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Curriculum Vitae
Hala Gali-Muhtasib
CURRICULUM VITAE
Hala U. Gali-Muhtasib
Department of Biology
American University of Beirut
P.O. Box 11-0236, Beirut 1107 2020, Lebanon
Tel: +961 3 973820 (home), +961 1 3374374 ext. 3894 (office)
Fax: +9611 351706, E-mail: [email protected]
Education
Ph.D. Biology, Kansas State University, Manhattan, Kansas, 1990.
M.Sc. Biology, American University of Beirut, Beirut-Lebanon, 1985.
B.Sc. Biology, American University of Beirut, Beirut-Lebanon, 1983.
Academic History
20062004-2006
1998-2004
1994-1998
1993-1994
1990-1993
1986-1989
Professor and Chairperson of the Department of Biology, AUB
Professor, Department of Biology, American University of Beirut, Beirut,
Lebanon
Associate Professor, Department of Biology, American University of
Beirut, Beirut, Lebanon
Assistant Professor, Department of Biology, American University of
Beirut, Beirut, Lebanon
Senior Research Associate, Case Western Reserve University, School of
Medicine, Department of Physiology and Biophysics, Cleveland, Ohio
Postdoctoral Research Fellow, Anti-Cancer Drug Laboratory, Kansas
State University, Manhattan, Kansas
Supervising and Coordinating Laboratory Courses in Biology and Human
Anatomy and Physiology, Kansas State University, Manhattan, KS.
Honors and Awards
-1st prize for best poster presented at the first regional scientific
conference on traditional Arabic and Islamic medicine, Amman, Jordan
-1st prize for best poster presented at the KHCBI-NCI-DUKE University
Middle East and North Africa (MENA) Cancer Research Conference,
Amman, Jordan
- 1st prize Abdul Hameed Shoman for contribution to medical sciences
- 1st prize Suad al-Sabbah Award for best research manuscript
- Nominated for the AACR- CRFA Award in Cancer Prevention Research
- Travel award- Immunologic Center of the Medical Faculty of
the University of Magdeburg”initiate studies on TQ using DNA microarrays”
- DAAD scholarship-investigate telomerase activity in colon cancer
2001
Research Scholarship, Case Western Reserve University School of
Medicine, Department of Dermatology, Cleveland, OH
- Teaching Award, William Stamey Award for Excellence in Teaching
Kansas State University, Manhattan, KS
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2007
2007
2004
2003
2002
2002
1993
1989
Curriculum Vitae
Hala Gali-Muhtasib
- Dean’s Honor List, Kansas State University, Manhattan, KS
Professional Societies
Member, American Association for Cancer Research, USA
Member, American Association for the Advancement of Science, USA
Member, Lebanese Association for the Advancement of Science,
Beirut, Lebanon
Member, Arab Society for Plant Protection, Beirut, Lebanon
Associate Member, American Association for Cancer Research, USA
Member, Sigma Xi Scientific Research Society, USA
1985-1990
2000-2006
1996-1999
19961996-1999
1991-2000
1991-1994
Reviewer for
Biochimica et Biophysica Acta-General Subjects
Journal of Pharmacology and Experimental Therapeutics
Current Medicinal Chemistry
Biochemical Pharmacology
Expert opinion on pharmacotherapy
Drug Discovery Today
Journal of Pharmacy and Pharmacology
Anticancer Drugs
Research
Publications: *corresponding or principal author
Refereed Articles in International Journals
1. Gali-Muhtasib H, Kuester D, Mawrin C, Bajbouj K, Diestel A, El-Najjar N, Peters B,
Jurjus A, Roessner A, Schneider-Stock R. Thymoquinone triggers inactivation of the
stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal
cancer cells: an in vitro and in vivo study, Cancer Research, in press.
2. *Gali-Muhtasib H, Ocker M, Kuester D, Krueger S, Evert M, El-Hajj Z, Diestel A, ElNajjar N, Peters B, Jurjus A, Roessner A and Schneider-Stock R. 2008.
Thymoquinone inhibits invasion of mouse colon tumor cells and growth of murine
colon cancer models. Journal of Cellular and Molecular Medicine, J Cell Mol Med.,
12(1):330-42.
3. El-Najjar N, Dakdouki S, Darwiche N, El-Sabban M, Saliba N and *Gali-Muhtasib H.
2008. Anti-colon cancer effects of Salograviolide A isolated from Centaurea
ainetensis. Oncology Reports,19(4):897-904.
4. Haykal J, Fernainy P, Itani W, Haddadin M, Geara F, Smith C, *Gali-Muhtasib H.
2008. Radiosensitization of EMT6 mammary carcinoma cells by 2-benzoyl-3-phenyl6,7-dichloroquinoxaline 1,4-dioxide. Radiother Oncol. 86(3):412-8. Epub 2007 Nov
19.
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Curriculum Vitae
Hala Gali-Muhtasib
5. Ghantous A, Abou Tayyoun A, Abou Lteif G, Saliba N, Gali-Muhtasib H, El-Sabban
M, Darwiche N. 2008. Purified Salograviolide A isolated from Centaurea ainetensis
causes growth inhibition and apoptosis in neoplastic epidermal cells. International
Journal of Oncology, 32(4):841-9.
