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WHAT YOU CAN’T AFFORD TO MISS The AACR Annual Meeting covers the full spectrum of cancer research—including basic, translational, clinical, and population research—through a variety of session formats. You will join more than 18,000 fellow attendees, be among the best and brightest researchers and clinicians in cancer research, and have the opportunity to network and form collaborations with colleagues from more than 70 countries. As an Annual Meeting attendee, you will have IMPORTANT DATES January 20, 2015 Membership Application Deadline for Prospective Late-Breaking Abstract Sponsors Regular Abstract Status Notifications Sent February 2, 2015 Late-Breaking Abstract Submission Deadline January 27, 2015 Membership Application Deadline for Advance Registration Rate Clinical Trials Placeholder Abstracts – Final Results and Conclusions Deadline February 27, 2015 Online Itinerary Planner Available February 19, 2015 Advance Registration Deadline February 9, 2015 Late-Breaking Abstract Status Notifications Sent • A full day of Educational Sessions and Methods Workshops Housing Reservation Deadline access to: • Four Plenary Sessions of important general interest • A new Wrap-Up Plenary Session on Wednesday, April 22, featuring key opinion leaders presenting highlights from the meeting and their vision of future trends in cancer research March 4, 2015 March 6, 2015 Cancellation Deadline for Registration Refunds (less $75 processing fee) Onsite Registration Opens (Pennsylvania Convention Center) April 17, 2015 Regular Abstract Bodies Posted to Online Itinerary Planner March 18, 2015 Late-Breaking Abstract Bodies Posted to Online Itinerary Planner • Over three dozen Major Symposia • Over two dozen Recent Advances in Organ Site Research, Diagnostics and Therapeutics Research, and Epidemiology and Prevention Research Sessions April 18, 2015 Annual Meeting Begins • Minisymposia featuring short talks from highly rated proffered abstracts Annual Meeting 2015 Program Guide App • Thousands of posters highlighting the latest discoveries in cancer research • Opportunities for networking and professional development Carry the Annual Meeting with you wherever you go—with or • Over 50 Meet-the-Expert Sessions, where attendees can hear from renowned researchers on specialized topics without a network connection. The Program Guide App is • Twelve Forums in which scientific leaders debate controversial subjects in cancer research available in native versions to serve users of iPhone, iPad, and Android devices and also in a browser-based version for use on most webenabled smartphones and tablets. Available in Visit www.AACR.org/Program2015 to view the full list of exciting sessions at the AACR Annual Meeting 2015. late March 2015. Follow us on Visit www.AACR.org/Program2015 to view the full list of exciting sessions at the AACR Annual Meeting 2015. DONATE Continuing Medical Education ActivityAMA PRA Category 1 CreditsTM Available January 27, 2015 Late-Breaking and Placeholder Abstract Submission Deadline: 615 Chestnut Street | 17th Floor Philadelphia, PA 19106 Email: [email protected] Telephone: 215-440-9300 Toll-free Telephone: 866-423-3965 April 18-22, 2015 • Pennsylvania Convention Center • Philadelphia, PA • www.AACR.org • #AACR15 See inside for details! • Clinical Trials Symposia • Minisymposia • Poster Sessions Clinical Trials featured in: We look forward to seeing you in Philadelphia, PA, AACR’s home town! Submission Deadline: January 27, 2015 Continuing Medical Education ActivityAMA PRA Category 1 Credits™ available LATE-BREAKING AND PLACEHOLDER ABSTRACTS AACR ANNUAL MEETING 2015 Late-Breaking Abstracts and Clinical Trials Submit your late-breaking abstracts Clinical Trials Presentations The deadline for late-breaking abstracts is January 27, 2015 and is an opportunity to submit results that were not available at the time of the regular abstract deadline. Abstracts detailing highly significant and timely findings