Download Cu-Algesic Equine Granules and Paste

Oral Anti-inflammatory,
Analgesic for Horses
Nature Vet Data Sheet
Cu-Algesic Equine Granules
and Paste
Oral, Non-Steroidal Anti-Inflammatory
(NSAID) with low gastro-intestinal
toxicity and rapid excretion
COMPOSITION
Cu-Algesic is a patented chelate formulation of Copper
Indomethacin, available as:
Cu-Algesic Equine Oral Paste Anti-Inflammatory for Horses:
Active constituent: Copper indomethacin 40 mg/g
Cu-Algesic Granules:
Active constituent: Copper indomethacin 10 mg/g
ACTIONS
Cu-Algesic is a potent non-steroidal anti-inflammatory and
analgesic for the treatment of acute and sub-acute musculoskeletal / locomotor inflammatory conditions in horses.
Cu-Algesic provides excellent analgesia, as well as potent antiinflammatory activity, with very low gastro-intestinal toxicity,
unlike most other NSAIDs. Cu-Algesic is the only NSAID known to be
a free radical scavenger. Cu-Algesic has a once daily dosage regime,
plus predictable short excretion rates, even with repeated dosing.
INDICATIONS
Cu-Algesic is indicated for conditions requiring a potent antiinflammatory action with excellent analgesia, with reduction of
side effects usually associated with long term use of other NSAIDs.
These conditions include acute and sub-acute musculoskeletal /
locomotor inflammatory conditions such as osteitis (shin soreness),
pedal osteitis, navicular disease, sesamoiditis, synovial arthritis,
osteoarthritis, bursitis, tenosynovitis, spondylitis, tendonitis and
ligament inflammation, and ocular conditions such as uveitis.
Copper chelation of the parent NSAID (Indomethacin) produces
a unique pharmacological substance with significantly increased
anti-inflammatory potency, broader inhibition of inflammatory
reactions, and virtual elimination of adverse side effects, especially
gastro-intestinal ulceration.
Copper indomethacin is a prostaglandin cyclo-oxygenase 1 & 2 (Cox
1 & 2) inhibitor. Additionally, the lipoxygenase pathway is inhibited.
It also inhibits kallikreins, and thereby bradykinin formation,
which, with histamine and prostaglandins, produce the pain of
inflammation.
Copper chelates are free radical scavengers by Superoxide
Dismutase mimetic activity. Superoxide free radicals are involved
in degradation of hyaluronic acid in inflamed joints and in
perpetuation of the inflammatory cycle. Copper indomethacin
is therefore ideal for use in joint disease, and is indicated for
prevention of reperfusion injury. The broad combination of modes
of action helps to reduce gastro-intestinal and renal toxicity.
Cu-Algesic is rapidly absorbed from the gastro-intestinal tract. Peak
plasma levels are achieved within 3 - 4 hours of administration.
Plasma half-life of Cu-Algesic in the horse is approximately 24
hours. Cu-Algesic is rapidly and predictably excreted, provided
hepatic and renal function are normal.
Copper indomethacin may be used with caution as subsequent oral
NSAID therapy following parenteral treatment with other NSAIDs
(e.g. phenylbutazone or salicylates). There is no evidence of either
synergy or antagonism between copper indomethacin and other
NSAIDs. Use of two NSAIDs together generally summate therapeutic
and toxic effects, and extends clearance times. Renal or hepatic
conditions may alter the pharmacokinetics.
DOSAGE AND ADMINISTRATION
Cu-Algesic Granules: 1 level scoop equals 20 g. Give 40 g/450 kg
bodyweight on food initially, then 20 - 40 g once daily thereafter.
Cu-Algesic Equine Paste: Plunger is marked in 5 g increments
Give 10 g / 500 kg bodyweight by direct oral dosing initially, then
5 g / 500 kg once daily thereafter (i.e. 1 g per 100 kg bodyweight
once daily)
WARNINGS
Safety in young foals or during pregnancy has not been conclusively
demonstrated, and veterinarians should exercise normal caution in
prescribing anti-inflammatories during these times.
Meat Withholding Period (Horses): DO NOT USE less than 28 days
before slaughter for human consumption.
PRESENTATION
Paste: 40 mg/g, 30 g oral paste syringe (5 day course)
Granules: 10 mg/g, 200 g tub (10 day course)
STORAGE
Store below 25˚C (Air Conditioning). Protect from moisture.
AVAILABILITY
S4 - By Veterinary Prescription
(APVMA 56262 [Paste], 40301 [Granules])
Freecall (Australia) 1800 624 174 Telephone (+61) 2 9652 7000 Web: www.naturevet.com