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The Ernest Mario School of Pharmacy Honors Program Established in 1952, the Honors Program of the Ernest Mario School of Pharmacy of Rutgers, The State University of New Jersey is a research-oriented program that provides pharmacy students of exceptional merit the opportunity to extend their professional education. The Honors Program is a challenging learning experience that becomes an integral component of an Honor Student’s professional program in pharmacy. Designed for a small group of well-qualified students, the School of Pharmacy Honors Program offers students the opportunity to pursue special research interests with a high degree of individual attention by faculty advisors. A priority of the Honors Program is to further develop basic skills such as motivation, independence, and creative problem solving. Hands-on experience in using contemporary scientific methodologies also develops advanced skills in experimental design and modern research techniques. Students in the Honors Program experience an early introduction to pharmacy subject matter, greater access to faculty and personalized counseling about courses, academic programs, and potential career options. Students considering graduate school find that training in the Honors Program allows them to compete more successfully for admission into top graduate programs. Admissions Requirements Pharmacy students having a GPA rounding to 3.5 or greater in their first year of study are invited to apply for admission into the Honors Program during their second academic year. . Students accepted into the program are selected a faculty advisor who will guide each student in selecting a research advisor. The relationship between an honors student and a research advisor is a unique one as the student receives one-on-one mentoring for about four years. Working together with research advisors, honors students will formulate and complete an Honors Research Project which culminates in a Research Thesis. Upon completing the required course work and research thesis, students are considered graduates of the Ernest Mario School of Pharmacy Honors Program, and a notation to this effect is recorded on the student’s transcript of study and is officially held on file at the Rutgers University registrar’s office. In addition, matriculation through the Honors Program is-considered a high honor which is duly recognized by the presentation of a special Honors Certificate along with individual recognition in the graduation program and ceremony. Research Fellowships Honors Program students may have the option of performing research during the summer in the laboratory of the student’s Research Advisor. Although optional, many students take advantage of this opportunity to gain additional expertise in advanced laboratory techniques and to further their research project. Stipends are available on a competitive basis to students as arranged through either the Research Advisor or the Honors Program. Research Diversity Ernest Mario School of Pharmacy Honors Program 1 Honors Program students have available a diverse selection of research projects from which to select and develop an Honors Research Project. These options allow each student the ability to select an area of research of interest to him/her. Diversity is provided by participating School of Pharmacy faculty who has ongoing research programs in the Pharmaceutical Science Graduate Program, the Medicinal Chemistry Graduate Program, the Joint Graduate Program in Toxicology, the Doctor of Pharmacy Program and the graduate programs in Biochemistry and Molecular Biology, and Microbiology. Research Facilities Principal research facilities for honors research projects are made available through faculty research laboratories primarily located in the School of Pharmacy building (William Levine Hall) on the Busch campus, with additional state-of-the-art research facilities located at the Gordon Road Research Complex, the Susan Lehman Cullman Laboratory for Cancer Research and the Environmental, Occupational and Health Sciences Institute (EOHSI). As members of research teams, honors students have access to state-of-the-art instrumentation usually only available for senior investigators, postdoctoral fellows or graduate students. Honors students have the opportunity to gain considerable hands-on