Download Drotaverine

DOT
Drotaverine
DESCRIPTION
DOT (Drotaverine Hydrochloride) is a benzylisoquinoline derivative. It is a new
highly potent synthetic antispasmodic drug which is capable of relieving spasms
of various organs. Drotaverine selectively inhibits the phosphodiesterase enzyme
that leads to an increase of the cAMP level producing smooth muscle relaxation.
Like papaverine, it acts directly on the smooth muscle fibers, exceeding
however, the antispasmodic effect of the standard preparations. Drotaverine
Hydrochlo-ride has rapid onset of action, which is very advantageous in cases of
acute painful spastic conditions. In addition to its spasmolytic and vasodilatory
actions Drotaverine Hydrochloride elicits a selective blockade of cardiac betareceptor.
COMPOSITION
Tablet: Each tablet contains Drotaverine Hydrochloride INN 40 mg.
Injection: Each 2 ml ampoule contains Drotaverine Hydrochloride INN 40 mg.
INDICATIONS
● Gastric, Intestinal or pyloric spasm, Irritable bowel syndrome, Spastic
constipation, Tensmus in dysentery
● Cholelithiasis, Cholecystitis, Cholangitis Nephrolithiasis, Ureterolithiasis,
Cystitis
● Spasm of the uterial orifice during delivery, Threatened abortion, Spastic
dysmenorrhoea, Acute parametritis
● Cardio-spasm, Coronary insufficiency, Angina pectoris, Peripheral vascular
disorder.
DOSAGE AND ADMINISTRATION : Tablet
Adult :
The usual dose is 1 to 2 tablets, 3 times daily.
Children :
Children (1-6 years): 1/4 to 1/2 tablet, 1-2 times daily.
Children (>6 years): 1/2 to 1 tablet, 1-2 times daily.
In peptic ulcer, it is expedient to combine Drotaverine Hydrochloride with
atropine or atropine like compounds.
Injection
Subcutaneously or intramuscularly - Usually 2 to 4 ml (1 - 2 ampoules) injection,
1-3 times daily. In case of acute stone colic, 2 to 4 ml (1 - 2 ampoules) may be
given by slow intravenous injection. In case of peripheral arterial spasm or
obstruction, it may be injected intra-arterially.
SIDE EFFECTS
Side effects of Drotaverine are usually mild. In rare cases, dryness of mouth,
nausea and vomiting may occur. Arterial blood pressure may drop following too
rapid intravenous injection.
CONTRAINDICATIONS
Drotaverine is contraindicated in patients who are hypersensitive to this drug.
PRECAUTIONS
Caution should be taken for those patients suffering from hepatic and renal
impairment.
Use in pregnancy
Effect of Drotaverine Hydrochloride in pregnant women is still unknown. So
caution should be taken in pregnancy.
Use in lactation
There is no sufficient data that Drotaverine is excreted in human milk. So caution
should be exercised when Drotaverine is administered to a nursing mother.
DRUG INTERACTIONS
Effects of anti-parkinsonian drugs may be decreased.
SUPPLY
Tablet : Each box contains 10 X 10 tablets in blister pack.
Injection: Each box contains 2 X 5 ampoules in blister pack.
FOR HEALTH, VIGOUR AND HAPPINESS
.
Dhamrai, Dhaka, Bangladesh.