5mg’ 11 Good Prescribing Guideline Abbreviations Drug name and dose written closely (especially problematic for drug names that end with letter ‘l’ e.g. Metoprolol50mg; Bisoprolol5mg) Intended Meaning Metoprolol 50mg Misinterpretation Mistaken as Metoprolol 150mg Bisoprolol 5mg Mistaken as Bisoprolol 15mg Large doses without properly placed commas e.g. 100000 units; 1000000 units 100,000 units 100000 has been mistaken as 10,000 or 1,000,000; 1000000 has been mistaken as 100,000. Sound alike brand names e.g. ‘Losec’ and ‘Lasix’ Either one of the drug Correction Place adequate space between the drug name, dose and unit of measure. Use commas for dosing units at or above 1,000 or use words such as ‘100 thousand’ or ‘1 million’ to improve readability. Omeprazole (Losec) has been Use generic names mistaken as Frusemide (Lasix). except for acceptable brand names. Refer to Appendix 1 List of Acceptable Brand Names x3d / (slash mark) 12 For three days Mistaken as ‘3 doses’ Separates two doses Mistaken as the number ‘1‘. or indicates ‘per’ e.g. ‘25 units / 10 units’ misread as ‘25 units and 110 units’ Use ‘x3 days’ or ‘3/7’ Use ‘per’ rather than a slash mark to separate doses @ at Mistaken as number ‘2’ Use ‘at’ & and Mistaken as number ‘2’ Use ‘and’ + plus or and Mistaken as number ‘4’ Use ‘and’ Good Prescribing Guideline Acceptable Terms and Abbreviations Abbreviations should be avoided at all if possible, but in the event of abbreviations being utilised, only those approved and contained within this document are permitted to be used within MOH facilities in Penang State. A. DRUG NAME 1. Drug names must always be written in full generic names. 2. It may sometimes be appropriate to use the brand name (innovator drug) to avoid confusion, such as in: Insulins Combination products Multi-ingredient preparations Overly long and complicated drug names 3. Drug names MUST NEVER be abbreviated under any circumstance. Exceptions: Modified release products - slow release, controlled release, continuous release or other modified release products, the description used in the brand name to denote the release characteristics should be included with the generic drug name, for example tramadol SR, carbamazepine CR Refer to Appendix 1 - List of Acceptable Brand Names Appendix 2 - List of Acceptable Drug Name Abbreviations B. PRESCRIBING TERM 1. Write in full - avoid using abbreviations wherever possible, including Latin abbreviations. 2. Abbreviations used should be commonly used, understood and universal. 3. Do not use symbols. Refer to Appendix 3 - List of Acceptable Terms or Abbreviations 13 Good Prescribing Guideline References 14 1. Kohn LT, Corrigan JM, Donaldson MS, eds. To Err Is Human: Building A Safer Health System. Washington, DC: Committee on Quality of Health Care in America, Institute of Medicine. National Academy Press; 1999. 2. The Joint Commission: Sentinel Events Data: Root Causes by Event Type. [cited 2013 Jul 7]. Available from: http://www.jointcommission.org/assets/1/18/Root_Causes_by_Event_Type_2004-2Q2013.pdf 3. Zaiton K., Abd Haniff M.Y., Siti Norlina S., Atia H., Norma A., Fuziah A.R. Medication Error And Adverse Drug Event Rates Through Medical Records Review. Institute for Health Systems Research. 