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Psychiatric Pharmacy Options LT Anna Stevenson PharmD Federal Bureau of Prisons Federal Medical Center Devens Objectives • At the end of this presentation, participants will be able to • Describe the role a pharmacist can play in the management of psychiatric inmates • Have a better understanding of how to design a monitoring plan for patients on psychiatric medications • Understand appropriate use of psychiatric medications in a correctional setting Clinical Pharmacy In the BOP • • • • 93 Collaborative Practice Agreements (CPAs) 57 pharmacists involved 12 distinct areas of medicine DUE Outcome Measures for most CPAs • Clinical Pharmacist Protocol Review • In 2011, the Clinical Psychiatric Pharmacy Clinic was opened at FMC Devens marking the first formalized psychiatric clinic in the BOP. Is there a need? Clinical Psychiatric Pharmacy Clinic • What do I do? • Promote appropriate, safe, and cost-effective drug therapy in order to achieve outcomes that improve • Functioning within a correctional facility • Ability to successfully transition back into society upon completion of their sentence. • Primary functions • Assessing and monitoring response to drug therapy • Work collaboratively with treatment teams to optimize pharmacotherapy • Providing drug information • Counseling patients on the proper use of medications • Formulary management Assessment • Indication for use • Efficacy • Safety • Adverse effects • Drug interactions • Adherence • Comprehensive Medication Management Comprehensive Medication Management Defined • Review all Medications • Are they compliant? • Review appropriateness of medications in relation to other chronic diseases the patient may have • Ensure appropriate monitoring has been completed and is within range Medication Monitoring • Compliance • Counsel inmates who have missed more than 10 doses • High risk medications • • • • • Clozapine Lithium Valproic Acid Carbamazapine Phenytoin • High dose medications • Multiple psychotropic medications in the same class • The prevention, identification, and management of side effects, including Tardive Dyskinesia Medication Compliance • “Drugs don’t work in patients who don’t take them” C. Everett Koop, M.D. • The most expensive pill is that which is not taken or taken inappropriately. • Patients are often non-compliant with their antipsychotic regimen. • Simplify the regimen • Some medications could be consolidated into once-a-day scheduling • Utilize depot formulations when available • Side effects need to be watched for and treated as soon as possible Important considerations • Many patients take subtherapeutic trials of medications. • Inadequate dose • Inadequate duration (6-8 weeks) • Antipsychotic medications are slower to take clinical effect than the onset of side effects. • Newer (atypical) Second Generation Antipsychotics (SGAs) cost roughly 10 times as much as the older (typical) FGAs • CATIE trial (2005) showed comparable efficacy between First generation antipsychotics (FGAs) and SGAs. Antipsychotics • Side effects form a critical aspect of treatment because they frequently affect medication choice, and decisions to discontinue them. • SGAs and TGAs, in low doses, are less likely than FGAs to cause significant extra pyramidal symptoms (EPS). • There is some evidence to support that at least one SGA, clozapine, may actually improve TD. • However, many SGAs have their own troublesome side effects that make them less acceptable than FGAs for some patients. Medications at risk for abuse • Lifetime prevalence of substance abuse in 74% of mentally ill criminal offenders (Putkonen) • Trihexypehnidyl • Gabapentin • Benzodiazepines • Buspirone • TCAs Wellbutrin • DA/NE reuptake inhibitor (unique mechanism) • Few side effects and lack of weight gain • Lowers seizure threshold • Only antidepressant that does not appear to increase the risk of mania in susceptible patients • Within the BOP only to be used for anergic depression, depression with bipolar, ADHD symptoms, and cardiac disease • Security concern • Structurally similar to stimulants such as methamphetamine and amphetamine • Can be crushed and snorted or taken in large doses to obtain a high • Has been reported that 1 tablet can be exchanged for 1 book of stamps Seroquel (Quetiapine) • Use in psychotic disorder, bipolar disorder, or borderline personality disorders only • Concerns • Cases of abuse (including oral, intranasal, and intravenous) have been documented in the literature, and multiple BOP institutions have reported incidents of inmates selling their quetiapine • Should be reserved for those cases refractory to other SGAs and TGAs • Should be administered crushed or in liquid formulation to reduce diversion. • An extended-release formulation of quetiapine is now available that is less abusable and better tolerated than the immediaterelease version. (preferred in the BOP) Value • Improves patient outcomes • Improves access to care • Decreases resource utilization • Admissions to lock-up units • Suicide-watch • Improves patient satisfaction • Increase safety for both inmates and staff Case #1 • Schizophrenic inmate taking quetiapine ER • Complaining of migraines • Previously managed on sumatriptan • Increasing in frequency and no-longer adequately managed on sumatriptan • Providers administering off-label IV metoclopramide with good effect • Increasing use up to 2-3 times per day • When non-formulary request submitted, request was not approved • Upon medication review, it was found that migraine frequency positively correlated to increased dosing of quetiapine • Quetiapine dose was lowered and psychiatric medication was augmented. Migraines subsided and inmate is now managed only with occasional sumatriptan use. Case #2 • Inmate housed in Mental Health secure housing due to behavioral issues from psychiatric disorders and medication non-compliance • Schizoaffective disorder- bipolar, HepC, COPD, Heart Failure • Non-compliant with all medications • Pharmacy Encounter to discuss medications with inmate • Stated non-compliance because he didn’t want to take that many pills • Discovered that he had about 7 medications for GI/constipation but inmate was not having any GI problems. Able to eliminate these meds • Had standing orders for APAP and Ibuprofen (able to d/c) • Contacted medical provider and able to narrow down cardiac medications from 4 to 2 medications. • After encounter, inmate became compliant and psychiatric symptoms began to become controlled. • Inmate was then able to participate in behavioral treatment • Decreased number of incident reports for behavioral issues Case #3 • Psychiatric Inmate presented complaining of increased anxiety over past month. • Symptoms: chest tightness, shortness of breath, headache, trouble sleeping • Psychiatrist was prescribing benzodiazepine for short-term use as management. • During medication review it was discovered that inmate had been non-compliant with asthma medications. • After pharmacist counseling, inmate began using inhalers again and symptoms subsided. Thank you ! Questions & Comments? Contact Information: LT Anna Stevenson Federal Bureau of Prisons FMC Devens [email protected] 978-796-1000 ext 4457 References • BOP Clinical Practice Guidelines: Pharmacologic Management of Schizophrenia. June 2010. • Putkonen A. Comorbid personality disorders & substance use of mentally ill homicide offenders. Schizophr Bull 2008;30:59-72. • National Institute of Mental Health [homepage on the internet]. Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): NIMH Study To Guide Treatment Choices for Schizophrenia. Available at: http://www.nimh.nih.gov/health/trials/practical/catie/index.shtml. Accessed March 1, 2011. • Swartz, M.S., Swanson, J.W., Hiday, V.A., Borum, R., Wagner, R., & Burns, B.J. (1998). Taking the wrong drugs: the role of substance abuse and medication noncompliance in violence among severely mentally ill individuals. Social Psychiatry and Psychiatric Epidemiology (supplement), 33, S75-S80.