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ANTI-BACTERIAL ANTI-INFLAMMATORY ANTI-FUNGAL The triple-action treatment that’s effective, easy and beneficial to your business. TRESADERM (thiabendazole-dexamethasone-neomycin sulfate) TRESADERM® (thiabendazole-dexamethasone-neomycin sulfate) THE THE SOLUTION SOLUTION IS IS TRESADERM® (thiabendazole-dexamethasone-neomycin sulfate) THE SOLUTION IS IS Ringworm Otitis Externa • Flea Allergy Dermatitis • Hot Spots • Cutaneous Fungal Infections • Focal Pyoderma • Ringworm Otitis Externa • Flea Allergy Dermatitis • Hot Spots • Cutaneous Fungal Infections • Focal Pyoderma • Ringworm TRESADERM® (thiabendazole-dexamethasone-neomycin sulfate) THE SOLUTION IS The underlying cause of a pet’s dermatosis can be difficult to diagnose. And while skin rashes and hot spots may seem like minor irritations to pet owners, they can actually have rashes hot spotsfor may likeofminor irritations to pet owners, they can actually seriousand implications theseem health pets. TRESADERM makes treatment easy – evenhave when serious implications for the health of pets. TRESADERM makes treatment easy – even when the underlying cause is unclear. Here are some of the ways in which TRESADERM treats the cause is make unclear. Here areSpots some the waysFungal in which TRESADERM treats • Ringworm Otitis Externa • Flea Allergy Dermatitis Cutaneous Infections • Hot • of • Focal Pyoderma the underlying conditions that can your patients miserable: the conditions that can make your patients miserable: Otitis Externa Cutaneous Infections • Flea Allergy • Hot Spots • Focal The underlying causeDofermatitis a pet’s dermatosis can• be difficult toFungal diagnose. And while skin Pyoderma • Ringworm neo com that com • no • ra no • ef ra • gr ef The underlying cause of a pet’s dermatosis can be difficult to diagnose. And while skin ANTI-BACTERIAL ANTI-INFLAMMATORY ANTI-FUNGAL neomycin sulfate quickly kills bacteria dexamethasone, a fast-acting thiabendazole treats the most common rashesthat and hot spots may seem like minor irritations to pet owners, they can actually have can cause otitis externa and corticosteroid, reduces inflammation causes of mycotic dermatoses. skin infections. and relieves pain and itching. seriouscommon implications for theof health of pets. TRESADERM treatment easy – even when and •And helps treat fungal skin conditions The underlying cause a pet’s dermatosis can be difficultmakes to diagnose. while skin • not absorbed through skin • acts as a potent steroid otitis externa the underlying cause is unclear. Here are some of the ways in which TRESADERM and hot spots may seem like•minor irritations to pet owners, they•can actually havetreats helps prevent fungal overgrowth •rashes rarely allergenic relieves pain when bacteria are eliminated serious implications for the health of pets. TRESADERM makes treatment easy – even when • effective against gram-positive • quicklymiserable: reduces swelling the conditions that can make and your patients • effective against the three dermatophyte gram-negative bacteria • alleviates itching OTITIS EXTERNA the underlying cause is unclear. Here are some of the ways in which TRESADERM species thattreats cause 99% of ringworm •OTITIS kills bacteria that cause otitis externa EXTERNA infections in dogs and cats1 the conditions that can make your patients miserable: gr AN neom that c comm TRE • TRE no oin • oin rar to a • eff to a can gra itching • relieves kills bacteria that cause otitis externa • controls secondary infections relieves itching can • controls secondary infections TRESADERM is a true solution, not an FOCAL PYODERMA ointment or that a salve. That makes it easier •FOCAL kills pathogens cause PYODERMA administer, focal pyodermathatwith • to kills pathogens cause no clogging in the ear OTITIS EXTERNA • canal reduces inflammation focal pyoderma clumping in an animal’s fur. OTITISorEXTERNA • kills bacteria that cause otitis externa • eases pain and discomfort reduces inflammation • kills bacteria that cause otitis externa • relieves itching • eases pain and discomfort HOT SPOTSinfections • controls secondary SECONDARY INFECTIONS DUE TO EAR MITES TRE oint to a can • kills the opportunistic organisms that feed on ear mite infections • relieves itching and discomfort • relieves itching •cools controls secondary infections •HOT hot spots SPOTS