4. National Terminology, Abbreviations and Symbols to be Used in The Prescribing and Administering of Medicines in Australian Hospitals. Australian Commission on Safety and Quality in Healthcare; October 2006. 5. All Wales Prescription Writing Standards. Clinical Pharmacy Sub group of Welsh Chief Pharmacists Committee; September 2004. 6. Guidelines for Prescription Writing and Handling of Prescriptions and Prescription Medicines. The Voluntary Health Association of Goa; April 2011 7. Laws of Malaysia: Poison Act 1952 (revised 1989). 8. Sentinel Event Alert - Medication Errors Related to Potentially Dangerous Abbreviations: Joint Commission on Accreditation of Healthcare Organisations; 2001. 9. List of Error-Prone Abbreviations, Symbols, and Dose Designations: Institute for Safe Medication Practices; 2005. 10. Insulin Errors – Abbreviations Will Get U in Trouble: Medication Safety Alert! Acute Care Institute for Safe Medication Practices (Edition August 13); 1997. 11. Drug Formulary Ministry of Health Malaysia; 2013. Good Prescribing Guideline Appendices Appendix 1 - List of Acceptable Brand Names 1 Acetylsalicylic Acid 100mg and Glycine 45mg Tablet Acceptable Brand Names Cardiprin 2 Alendronate Sodium 70mg and Cholecalciferol 5600 IU Tablet Fosamax Plus 3 All-Trans Retinoic Acid 10mg Capsule ATRA 4 Amiloride HCl 5mg and Hydrochlorothiazide 50mg Tablet Moduretic 5 Exforge 7 Amlodipine 5mg / 10mg and Valsartan 160mg Tablet Ammonium Bicarbonate, Tincture Ipecac (Mixture Expect Stimulant) Amorolfine 5% Nail Lacquer 8 Amoxicillin and Clavulanate Tablet / Injection / Syrup Augmentin 9 Unasyn 12 Ampicillin and Sulbactam Tablet / Injection / Syrup Anti RhD Gamma Globulin 250mcg/ 2ml Injection (500 units=100mcg) Antilymphocyte / Antithymocyte Immunoglobulin (from horse) Injection Antithymocyte Immunoglobulin (from rabbit) Injection 13 Artemether 20mg and Lumefantrine 120mg Tablet Riamet 14 Drapolene 16 Benzalkonium 0.01% Cream Beractant Intratracheal Suspension (200mg phospholipids in 8 ml vial) Betamethasone 17-valerate Cream 17 Betamethasone 17-valerate Ointment Betnovate Oint. 18 Bismuth Subgallate and Benzyl Benzoate Suppository Anusol 19 Symbicort 24 Budesonide 160mcg and Formoterol 4.5mcg Inhalation Calcipotriol Hydrate 50mcg/g and Betamethasone Dipropionate 0.5 mg/g Ointment Cefoperazone Sodium 500mg and Sulbactam Sodium 500mg Injection Chlorpheniramine Maleate Tablet / Injection Choline Salicylate 8.7% and Cetylkonium Chloride 0.01% Dental Gel Chorionic Gonadotrophin Human (HCG) 5000 IU Injection 25 Clobetasol Propionate 0.05% Cream / Ointment Dermovate Cr / Oint. No. 6 10 11 15 20 21 22 23 Generic Names Expect Stimulant Loceryl Rhogam Atgam Thymoglobulin Survanta Betnovate Cream Daivobet Sulperazone Piriton Bonjela Pregnyl 15 Good Prescribing Guideline 26 Clobetasone Butyrate 0.05% Cream / Ointment Acceptable Brand Names Eumovate Cr / Oint. 27 