6.
Darwiche N, El-Banna S, and *Gali-Muhtasib, H. 2007. Cell cycle modulatory and
apoptotic effects of plant-derived anticancer drugs in clinical use or development.
Expert Opinion on Drug Discovery, 2(3):361-379.
7. El-Najjar N, Saliba N, Talhouk S and *Gali-Muhtasib H. 2007. Onopordum
cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazineinduced colon cancer. Oncology Reports 17(6):1517-23.
8.
Itani W, Geara F, Haykal J, Haddadin M, and *Gali-Muhtasib H. 2007.
Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under
oxia and hypoxia in human colon cancer cells. Radiation Oncology, 2:1.
9.
Roepke M, Diestel A, Bajbouj K, Diana Walluscheck, Schonfeld P, Roessner A,
Schneider-Stock R, *Gali-Muhtasib H. 2007. Lack of p53 augments thymoquinoneinduced apoptosis and caspase activation in human osteosarcoma cells. Cancer
Biology and Therapy, 6(2):160-169.
10.
Al-Ayyoubi, S. and *Gali-Muhtasib, H. 2007. Differential Apoptosis by Gallotannin
in Human Colon Cancer Cells with Distinct p53 Status. Molecular carcinogenesis,
46(3):176-186.
11. *Gali-Muhtasib H, Roessner A, Schneider-Stock R. 2006. Thymoquinone: a
promising anti-cancer drug from natural sources. International Journal of Biochemistry
and Cell Biology 38(8):1249-53
12. *Darwiche N, Bazzi H, El-Touni L, Abou-Lteif G, Doueiri R, Hatoum A, Maalouf S,
*Gali-Muhtasib H. 2005. Regulation of ultraviolet B radiation-mediated activation of
AP-1 signaling by retinoids in primary keratinocytes. Radiation Research, 163(3):296306.
13. *Schneider-Stock R, Diab-Assef M, Rohrbeck A, Foltzer-Jourdainne C, Boltze C,
Hartig R, Schönfeld B, Roessner A, *Gali-Muhtasib, H. 2005. 5-AZA-cytidine is a
potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT116
colon cancer cells via Gadd45- and p53-Dependent Mechanisms. Journal of
Pharmacology and Experimental Therapeutics, 312(2):525-536.
14. *Gali-Muhtasib H.U., Diab-Assaf M. and Haddadin M.J. 2005. Quinoxaline 1,4dioxides Induce Cell Cycle Arrest, Apoptosis and changes in transforming growth
factors and Extracellular signal-regulated kinase expression in Human colon cancer
cells. Cancer Chemotherapy and Pharmacology, 55(4):369-378.
15. *Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A and
Schneider-Stock R. 2004. Thymoquinone extracted from black seed triggers
apoptotic cell death in human colorectal cancer cells via a p53-dependent
mechanism. International Journal of Oncology 25(4), 857-866.
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Hala Gali-Muhtasib
16. Harakeh S, Diab-Assef M, El-Sabban M, Haddadin M, *Gali-Muhtasib H. 2004.
Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7dichloroquinoxaline 1,4-dioxide in adult T cell leukemia cells. Chemico-Biological
Interactions 148(3), 101-113.
17. *Gali-Muhtasib H.U., Aboukheir W., Kheir L., Darwiche N., Crooks P. 2004.
Molecular pathway for Thymoquinone-induced cell cycle arrest and apoptosis in
neoplastic keratinocytes. Anticancer Drugs 15 (4), 389-399.
18. *Gali-Muhtasib H.U., Sidani M., Geara F., Assaf-Diab M., Al-Hmaira J., Haddadin
M.J., Zaatari G. 2004. Quinoxaline 1,4-dioxides are Novel Angiogenesis Inhibitors
that Potentiate Antitumor Effects of Ionizing Radiation. International Journal of
Oncology 24, 1121-1131.
19. *Gali-Muhtasib, H.U. and Bakkar, N. 2002. Modulating Cell Cycle: Current
Applications and Prospects for Future Drug Development. Current Cancer Drug
Targets 2: 309-336.
20. *Gali-Muhtasib, H.U., Diab-Assef, M, and Haddadin, M.J. 2002. Hypoxic cells in
tumors as a target for cancer therapy. Lebanese Medical Journal 50 (4): 175-179.
21. Maalouf, S., El-Sabban, M., Darwiche, N. and *Gali-Muhtasib, H.U. 2002. Protective
effect of vitamin E on ultraviolet B light-induced damage in keratinocytes.
Molecular Carcinogenesis 34: 121-130.
22. Diab-Assaf, M., Haddadin, M.J., Yared, P., Assaad., C., and *Gali-Muhtasib, H.U.
2002. Quinoxaline 1,4-dioxides: hypoxia selective therapeutic agents. Molecular
carcinogenesis 33 (4): 198-205.
23. Farhat, G., Affara, N. and *Gali-Muhtasib, H.U. 2001. Seasonal changes in the
composition of the essential oil extract of East Mediterranean Sage (Salvia
libanotica) and its toxicity in mice. Toxicon 39: 1601–1605.
24. *Gali-Muhtasib, H.U., Haddadin, M.J., Rahhal, D.N. and Younes, I. 2001.
