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Chapters 5 & 6, and sample questions at end of each chapter. Bookmark figure 6.2 and refer to it before studying each biochemical pathway. Continue Biochemistry Assignments Chapters 11, 12, 13 & questions Chapter 7 & questions Chapter 8 & questions, Review Figure 6.2 again! Chapter 9 & questions Basic Metabolism Day 2 Objective Structure & Metabolism of Carbohydrates Glycolysis Gluconeogenesis Citric Acid Cycle Hexose Monophosphate Chapter 10 & questions Shunt Read Through Section Introductory First Aid Material from First Aid , and Skim Section II General overview of material to be covered Lippincott's Biochemistry Lippincott's Biochemistry Lippincott's Biochemistry Lippincott's Biochemistry Source Lippincott's Biochemistry Lippincott's Biochemistry Skim reactions and focus on G6PD deficiency Focus on start and end points, place in overall metabolism, and regulation. Study it by comparison to glycolysis. Know the reactions & regulation unique to gluconeogenesis. Know the start and end points, hormonal regulation, energy yield, and various fates of pyruvate. Details Review the digestion of sugars and disorders of fructose, galactose, and lactose metabolism. Spend more time on glycogen metabolism, its regulation, and related disorders. Use Figure 13.7 to memorize the glycogen storage diseases. Understand the role of ATP. Know where the electron transport chain, and oxidative phosphorylation occur and how they fit into the overall metabolic scheme. Review the main classes of cell receptors and signaling mechanisms. Learn about the test, and how to best use First Aid as a resource. Source Details NBME CD-ROM or download Complete 150 sample questions, and note trouble areas to from www.nbme.org focus on. General Overview & Begin Biochemistry Assignments Complete sample test materials from NBME Day 1 Objective Self Assessment 1 hr 1 hr 1 hr 1.5 hrs Est. Time 3 hrs 2.5 hrs 4 hrs Est. Time 3 hrs Lippincott's Biochemistry Chapter 20, Sect. I-VII Chapter 20, Sect. VII Continue Biochemistry Assignments Chapters 1-4 & questions Chapter 21 & questions Cholesterol & Steroid Metabolism Steroid Hormones Day 4 Objective Protein & Enzymes Digestion of Dietary Proteins and Nitrogen Metabolism Lippincott's Biochemistry Source Lippincott's Biochemistry Lippincott's Biochemistry Lippincott's Biochemistry Skim Chapters 18, 19 Phospholipids & Glycolipids Source Lippincott's Biochemistry Continue Biochemistry Assignments Chapter 17 & questions Day 3 Objective Lipid Metabolism Learn the various pancreatic proteases and how they are regulated. Understand transamination and oxidative deamination, but don't memorize pathways. Spend more time on urea cycle and ammonia metabolism focusing on figures 21.4, 21.11, 21.17. Details Become familiar with basic properties of amino acids, levels of protein structure, hemoglobin, and collagen. For enzymes, focus on appreciating ( not memorizing) the Michaelis-Menten equation, types of enzyme inhibition, modes of enzyme regulation, and the use of enzymes in clinical diagnosis. Know the major enzyme deficiencies in steroid synthesis and know where steroid receptors act in the cell. Study figures 20.19, 20.20. Review cholesterol synthesis (esp. the role of HMG CoA reductase) and its regulation. Understand synthesis and role of bile salts. Review biology of lipoproteins and their role in atherogenesis. Key figures are 20.12, 20.14, 20.16. Gain a sense of what these are, but do not memorize structures or pathways. Focus on related disorders instead, using figures 18.10, 19.4. Details Focus on roles of pancreatic lipase and bile salts. Fatty acid metabolism: know where synthesis occurs, relationship to glucose metabolism, and role of triacylglycerols