Clostridium Botulinum Toxin Type A 100 units Botox 28 Clostridium Botulinum Toxin Type A 500 units Dysport 29 Coal Tar, Salicylic Acid and Pinetar Liquid Conjugated Oestrogen 0.625mg and Medroxyprogesterone Acetate 2.5mg Tablet Cyclopentolate 0.2% with Phenylephrine 1% Eye Drops Sebitar Diane 35 34 Cyproterone Acetate 2mg and Ethinyloestradiol 0.035mg Tablet Dexamethasone and Neomycin Sulphate and Polymyxin B Eye Ointment Dexamethasone Sodium Phosphate 0.1% Eye Drops 35 Dinoprostone (Prostaglandin E2 ) 3mg Vaginal Tablet Prostin E2 36 Daflon 38 Diosmin 450mg and Hesperidin 50mg Tablet Diphenhydramine 14mg/ 5ml and Ammonium Chloride 135mg/ 5ml Expectorant Syrup Diphenoxylate with Atropine Sulphate Tablet 39 Dorzolamide HCl 2% Ophthalmic Solution Trusopt 40 Erythropoietin Human Recombinant Injection (alfa) Eprex 41 Erythropoietin Human Recombinant Injection (beta) Recormon 42 Essentiale 44 Essential Phospholipids Capsule Estradiol 1mg (14 tablet) and Estradiol 1mg with Dydrogesterone 10mg (14 tablet) Estradiol 1mg and Dydrogesterone 5mg Tablet 45 Estradiol Valerate 2mg and Norgestrel 0.5mg Tablet Progyluton 46 Ezetimibe 10mg and Simvastatin 20mg Tablet Vytorin 47 Factor IX Injection Factor VII - Factor VIIa (Recombinant) Eptacog Alfa (activated) 100 KIU (2 mg) Injection Ferrous Fumarate, Folic Acid and B Complex Tablets Octaplex / Replenine Gonad F 52 Follitropin Alpha (Recombinant Human FSH) 300 IU Injection Framycetin Sulphate 0.5%, Dexamethasone 0.05% and Gramicidin 0.005% Ear Drops Fusidic Acid 2% in Betamethasone Valerate 0.1% Cream 53 Gamma Benzene Hexachloride 0.1 % Lotion Lindane 54 Gemeprost (Prostagladin E1 Synthetic Analogue) 1mg Pessary Cervagem No. 30 31 32 33 37 43 48 49 50 51 16 Generic Names Premelle 2.5 Cyclomydril Maxitriol Maxidex Benadryl Lomotil Femoston 1/10 Femoston Conti Novoseven Hematinic Sofradex Fucicort Good Prescribing Guideline 55 Glycerin 25% and Sodium Chloride 15% Enema Acceptable Brand Names Ravin enema 56 Hypromellose 0.3% Eye Drops Artificial tears 57 Hypromellose 0.3%, Carbomer 980 Ophthalmic Gel Genteal Gel 58 Tienam 63 Imipenem 500mg and Cilastatin 500mg Injection Insulin Aspart 30% and Protaminated Insulin Aspart 70% 100 U/ml Injection Insulin Recombinant Neutral Human, short-acting 100 IU/ml Injection Insulin Recombinant Synthetic Human, intermediate-acting 100 IU/ml Injection Insulin Recombinant Synthetic Human, pre-mixed 100 IU/ml Injection Interferon Alfa-2b 18 MIU Multidose Injection Pen 64 Interferon Beta-1a 44 mcg Injection Rebif 65 Ipratropium Bromide MDI / Inhalation Solution Atrovent 66 Combivent 68 Ipratropium Bromide and Salbutamol MDI / Inhalation Solution Ipratropium Bromide 20mcg and Fenoterol 50mcg/dose Inhalation Irbersartan and Hydrochlorothiazide Tablet 69 Isosorbide Dinitrate Tablet / Injection Isordil 70 Isorsorbide Mononitrate 50mg SR Capsule Elantan 71 Isorsorbide-5-Mononitrate 30mg or 60mg SR Tablet Imdur SR 72 Levodopa 100mg and Carbidopa 25mg Tablet Sinemet 73 Levodopa 100mg and Benserazide 25mg HBS Capsule Madopar HBS 74 Levodopa 200mg and Benserazide 50mg Tablet