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NUTREX RESEARCH Product Knowledge Key Points LIPO-6 is a powerful and extremely popular fat-burner that utilizes maximum strength liquid capsules for superior absorption and rapid results. This highly advanced method of delivering fast-acting fat-burning compounds makes LIPO-6 a great choice when it comes to weight-loss products. When LIPO-6 was released in 2005 it was the world’s first liquid capsule fat burner. Over the years LIPO-6 has established itself as a proven and reliable tool to lose weight fast. It works great for everyone, man or woman, fitness enthusiast or bodybuilder. LIPO-6 consists of only pure pharmaceutical-strength ingredients that allow for a pronounced, yet consistent and predictable fat-loss effect. Furthermore LIPO-6 is the only liquid capsule fat burner that utilizes all natural vegetable capsules which are completely devoid of any animal products. It is no wonder that LIPO-6 was voted ‘Fat-Loss Product of the Year’ in 2005, 2006, 2007 and 2008 by the popular consumer & industry website www.bodybuilding.com. To this day LIPO-6 is the benchmark for all other liquid capsule fat burners. Some key product highlights include: Synephrine HCL SUPPLEMENT FACTS Serving Size: 2 Liqui-caps • Boosts norepinephrine levels Amount per serving % Daily Value* Synephrine HCL 20mg * • Increases thermogenesis, Synthetic 99% Guggulsterones Z&E 1:1 20mg * enhancing the breakdown of Yohimbine HCL 3mg * Caffeine Anhydrous USP 200mg * fat with muscle-sparing effect Bioperine ** 5mg * • Revs your metabolism without * Daily Value not established. Other Ingredients: Vegetable Cellulose , Purified Water altering heart rate or blood **Bioperine is a registered trademark of Sabinsa Corp. pressure • Exerts a strong appetite suppressing effect ® † ® Synthetic 99% Guggulsterones Z&E 1:1 • Increases thyroid hormone activity, significantly augmenting metabolism • Decreases body fat levels This Product Utilizes • Lowers LDL cholesterol • Inhibits excessive inflammation from intense exercise Yohimbine • Increases lipolytic activity (breakdown of stored body fat) • Improves cognitive alertness and overall mental function Caffeine Anhydrous USP Free of Animal Products • Boosts metabolism, helps shed body fat • Catalyzes neuromuscular transmission, enhancing strength gains and increasing work volume • Improves mental alertness and enhances mood Bioperine® • Enhances the absorption of key ingredients in LIPO-6 making them more potent • Induces thyroid hormone stimulation, increasing metabolism • Augments antioxidant activity in your body and from foods Available in 120 ct and 240 ct. LIPO-6 Detailed Facts Synephrine HCL Synephrine activates ß-3 adrenoreceptors and, therefore, displays a lipolytic and thermogenetic capacity as it boosts norepinephrine levels (1). By consuming synephrine prior to workouts, you enhance fat breakdown with its subsequent utilization for energy. Furthermore, synephrine has a significant muscle-sparing effect while expending energy at the expense of body fat. (2) Synephrine has demonstrated its efficacy as an ephedra alternative for revving your metabolism without altering heart rate or blood pressure. (3-6) Synephrine also exerts a strong appetite suppressing effect making it the ideal compound for calorie-restricted diets. Synthetic 99% Guggulsterones Z&E 1:1 E- and Z-Guggulsterones are the bioactive compounds of Guggul (Commiphora Mukul) that have purported benefits for lowering LDL cholesterol and triglycerides. (7, 8) Guggulsterones also have the capacity to rev your metabolism by increasing the overall thyroid hormone activity with significant influence on triiodothyronine (T3) hormone (thyroid regulator). (9-11) By supplementing with guggulsterones you are also inhibiting excessive inflammatory responses you experience from your exercise regimen. (12) LIPO-6 utilizes a 99% pure 1:1 ratio of synthetic Guggulsterones Z&E. Yohimbine HCL Yohimbine is just right for the thermogenetic concoction in LIPO-6 to help induce lipolysis (fat burning) without the side effects from other fat burners (i.e. increased heart rate, increased blood pressure, anxiety)(14, 15) In particular, Yohimbine induces fat breakdown where fat stores prevail as problem areas. Furthermore, yohimbine induces excitatory effects, improving elements of cognitive function, primarily alertness. (15) Caffeine Anhydrous USP Caffeine provides a variety of enhancements for the neuromuscular system; including increases in secretion of catecholamines (16-18) and calcium release from the sarcoplasmic reticulum (19). Caffeine, with its capacity to optimize skeletal muscle contraction from augmented neuromuscular transmission (20), has demonstrated its ability to enhance strength gains and increase work volume (21-23). While allowing you to work harder