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Speaker: Cori Bargmann Title: Using Fixed Circuits to Generate Flexible Behaviors Biographical Information: Cori Bargmann, Ph.D. HHMI Investigator Torsten N. Wiesel Professor Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior The Rockefeller University, New York Dr. Bargmann studies the relationships between genes, circuits, and behaviors in the genetically tractable nematode worm Caenorhabditis elegan, the only animal whose complete synaptic connectivity has been reconstructed from electron micrographs. The worm’s highly developed senses of smell and taste elicit strong innate behaviors, but also allow context-specific responses and experience-dependent learning. By mapping specific behaviors onto individual neurons, manipulating genes that are important for nervous system function, and monitoring the activity of neurons during behavior, the lab asks how environmental variation and genetic variation converge to generate flexible behaviors. Bargmann received a B.S. from the University of Georgia and a Ph.D. from MIT, where she did her thesis work for Robert A. Weinberg and performed postdoctoral research with H. Robert Horvitz. She was on the faculty at the University of California, San Francisco from 1991-2004, and joined Rockefeller University in 2004.