Quinoxaline 1,4-dioxides as anticancer and hypoxia-selective drugs. Oncology
Reports 8: 679-684.
25. *Gali-Muhtasib, H.U., Younis, I., Karchesy, J. and El-Sabban, M. 2001. Plant
tannins inhibit the induction of aberrant crypt foci and colonic tumors by 1,2-dimethyl
hydrazine in mice. Nutrition and Cancer 39: 108-116.
26. *Gali-Muhtasib, H.U., Yamout, S.Z. and Sidani, M. 2000. Tannins protect against
skin tumor promotion induced by ultraviolet B radiation in hairless mice. Nutrition and
Cancer 37: 73-77.
27. *Gali-Muhtasib, H.U., Hilan C. and Khater, C. 2000. Traditional uses of Salvia
libanotica (East Mediterranean Sage) and the effects of its essential oils. Journal of
Ethnopharmacology 71: 513-520.
28. *Gali-Muhtasib, H.U. and Affara, N. 2000. Chemopreventive effects of sage oil on
skin papillomas in mice. Phytomedicine 7: 129-136.
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Hala Gali-Muhtasib
29. *Gali-Muhtasib, H.U., Yamout, S., and Sidani, M.M. 1999. Plant tannins as
Inhibitors of hydroperoxide production and tumor promotion induced by ultraviolet B
Radiation in mouse skin in vivo. Oncology Reports 6: 847-853.
30. *Gali-Muhtasib, H.U., Haddadin, M.J., Nazer, M., Sodir, N and Maalouf, S. 1998.
Photoprotective effects of some quinoxaline 1,4-dioxides in hairless mice. Medical
Oncology 15: 262-269.
31. Ahmad, N., Gali, H., Javed, S., and Agarwal, R. 1998. Skin cancer chemopreventive
effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor
tyrosine kinase signaling and perturbation in cell cycle progression. Biochemical
and Biophysical Research Communications 248: 294-301.
32. *Gali-Muhtasib, H.U., Perchellet, J.P., and Khatib, S.H. 1998. Inhibitory effects of
plant tannins on ultraviolet light-induced epidermal DNA synthesis in hairless mice.
Photochemistry and Photobiology 67: 663-668.
33. *Gali-Muhtasib, HU, Reichman, J, and Smith, C. 1998. The significance of isolation
and body size on the aggression and dominance of the crayfish Orconectes nais.
Transactions of the Kansas Academy of Science 101: 11-16.
34. *Gali-Muhtasib, HU, Perchellet, JP and Khatib, SH. 1997. Inhibition of Ultraviolet
B radiation induced ornithine decarboxylase activity and edema formation by
hydrolyzable and condensed tannins in mouse skin in vivo. Anticancer Research 17:
4507-4514.
35. Castonguay, A, Gali, HU, Perchellet, EM, Gao, XM, Boukharta, M, Jalbert, G,
Okuda T, Yoshida, T, Hatano, T, and Perchellet, JP. 1997. Antitumorigenic and
antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and
procyanidin. International Journal of Oncology 10: 367-373.
36. Perchellet, EM, Gali, HU, Makkar, HPS, and Perchellet, JP. 1996. Ability of tannins
extracted from various tree leaves to inhibit the biomarkers of tumor promotion in
mouse skin in vivo. International Journal of Oncology 9: 801-809.
37. Welter, JF, Gali, HU, Crish, J, and Eckert, RL. 1996. Regulation of human involucrin
promoter activity by POU domain proteins. Journal of Biological Chemistry 271:
14727-14733.
38. Gao, XM, Perchellet, EM, Gali, HU, Rodriguez, L, Hemingway, RW, and Perchellet,
JP. 1994. Antitumor-promoting activity of oligomeric proanthocyanidins in mouse
epidermis in vivo. International Journal of Oncology 5: 285-292.
39. Gali, HU, Perchellet, EM, Gao, XM, Karchesy, JJ, and Perchellet, JP. 1994.
Comparison of the inhibitory effects of monomeric, dimeric and trimeric procyanidins
on the biochemical markers of skin tumor promotion in mouse epidermis in vivo.
Planta Medica 60: 235-239.
40. Perchellet, EM, Gali, HU, Gao, XM, and Perchellet, JP. 1993. Ability of the
nonphorbol ester-type tumor promoter thapsigargin to mimic the stimulatory effects
of 12-O-tetradecanoylphorbol-13-acetate on ornithine decarboxylase activity,
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Hala Gali-Muhtasib
hydroperoxide production, and macromolecule synthesis in mouse epidermis in
vivo. International Journal of Cancer 55: 1036-1043.
41. *Gali, HU, Perchellet, EM, Gao, XM, Laks, PE and Perchellet, JP. 1993. Inhibitory
effects of semisynthetic flavanoid derivatives on the biochemical markers of tumor
promotion in mouse epidermis in vivo. Cancer Letters 72: 149-156.
42. *Gali, HU, Perchellet, EM, Gao, XM, Bottari, V, and Perchellet, JP. 1993. Antitumorpromoting effects of gallotannins extracted from various sources in mouse skin in
vivo. Anticancer Research 13: 915-922.