experience in pharmaceutics, pharmacology and toxicology, medicinal chemistry, molecular and cellular biology and biochemistry along with experience in using research instrumentation and techniques such as electron microscopy, gas chromatography, highperformance liquid chromatography, enzyme isolation and assays, centrifugation, gel electrophoresis, NMR, integrated compaction research system, small animal surgery, computerized data analysis, DNA cloning and sequencing, genetic engineering, tissue culture, and the production of monoclonal antibodies. that reserves time to perform advanced work toward the completion of their Honors Research Project. These courses carry semester credits that may be used for degree credits as outlined to the right. Students are required to maintain an overall GPA of 3.5 or better throughout their studies. In addition to the GPA requirement and research work, all Honors Students are required to attend informal meetings held in a seminar format. These meetings are used to initiate discussions on research topics of current interest. Third Year Fall 30:720:394 Honors Seminar/Tutorial I (1 credit) 30:720:395 Honors Independent Research I (1 credit) Spring 30:720:396 Honors Seminar/Tutorial II (1 credit) 30:720:397 Honors Independent Research II (1 credit) Fourth Year* Fall 30:720:494 Honors Independent Research III (2 credits) Spring 30:720:495 Honors Independent Research IV (3 credits) Fifth Year Fall 31:720:594 Spring 31:720:596 * Honors Thesis Preparation (2 credits) Honors Thesis Presentation (2 credits) Credits may be used as fourth year professional electives. Sequence of Courses Honors Program students enroll in a core of courses Ernest Mario School of Pharmacy Honors Program 2 Departmental Research Profiles Pharmacy Practice and Administration Research in this department is oriented towards expanding current concepts in basic pharmacotherapeutics with emphasis on addressing clinically-oriented problems encountered in patient care. Research programs in this department focus on the use of drugs in various diseases states. Research involves reviewing patient records, interviewing patients, and assessing physical and patient outcomes. Pharmaceutics Research in this department focuses on drug transport, drug delivery, drug absorption, pharmacokinetics, pharmacodynamics, and pharmacogenomics. The overall objective is to offer students the research environments where cutting edge research utilizing the latest technology to study the biopharmaceutical and pharmacological properties of drugs. Medicinal Chemistry Chemical Biology Research in this department places particular emphasis on the areas of (a) mechanisms of carcinogenesis and mutagenesis, (b) cancer chemoprevention, and (c) metabolism of drugs, steroid hormones, and carcinogens. Examples of specific research projects in which honors students could become involved include: studies of mechanisms of chemoprevention of cancer by naturally-occurring dietary substances, mechanisms of cancer causation by major constituents of tobacco smoke, regulation and function of major enzymes involved in drug and carcinogen metabolism, mechanisms of differentiation, a transgenic mouse model of melanoma, factors influencing the development of the central nervous system and neurological diseases and mechanisms of DNA repair. Research in this department emphasizes the area of pharmaceutical analysis and medicinal chemistry. Examples of research in the area of pharmaceutical analysis include fundamental investigations of analytical methods, drug analysis and analytical methods, drug analysis and quality control, and biochemical analysis. In the area of medicinal chemistry programs are investigating novel approaches to the synthesis of new medicinal agents, mechanisms associated with biological activity, synthesis and structural elucidation of novel antineoplastic agents. Pharmacology and Toxicology Research in this department is directed toward understanding the mechanisms of chemically-induced toxicity, drug metabolism, neuropharmacology and cancer biology. Specific research programs are investigating enhanced sensitivity of newborns and the elderly to drugs and toxic chemicals, alcohol hepatotoxicity, influence of nutrients on the metabolism and release of injurious chemicals from the liver, immunotoxicity, and mechanisms of toxicant-induced neural