in any area of cancer research may be submitted to one of ten late-breaking abstract submission categories. A special subcommittee of the Program Committee will evaluate the merit of late-breaking abstracts. Only those abstracts that are deemed to be of high scientific priority will be accepted for presentation at the Annual Meeting. Select highly rated abstracts may be chosen for oral presentation in minisymposia. Submit your phase I, II, III, or combination clinical trials abstracts, from national or international clinical trials, to the Clinical Trials categories (CT01-CT08) by the late-breaking abstract deadline of January 27, 2015. • Every abstract is considered for one of the 38 oral presentation opportunities. • Four Clinical Trials Symposia offer companion presentations explaining the science behind the presented trials. • All stakeholders, including members of industry, are eligible to present their work. Please visit www.AACR.org/LBA15 for details on the abstract submission process. Data not ready yet? Submit a placeholder abstract to the appropriate PL category. Are you interested in sponsoring a late-breaking or placeholder abstract, but you haven’t become an AACR member yet? Visit www.AACR.org/CT15 for instructions on abstract submission. Clinical Trials in Progress Poster Session Become an AACR member today and enjoy the privilege of sponsoring abstracts for AACR Annual Meetings. To sponsor a late-breaking or placeholder abstract, be sure to submit your membership application by January 20, 2015. Late-breaking abstracts submitted to the Clinical Trials in Progress (CT08) category should summarize promising ongoing trials that have not yet yielded results. A separate poster session will be dedicated to the presentation of abstracts accepted to this category. Visit www.AACR.org/Benefits to learn more about the benefits of AACR membership such as reduced registration rates for conferences, discounts on the AACR’s publications, eligibility to join the association’s special interest groups, and more. Please visit www.AACR.org/CT15 for additional information. Clinical Trials Placeholder Abstracts If you anticipate obtaining final results of your trial after the latebreaking deadline, submit a placeholder abstract containing your preliminary data to the appropriate Placeholder category (PL01-PL07) by January 27, 2015. Completed abstracts, including all final data and analyses, must be submitted by February 27, 2015. What qualifies as a late-breaking abstract? An abstract that details highly significant and timely findings in any area of cancer research that were not available at the time of the December 3 regular abstract deadline. Visit www.AACR.org/Program2015 to view the full list of exciting sessions at the AACR Annual Meeting 2015. PROGRAM HIGHLIGHTS April 18-22, 2015 • Pennsylvania Convention Center • Philadelphia, PA On Saturday, April 18, 2015, a full program of Educational Sessions, Methods Workshops, Meet-the-Expert Sessions, and Award Lectures will be presented beginning at 8:00 a.m. The Opening Ceremony and the Opening Plenary Session will take place on Sunday morning, April 19. The meeting will conclude at 1:30 p.m. on Wednesday, April 22. The 2015 Program in Progress follows. Plenary Sessions Stem Cells and Cancer Cell of Origin Value-Based Drug Development SUNDAY, APRIL 19 Targeted Therapies in Hematologic Malignancies What Comes First? Is Deregulation the Chicken or the Egg? Opening Plenary Session: The Genome and Beyond Targeting Macromolecular Signaling Complexes What Is the Real Target of Bromodomain Inhibitors? Chairperson: Lewis C. Cantley Targeting MYC Speakers: Michael R. Stratton, Stephen B. Baylin, Tyler Jacks, and Robert D. Schreiber Targeting Pathway Rewiring to Improve Cancer Therapy Regulatory Symposia Tumor Heterogeneity: Targets and Mechanisms Clinical Trial Strategies Additional speaker to be announced Tumor Microenvironment Immunotherapies The Tumor Proteome as a Guide for Precision Medicine Laboratory-Developed