Madopar 75 Lopinavir 200mg and Ritonavir 50mg Tablet Kaletra 76 Loratadine 5mg and Pseudoephedrine Sulphate 120mg Tablet Clarinase 77 Losartan and Hydrochlorothiazide Tablet Hyzaar 78 Magnesium Trisilicate Tablet Gelusil 79 Meclozine HCl and Pyridoxine Tablet Veloxin 80 Medroxyprogesterone Acetate Tablet / Injection Provera 81 Metformin and Glibenclamide Tablet Glucovance 82 Metformin and Sitagliptin Tablet Janumet 83 Metformin and Vildagliptin Tablet Methoxy Polyethylene Glycol-epoetin Beta 100mcg/ 0.3ml Injection in Prefilled Syringe GalvusMet No. 59 60 61 62 67 84 Generic Names Novomix Actrapid, Humulin R Insulatard, Humulin N Mixtard, Humulin 30/70 Intron A Berodual N CoAprovel Mircera 17 Good Prescribing Guideline No. 85 Acceptable Brand Names Gelafundin 87 Modified Fluid Gelatin 4% Injection Monobasic Sodium Phosphate 48% and Dibasic Sodium Phosphate 18% Oxytocin 5 units and Ergometrine Maleate 0.5mg/ml Injection 88 Paradichlorobenzene, Turpentine Oil and Chlorbutol Ear Drops Cerumol 89 Peginterferon Alpha-2a 135mcg Prefilled Syringe Pegasys 90 Pegylated Interferon Alpha-2b 100mcg Injection Peg-Intron 91 Phenoxymethyl Penicillin 125mg Tablet Penicillin V 92 Piperacillin 4g and Tazobactam 500 mg Injection Tazocin 93 Potassium Chloride 600mg SR Tablet Slow K 94 Solcoseryl Gel / Oint. 97 Protein Free Haemodialysate 10% Jelly / Ointment Rifampicin 150mg, Isoniazid 75mg and Pyrazinamide 400mg Tablet Rifampicin 150mg, Isoniazid 75mg, Pyrazinamide 400mg and Ethambutol HCl 275mg Tablet Salicylic Acid, Lactic Acid and Oxypolyethoxy Solution 98 Salmeterol 25mcg and Fluticasone Propionate 125mcg Inhalation Seretide 99 Sodium Biphosphate 16% and Sodium Phosphate 6% Solution Fleet enema 100 Sodium Chloride 0.9% Normal Saline 101 Opticrom 103 Sodium Cromoglycate 2% Eye Drops Stavudine 30mg, Lamivudine 150mg and Nevirapine 200mg Tablet Sulfadoxine 500mg and Pyrimethamine 25mg Tablet 104 Sulphamethoxazole 400mg and Trimethoprim 80mg Tablet Bactrim 105 Sulphur 2% and Resorcinol 2% in Calamine Lotion Acne Lotion 106 Tar, Coal Tar and Oleyl Alcohol Liquid Polytar 107 Telmisartan 80mg and Hydrochlorothiazide 12.5mg Tablet Micardis Plus 108 Tywnsta 111 Telmisartan and Amlodipine Tablet Tenofovir Disoproxil Fumarate 300mg and Emtricitabine 200mg Tablet Triamcinolone Acetonide, Neomycin Oil, Gramicidin and Nystatin Ear Drop Triprolidine HCl 2.5mg and Pseudoephedrine HCl 60mg Tablet 112 Ursodeoxycholic Acid 250 mg Capsule Ursofalk 113 Varenicline Tartrate Tablet Champix 114 Zidovudine 300mg and Lamivudine 150mg Tablet Combivir 86 95 96 102 109 110 18 Generic Names Fleet Phospho-Soda Syntometrine Rimcure 3-FDC Akurit-4 Collomack Soln SLN 30 Fansidar Tenvir-Em Kenacomb Actifed Good Prescribing Guideline Appendix 2 - List of Acceptable Drug Name Abbreviations No. Generic Names Acceptable Drug Name Abbreviations 1 Acriflavine 0.1% Lotion Flavin 2 Aqueous Cream Aq Cream 3 Ascorbic Acid Vit C 4 Benzyl Benzoate Emulsion EBB 5 Chloramphenicol CMC 6 Didanosine 250 mg Enteric Coated Capsule Didanosine EC 250mg 7 Dihydrocodeine Bitartrate DF118 8 Emulsifying