damage and repair. Ernest Mario School of Pharmacy Honors Program 3 Faculty Research Profiles See: • • • • • Chemical Biology Medicinal Chemistry Pharmaceutics Pharmacy Practice and Administration Pharmacology & Toxicology or the Faculty Directory http://pharm.rutgers.edu/content/facultystaff_directory for information on faculty research. Ernest Mario School of Pharmacy Honors Program 4 Recently Completed Honors Theses Class of 2003 Melissa Pao “Characterization of mdr1 and cMOAT Gene Expression in Human and Rat Intestine” Advisor: Professor Patrick Sinko Patrick T. Wong “Synthesis of Peptide Substrate and Intermediates of Peptide-Linked Analogues of Cyclophosphamide for Site Specific Activation in the Treatment of Prostate Cancer” Advisor: Professor Longqin Hu Class of 2004 Nesreen S Eltoukhy “Preliminary Molecular and Functional Characterization of Human Peptide/Histidine Transporters” Advisor: Professor Gregory T. Knipp Lucy X Jiang “Synthesis of Topoisomerase I Inhibitors for the Treatment of Cancer” Advior: Professor Edmond J. La Voie Jillian L. Maciejewski “In Vitro Metabolism of 7H-Benzo[c]fluorine” Advisor: Professor Eric H. Weynd Mark T. McIntyre A“PSA-NCAM Expression and Autistic Symptoms in Adult Mice Treated with Valproate” Advisor: Professor Kenneth Reuhl Felice I. Peng “Molecular and Functional Characterization of Fatty Acid Translocase/CD36” Advisor: Professor Gregory T. Knipp Sonal S. Shah “Role of Ubiquitin Proteolysis in Neurotoxic Injury” Advisor: Professor Dr. Kenneth Reuhl Staci Siconolfi “Utility of Levofloxacin for Empiric Management of Suspected Respiratory Infections in Renal Transplant Recipients” Advisor: Professor A. Scott Mathis “Deepa Trivedi S-A-R of Benzimidazoles and Related Heterocycles as Top-I inhibitors” Advisor: Professor Edmond J. Lavoie Class of 2005 C. Andrew Kistler “Altered Collagen Fibril Architecture in Fetal Growth Restriction” Advisor: Professor Dr. Marion K. Gordon Sabrina Lee “Effect of 1 2-O-tetradecanoylphorbol- 13acetate (TPA) alone or in combination with alltrans retinoic acid on the growth of prostate Ernest Mario School of Pharmacy Honors Program cancer LNCaP cells.” Advisor: Professors Allan Conney and Xi Zheng Melinda A. O’Shanughnessy “Effect of 2-methoxyestradiol and 2hydroxyestradiol on Estradiol-induced Mammary Cancer in ACI rsts” Advisor: Professor Paul E. Thomas 5 Suzanne Rzuczek “Synthesis of the Topoisomerase I Inhibitor Bulgarein” Advisor: Professor Joseph E. Rice Michelle Sander “EGCG May Prevent Parkinson’s Disease by Inhibiting COMT and Prolonging the Half-Lives of Catecholamines.” Advisor: Professor Chung S. Yang Class of 2006 Peter Chang “3-Morpholinopropyl isothiocyanate is a novel, strong inducer of phase II enzymes” Advisor: Ah Ng Tony Kong James Gugger “Percutaneous Coronary Intervention-Related Bleeding Risk Factors in Current Practice” Advisor: A. Scott Mathis Eugenia Levi “Effects of Cyclosporine and Tacrolimus on Atherosclerosis” Advisor: A. Scott Mathis Lemuel Liou “Preparation and Characterization of MultiComponent Biodegradable Poly(anhydride ester) Microspheres” Advisor: Thomas J. Cook Yvonne Tsao “Effect of Sulforaphane on Gene Expression in the Rat Intestine” Advisor: Thomas J. Cook William R. Vincent “Perinatal Changes in the Collagen Fibril Structure of the Cervix” Advisor: Marion K. Gordon Dorothy Surowiec “The effects of 12-O-tetradecanoylphorbol-13acetate (TPA) and other compounds on the growth of A549 and H1299 lung cancer cell lines” Advisor: Allan Conney Ernest Mario School of Pharmacy Honors Program 6 Thesis Guidelines Research accomplishments and educational experiences of Pharmacy Honors Program students culminate in the preparation of a Honors Program Thesis. Material presented in the Thesis is at the discretion of the student and Research Advisor. The format of a Thesis should include the following: Title Page, Abstract, Introduction, Materials and Methods, Results, Discussion, References, Tables and Figures Ernest Mario School of Pharmacy Honors Program 7 Title Page Format “Thesis Title” By “Student Name” This thesis is submitted in partial fulfillment of the requirements for graduating from the ERNEST MARIO SCHOOL OF PHARMACY HONORS PROGRAM May __, 2005 APPROVED: Faculty Advisor, “name” Members of the Honors Program Committee “name” “name” “name” “name” “name”, Chairman Ernest Mario School of Pharmacy Honors Program 8