Tests Minimal Residual Disease Precision Medicine Comes to Cancer Prevention and Screening Recent Advances in Organ Site Research Sessions Chairperson: Andrew J. Dannenberg Barrett’s Esophagus: Models, Genomics, and Genetics NGS-Based Onco-Panels Speakers: Andrew T. Chan, Douglas R. Lowy, David A. Ahlquist, and Anna Mae E. Diehl Colorectal Cancer Subtypes Patient-Reported Outcomes Elucidating Mechanisms that Underlie the Development of Pediatric Brain Cancers Regulatory Strategies MONDAY, APRIL 20 TUESDAY, APRIL 21 Drug Resistance Chairperson: Bert Vogelstein Speakers: Bert Vogelstein, Alan Ashworth, Alice T. Shaw, and Joan S. Brugge Heterogeneity and Microenvironment: Drivers of Breast Cancer Evolution Localized Prostate Cancer: Next-Generation Signaling and Beyond Metastatic Prostate Cancer Precision Medicine: Challenges and Solutions Neoadjuvant Treatment Tyrosine Kinase Inhibitors Science Policy Sessions International Patient Advocacy NIH-NCI Funding Tobacco and E-Cigarettes WEDNESDAY, APRIL 22 MicroRNAs and Noncoding RNAs in the Pathogenesis of Liver Cancer and Therapeutic Implications Value-Based Drug Development Forum Oncology Meets Immunology: Not Just Another "Hallmark" Modeling Human Sarcomas Chairperson: Robert H. Vonderheide Multimodality Prostate Cancer Imaging Educational Sessions and Methods Workshops Speakers: Glenn Dranoff, Lisa M. Coussens, Elizabeth M. Jaffee, and Ira Mellman New Insights in Estrogen Receptor Biology and Implications for Treatment WEDNESDAY, April 22 New Insights into the Role of Ultraviolet Radiation in Melanoma NEW Wrap-Up Plenary Session AACR Annual Meeting 2015: Latest Developments, Future Trends Basic Science: Lewis C. Cantley Clinical and Translational Science: Carlos L. Arteaga Prevention and Early Detection: William G. Nelson Wrap-Up and Vision for the Future The New Landscape of Epigenetic Therapy for Lymphoid Malignancies Pancreatic Cancer in 2015: An Integrated View of a Complex Disease Pancreatic Cancer: The Promise and Pitfalls of Targeting the Stroma Progress in Understanding Small Cell Lung Cancer Recent Advances in Skin Development and Skin Cancers Major Symposia Translational Advances in Brain Cancer Adoptive T-Cell Therapy What Does Stem Cell Reprogramming Teach Us about Hematologic Malignancies? A full day of educational programming will take place on Saturday, April 18. Educational Sessions provide broad, stateof-the-art overviews of important areas in the field and will benefit individuals who want to learn more about an area in which they are not expert. During Methods Workshops, investigators carefully describe laboratory techniques and their potential for cancer research such that participants can determine how to apply the techniques to their own research. Over 50 sessions on topics such as big data, models of cancer, precision radiotherapy, and the tumor microenvironment will comprise the educational program. The “From Chemistry to the Clinic: Pathways for Drug Development” series and the popular “Tumor Immunology for the Non-Immunologist” session will once again be offered. The program will also feature sessions on Regulatory Science with speakers from the U.S. Food and Drug Administration. Visit www.AACR.org/Program2015 to view the latest updates. Aging and Senescence Antiangiogenesis Revisited Applying Systems Biology in the Oncology Clinic Autophagy and Cancer Cancer, Type 2 Diabetes, and Cardiovascular Disease: Comparison of Risk Factors Cell Death and Cancer Therapy: Why Has Conventional Chemotherapy Been So Successful? Cellular Reprogramming in Carcinogenesis: Implications for Tumor Heterogeneity, Prognosis, and Therapy Challenges in Mutation Detection Recent Advances in Diagnostics and Therapeutics Research Sessions Ablation of Oligometastases during Systemic Therapy Biomarkers for Immunotherapy Response Biomarkers of Antiangiogenic Therapy: Are We Lost in Translation? Clinical Applications of Liquid Biopsy: Current Status and Future Developments Dose Optimization for 21st