Download Welcome to the course on Cancer Biology

Cancer Biology – BL7005 – 7.5 ECTS (7.5 hp)
Swedish title: Cancerns biologi
Welcome to the course on Cancer Biology
The course will be held from 26th November 2009 -15th January 2010. There will be a break in the course schedule for
Christmas holidays, from Monday 21st December 2009 to Friday 8th January 2010.
Lectures:
All lectures will be held in the Seminar Room D508, Svante Arrhenius väg 16D, floor 5.
Lectures will consist of 2 x 1 hour presentations with a break for 30 minutes.
The titles of the individual lectures are based on the book chapters. It is therefore very important to read the chapter(s)
in advance of each lecture.
Group work and course examination:
Much of the course work is based on individual or group work and there will be ample time during the course for self-study
and preparation of group presentations.
The course examination will consist of group presentations and a final written examination.*
Course literature:
The Biology of Cancer, Robert A. Weinberg (ISBN 0-8153-4076-1)
The group work will be based on chapters in The molecular basis of human cancer, (Eds Coleman &
Tsongalis)
Course organizers:
Ulf Rannug
Department of Genetics, Microbiology and Toxicology.
Telephone: 08-16 29 15
Email: [email protected]
Course Lecturers: Thomas Helleday (TH), Mary Hunt (MH), Ann-Sofie Jemth (ASJ), Dag Jenssen (DJ), Ulf Rannug (UR), Niklas Schultz
(NS), Tatjana Djureinovic (TD), Andrzej Wojcik (AW).
Please note there may be changes to the schedule.
Welcome
Week (dates)
Monday
Tuesday
Wednesday
26th -27th November
(Week 48)
30th November 4th December
(Week 49)
7th -11th December
(Week 50)
14th -18th December
(week 51)
Thursday
Friday
12.30 – 13.00
INTRODUCTION
Assignment of group
work
Individual
study/preparation
of group work
Individual
study/preparation of
group work
13.00 – 14.30
Growth Factors and
their Receptors (ASJ)
13.00-14.00
The Biology and
Genetics of Cells and
Organisms (UR)
14.30-15.30
The Nature of Cancer
(DJ)
Individual
study/preparation of
group work
Cellular Oncogenes
(TD)
Individual
study/preparation of
group work
13.00 – 15.30
Tumor Suppressor
Genes (UR)
13.00-14.00
Group discussions on
scientific article
13.00-15.30
pRb and control of the
Cell Cycle Clock (NS)
13.00-14.00
Group discussions
on scientific article
13.00 – 15.30
Radiation induced
cancer (AW)
Individual
study/preparation of
group work
13.00 – 14.30
Eternal Life: Cell
Immortalization and
Tumorigenesis (DJ)
Individual
study/preparation of
group work
13.00-15.30
Maintenance of
Genomic Integrity and
the Development of
Individual study
Individual study
13.00 – 15.30
p53 and Apoptosis:
Master Guardian
and Executioner
(TH)
Targeting DNA in
anti-cancer therapy
(TH)
10.00EXAMINATION
END OF
COURSE
13.00 – 14.30
Tumor Viruses (MH)
Chernobyl accident
22 years after: causes
and health effects
(AW)
11th -15th January
(week 3)
13.00 Presentation of
group work
Individual
study/preparation
of group work
Cancer (DJ + UR)
* The course covers cancer processes from a biological point of view and describes the mechanisms for the origin of cancers. The course also
illustrates the genetic and epigenetic changes involved in tumor development. The following areas will be addressed: cell signalling, cyclins and
cyclin-dependent kinases, receptors and growth factors, oncogenes and tumor supressor genes, genomic instability and DNA repair, telomeres
and aging, mechanism-based cancer therapy and risk models of cancer.
After completion of the course it is expected that the student should:
•
•
•
Know the incidence of different tumors, inherited and sporadic, together with different types of risk factors
Know the molecular and cellular changes that are characteristic of cancer development
Be able to read and critically analyze relevant original scientific literature
Course requirements and assessment
The written examination will be graded on a seven grade system as follows.
Grading criteria
The grade A is awarded if the student has achieved at least 95% of the maximum points available in the written examination.
The grade B is awarded if the student has achieved at least 85% of the maximum points available in the written examination.
The grade C is awarded if the student has achieved at least 75% of the maximum points available in the written examination.
The grade D is awarded if the student has achieved at least 65% of the maximum points available in the written examination.
The grade E is awarded if the student has achieved at least 60% of the maximum points available in the written examination.
The grade Fx is awarded if the student has achieved at least 50% of the maximum points available in the written examination.
The grade F is awarded if the student has achieved less than 50% of the maximum points available in the written examination.
Both Fx and F are ‘fail’ and the student must resit the complete examination.