43. Perchellet, JP, Gali, HU, Perchellet, EM, Klish, DS, and Johnson, JM. 1992.
Hydrolyzable tannins: potent antioxidant and antitumor-promoting activities in
mouse skin in vivo. 16th International Conference on Polyphenols, JIEP, 16: 304307.
44. *Gali, HU, Perchellet, EM, Klish, DS, Johnson, JM, and Perchellet, JP. 1992.
Hydrolyzable tannins: potent inhibitors of hydroperoxide production and tumor
promotion in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate in vivo.
International Journal of Cancer 51: 425-432.
45. *Gali, HU, Perchellet, EM, Klish, DS, Johnson, JM, and Perchellet, JP. 1992.
Antitumor-promoting activities of hydrolyzable tannins in mouse skin.
Carcinogenesis 13: 715-718.
46. Perchellet, JP, Gali, HU, Perchellet, EM, Klish, DS, Armbrust, AD. 1992. Antitumorpromoting activities of tannic acid, ellagic acid, and several gallic acid derivatives in
mouse skin. Basic Life Sciences 59: 783-801
47. *Gali, HU and Smith, CC. 1992. Effect of silicon supply on growth, fertility and
mineral composition of an annual brome, Bromus secalinus. American Journal of
Botany 79: 1259-1263.
48. *Gali-Muhtasib, H., Smith, CC, and Higgins, JJ. 1992. The effect of silica in grasses
on the feeding behavior of the prairie vole Microtus ochrogaster. Ecology 73: 17241729.
49. *Gali, HU, Perchellet, EM, and Perchellet, JP. 1991. Inhibition of tumor promoterinduced ornithine decarboxylase activity by tannic acid and other polyphenols in
mouse epidermis in vivo. Cancer Research 51: 2820-2825.
50. *Muhtasib, HU, and Evans, DL. 1987. Linamarin and histamine in the defense of
adult Zygaena filipendulae. Journal of the Chemical Ecology 13: 133-142.
Invited Book Chapters (Refereed)
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Hala Gali-Muhtasib
1. Al-Ayyoubi S and *Gali-Muhtasib H. Anti-Tumor Signaling Pathways Modulated by
Plant Polyphenols. In: New Cell Apoptosis Research, Rafe G. Valentino. (ed.). Nova
Science Publishers, Inc, p. 85-105.
2. Chatila, M. and *Gali-Muhtasib H. Quinones as Antiangiogenic Agents. In: New
Research on Angiogenesis inhibitors, Columbus, F. (ed.). Nova Science Publishers,
Inc, (in press).
3. Fernainy P., Sidani M., Haddadin M., and *Gali-Muhtasib H. Radiosensitizers as
chemotherapeutic agents. In: New Topics in Cancer Research, Drabell, F.G. (ed.).
Nova Science Publishers, Inc, (in press).
4. *Gali-Muhtasib, H.U. 2006. Cyclin Dependent Kinase Inhibitors from Natural
Sources: Recent Advances and Future Prospects for Cancer Treatment. In: New
Trends in Research Strategies on Lead Molecules from Natural Products. M.T. Khan
(Ed.), pp. 155-167, Elsevier Publishers.
5. *Gali-Muhtasib, H.U. 2006. Anticancer and Medicinal Properties of Essential Oil and
Extracts of East Mediterranean Sage (Salvia triloba). In: New Trends in Research
Strategies on Lead Molecules from Natural Products. M.T. Khan (Ed.), pp. 169-180,
Elsevier Publishers.
6. *Gali-Muhtasib, H.U. El-Najjar, N. and Schneider-Stock R. 2006. The Medicinal
Potential of Black seed (Nigella sativa) and its Components. In: New Trends in
Research Strategies on Lead Molecules from Natural Products, M.T. Khan (Ed). pp.
133-153, Elsevier Publishers.
7. Perchellet, JP, Perchellet, EM, Gali, HU, and Gao, XM. 1995. Oxidant stress and
multistage skin carcinogenesis. In: H. Mukhtar (ed.), Skin Cancer: Mechanisms and
Human Relevance, CRC Press, Boca Raton, FL, pp. 145-180.
8. Perchellet, JP, Gali, HU, Perchellet, EM, Laks, PE, Bottari, V, Hemingway, RW and
Scalbert, A. 1994. Antitumor-promoting effects of gallotannins, ellagitannins, and
flavonoids in mouse skin in vivo. In: M.-T. Huang, T. Osawa, C.-T. Ho, and R.T.
Rosen (eds.), Food Phytochemicals for Cancer Prevention, American Chemical
Society Symposium Series Books, Washington, DC, 546: 303-327.
9. Perchellet, JP, Gao, XM, Perchellet, EM, Gali, HU, Rodriguez, L, and Hemingway,
RW. 1995. Antitumor-promoting activity of loblolly pine bark condensed tannin in
mouse epidermis in vivo. In: R. Brouillard, M. Jay, and A. Scalbert (eds.),
polyphenols 94, 17th International Conference on Polyphenols, INRA Editions, Paris,
Les Colloques, Vol. 69, pp. 407-408.
10. Perchellet, JP, Gali, HU, Perchellet, EM, Klish, DS and Armbrust, AD. 1992.
Antitumor-promoting activities of tannic acid, ellagic acid and several gallic acid
derivatives in mouse skin. In: R.W. Hemingway and P.E. Laks (eds.). Plant
Polyphenols: Synthesis, Properties, Significance, Plenum Press, NY, pp.783-801.
