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11/13/14 ¨ ¨ ¨ Severe Intractable Watery Rhinorrhea unresponsive to intranasal Steroids/ Atrovent Highly Successful Major risks: Bleeding Drying of Eye Failure to control symptoms Sup. Salivary nucleus VII Sup Petrosal nerve PARASY MP IX Greater deep Petrosal Nerve SYMP Pericarotid SYMP Vidian Nerve V2 Sensor y fibers ¨ ¨ ¨ ¨ Sphenopalatin e ganglion Lacrim al nerve S P F Posterior Nasal Nerve Palata l nerve Not first line management- last resort Intractable Vasomotor rhinitis (NAR) unresponsive to treatment Allergic rhinitis unresponsive to treatment Treatment includes antihistamines, topical/ systemic steroids/topical anti-cholinergics/ tissue volume reduction of inferior turbinates/ SIT/SLIT. Allergen avoidance 1 11/13/14 ¨ Transient cheek & dental numbness – damage to maxillary nerve (foramen rotundum) Nasal crusting, dryness Initiation of bronchial asthma Ocular complications Bleeding ¨ Kamel & Zaher. 1991 first used endoscopic sub periosteal ¨ El Shazly, El-Guindy. 1994 (endoscopic transeptal ¨ Robinson & Wormald. 2006 (endoscopic SPF) SPA ¨ Caldwell Luc approach (transantral) Transpalatal Transnasal – septum Transnasal microscopic Endoscopic ¨ Golding-Wood 1972- n=185 5-15 year follow up 94% relief rhinorrhea ¨ ¨ ¨ approach behind SPF (n=15 cadavers, n=16 patients) approach on face of sphenoid) n=11 ¨ Krant 1979- 71% long term recurrence ¨ Dry Eye reported postoperatively ¨ ¨ ¨ ¨ ¨ Yin recurrence of 66% at 1 year, 85% after 5 years (1990) cauterised, SPF identified first, then ant face sphenoid was opened. Then SPF was enlarged posteriorly up to ant face sphenoid exposing periost of PPF. Incised and transected Vidian nerve before entry into PPF ¨ Lee endoscopic. 2009 transphenoid / Intra sphenoidal approach for embedded Vidian canal with CT imaging n=100 Lee* recommended scanning all patients Classified 3 types of Vidian nerve position Recommended type 1 & 2 INTRA sphenoid approach Type 3 TRANSsphenoid approach Lee J-C & Lin Y-S. Endoscopic Vidian Neurectomy: update on techniques & evidence. Curr Opin Otolaryngol Head Neck Surg 2012, 20:66-72 2 11/13/14 Authors Significa No significant nt changes improve ment Number Follow up patients period Side effects Robinson & Wormald 2006 Rhinorrh Sneezing worse in ea 3/14 patients Nasal Obstructi on 14 35% mild occasional eye dryness 1 permanent 28% nasal crusting Jang et al 2010 Rhinorrh ea Nasal Obstructi on (VAS) Lee et al. 2011 91% satisfied Tan et al 2012 64% ¨ ¨ ¨ ¨ ¨ 2 years 7/14 deemed operation to be highly successful No change in 6 sneezing/itchiness 1/6 patient worse after operation 7 years No additional treatment antihistamine /steroids Mild dry eyes for 1 month 1> 2 months Shirmers pre post op day 1, 30,60 Crusting 84 1.5 years 23% dry eyes post op 93 6 years 30% dry eyes 30d 8% permanent 236 patients self selected one of three treatments Bilateral VN (n=93)/ Septoplasty + inf turbinectomy (n= 51)/nasal steroids for 3 months (n=92) Follow up at 6months, 1 year & 3 & 6 years Rhinoconjunctivitis Qol questionnaire After 6 years 64.7% vs. 6.5% vs. 1.5% much improved ¨ ¨ ¨ *Long term effectiveness and safety of endoscopic VN CEO vol. 3,No 4 Dec 2010 ¨ ¨ ¨ ¨ ¨ ¨ ¨ ¨ ¨ ¨ Troublesome bleeding/fat in PPF Technically challenging Narrow operative field Incorrect identification nerve (pharyngeal Nerve) Incomplete resection of nerve Regeneration nerve ? synkinesis Safety and complications 30.6% dry eyes resolved after one month with sodium hyaluronate eye drops 8.2% no tears with sadness or pain 15% mild nasal dryness 9% numbness upper lip –resolved after 12 months Tan G et al. Arch Otolaryngol Head Neck Surg ,2012,. 138 492-7 Tan G et al. Arch Otolaryngol Head Neck Surg ,2012,. 138 492-7 ¨ Loss of post ganglionic secretomotor fibers to lacrimal gland Incidence in literature of 12-30% Jang TY * Shirmers test pre op, day 1 , 1& 2 months post op. All patients dry eye but improved by 2 months ¨ ¨ ¨ Non selective autonomic denervation of the Pterygopalantine ganglion Similar to a Vagotomy. Is there another approach e.g. Highly selective Vagotomy and will we doing this in the future VN is an evolving operative concept 3 11/13/14 ¨ ¨ ¨ Ikeda*- performed posterior nasal nerve (PNN) Neurectomy to replace VN as it emerged from SPF (2006) together with Inf turbinate submucous resection. Describes PNN as PARAsymp and SYMP fibers always exiting SPF Describes favorable results but 42% submaximal improvement . Ikeda K, Osh et al.Acta Otolaryngol. 2006 Jul;126(7):739-45 ¨ ¨ ¨ ¨ ¨ ¨ ¨ ¨ ¨ Challenge our anatomical teaching of post ganglionic fibers showed multiple individual postganglionic rami to nasal mucosa from PPG (posterior superior to horizontal attachment of IT) 14/16 cadaver sides 2 principal groups fibers and don’t traditionally follow trigeminal nerves Rami sphenoethmoidalis and rami orbitonasalis(ant/post ethmoidal foramen) 3rd group-rami lacrimalis to orbital apex Showed that nasal mucosa is innervated by array of multiple small neurovascular fascicles through multiple fissures and foramina and not just SPF Anastamoses throughout palatine bone and loops with SPF and other nerves Possibility of selective postganglionic pterygopalantine parasymapthectomy (SP3) and avoid rami lacrimales and spare rami orbitofrontalis. Also preserve sympathetic function and increase tone and decrease congestion/nasal obstruction Bleier S & Schlosser R. Int Forum Allergy & Rhinology Vol1, no 2 2011 *International Forum of Allergy & Rhinology, Vol. 1, No. 2, March/ April 2011 Sydney Rhinology Technique Success Rate for resolution of symptoms high Complication rate following VN in both Tumour and Rhinitis patients appears extremely low SO– Currently performing 1.Meta-analysis and systematic review of literature to assess success 2.Prospective Study of Complications using PROMs , Schirmers Test and Dry Eye QOL questionnaires 4