Download DSM: Thesis SL-DSM-16-0185 - instn

DSM: Thesis SL-DSM-16-0185
RESEARCH FIELD
Solid state physics, surfaces and interfaces / Physique de l'état condensé, chimie et nanosciences
TITLE
lab on chip magnetoresistive biosensors for nano and micro magnetic biologic objects detection
ABSTRACT
The development of technology of early diagnosis, at the same time fast and sensitive, allowing the detection of very small quantities of
(sub) micrometric biological objetcs (cells, bacteria, proteins etc…) is a real challenge in the medical domain. One possible method consists
to label these biological objects with magnetic particles. This feature can be combined with magnetic detection, where magnetoresistive
sensors, developed in our lab (LNO) to measure very low magnetic signals, can be integrated within microfluidic channels to detect these
magnetically labelled biological objects.
During this PhD, the student will develop a lab on chip. He will use the cleaning room technicals to make the GMR sensors and the
microfluidic channels. He will adapt the electronic and the microfluidic parameters to optimize the signal noise ratio (SNR). In collaboration
with the LERI (DSV/IBITECS) specialized for several years in the development of fast tests of detection, he will functionalize magnetic
particles with various antibodies managed against various biological objects (cancer cells, bacteria and proteins).
LOCATION
Institut rayonnement et matière de Saclay
Service de Physique de l'Etat Condensé
Laboratoire Nano-Magnétisme et Oxydes
Place: Saclay
Start date of the thesis: 01/09/2016
CONTACT PERSON
Guenaelle Jasmin-Lebras
CEA
DSM/IRAMIS/SPEC/LNO
Bât 772 pièce 27
Orme des Merisiers
CEA-Saclay
91191 Gif dur Yvette
Phone number: +33 1 69 08 65 35
Email: [email protected]
UNIVERSITY / GRADUATE SCHOOL
Physique en Île-de-France (EDPIF)
Commissariat à l'énergie atomique et aux énergies alternatives
Institut national des sciences et techniques nucléaires
www­instn.cea.fr
1
FIND OUT MORE
http://iramis.cea.fr/Pisp/guenaelle.jasmin-lebras/
http://iramis.cea.fr/spec/LNO/
THESIS SUPERVISOR
Claude FERMON
CEA
DSM/IRAMIS/SPEC/LNO
Bât 776 pièce 2
IRAMIS/SPEC/LNO
Orme des Merisiers
CEA-Saclay
91191 Gif dur Yvette
Commissariat à l'énergie atomique et aux énergies alternatives
Institut national des sciences et techniques nucléaires
www­instn.cea.fr
Powered by TCPDF (www.tcpdf.org)
2