Abstracts and Paper Presentations
1. Gali-Muhtasib H, El-Banna S, Itani W, Hassan S, Larsson R, Bazarbachi A. 2008.
Molecular mechanisms of the antineoplastic components of Lebanese sage (Salvia
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Hala Gali-Muhtasib
triloba) essential oils. Accepted as poster at the Cell Death and Cellular Senescence,
Breckenridge Colorado, US, Feb 7-12, 2008.
2. Hassan S, Lindhagen E, El-Banna S, Gali-Muhtasib H, and Larsson R.
Antineoplastic effects of α-Terpineol, Linalyl Acetate and dl-Camphor, components of
Lebanese Sage essential oil. Accepted for presentation at the 1st International
Conference on Drug Design and Discovery, 4-7 February 2008, Dubai, UAE.
3. Gali-Muhtasib H, Ocker M, Kuester D, Krueger S, El-Hajj Z, Diestel A, Evert M, ElNajjar N, Peters B, Jusjus A, Roessner A, and Schneider-Stock R. Thymoquinone
reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon
cancer models. Accepted for presentation at the 1st International Conference on Drug
Design and Discovery. 4-7 February 2008, Dubai, UAE.
4. Gali-Muhtasib H, El-Banna S, Hassan S, Larsson R and Bazarbachi A. Molecular
Mechanisms of the Antineoplastic Components of Lebanese Sage (Salvia triloba)
Essential Oils. Accepted for presentation at the 1st International Conference on Drug
Design and Discovery, 4-7 February 2008, Dubai, UAE.
5. Haykal J, Fernainy P, Itani W, Haddadin M, Geara F, Smith C, and Gali-Muhtasib H,
The radiosensitizer DCQ induces DNA damage in murine mammary carcinoma cells:
The role of p-ATM and DNA-PK. Presented at the 12th World Congress on Advances
in Oncology and 10th International Symposium on Molecular Medicine, 11-13 October,
2007, Creta Maris, Hersonissos, Crete, Greece. Abstract published in International
Journal of Molecular Medicine, vol 20, supplement 1, S11.
6. Gali-Muhtasib, H. 2007. Thymoquinone: a natural anti-colon-cancer drug with prooxidant activities. Presented orally at the First Regional Scientific Conference on
Traditional Arabic and Islamic Medicine, Amman, Jordan, August 8-10, 2007.
7. Gali-Muhtasib H, Haykal J, Haddadin M, Geara F and Smith C. 2007. The
radiosensitizer 2-benzoyl-3-phenyl-6,7-dichoro-quinoxaline 1,4-dioxide induces DNA
damage and activates ATM and DNA-PK in EMT-6 cells. Presented at the KHCBINCI– DUKE University Middle East and North Africa (MENA) Cancer Research
Conference, Amman, Jordan, September 3-4, 2007.
Poster was awarded first prize for best poster presentation.
8. El-Najjar N, Dakdouki S, Darwiche N, El-Sabban M, Saliba N, Gali-Muhtasib, H.
2007. Anti-colon cancer effects of Salograviolide A isolated from Centuarea ainetensis.
Presented at the First Regional Scientific Conference on Traditional Arabic and Islamic
Medicine, Amman, Jordan, August 8-10, 2007.
Poster was awarded first prize for best poster presentation.
9. Itani W, Geara F, Haykal J, Haddadin M, Gali-Muhtasib H. 2007. DCQ is a potent
hypoxic radiosensitizer and DNA damaging agent in human colon cancer cells. 9th
World Congress on Gastrointestinal Cancer, June 27 - July 1 2007, Barcelona, Spain.
Annals of Oncology, vol 18, suppl 7: vii 39.
10. Morgenthal S, Poehlmann A, Gali-Muhtasib H, Roessner A, Schneider-Stock R.
Pretreatment with thymoquinone overcomes 5-Fluorouracil-induced drug resistance in
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Hala Gali-Muhtasib
p53 mutant colorectal cancer cells. Annual Congress of the German Society of
Pathology, Magdeburg, 30 May-2 June, 2007.
11. Kuester D, Gali-Muhtasib H, Ocker M, Kruger S, El-Hajj Z, Diestel A, Evert M, ElNajjar N, Peters B, Jurjus A, Roessner R, Schneider-Stock R. Thymoquinone
decreases tumor cell growth and invasion in colorectal cancer mouse models. Annual
Congress of the German Society of Pathology, Magdeburg, 30 May-2 June, 2007.
12. Roepke M, Diestel A, Bajbouj K, Schonfeld P, Roessner A, Gali-Muhtasib H,
Schneider-Stock R. Lack of p53 augments thymoquinone-induced apoptosis and
caspase activation in human osteosarcoma cells. Annual Congress of the German
Society of Pathology, Magdeburg, 30 May-2 June, 2007.
13. Schneider-Stock R, Mawrin C, Kuester D, Ocker M, Habold C., Foltzer-Jourdaine C,
Diestel A, Schönfeld P, Roessner A, *Gali-Muhtasib H. p53-dependent repression of
CHEK1 contributes to apoptosis in colorectal cancer cells: an in vitro and in vivo
study . Presented at the 18th EORTC-NCI-AACR Symposium on Molecular Targets
and Cancer Therapeutics, Prag, November 2006.