caffeine also boosts your metabolism, assisting in body fat loss while recruiting lean body mass. (24, 25) Caffeine also improves mental alertness and mood function, optimizing your level of focus through your workouts or fatigue-battling tasks. (26, 27) By providing caffeine in its anhydrous form, you’re getting a more pure, synthetic form for maximal potency. Bioperine® Bioperine is patented and powerful component of Piper Nigrum L (black pepper) that will stimulate your antioxidant capacity and induce thermogenesis. Bioperine enhances drug and nutrient absorption in the body which improves the effectiveness of the key ingredients in LIPO-6. Bioperine further helps to protect your body’s cells from the damages of oxidative stress. (28-30) In addition, Bioperine possesses thyroid-stimulating capability to significantly diminish body fat and help modulate insulin levels. (31) All numbered references marked above can be found in the References section to follow. LIPO-6 Product Label FAST-ACTING LIQUID CAPSULE FAT BURNER FOR MAXIMUM RESULTS LIPO-6 LIPO-6 LIPO-6 LIPO-6 LIPO-6 LIPO-6 LIPO-6 LIPO-6 SUPPLEMENT FACTS Serving Size: 2 Liqui-caps Amount per serving BURN FAT FAST Servings Per Container: 60 % Daily Value* Synephrine HCL 20mg Synthetic 99% Guggulsterones Z&E 1:1 20mg Yohimbine HCL 3mg Caffeine Anhydrous USP 200mg Bioperine®** 5 mg * Daily Value not established. With Liquid Capsule Technology * * * * * LIPO-6 is a ground breaking fat-loss formula that utilizes a modern liquid-capsule delivery system for maximum results. This unique product is the first and only weight loss agent that combines speed and strength with the usage of animal-free capsule material assuring rapid and healthy weight-loss. It is no wonder Lipo-6 was voted Fat-Loss Product of the Year three times in a row. Other Ingredients: Vegetable Cellulose†, Purified Water **Bioperine® is a registered trademark of Sabinsa Corp. † This product utilizes only natural vegetable capsules that are free of animal products. Strength: Lipo-6 consists of pure pharmaceutical-strength ingredients and does not contain inferior herbal compounds that cannot be efficiently absorbed by the human body. This allows for a pronounced, yet consistent and predictable, fat-loss effect with Lipo-6 as opposed to a guessing game in so called other fat burners that rely on herbal ingredients. MAXIMUM STRENGTH Accelerated Fat-Loss Formula Developed by and exclusively manufactured for: Nutrex Research, Inc. Oviedo, FL 32765 Lipo6.com • 1-888-3NUTREX 6 Dietary Supplement - 120 Liqui-Caps Animal-Free Capsule Material: Lipo-6 utilizes only natural vegetable capsules that are free of animal products. Offering capsules that are of plant origin makes Lipo-6 the ideal choice for the health conscious person. 53237 00080 The statements on this label have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Speed: Superior liquid capsules which have been developed by one of the world’s leading pharmaceutical companies offer a rapid and complete absorption of the powerful fat-burning components in Lipo-6. Without delay, Lipo-6 goes to work almost instantly by targeting stored body fat, controlling your appetite and speeding up your metabolism. 8 RECOMMENDED USE FOR FAT LOSS: Take 2 liqui-caps 30 minutes before breakfast and 2 more liqui-caps in the afternoon. Start off with only 2 liqui-caps on your first two days (1 in the morning and 1 in the afternoon) and increase dosage by 1 liqui-cap every two days until maximum dosage of 4 liqui-caps per day is reached. DO NOT EXCEED 4 LIQUI-CAPS PER DAY. Do not take within 6 hours of sleep. WARNING: Not for use by persons under age 18. Do not use if pregnant or nursing. Do not exceed recommended dose. Do not consume synephrine or caffeine from other sources, including but not limited to, coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine. Contains caffeine. Do not use for more than 8 weeks. Consult your physician prior to use if you are taking medication, including but not limited to, MAOI inhibitors, antidepressants, aspirin, non-steroidal anti-inflammatory drugs or products containing phenylephrine, ephedrine, pseudoephedrine, or other stimulants. Consult your physician prior to use if you have a medical condition, including but not limited to, heart, liver, kidney, or thyroid disease, psychiatric disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Discontinue 2 weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headaches or shortness of breath. KEEP OUT OF REACH OF CHILDREN. LIPO-6 References 1. D’Andrea G, Terrazzino S, Fortin D, Farruggio A, Rinaldi L, Leon A. HLPC electrochemical detection of trace amines in human plasma and platelets and expression of mRNA transcripts of trace amine receptors in circulating leukocytes. Neurosci Lett. 2003, 346:89-92. 