FLEA ALLERGY DERMATITIS • reduces cools hotinflammation spots • fights secondary bacterial reduces inflammation FOCAL PYODERMA and fungal infections • fights secondary bacterial • fights pruritus FOCAL PYODERMA •and killsfungal pathogens that cause infections • kills pathogens that cause focal pyoderma Important Safety Information: focal pyoderma TRESADERM is for topical use only in dogs and cats. On rare • reducesSafety inflammation Important Information: • reduces inflammation occasions, application of theuse product result erythema or • eases pain and discomfort TRESADERM is for topical only inmay dogs andincats. On rare in the treated area. Discomfort in the treated area • easesdiscomfort pain and discomfort occasions, application of the product may result in erythema or can last from to 48 hours. discomfort in 24 thehours treated area. Discomfort in the treated area HOT SPOTS can last from 24 hours to 48 hours. HOT SPOTS • cools hot spots • reduces • cools hot spots inflammation • fights secondary bacterial and fungal infections • reduces inflammation xtp239707_TresadermDetailer8.5x11fld_rsg.indd 3-4 • allows affected area to heal • helps prevent secondary bacterial infection DERMATOPHYTOSIS (RINGWORM) • controls the dermatophytes that can cause hair loss and scaly/crusty skin in dogs and cats • effective against the three dermatophyte species that cause 99% of ringworm infections in dogs and cats1 xtp239707_TresadermDetailer8.5x11fld_rsg.indd 3-4 • fights secondary bacterial and fungal infections Important Safety Information: TRESADERM is for topical use only in dogs and cats. On rare occasions, application of the product may result in erythema or Important Safety Information: discomfort in the treated area. Discomfort in the treated area TRESADERM isfrom for topical can last 24 hours use to 48only hours.in dogs and cats. On rare occasions, application of the product may result in erythema or discomfort in the treated area. Discomfort in the treated area can last from 24 hours to 48 hours. xtp239707_TresadermDetailer8.5x11fld_rsg.indd 3-4 AN neo AN that 4/6/15 1:55 PM ANTI-BACTERIAL ANTI-INFLAMMATORY • not absorbed through skin • acts as a potent steroid • rarely allergenic • relieves pain • effective against gram-positive and gram-negative bacteria • quickly reduces swelling neomycin sulfate quickly kills bacteria that can cause otitis externa and common skin infections. dexamethasone, a fast-acting corticosteroid, reduces inflammation and relieves pain and itching. • alleviates itching TRESADERM is a true solution, not an ointment or a salve. That makes it easier to administer, with no clogging in the ear canal or clumping in an animal’s fur. ANTI-FUNGAL thiabendazole treats the most common causes of mycotic dermatoses. • helps treat fungal skin conditions and otitis externa • helps prevent fungal overgrowth when bacteria are eliminated • effective against the three dermatophyte species that cause 99% of ringworm infections in dogs and cats1 SECONDARY INFECTIONS DUE TO EAR MITES • kills the opportunistic organisms that feed on ear mite infections • relieves itching and discomfort FLEA ALLERGY DERMATITIS • fights pruritus • allows affected area to heal • helps prevent secondary bacterial infection DERMATOPHYTOSIS (RINGWORM) • controls the dermatophytes that can cause hair loss and scaly/crusty skin in dogs and cats • effective against the three dermatophyte species that cause 99% of ringworm infections in dogs and cats1 GOOD MEDICINE. GOOD BUSINESS. When it comes to skin conditions in cats and dogs, veterinarians have been reaching for TRESADERM for more than 30 years. But it’s more than just good medicine – it’s good business, too. As an excellent choice for so many common ear and skin conditions in both dogs and cats, TRESADERM is the one solution you can count on to meet your clinic’s unique stocking challenges. • Indicated for both acute and chronic dermatoses of multiple origins • Effective against otitis externa • Available in two convenient sizes: 7.5 mL and 15 mL • Has non-greasy formula • Is easy to apply; ideal for use at home, as well as in clinic TRESADERM (thiabendazole-dexamethasone-neomycin sulfate solution) Dermatologic Solution CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Dermatologic Solution TRESADERM® (thiabendazole-dexamethasone-neomycin sulfate solution) contains the