14. Al-Ayyoubi S and *Gali-Muhtasib H. Differential Apoptosis by Gallotannin in Human
Colon Cancer Cells with Distinct p53 Status. 8th World Congress on Gastrointestinal
Cancer, June 28 - July 1 2006, Barcelona, Spain. Annals of Oncology, Vol 17,
Supplement 6, p. 34.
15. El-Najjar N, Saliba N, Talhouk S and *Gali-Muhtasib H. Induction of apoptosis and
protection against DMH-induced colon cancer by the extract of Onopordum
cynarocephalum. 8th World Congress on Gastrointestinal Cancer, June 28 - July 1
2006, Barcelona, Spain. Annals of Oncology, Vol 17, Supplement 6, p. 35.
16. *Gali-Muhtasib H, Krueger S, El-Hajj Z, Kuester D, El-Najjar N, Peters B, Jurjus A,
Roessner A, Schneider-Stock R. Thymoquinone inhibits invasion of mouse colon
tumor cells and prevents 1,2-dimethylhydrazine-induced mouse colon carcinogenesis.
Presented at the 10th World Congress on Advances in Oncology and 8th International
Symposium on Molecular Medicine, 13-15 October, 2005, Creta Maris, Hersonissos,
Crete, Greece.
17. *Gali-Muhtasib H, Boltze C, Diab-Assaf M, Al-Hmaira J, Roessner A, SchneiderStock R. Thymoquinone is a potent growth inhibitor and inducer of apoptosis in
Human Colon Cancer HCT-116 cells. Proceedings of the American Association for
Cancer Research 47, April 2005.
18. Fernainy P, Geara F, Itani W, Haddadin M, *Gali-Muhtasib H. Molecular
Mechanisms of the Radiosensitizing Effects of a Quinoxaline Dioxide Derivative.
Accepted for presentation at the 52nd Annual Meeting of the Radiation Research
Society, October 16-19, Denver, Colorado.
19. *Gali-Muhtasib H, Guerin E, Diab-Assef M, Guenot D,, Abboud A, Yared P, Gaub
M-P. 2004. Chemoprevention of colon cancer by Gallotannin. Proceedings of the
Abstracts of 9th World Congress on Advances in Oncology, 14-16 October, 2004,
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Hala Gali-Muhtasib
Crete, Greece. Abstract published in International Journal of Molecular Medicine, Vol
14, supplement 1, S38.
20. *Gali-Muhtasib H.U., Carsten Boltze, Diab-Assaf M, Al-Hmaira J, Roessner A and
Schneider-Stock R. 2003. Thymoquinone extracted from Black seed is a potent
growth inhibitor and inducer of apoptosis in Human Colon Cancer HCT-116 cells.
Proceedings of the American Association for Cancer Research 44: 623.
21. *Gali-Muhtasib, H. Sidani, M., Diab-Assaf, M. Haddadin, M., Geara, F., and Zaatari,
G. 2003. An evaluation of the radiosensitization effects of quinoxaline 1,4-dioxides.
Second International Conference on Translational Research and Pre-Clinical
Strategies in Radio-Oncology. March 16-19, 2003, Lugano, Switzerland.
International Journal of Radiation Oncology Biology and Physics 55: 506.
22. *Gali-Muhtasib, H.U., Sidani, M.M., Diab-Assaf, M., and Haddadin, M.J. 2002. 2Benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide is a Novel Angiogenesis
Inhibitor that Potentiates the Antitumor Effects of Ionizing Radiation. Proceedings of
the 1st International Conference on Hypoxia/HIF Mediated Responses in Tumour
Biology. November 27-29, 2002, Manchester, UK. p. 6.
23. Assaf-Diab, M., Haddadin, M.J., and *Gali-Muhtasib, H.U. 2002. Effect of
quinoxaline 1,4-dioxides on epithelial cell proliferation, apoptosis and transforming
growth factors expression. 12th International Congress on Anti-Cancer Treatment.
February 4-7, 2002. Paris, France.
24. Assaf-Diab, M., Haddadin, M.J., and *Gali-Muhtasib, H.U. 2001. Quinoxaline 1,4dioxides: a new class of hypoxia-selective therapeutic agents. Proceedings of the
Abstracts of 6th World Congress on Advances in Oncology, 18-20 October, 2001,
Crete, Greece. Abstract published in International Journal of Molecular Medicine, vol
8, supplement 1.
25. Assaf-Diab, M., Haddadin, M.J. and *Gali-Muhtasib, H.U. 2001. Quinoxaline 1,4dioxides alter epithelial cell proliferation via changes in transforming growth factors
expression. Proceedings of the 5th Middle East Oncology Congress (COMO V), 2528 April, 2001, p.32.
26. *Gali-Muhtasib, H.U., Haddadin, M.J., Rahhal, D.N. and Younes, I. 2000.
Quinoxaline 1,4-di-N-oxides as anticancer and hypoxia-selective drugs.
Proceedings of the 14th Science Meeting, Beirut, Lebanon, November 23-25, 2000,
p. 153.
