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PCCA Lipoderm HMW ® TM High Molecular Weight PCCA # 30-4612 500 GM Container Lipoderm HMW is a base with a patented delivery system that is designed to deliver drugs with high molecular weights through the skin. Recently PCCA conducted a study with Lipoderm HMW using a “control” drug (radio-labeled human insulin) with a high molecular weight (over 5,500 daltons) to test transdermal absorption through human trunk skin. It should be noted that trunk skin is considered the hardest to penetrate, aside from the heel of your foot, since it is thick skin. The study results showed that Lipoderm HMW was able to deliver insulin into and through human skin, in vitro. Note: Human radio-labeled insulin was chosen as a control only due to its high molecular weight and availability from the testing company. PCCA is not claiming safety and/or efficacy of human insulin delivered transdermally. EXCLUSIVE Lipoderm HMW works with solvents commonly used by compounding pharmacies such as propylene glycol, ethoxy diglycol, DMSO, purified water, glycerin and alcohol. The semi-clear emulsion gives it an elegant cosmetic feel. It is very easy to work with and is parabenand propylene glycol-free. Lipoderm HMW is not stable with high salt load drugs. USA: 1.800.331.2498 www.pccarx.com © 2014 PCCA. All Rights Reserved. l Canada: 1.800.668.9453 www.pccarx.ca l Australia: 02.9316.1500 www.pccarx.com.au PCCA Lipoderm HMW ® TM High Molecular Weight PCCA # 30-4612 500 GM Container Compounding Opportunities & Formulation Examples Lipoderm HMW does not contain lecithin, phospholipids or eggs so may be an appropriate transdermal base choice for special patient populations with sensitivities to those ingredients. Formulas That Contain APIs with a High Molecular Weight PCCA Formula #10139 Methylcobalamin 1000 mcg/0.25 ML Topical Lipoderm HMW™ (Molecular weight of Methylcobalamin is 1344.38) ® PCCA Formula #10140 Cyanocobalamin 1000 mcg/0.25 mL Topical Lipoderm HMW™ (Molecular weight of Cyanocobalamin USP (Vitamin B12) is 1355.37) ® PCCA Formula #10141 Hydroxocobalamin 1000 mcg/0.25 mL Topical Lipoderm HMW™ (Molecular weight of Hydroxocobalamin Hydrochloride (Vitamin B12a) is 1382.83) ® HCG Diet Due to HCG’s very high molecular weight, Lipoderm HMW may be a good option as a transdermal base. It contains only natural oils compatible with the HCG diet. PCCA Formula #10144 Chorionic Gonadotropin 500 U/GM Topical Lipoderm HMW™ (Molecular weight of HCG is ~39,500) ® Scan the QR to see all of PCCA’s Lipoderm studies or log onto pccarx.com/studies. USA: 1.800.331.2498 www.pccarx.com © 2014 PCCA. All Rights Reserved. l Canada: 1.800.668.9453 www.pccarx.ca l Australia: 02.9316.1500 www.pccarx.com.au