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EVERYTHING YOU SHOULD KNOW BEFORE AESTHETIC OPERATIONS AND TREATMENTS DRUGS AND MEDICINAL PRODUCTS AGAINST HAIR LOSS They are divided into DHT inhibitors – finasteride and dutasteride, followed by stimulants of hair growth – minoxidil and finally anti-inflammatory preparations – special shampoos. Finasteride (for men) is an oral drug. It is mostly known under the trade names Propecia, Proscar, FIncat, Finax, Finara, Prosteride, Gefina. It is primarily used for the treatment of enlarged prostate, and the discovery of its effect on hair growth was accidental. It inhibits the 5-alpha-reductase enzyme, whereby the conversion of testosterone into dihydrotestosterone (DHT) is disabled. Finasteride is nowadays avoided in the stimulation of hair growth due to its many side-effects (post-finasteride syndrome) which may last for months, even years after the cessation of its use. These side-effects are: weakened libido, erectile dysfunction, difficulty in reaching an orgasm or its fading, depression, Peyronie’s disease and gynaecomasty. Dutasteride is known under the trade name Avodart. It has almost identical properties as finasteride, only its effect in the treatment of prostate is greater. By contrast to finasteride, the FDA did not approve it in the treatment of baldness. Minoxidil (2% for women and 5% for men) is a solution for external use. It is known as Rogaine, Regaine, Mintop, Avacor. It was initially used to treat increased blood pressure, and only later the effect of hair growth was accidentally observed. With regard that it expands blood vessels, it enables a better circulation in the scalp. Although these drugs have a scientifically proven effect on hair growth in a certain percentage of patients, they show side-effects and negative consequences. Thus, in long-term use of finasteride and dutasteride in a certain proportion of men depression is observed, along with impotence, disorders of ejaculation, erectile dysfunction, breast growth, reduced libido and increased hairiness all over the body. For minoxil it has been established that it interferes with heart function, influences blood pressure, causes redness, itching and dandruff on the scalp. All in all, not a nice picture, especially when we know that we are dealing with men between the age of 20 and 50, a period of life in which it is difficult to put up with side-effects which discourage sexual life. 192