27. Bazzi, H., Al-Maalouf, S., Hatoum, E., Gali-Muhtasib, H.U. and Darwiche, N. 2000.
Retinoic acid inhibits early vitamin A deficiency induced by ultraviolet irradiation of
primary mouse keratinocytes. Proceedings of the 14th Science Meeting, November
23-25, 2000, Beirut, Lebanon, p. 169.
28. *Gali-Muhtasib, H.U., Younis, I., Karchesy, J. and El-Sabban, M. 2000. Plant
tannins as chemopreventive agents against colon cancer: Mechanistic aspects of
action in human colon cancer cell lines. Proceedings of the Abstracts of 5th World
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Curriculum Vitae
Hala Gali-Muhtasib
Congress on Advances in Oncology, 19-21 October, 2000, Crete, Greece. Abstract
published in International Journal of Molecular Medicine, vol 6, supplement 1: S81.
29. *Gali-Muhtasib, H.U., Al-Maalouf, S., Tabbal, M., and El-Sabban, M. 2000. Vitamin
E protects against UVB-induced damage in murine keratinocytes. Proceedings of
the 7th International Conference on Antimutagensis and Anticarcinogenesis,
September 23-27, 2000, Michigan, USA, p. 149.
30. *Gali-Muhtasib, H.U., Younes, I., Abou-Karam, M. and El-Sabban, M. 2000.
Gallotannin induces cell cycle arrest and apoptosis in human colon cancer cell
lines. Proceedings of the 7th International Conference on Antimutagensis and
Anticarcinogenesis, September 23-27, 2000, Michigan, USA, p. 70.
31. Affara, N. and *Gali-Muhtasib, H.U. 1999. Chemopreventive effects of sage oil on
skin papillomas in mice. Oral presentation at the13th Science Meeting, Beirut,
Lebanon. Proceedings of the 13th Science Meeting, p. 30.
32. Al-Maalouf, S., El-Sabban, M., Darwiche, N., and *Gali-Muhtasib, H.U. 1999. The
effect of vitamin E on UVB-induced apoptosis in murine keratinocytes. Oral
presentation at the 13th Science Meeting, Beirut, Lebanon. Proceedings of the 13th
Science Meeting, p. 31.
33. Younis, I., El-Sabban, M., and *Gali-Muhtasib, H.U. 1999. In vitro effects of
gallotannin on a human colon cancer cell line. Oral presentation at the 13th Science
Meeting, Beirut, Lebanon. Proceedings of the 13th Science Meeting, p. 49.
34. Younis, I., El-Sabban, M. and *Gali-Muhtasib, H.U. 1999. Gallotannin induces cell
cycle arrest and apoptosis in a human colon cancer cell line. Oral presentation at
the the 4th World Congress on Advances in Oncology, 7-9 October 1999, Athens,
Greece. Published in International Journal of Molecular Medicine vol. 4: S35.
35. Rahhal, D., Haddadin, M.J., and *Gali-Muhtasib, H.U. 1999. In vitro effects of
quinoxaline 1,4-dioxides in a mouse papilloma derived cell line. Presented at the
4th Middle East Oncology Congress, 28 April- 1 May, 1999; Forum De Beyrouth,
Beirut, Lebanon.
36. *Gali-Muhtasib, H.U., Al-Maalouf, S., Darwiche, N., Hazimeh, Y. and El-Sabban,
M. 1999. In vitro effects of vitamin E and analogues on UVB-induced apoptosis.
Proceedings of the American Association for Cancer Research 40: 225.
37. *Gali-Muhtasib, H.U., Affara, N., Khater, C. and Christo, H. 1999. The essential oil
of Salvia libanotica (sage) protects against chemically induced tumors in the skin.
Proceedings of the American Association for Cancer Research 40: 258.
38. *Gali-Muhtasib, H.U. and Yamut, S. 1998. Photoprotective and antioxidant effects of
hydrolyzable and condensed tannins in the skin of hairless mice. Abstract presented
at the Sixth International Conference of Anticancer Research, October 21-25, 1998,
Kallithea, Halkidiki, Greece. Anticancer Research 18: 4867.
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Curriculum Vitae
Hala Gali-Muhtasib
39. *Gali-Muhtasib, H.U. and Rubeiz, N. 1997. The role of vitamins C, E and their
analogs on ultraviolet radiation-induced effects in the skin. Lebanese Abstracts vol.
III: 418.
40. *Gali-Muhtasib, H.U. and Yamut, S. 1997. Inhibition of hydroperoxide production
and tumor promotion by hydrolyzable and condensed tannins in mouse skin treated
with ultraviolet B radiation. Lebanese Abstracts vol. III: 417.
41. *Gali-Muhtasib, H.U., Khatib, S.H., and Sodir, N.M. 1997. Protection against
ultraviolet B radiation-induced effects in murine skin by naturally occurring plant
polyphenols. 3rd International Epidemiological Association Eastern Mediterranean
Regional Scientific Meeting, AUB, Beirut, Lebanon, October 22-25, 1997, P/14/EO.
42. *Muhtasib, H.U. and Smith, C.C. 1997. Effect of silicon and nitrogen nutrition on the
palatability of grasses: implications for pest control. Arab Journal of Plant Protection
15: 119.