for storage of fatty acids. Review mobilization of and oxidation of fatty acids. Finally, carefully review eicosanoids, focusing on figure 17.20 2 hrs Est. Time 4 hrs 1 hr 2 hrs 1 hr Est. Time 3 hrs Lippincott's Biochemistry Lippincott's Biochemistry Glycosaminoglycans and Skim Chapters 14, 15 Glycoproteins Chapters 27, 28 Chapter 29 Finish Biochemistry Assignments Chapters 24, 25, 26 General Pharmacology Assignments Chapters 1,2 Chapters 3-7 Nutrition and Vitamins Nucleotide Metabolism Day 6 Objective Integrative Metabolism Day 7 Objective Pharmacokinetics & Pharmacodynamics Autonomic Drugs Lippincott's Pharmacology Source Lippincott's Pharmacology Source Lippincott's Biochemistry Lippincott's Biochemistry Source Lippincott's Biochemistry Continue Biochemistry Day 5 Lippincott's Biochemistry Objective Assignments Heme, Porphyrins, Chapter 23 Serotonin, Histamine and Catecholamines Chapter 22 Metabolism of Amino Acid Carbon Skeletons Know different types of adrenergic and cholinergic receptors cold. Study figures 3.3, 3.6, 4.2, 5.2, 6.15, 7.10. Details Study general principles of pharmacology. Specific agents will be covered with relevant organ systems. Details Synthesize the information you've reviewed this week by studying insulin, glucagon, the fed/starved states, and the metabolic aspects of diabetes mellitus. Time spent on these topics will be VERY WORTHWHILE. Understand differences between de novo and salvage purine synthesis. Study purine degradation and the pathophysiology of gout and ADA deficiency. Study figures 29.7, 29.9, 29.10. Know the daily energy requirements and vitamin deficiences. Focus on absorption of vitamin B12 and pernicious anemia, as well as vitamin D. Focus on figures 28.12, and 28.18. Know what they are and know the related disorders. Don't get too bogged down in details - just study figures 14.12 and 15.4, then move on. Details Focus on the porphyrias and bilirubin metabolism. Focus on figures 23.5 and 23.7. Emphasize relevant disorders. Focus on figures 22.2, 22.16. 5 hrs Est. Time 2 hrs Est. Time 5 hrs 2 hrs 3 hrs 1 hr Est. Time 1 hr 1 hr Chapter 20 Chapter 34 Finish Microbiology Assignments Chapters 22-29 Chapter 37 Chapters 30, 31 Chapters 35, 36 Fungi Antifungals Day 10 Objective Viruses Antivirals Parasites Antiparasitics Clinical Vignettes Continue Microbiology Assignments Chapters 28-33 Day 9 Objective Antibiotics Begin Microbiology Assignments Chapters 1-15 Day 8 Objective Bacteria Underground Clinical Vignettes - Microbiology Lippincott's Pharmacology Clinical Microbiology made Ridiculously Simple Lippincott's Pharmacology Source Clinical Microbiology made Ridiculously Simple Lippincott's Pharmacology Clinical Microbiology made Ridiculously Simple Source Lippincott's Pharmacology Source Clinical Microbiology made Ridiculously Simple Good for group study, and another way to keep sharpening buzzword recall. Review antiprotozoal and antihelminthic agents, particularly multi-drug regimens This is high yield material, read, review and continue to do Qbank questions to keep building buzzword associations. Review antiviral agents, particularly mechanisms of action. Details This is high yield material, read, review and continue to do Qbank questions to keep building buzzword associations. This is high yield material, read, review and continue to do Qbank questions to keep building buzzword associations. This is high yield material, read, review and continue to do Qbank questions to keep building buzzword associations. Details This is high yield material, read, review and continue to do Qbank questions to keep building buzzword associations. Details Rely heavily on charts. Start building buzzword associations with characterisitics of each organism and how is identified (with a special stain, culture medium, etc.) Also, time spent with Qbank questions here will be golden. 