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DSM: Thesis SL-DSM-16-0185 RESEARCH FIELD Solid state physics, surfaces and interfaces / Physique de l'état condensé, chimie et nanosciences TITLE lab on chip magnetoresistive biosensors for nano and micro magnetic biologic objects detection ABSTRACT The development of technology of early diagnosis, at the same time fast and sensitive, allowing the detection of very small quantities of (sub) micrometric biological objetcs (cells, bacteria, proteins etc…) is a real challenge in the medical domain. One possible method consists to label these biological objects with magnetic particles. This feature can be combined with magnetic detection, where magnetoresistive sensors, developed in our lab (LNO) to measure very low magnetic signals, can be integrated within microfluidic channels to detect these magnetically labelled biological objects. During this PhD, the student will develop a lab on chip. He will use the cleaning room technicals to make the GMR sensors and the microfluidic channels. He will adapt the electronic and the microfluidic parameters to optimize the signal noise ratio (SNR). In collaboration with the LERI (DSV/IBITECS) specialized for several years in the development of fast tests of detection, he will functionalize magnetic particles with various antibodies managed against various biological objects (cancer cells, bacteria and proteins). LOCATION Institut rayonnement et matière de Saclay Service de Physique de l'Etat Condensé Laboratoire Nano-Magnétisme et Oxydes Place: Saclay Start date of the thesis: 01/09/2016 CONTACT PERSON Guenaelle Jasmin-Lebras CEA DSM/IRAMIS/SPEC/LNO Bât 772 pièce 27 Orme des Merisiers CEA-Saclay 91191 Gif dur Yvette Phone number: +33 1 69 08 65 35 Email: [email protected] UNIVERSITY / GRADUATE SCHOOL Physique en Île-de-France (EDPIF) Commissariat à l'énergie atomique et aux énergies alternatives Institut national des sciences et techniques nucléaires wwwinstn.cea.fr 1 FIND OUT MORE http://iramis.cea.fr/Pisp/guenaelle.jasmin-lebras/ http://iramis.cea.fr/spec/LNO/ THESIS SUPERVISOR Claude FERMON CEA DSM/IRAMIS/SPEC/LNO Bât 776 pièce 2 IRAMIS/SPEC/LNO Orme des Merisiers CEA-Saclay 91191 Gif dur Yvette Commissariat à l'énergie atomique et aux énergies alternatives Institut national des sciences et techniques nucléaires wwwinstn.cea.fr Powered by TCPDF (www.tcpdf.org) 2