43. *Gali-Muhtasib, H.U., Haddadin, M.J., and Sodir, N.M. 1997. 2-Benzoyl-3phenylquinoxaline 1,4-dioxide protects against ultraviolet B radiation induced
effects in the skin of hairless mice”. Proceedings of the 2nd World Congress on
Advances in Oncology published in International Journal of Oncology (supplement)
11: 936.
44. *Gali, H, Ahmad, N, Jawed, S, Mukhtar, H, and Agarwal, R. 1997. Inhibition of
epidermal growth factor receptor (EGFr) tyrosine kinase activity by silymarin, a
polyphenolic antioxidant and potent cancer chemopreventive agent. Proceedings of
the American Association for Cancer Research 38: 263.
45. *Gali-Muhtasib, HU, Khatib, S, Perchellet, JP and Samad, A. 1997. Inhibition by
gallotannins and proanthocyanidins of the biochemical markers of skin tumor
promotion by Ultraviolet B radiation. Proceedings of the American Association for
Cancer Research 38: 247
46. Perchellet, JP, Perchellet, EM, Gao, XM, Gali, HU, Newell, SW, Chen, G, and
Bottari, V. 1995. Characterization of the tumor-promoting activity of thapsigargin in
SENCAR mouse skin and its modulation by gallotannin. Proceedings of the
American Association for Cancer Research 36: 123.
47. Perchellet, JP, Gao, XM, Perchellet, EM, Gali, HU, Rodriguez, L, and Hemingway,
RW. 1994. Antitumor-promoting activity of loblolly pine bark condensed tannin in
mouse epidermis in vivo. Proceedings of the17th International Conference on Group
Polyphenols, JIEP, 11:33.
48. Gao, XM, Perchellet, EM, Gali, HU, Rodriguez, L, Hemingway, RW and Perchellet,
JP. 1994. Inhibition of mouse skin tumor promotion by oligomeric proanthocyanidins
from loblolly pine bark. 7th Annual Kansas Health Foundation Cancer Research &
Training Program Abstract 24, p.37.
49. Perchellet, JP, Gao, X.M, Perchellet, EM, Gali, HU, Rodriguez, L, and Hemingway,
RW. 1994. Inhibition of mouse skin tumor promotion by oligomeric proantho-
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Curriculum Vitae
Hala Gali-Muhtasib
cyanidins from loblolly pine bark. Proceedings of the American Association for
Cancer Research 35:139.
50. *Gali, HU, Perchellet, EM, Gao, XM, Bottari, V, and Perchellet, JP. 1993.
Hydrolyzable tannins: potent inhibitors of the biochemical markers of skin tumor
promotion by thapsigargin in mouse epidermis in vivo. Proceedings of the American
Association for Cancer Research 34:180.
51. Perchellet, JP, Perchellet, EM, Gali, HU, and Gao, XM. 1993. Characterization of
the hydroperoxide response to thapsigargin in mouse epidermis in vivo.
Proceedings of the American Association for Cancer Research 34:173.
52. *Gali, HU, Perchellet, EM, Gao, XM, Bottari, V and Perchellet, JP. 1993. Antitumorpromoting effects of hydrolyzable tannins from various sources. Proceedings of the
American Association for Cancer Research 34: 165.
53. Perchellet, JP, Gali, HU, Perchellet, EM, Laks, PE, Bottari, V, Hemingway, RW, and
Scalbert, A. 1992. Antitumor-promoting effects of gallotannins, ellagitannins and
flavonoids in mouse skin in vivo. Proceedings of the International Symposium on
Food Phytochemicals for Cancer Prevention, 204th Annual Meeting of the American
Chemical Society, Washington, DC, 303.
54. Perchellet, JP, Perchellet, EM, and Gali, HU. 1992. Biochemical markers of skin
tumor promotion by thapsigargin. Proceedings of the American Association for
Cancer Research 33: 186.
55. Perchellet, JP, Gali, HU, Perchellet, EM, Klish, DS and Johnson, JM.
1992.Hydrolyzable tannins:potent antioxidant and antitumor-promoting activities in
mouse skin in vivo. Proceedings of the16th International Conference on Group
Polyphenols, JIEP, 92, Lisbon, Portugal, Polyphenols Actualites 8: 28.
56. *Gali, HU, Perchellet, EM, Bottari, V, Hemingway, RW, Scalbert, A and Perchellet,
JP. 1992. Inhibition of the biochemical markers of skin tumor promotion by ellagitannins, gallotannins and proanthocyanidins. Proceedings of the American
Association for Cancer Research 33: 162.
57. Perchellet, JP, Gali, HU, Perchellet, EM, Klish, DS, and Armbrust, AD. 1991.
Inhibition of the ornithine decarboxylase-inducing and tumor-promoting activities of
12-O-tetradecanoylphorbol-13-acetate in mouse skin by various plant polyphenols.
Proceedings of the 2nd North American Tannin Conference, Michigan Tech Univ.,
Houghton, MI.
58. *Muhtasib, HU, Perchellet, EM, and Perchellet, JP. 1991. Tannic acid inhibition of
phorbol ester-induced ornithine decarboxylase activity in mouse epidermis in vivo.
Proceedings of the American Association for Cancer Research 32: 151.
13