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Name Legalon Silymarin Capsules 140 mg. Composition Legalon 140 mg capsules: Each capsule contains 140 mg silymarin. Indications Toxic liver disease (environmental-, drug- and alcohol-induced), supportive treatment of chronic inflammatory hepatic disease and liver cirrhosis. Properties Improve liver functions -protect against liver damage Silymarin is the active principle of LEGALON, it is of plant origin. Its therapeutic activity is based on three mechanisms: - Silymarin alters the structure of the outer cell membrane of the hepatocytes to prevent penetration of liver toxin into the interior part of cell. - Silymarin stimulates the action of nucleolar polymerase A, resulting in an increase in ribosomal protein synthesis and thus stimulates the regenerative ability of the liver and the formation of new hepatocytes. - Silymarin acts as antioxidant, it reacts with free radicals transforming them into more stable and less reactive compounds. These mechanisms make LEGALON very useful as hepatoprotective that promote faster regeneration of diseased liver tissue, which then reflected in improvement in general condition of patients. Dosage 210 - 420 mg daily in divided doses according to the case. Legalon 140 mg capsules: I capsule three times daily. Side effects A mild laxative action has been observed in occasional instances. Drug interactions None known Contra-indications It should not be used in children under 12 years of age. Precautions Pregnancy and lactation: It should be used only after consultation with the doctor. Storage Keep in a cool and dry place. Packs Manufacturers packs of 30 capsules each of 140 mg. Company Product of: Chemical Industries Development (CID), GIZA - A.R.E. - G.C.R.19717 Under Licence of: MADAUS GmbH. - GERMANY