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The Hazelden Betty Ford Foundation’s treatment for opioid addiction In response to the nation’s prescription medication crisis and the rising death toll from accidental overdoses, the Hazelden Betty Ford Foundation formed a cross-disciplinary team of medical, clinical, research, administrative and communications professionals to research, study and implement solutions to the problem in 2012. To give our patients the best chance for long-term recovery, we enhanced treatment programming to include new tracks for those with opioid use disorders. The innovative programming includes alterations to group therapy and lectures as well as the use of certain medications to assist people to a stable, Twelve Step-based recovery lifestyle and ultimate abstinence from opioids. Here are some frequently asked questions about our new treatment for opioid use disorders. Q: Why did the Hazelden Betty Ford Foundation enhance its treatment for opioid use disorders? A: We responded to the national crisis of addiction to opioids, including prescription painkillers (OxyContin, Vicodin, Demerol, etc.) and heroin, and a corresponding increase in the number of accidental deaths related to opioid addiction. Our facilities were seeing an increase in the number of patients seeking treatment for opioid use disorders. In Center City, Minn., for example, those seeking treatment for opioid use disorders rose from 19 percent of patients in 2001 to 30 percent of patients in 2011. A more dramatic jump was seen at our facility for young adults and adolescents in Plymouth, Minn. – from 15 percent of patients in 2001 to 41 percent of patients in 2011. Those with opioid use disorders are highly vulnerable, at-risk patients. They are: • • • More likely to leave treatment before it is completed. Hypersensitive to physical and psychic pain, putting them at higher risk of relapse. At higher risk of death from accidental overdose during relapse. Risk of accidental death increases after people withdraw from opioids and remain abstinent for a period of time, losing tolerance they had established. If they relapse on an opioid dosage they were accustomed to prior to abstinence, when they were highly tolerant, overdose is a likely result. Breathing might be suppressed, resulting in respiratory arrest and death. According to the Centers for Disease Control, about 12 million Americans (age 12 or older) reported nonmedical use of prescription painkillers in 2010; nearly half a million emergency department visits in 2009 were due to people misusing prescription painkillers; and the death toll from prescription painkiller overdose increased more than fivefold in the U.S., from 3,000 deaths in 1999 to 15,500 deaths in 2009. In fact, deaths from drug overdose, driven by the increase in prescription painkiller misuse, now outnumber those caused by car accidents. Q: How is the Hazelden Betty Ford Foundation using medications to treat opioid use disorders? A: We have implemented the extended, adjunctive use of medicines -- in combination with psychological and psychiatric care, Twelve Step based counseling and other therapies -- to increase the potential for those with opioid use disorders to achieve long-term recovery. Q: Which medications does the Hazelden Betty Ford Foundation use, and what are the relative benefits and risks? A: To give patients the best chance at long-term recovery and abstinence, we use two medicines: • Naltrexone. Extended-release naltrexone (which has been used at Hazelden Betty Ford Foundation facilities since 2006 for alcohol dependence) is an opioid receptor blocker (opioid antagonist). When used in the treatment of opioid use disorders, it is administered as an injection once a month. It prevents the binding of opioids to receptors in the brain, eliminating the drug’s ability to produce intoxication or reward. It has been shown to improve treatment retention and reduce craving and relapse. Naltrexone has no abuse potential. • Buprenorphine/naloxone. Buprenorphine/naloxone, taken sublingually on a daily basis, is a partial opioid agonist that activates opioid receptors just as morphine, oxycodone and heroin do, but not to the same degree. It has a very high affinity for opioid receptors, thus preventing the effects of other opioids. Buprenorphine/naloxone inhibits craving, reduces relapse to opioid use and improves treatment retention. It is becoming the primary treatment for opioid use disorders in the United States. It has been shown to improve self‐help group attendance and to be effective for both youths and adults. Treating opioid use disorders with naltrexone and buprenorphine/naloxone is supported by scientific research and recommended by the U.S. Department of Health and Human Services Substance Abuse and Mental Health Services Administration (SAMHSA), National Institute on Drug Abuse (NIDA), Washington Circle (a policy group devoted to improving care for substance use disorders) and the Veterans Administration. Q: Who should get these medications? A: Anyone who is addicted to opioids and at high risk of relapse could be eligible for these medications. The decision, however, will always be voluntary and based on individualized medical assessments. There are some contraindications, such as significant liver or respiratory disease, and these conditions must be carefully assessed. Before using these medications, we work to ensure patients will have access to adequate continuing care, including doctors who are licensed to administer the medications and Twelve Step groups that are receptive to those who are using them. Q: Does this contradict the Hazelden Betty Ford Foundation’s Twelve Step, abstinencebased treatment philosophy? A: We use medications only as an adjunct to, and never as a substitute for, Twelve Step, evidencebased recovery programming. The aim is to engage patients for a long enough period of time to allow them to complete treatment, acquire new information, establish new relationships and become solidly involved in recovery. The goal is always abstinence. Q: How does the Hazelden Betty Ford Foundation define abstinence for someone on buprenorphine/naloxone? A: A person who has an opioid use disorder and is taking medication under the advice and care of a physician to treat the disease is not unlike a post-surgery patient who is using pain medication. If used as directed and not for the purpose of becoming intoxicated, the medication greatly assists in recovery. We can learn from Overeaters Anonymous (OA) and Sex Addicts Anonymous (SAA) to understand how abstinence is defined when the “drug of no choice” or the addictive behavior cannot be entirely eliminated. Those in recovery in these programs specifically define what foods and behaviors constitute recovery and relapse. They continue to eat and to have sex consistent with defined recovery, but not in the same manner as they had during active addiction. Recovery defined by the establishment of new behaviors in this manner is necessary. We view those working a recovery program while using buprenorphine/naloxone as prescribed as being in recovery, and our goal is abstinence. Q: What other protocols are included in your treatment for opioid use disorders? A: Other clinical protocols include opioid-specific groups, lectures and individual therapy. The features of opioid dependence, opioid withdrawal and recovery are incorporated into all aspects of treatment. These treatment protocols focus on engagement over a longer period of time. Therefore, family and recovery community support, along with the use of recovery management interventions that provide significant structure and accountability, are integral parts of the treatment. Q: Is the Hazelden Betty Ford Foundation the only Twelve Step based treatment facility to offer buprenorphine/naloxone? A: We are a leader in the use of certain medications within an abstinence-based Twelve Step recovery program. Our Butler Center for Research is studying the results of our new approach and will disseminate findings. Q: When did the Hazelden Betty Ford Foundation implement the new treatment? A: We launched the new programming at the end of 2012.