Ointment Emulsificant Oint. 9 Ferric Ammonium Citrate FAC 10 Glyceryl Trinitrate GTN 11 Liquor Picis Carbonis (Coal Tar) LPC 12 Magnesium Trisilicate Mixture MMT 13 Methyl Salicylate Ointment OMS 14 Oral Rehydration Salt ORS 15 Paracetamol PCM 16 Paste Bismuth Subnitrate, Iodoform and Liquid Paraffin BIPP 17 Potassium Chloride KCl 18 Potassium Citrate Pot. Citrate 19 Potassium Dihydrogen Phosphate Injection KH2PO4 20 Potassium Permanganate KMNO4 21 Silver Sulfadiazine Cream SSD Cream 22 Vitamin B Complex Vit. B Co 23 Vitamin B1 B6 B12 Vit B1 B6 B12 24 White Soft Paraffin WSP 25 White Soft Paraffin 60% and Liquid Paraffin 40% WSP 60% and LP 40% 19 Good Prescribing Guideline Appendix 3 - List of Acceptable Terms or Abbreviations (a) Frequency or Timing Intended Meaning (in the) morning om evening or afternoon pm (at) night on once daily daily twice a day bd three times a day tds four times a day qid every 4 hours every 4 hrs or 4 hourly or 4 hrly every 6 hours every 6 hrs or 6 hourly or 6 hrly every 8 hours every 8 hrs or 8 hourly or 8 hrly every other day eod hourly hrly once a week three times a week 20 Acceptable Terms or Abbreviations Once a week and specify the day in full. e.g. Once a week on Tuesday or 1x / week (Tuesday) Three times a week and specify the days in full. e.g. Three times a week on Mondays, Wednesdays and Saturdays or 3x / week (Mondays, Wednesdays and Saturdays) when required prn immediately stat Good Prescribing Guideline (b) Route of Administration Intended Meaning Acceptable Terms or Abbreviations Epidural Epidural Inhalation Inhalation Intraarticular Intraarticular Intramuscular IM Intrathecal Intrathecal Intranasal Intranasal Intravenous IV Irrigation Irrigation Left Left or ( L ) or Nebulised NEB Naso-gastric NG Oral PO Percutaneous enteral gastrostomy PEG Per vagina PV Per rectum PR Peripherally inserted central catheter PICC Right Right or ( R ) or Subcutaneous S/C Sublingual S/L Topical Topical or LA L R 21 Good Prescribing Guideline (c) Units of Measure and Concentration Intended Meaning 22 Acceptable Terms or Abbreviations gram(s) g international unit(s) units units units kilogram(s) kg litre(s) L milligram(s) mg millilitre(s) mL or ml microgram(s) microgram or mcg percentage % millimole mmol Good Prescribing Guideline (d) Dosage Forms Intended Meaning Acceptable Terms or Abbreviations Ampule Amp Capsule C. or Cap. Cream Cream Controlled Release CR Ear Drops Ear drops Eye Drops Eye drops or Gutt. Eye Ointment Eye ointment or Eye Oint. or Occ. Extended Release XR Immediate Release IR Injection Inj Metered Dose Inhaler Metered dose inhaler or MDI Modified Release MR Mixture Mixture or Mixt. Nasal Spray Nasal spray Ointment Ointment or oint. Pessary Pessary Powder Powder Suppository Supp. Suspension Susp. Syrup Syr Slow Release SR Tablet T. or Tab. Patient Controlled Analgesia PCA 23 Pharmaceutical Services Division, Penang State Health Department Aras 8, Bangunan Persekutuan, Jalan Anson, 10400 Pulau Pinang, Malaysia. Tel : 04 - 2292319 Fax : 04 - 2280314 Website : www.jknpenang.moh.gov.my