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Cancer Biology – BL7005 – 7.5 ECTS (7.5 hp) Swedish title: Cancerns biologi Welcome to the course on Cancer Biology The course will be held from 26th November 2009 -15th January 2010. There will be a break in the course schedule for Christmas holidays, from Monday 21st December 2009 to Friday 8th January 2010. Lectures: All lectures will be held in the Seminar Room D508, Svante Arrhenius väg 16D, floor 5. Lectures will consist of 2 x 1 hour presentations with a break for 30 minutes. The titles of the individual lectures are based on the book chapters. It is therefore very important to read the chapter(s) in advance of each lecture. Group work and course examination: Much of the course work is based on individual or group work and there will be ample time during the course for self-study and preparation of group presentations. The course examination will consist of group presentations and a final written examination.* Course literature: The Biology of Cancer, Robert A. Weinberg (ISBN 0-8153-4076-1) The group work will be based on chapters in The molecular basis of human cancer, (Eds Coleman & Tsongalis) Course organizers: Ulf Rannug Department of Genetics, Microbiology and Toxicology. Telephone: 08-16 29 15 Email: [email protected] Course Lecturers: Thomas Helleday (TH), Mary Hunt (MH), Ann-Sofie Jemth (ASJ), Dag Jenssen (DJ), Ulf Rannug (UR), Niklas Schultz (NS), Tatjana Djureinovic (TD), Andrzej Wojcik (AW). Please note there may be changes to the schedule. Welcome Week (dates) Monday Tuesday Wednesday 26th -27th November (Week 48) 30th November 4th December (Week 49) 7th -11th December (Week 50) 14th -18th December (week 51) Thursday Friday 12.30 – 13.00 INTRODUCTION Assignment of group work Individual study/preparation of group work Individual study/preparation of group work 13.00 – 14.30 Growth Factors and their Receptors (ASJ) 13.00-14.00 The Biology and Genetics of Cells and Organisms (UR) 14.30-15.30 The Nature of Cancer (DJ) Individual study/preparation of group work Cellular Oncogenes (TD) Individual study/preparation of group work 13.00 – 15.30 Tumor Suppressor Genes (UR) 13.00-14.00 Group discussions on scientific article 13.00-15.30 pRb and control of the Cell Cycle Clock (NS) 13.00-14.00 Group discussions on scientific article 13.00 – 15.30 Radiation induced cancer (AW) Individual study/preparation of group work 13.00 – 14.30 Eternal Life: Cell Immortalization and Tumorigenesis (DJ) Individual study/preparation of group work 13.00-15.30 Maintenance of Genomic Integrity and the Development of Individual study Individual study 13.00 – 15.30 p53 and Apoptosis: Master Guardian and Executioner (TH) Targeting DNA in anti-cancer therapy (TH) 10.00EXAMINATION END OF COURSE 13.00 – 14.30 Tumor Viruses (MH) Chernobyl accident 22 years after: causes and health effects (AW) 11th -15th January (week 3) 13.00 Presentation of group work Individual study/preparation of group work Cancer (DJ + UR) * The course covers cancer processes from a biological point of view and describes the mechanisms for the origin of cancers. The course also illustrates the genetic and epigenetic changes involved in tumor development. The following areas will be addressed: cell signalling, cyclins and cyclin-dependent kinases, receptors and growth factors, oncogenes and tumor supressor genes, genomic instability and DNA repair, telomeres and aging, mechanism-based cancer therapy and risk models of cancer. After completion of the course it is expected that the student should: • • • Know the incidence of different tumors, inherited and sporadic, together with different types of risk factors Know the molecular and cellular changes that are characteristic of cancer development Be able to read and critically analyze relevant original scientific literature Course requirements and assessment The written examination will be graded on a seven grade system as follows. Grading criteria The grade A is awarded if the student has achieved at least 95% of the maximum points available in the written examination. The grade B is awarded if the student has achieved at least 85% of the maximum points available in the written examination. The grade C is awarded if the student has achieved at least 75% of the maximum points available in the written examination. The grade D is awarded if the student has achieved at least 65% of the maximum points available in the written examination. The grade E is awarded if the student has achieved at least 60% of the maximum points available in the written examination. The grade Fx is awarded if the student has achieved at least 50% of the maximum points available in the written examination. The grade F is awarded if the student has achieved less than 50% of the maximum points available in the written examination. Both Fx and F are ‘fail’ and the student must resit the complete examination.