following active ingredients per ml: 40 mg thiabendazole, 1 mg dexamethasone, 3.2 mg neomycin (from neomycin sulfate). Inactive ingredients: glycerin, propylene glycol, purified water, hypophosphorous acid, calcium hypophosphite; about 8.5% ethyl alcohol and about 0.5% benzyl alcohol. INDICATIONS:Dermatologic solution TRESADERM is indicated as an aid in the treatment of certain bacterial, mycotic, and inflammatory dermatoses and otitis externa in dogs and cats. Both acute and chronic forms of these skin disorders respond to treatment with TRESADERM. Many forms of dermatosis are caused by bacteria (chiefly Staphylococcus aureus, Proteus vulgaris and Pseudomonas aeruginosa). Moreover, these organisms often act as opportunistic or concurrent pathogens that may complicate already established mycotic skin disorders, or otoacariasis caused by Otodectes cynotis. The principal etiologic agents of dermatomycoses in dogs and cats are species of the genera Microsporum and Trichophyton. The efficacy of neomycin as an antibacterial agent, with activity against both gram-negative and grampositive pathogens, is well documented. Detailed studies in various laboratories have verified the significant activity thiabendazole displays against the important dermatophytes. Dexamethasone, a synthetic adrenocorticoid steroid, inhibits the reaction of connective tissue to injury and suppresses the classic inflammatory manifestations of skin disease. The formulation for TRESADERM combines these several activities in a complementary form for control of the discomfort and direct treatment of dermatitis and otitis externa produced by the above-mentioned infectious agents. DOSAGE AND ADMINISTRATION: Prior to the administration of Dermatologic Solution TRESADERM, remove the ceruminous, purulent or foreign materials from the ear canal, as well as the crust which may be associated with dermatoses affecting other parts of the body. The design of the container nozzle safely allows partial insertion into the ear canal for ease of administration. The amount to apply and the frequency of treatment are dependent upon the severity and extent of the lesions. Five to 15 drops should be instilled in the ear twice daily. In treating dermatoses affecting other than the ear the surface of the lesions should be well moistened (2 to 4 drops per square inch) with Dermatologic Solution TRESADERM twice daily. The volume required will be dependent upon the size of the lesion. Application of TRESADERM should be limited to a period of not longer than one week. PRECAUTIONS: On rare occasions dogs may be sensitive to neomycin. In these animals, application of the drug will result in erythema of the treated area, which may last for 24 to 48 hours. Also, evidence of transient discomfort has been noted in some dogs when the drug was applied to fissured or denuded areas. The expression of pain may last 2 to 5 minutes. Application of Dermatologic Solution TRESADERM should be limited to periods not longer than one week. While systemic side effects are not likely with topically applied corticosteroids, such a possibility should be considered if use of the solution is extensive and prolonged. If signs of salt and water retention or potassium excretion are noticed (increased thirst, weakness, lethargy, oliguria, gastrointestinal disturbances or tachycardia), treatment should be discontinued and appropriate measures taken to correct the electrolyte and fluid imbalance. Store in a refrigerator 36°-46°F (2°-8°C). WARNING: For topical use in dogs and cats. Avoid contact with eyes. Keep this and all drugs out of the reach of children. The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information. To report adverse effects in users, to obtain an MSDS, or for assistance call 1-888-6374251. HOW SUPPLIED: Product 55871- Dermatologic Solution TRESADERM Veterinary is supplied in 7.5-ml and 15-ml dropper bottles, each in 12-bottle boxes. To order, contact your Merial Sales Representative or your Merial Distributor Representative. -ORCall Merial Customer Care 1-888-Merial-1 1 Kahn CM, Line S. The Merck Veterinary Manual. 9th ed. Whitehouse Station, NJ: Merck & Co., Inc., 2005. ®TRESADERM is a registered trademark, and SMMERIALconnect.com is a service mark, of Merial. ©2015 Merial, Inc., Duluth, GA. All rights reserved. TRE12DTDETAILER-Renewal (4/15). Visit MERIALconnect.comSM