2. Kalman DS, Colker CM, Shi Q, Swain MA. Effects of a weight-loss aid in healthy overweight adults: double-blind, placebo-controlled clinical trials. Curr Ther Res. 2000; 61(4):199-205. 3. Colker CM, Kalman DS, Torina GC, Perlis T, Street C. Effects of Citrus aurantium Extract, Caffeine, and St. John’s Wort on body fat loss, lipid levels, and mood states in overweight healthy adults. Curr Ther Res. 1999; 60(3):145-153. 4. Pensak SR, Jann MW, Cold JA, Hon YY, Desai HD, Gurley BJ. Seville (sour) orange juice: synephrine content and cardiovascular effect in normotensive adults. J Clin Pharmacol. 2001, 41(10):1059-63. 5. Moro CO, Basile G. Obesity and medicinal plants. Fitoterapia. 2000, 71 Suppl 1:S73-82. 6. Kreider RB, Almada AL, Antonio J, Broeder C, Earnest C, Greenwood M, Incledon T, Kalman DS, Kleiner SM, Leutholtz B, Lowery LM, Mendel R, Stout JR, Willoughby DS, Ziegenfuss TN. ISSN exercise & sport nutrition review: research and recommendations. Sport Nutr Rev J. 2004, 1(1):1-44. 7. Nityanand S, Srivastava JS, Asthana OP. Clinical trials with guglipid. A new hypolipidaemic agent. J Assoc Physicians India. 1989; 37(5):323-8. 8. Urizar NL and Moore DD. GUGLIPID: a natural cholesterol-lowering agent. Annu Rev Nutr. 2003; 23:303-13. 9. Panda S and Kar A. Guggulu (Commiphora mukul) induces triiodothyronine production: possible involvement of lipid peroxidation. Life Sci. 1999; 65(12):PL137-41. 10. Panda S and Kar A. Guggulu (Commiphora mukul) potentially ameliorates hypothyroidism in female mice. Phytother Res. 2005; 19(1):78-80. 11. Kreider RB, Almada AL, Antonio J, Broeder C, Earnest C, Greenwood M, Incledon T, Kalman DS, Kleiner SM, Leutholtz B, Lowery LM, Mendel R, Stout JR, Willoughby DS, Ziegenfuss TN. ISSN exercise & sport nutrition review: research and recommendations. Sport Nutr Rev J. 2004, 1(1):1-44. 12. Deng R. Therapeutic effects of guggul and its constituent gugglesterone: cardiovascular benefits. Cardiovasc Drug Rev. 2007; 25(4):375-90. 13. Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players. Res Sports Med. 2006; 14(4):289-99. 14. McCarty MF. Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis. Med Hypotheses. 2002; 58(6):491-5. 15. Morgan CA 3rd, Southwick SM, Grillon C, Davis M, Krystal JH, Charney DS. Yohimbine-facilitated acoustic startle reflex in humans. Psychopharmacology (Berl). 1993; 110(3):342-6. 16. Costill, D. L., Dalsky, G. P., Fink, W. J. Effects of caffeine ingestion on metabolism and exercise performance. Med. Sci. Sports Exerc. 1978, 10:155-158. 17. Graham, T. E. Caffeine and exercise: Metabolism, endurance, and performance. Sports Med. 2001, 31:786-807. 18. Ivy, J. L., Costill, D. L., Fink, W. J., Lower, R. W. Influence of caffeine and carbohydrate feedings on endurance performance. Med Sci. Sports Exerc. 1979, 11:6-11. 19. Lopes, J. M., Aubier, M., Jardim, J., Aranda, J. V., and Macklem, P. T. Effect of caffeine on skeletal muscle function before and after fatigue. J Appl. Physiol. 1983, 54:1303-1305. 20. Williams, J. H. Caffeine, neuromuscular function and high-intensity exercise performance. J Sports Med. Phys. Fitness 31:481-489. 1991. 21. Kalmar, J. M., and Cafarelli, E. Effects of caffeine on neuromuscular function. J Appl. Physiol. 1999, 87:801-808. 22. Beck, T. W., Housh, T. J., Schmidt, R. J., Johnson, G. O., Housh, D. J., Coburn, J. W., and Malek, M. H. The acute effects of a caffeine-containing supplement on strength, muscular endurance, and anaerobic capabilities. J Strength Cond Res. 2006, 20(3):506-510. 23. Astorino, T. A., Rohmann, R. L., Firth, K. Effect of caffeine ingestion on one-repitition maximum muscular strength. Euro J of Appl Physiol. 2008. 102(2):127-132. 24. Acheson, K. J., Zahorska-Markiewicz, B., Pittet, P., Anantharaman, K., and Jequier, E. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. American Journal of Clinical Nutrition. 1980. Vol 33, 989-997. 25. Dulloo, A. G., Geissler, C. A., Horton, T., Collins, A., Miller, D. S. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr. 1989. 49:44-50. 26. Lieberman HR, Tharion WJ, Shukitt-Hale B, Speckman KL, Tulley R. Effects of caffeine, sleep loss and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology (Berl). 2002, 164(3):250-61. LIPO-6 References 27. Haskell CF, Kennedy DO, Wesnes KA, Scholey AB. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology (Berl). 2005, 179(4):813-25. 28. Vijayakumar RS, Surya D, Nalini N. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidated stress. Redox Rep. 2004; 9(2):105-10. 29. Srinivasan K. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr. 2007; 47(8):735-48. 30. Badmaev V, Majeed M, Norkus EP. Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. J Nutr Biochem. 2000; 11:109-113. 31. Vijayakumar RS and Nalini N. Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipedeic rats. J Basic Clin Physiol Pharmacol. 2006; 17(2):71-86.