3 hrs 1 hr 2 hrs 1 hr Est. Time 6 hrs 1 hr 1.5 hrs Est. Time 6 hrs Est. Time 10 hrs BRS Pathology BRS Pathology Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Inflammation Hemostasis Genetic Disorders Immune Dysfunction Neoplasia Environmental Pathology Chapter 7 Nutritional Disorders Cellular Biology Assignments Chapters 30 - 33 Chapter 1 Chapter 2 Day 12 Objective DNA, RNA, Proteins Cell Membranes Nucleus Chapter 8 BRS Pathology Chapter 1 Cellular Injury Details Know mechanisms of DNA repair, different types/roles of RNA, mechanism of translation, and molecular biology techniques. Focus on figures 30.2, 30.16, 30.19, 30.22, 31.11, 32.9. Review vitamin deficiencies to refresh biochem memory. Quickly review Distinguish between tumor suppressor genes & oncogenes, know mechanisms of carcinogenesis, and the properties of malignant cells. Focus on immune deficiency disorders, autoimmunity, and collagen vascular disease Know coagulation cascade, types of embolism, and types of shock. Distinguish mechanisms and histologic characteristics of acute vs. chronic inflammation. Focus on mechanisms of cellular injury and differences between necrosis & apoptosis Details Excellent, concise summary of immunology. BRS Cell Biology & Histology Know contents of nuclei, and RNA import/export mechanisms. BRS Cell Biology & Histology Know properties of membranes and membrane proteins. Source Lippincott's Biochemistry BRS Pathology BRS Pathology BRS Pathology BRS Pathology BRS Pathology Source Medical Microbiology & Immunology: Examination and Board Review Immunology & General Pathology Assignments Part VII Day 11 Objective Review Immunology 0.5 hr 1 hr Est. Time 3.5 hrs 0.5 hr 0.5 hr 1 hr 0.5 hr 0.5 hr 1 hr 1 hr 0.5 hr Est. Time 4 hrs Chapters 1-4 Chapters 17, 18 Diagnostic Test Thorax Assignments Chapters 5, 11 Chapter 2 (Also use Netter's Atlas for reference) Chapters 11, 15 Embryology Birth Defects Exam Day 14 Objective Embryology of thorax Thoracic Anatomy Histology of thoracic viscera Details Know the congenital cardiac abnormalities, and fetal circulation. Also understand the stages of fetal lung maturation. Good opportunity to identify weaknesses in organ system areas. Know stages from zygote through embryo. Review 3 Germ cell layers and their derivative tissues. Details Know mechanisms of ion transport, action potentials. BRS Cell Biology & Histology Be able to distinguish arteries and veins in cross section. Understand architecture of the gas diffusion barrier in the lungs. High Yield Gross Anatomy Source BRS Embryology Board Simulator Series Body Systems Review BRS Embryology BRS Embryology Source BRS Physiology Cellular Physiology & General Embryology BRS Cell Biology & Histology Review types of epithelia and locations of each. Review connective tissue focusing on bone histology. Assignments Chapter 1 Chapters 5,6 Epithelia & Connective Tissue BRS Cell Biology & Histology Know different types of collagen, basement membrane composition, and other ECM components. Day 13 Chapter 4 Extracellular Matrix BRS Cell Biology & Histology Review organelles and function Objective Cell Physiology Chapter 3 Cytoplasm 1 hr 3 hrs Est. Time 3.5 hrs 2 hrs 1.5 hrs 3 hrs Est. Time 1 hr 1.5 hrs 1 hr 0.5 hr Chapter 13 Chapters 10, 12 (and a histologic atlas for further review) Histology of Bone Marrow, Spleen, & Lymph Nodes Hemorrhagic Disorders Volume 1: Cases 1-19, Volume 2: Cases 52-66 Clinical Vignettes Chapter 12 Chapter 22 Respiratory Pharmacology Hempatopoietic & Lymphoreticular Neoplasia Chapter 14 Respiratory Pathology Finish Hematology Assignments Chapter 4 Objective Respiratory Physiology Assignments Chapter 11 Respiratory System & Begin Hematology Day 16 Day 17 Chapters 16-19, 21 Cardiovascular Pharmacology Objective Anemia Chapter 9 Vascular Pathology Good opportunity for group review. Study this chapter thoroughly. Details Know the various lung volume measurements, and understand acid - base disorders. Know drugs used to treat CHF, HTN, arrhythmias, angina, and hyperlipidemia. Study this chapter thoroughly. Study this chapter thoroughly. Details Review hemodynamics, electrophysiology, cardiac cycle, blood pressure regulation, responses to exercise, volume loss, altitude. Understand pre-load, after-load, Frank-Starling curve, and conduction. BRS Pathology BRS Pathology Source BRS Pathology Know how to diagnose and correct each disorder. Distinguish between leukemia & lymphoma. Understand different types of each. Details Know pathophysiology and lab differentiation of various etiologies of anemias. BRS Cell Biology & Histology Familiarize yourself with lymph node architecture, and understand the spleen. Understand RBC, WBC, platelet lineages. Underground Clinical Vignettes - Patho-physiology Lippincott's Pharmacology BRS Pathology Source BRS Physiology Lippincott's Pharmacology BRS Pathology BRS Pathology Chapter 10 Cardiac Pathology Source BRS Physiology Cardiovascular System Assignments Chapter 3 Day 15 Objective Cardiovascular Physiology 1 hr 2 hrs Est. Time 2 hrs 3 hrs 2 hrs 0.5 hrs 1.5 hrs Est. Time 1.5 hrs 5 hrs 1 hr 1.5 hrs Est. Time 1.5 hrs Gastrointestinal System Assignments Chapter 15 Chapter 16 Chapter 24 Volume 1: Cases 40-73 Day 19 Objective Gastrointestinal Pathology Hepatobiliary and Exocrine Pancreatic Pathology GI Pharmacology Clinical Vignettes GenitoUrinary System Chapter 6 GI Physiology Assignments Chapter 6 Histology of GI Tract Day 20 Chapter 3 (Also refer to Netter's atlas) Abdominal Anatomy Objective Gastrointestinal System Assignments Chapters 10, 16 Volume 1: Cases 74-102 Clinical Vignettes Day 18 Chapter 38 Anticancer Drugs Objective Embryology of Gut and Body Cavities Chapter 20 Drugs affecting coagulation Details Understand rotation of gut and related malformations. Know which structures are derived of foregut, midgut, hindgut, in addition to vascular supplies. Source Underground Clinical Vignettes - Patho-physiology Lippincott's Pharmacology BRS Pathology Source BRS Pathology BRS Physiology Details Good opportunity for group review. Know GI drugs as well as antiemetics. Study this chapter thoroughly. Details Study this chapter thoroughly. Understand innervation of gut and gut hormones BRS Cell Biology & Histology Know layers of gut wall. Understand liver structure, portal blood flow, and bile flow. High Yield Gross Anatomy Source BRS Embryology Underground Clinical Vignettes - Patho-physiology Lippincott's Pharmacology Lippincott's Pharmacology Est. Time 2 hrs 2 hrs 2 hrs Est. Time 2 hrs 1 hr 1.5 hrs 2 hrs Est. Time 1.5 hrs 2 hrs 1.5 hrs 1.5 hrs Chapter 17 Chapter 18 Chapter 19 Volume 2: Cases 30-51, and 83-103 Underground Clinical Vignettes - Patho-physiology Endocrine System Assignments Chapter 13 Chapter 7 Chapter 26 Chapter 27 Renal & Urinary Tract Pathology Male Reproductive Pathology Female Reproductive Pathology Clinical Vignettes Day 22 Objective Histology of Endocrine System Physiology Insulin and oral hypoglycemics Steroid Hormones Lippincott's Pharmacology Lippincott's Pharmacology BRS Physiology Source BRS Embryology BRS Pathology BRS Pathology BRS Pathology Lippincott's Pharmacology Chapter 23 Diuretics Source BRS Physiology GenitoUrinary System Know different types of insulin and their half lives. Know classes of oral hypoglycemics and side effects. Know hormonal axes Details Review structure of endocrine organs, and use an atlas for additional pictures. Good opportunity for group