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Transcript
Speaker: Cori Bargmann
Title: Using Fixed Circuits to Generate Flexible Behaviors
Biographical Information:
Cori Bargmann, Ph.D.
HHMI Investigator
Torsten N. Wiesel Professor
Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior
The Rockefeller University, New York
Dr. Bargmann studies the relationships between genes, circuits, and behaviors in the genetically tractable
nematode worm Caenorhabditis elegan, the only animal whose complete synaptic connectivity has been
reconstructed from electron micrographs. The worm’s highly developed senses of smell and taste elicit
strong innate behaviors, but also allow context-specific responses and experience-dependent learning. By
mapping specific behaviors onto individual neurons, manipulating genes that are important for nervous
system function, and monitoring the activity of neurons during behavior, the lab asks how environmental
variation and genetic variation converge to generate flexible behaviors.
Bargmann received a B.S. from the University of Georgia and a Ph.D. from MIT, where she did her thesis
work for Robert A. Weinberg and performed postdoctoral research with H. Robert Horvitz. She was on
the faculty at the University of California, San Francisco from 1991-2004, and joined Rockefeller
University in 2004.