Century Oncology Drugs DNA Repair Deficiencies Meet-the-Expert Sessions Sixty Meet-the-Expert Sessions will be held throughout the meeting. During these sessions, leaders in the field provide a synthesis of recent research advances and engage audience members in discussion. A list of experts and their topics will be added to the online program as they are available. Visit www.AACR.org/Program2015. Professional and Career Advancement Sessions Genomic Investigations in Childhood Cancer 10th Annual Undergraduate Student Caucus and Poster Competition Germline Alterations and Susceptibility to Childhood Cancer 18th Annual Grant Writing Workshop Metabolism and Adaptive Immune Responses Cancer and Biomedical Research Career Fair New Strategies in Theranostics Career Conversations Deregulation of Cancer Hallmarks by microRNAs and other Noncoding RNAs Novel Delivery Systems and/or Formulations in Cancer Treatment Careers in the Biotechnology and Pharmaceutical Industries Diverse Approaches for Targeting RAS-Driven Cancers Phenotypic Screening for Optimizing Cancer Therapy Careers in Clinical and Translational Cancer Research Roundtable Empowering Antibodies to Fight Cancer: ADCs and Immunoconjugates Predictive Biomarkers of DNA Repair Effective Communication with Peers and the Public Enhancing Efficacy of Cancer Immunotherapy by Use of Ablative Therapy Recent Advances in Epidemiology and Prevention Research Sessions Meet the Research Icon Breast Cancer around the World: Is It the Same Disease? Networking Hubs Cancer Risk Factors and Targeted Screening Personalized Career Discussions Early Detection/Overdiagnosis Science Reproducibility: Proper Management and Publication of Data Chemical Probes for Use in Cancer Research Chromatin and Senescence Chronic Infections Driving Cancer Computational Approaches to Cancer Target and Drug Discovery Epigenetic Mechanisms in Cancer Risk Gene Expression Programs Underlying the Stem Cell State How to Combine Targeted Therapy with Immunotherapy Imaging of Immunotherapy in Action In Vivo Modeling of the Noncoding RNA Revolution in Cancer Innate and Adaptive Immunity in Cancer Interpreting the Cancer Genome in the Clinic Intraoperative Imaging Liquid Biopsy Approaches for Detecting, Monitoring, and Characterizing Human Cancer Mechanisms of Resistance: From Signaling Pathways to Stem Cells Mechanisms of Tumor Immune Escape Metabolism and Aging Microbiome and Tumor Immunity Nucleotide Metabolism in Cancer Cell Growth and Survival Obesity, Energy Balance, and Cancer Oncometabolites Meet the Mentor: Undergraduate Focus Epidemiology of Obesity and Endometrial Cancer Immunoprevention Lung Cancer and COPD: Commonalities Navigating the Road to a Successful Career in Cancer Research Special Program for High School Students: The Conquest of Cancer and the Next Generation of Cancer Researchers WICR Professional Advancement Session Forums Are Cancer Stem Cells Relevant to the Success of Human Cancer Therapy? Avatar Mouse Models for Personalized Cancer Treatment Bridging the Gap between Academia and Industry in Drug Discovery Challenges in Trial Design for the Genomic Era Controversies in RAS Signaling: Wild Type RAS—Tumor Suppressor or Partner in Tumorigenesis? Dietary Supplements and Cancer Risk and Prognosis Is MET Still a Relevant Target in Lung Cancer? Pan-Cancer Analysis of Whole Genomes Opportunities and Challenges in the Use of Animal Models for Cancer Target Validation and Drug Development Proteogenomics and Phosphoproteomics in Cancer: Analysis of the TCGA Tumor Samples Role of Autophagy in Cancer Development, Progression, and Therapy AACRcentral At the crossroads of the Exhibit Hall, AACRcentral is your one-stop source for information on and assistance with all AACR programs. Whether you need to ask a question, find a job, check your email, or meet up with a colleague, make AACRcentral the starting point when you tour the exhibits. The program is subject to change. Please visit www.AACR.org/Program2015 for the latest details.