review. Understand cervical, uterine cancer. Know the different types of testicular cancer, and the biology of BPH and prostate cancer Study this chapter thoroughly. Details BRS Cell Biology & Histology Know the maturation sequence of spermatocytes and ovarian follicles. Know the anatomy of the nephron. Assignments Chapter 5 Chapters 18, 19, 20 Histology of GU Organs High Yield Gross Anatomy Day 21 Chapters 4, 5 Anatomy of Pelvis and Perineum BRS Embryology Objective Renal Physiology Chapters 6, 13, 14 Embryology of GU Organs 1 hr 1.5 hrs 2.5 hrs Est. Time 1 hr 2 hrs 1.5 hrs 1 hr 1.5 hrs 1.5 hrs Est. Time 1.5 hrs 3 hrs 3 hrs 3 hrs Body Systems III - Nervous System EXAM Day 23 Nervous System Assignments Chapter 2 Chapter 23 Volume 2: Cases 45-61, Anatomy Cases 40-56. Chapters 8, 10, 11, 14, 15 Musculoskeletal System Assignments Chapter 15 Chapters 1, 6, 7 (also use Netter) Chapters 7, 8, 10 Day 24 Neuropathology Clinical Vignettes Neuropharmacology Day 25 Objective Embryology Anatomy of Limbs and Back Histology Chapters 1-23 Neuroanatomy Objective Neurophysiology High Yield Gross Anatomy Chapter 8 (also refer to Netter) Head & Neck Anatomy Details Review drugs used to treat epilepsy, Parkinson's. Also review anesthetics and analgesics. Good opportunity for group review. Know types of CNS infections, tumors, and vascular disorders. Details Understand Synaptic transmission and axonal conduction Details Know branchial arches/clefts and their derivatives. Understand the transition from neural plate to mature CNS. Know fate of neural crest cells. Tough questions, but great explanations. Well worth the time to push yourself a bit and solidify the material you've learned. Good opportunity for group review. BRS Cell Biology & Histology Review histology of skin, muscle, bone, and cartilage High Yield Gross Anatomy Source BRS Embryology Lippincott's Pharmacology Underground Clinical Vignettes - Patho-physiology BRS Pathology Source BRS Physiology High Yield Neuroanatomy Source BRS Embryology Board Simulator Series Body Systems Review Underground Clinical Vignettes - Patho-physiology Objective Assignments Embryology of Head, Chapters 7, 8, 9, 10 Neck, & Nervous System Test 1 Volume 1: Cases 25-38 Clinical Vignettes 2 hrs 3.5 hours Est. Time 1 hr 3.5 hrs 2 hrs 2 hrs Est. Time 2 hrs 6hrs 2 hrs Est. Time 3 hrs 1.5 hrs 2 hrs Anti-Inflammatory Agents Chapters 39, 40 and Autocoids Lippincott's Pharmacology 2 hrs Volume 3: Cases 9-18, and 96-104. Underground Clinical Vignettes - Patho-physiology Also Anatomy: Cases 62-84 Body Systems II - Test 1 Clinical Vignettes Exam Read entire book Final Review & Exam Logistics Assignments Biostatistics Day 28 Objective Final Review Rest & Relax Exam Logistics Chapters 9-12, 13 Psychotropic Drugs Source High Yield Biostatistics Lippincott's Pharmacology Source Underground Clinical Vignettes - Behavioral Sci. Behavioral Sciences & Biostatistics Assignments All cases Day 27 Objective Clinical Vignettes Board Simulator Series Body Systems Review BRS Pathology Chapter 22 Musculoskeletal Pathology Source BRS Pathology Musculoskeletal System Assignments Chapter 21 Day 26 Objective Dermatologic Pathology Prepare exam bag - with ID, ticket, directions to center, lunch. Details Review Any Remaining Topics and finish practice questions. Understand sensitivity, specificity, PPV, NPV. Be prepared to calculate risk, odds ratios, etc. Details Tough questions, but great explanations. Well worth the time to push yourself a bit and solidify the material you've learned. Good opportunity for group review. Details Focus on malignancies (melanoma, SCC, BCC) and refer to a dermatology atlas so that you can differentiate between them. Est. Time 4 hrs 4 hrs 3 hrs Est. Time 3 hrs 2 hrs 2 hrs 1.5 hrs Est. Time 1.5 hrs