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Anti-Metabolic Syndrome/blood glucose level control ROSE CRYSTA series ROSE CRYSTA-70 R (Rose Petal Extract) ROSE CRYSTA-70 (Concentrated Rose Polyphenol) is the natural product containing polyphenol concentrated from rose petal extract. Features of ROSE CRYSTA-70 ● ROSE CRYSTA-70 is the powdered extract by extracting from natural rose petals, and concentrating, and spray-drying. ● ROSE CRYSTA-70 contains more than 70% rose petal polyphenol. ● ROSE CRYSTA-70 can control blood glucose level after eating. ● ROSE CRYSTA-70 has more efficient activity in anti-oxidation than it in vitamin C. About Metabolic Syndrome Metabolic Syndrome is the syndrome from metabolic disorder not only in Japan, but whole world, especially in developed countries. First, visceral fat accumulates, and the second, one of abnormal sugar metabolism, high blood pressure, and high triglyceride/low HDL cholesterol is confirmed, you will be called "preliminary", two or all, you are in metabolic Syndrome. In metabolic syndrome, it is certain that circulatory organs become worse and diseases such as arteriosclerosis, further it will cause critical accidents like apoplectic accident and myocardial infarction. A half of male and one fifth of female persons is metabolic syndrome or preliminary, in more than 40 years old Japanese (Ministry of Health, Labour and Welfare, Japan, 2004). Primary and basic method of escape from metabolic syndrome is changing your lifestyle. It contains to change dietary habits, to do sports or practice, to manage stress... Changing dietary life is the most important. No eating must be adverse effect in diet, and changing quality of dietary foods is efficient. Lower calories, lower fat (especially animal fat), and more vegetables are necessary. ROSE POLYPHENOL relieves that exertion. ROSE POLYPHENOL can control blood glucose level, and it keeps blood glucose level low after eating. It also derives to keep insulin level low, to suppress producing fats from sugars. It is reported that ROSE POLYPHENOL inhibits lipase activity that degraded triglyceride to glycerol and fatty acids. This means that ROSE POLYPHENOL suppress absorption of fat and producing fat. As a result, ROSE POLYPHENOL/ROSE CRYSTA-70 is effective for improvement of your lifestyle. ROSE CRYSTA series ROSE CRYSTA-CO Product name Generic name Ingredients label Standard Doses Standard Package Use-by date Appearance Odor Polyphenol contents Heavy metals (as Pb) Arsenic (as As2O3) Number of viable cells for suppress sunburn, keep moisture, supple skin, anti-wrinkle Coriform group Mold/Yeast Usage ROSE CRYSTA-70 (Food ingredient) for prevention from diabetes and metabolic syndrome. ROSE CRYSTA (Food ingredient) for suppress anaphylaxis (type I) ] allergy,keep skin white, beauty. (Cosmetics material) R ROSE CRYSTA-70 ROSE PETAL EXTRACT ROSE PETAL EXTRACT 100 mg/day 1kg/alminum bag, 6 bags in a carton box 2 years from manufacturing date(incasebagiskeptclosed) Red purple to Red brown powder Characteristic Odor not less than 70% Not more than 20ppm Not more than 2ppm Not more than 3000cfu/g Negative(-) Not more than 300cfu/g Tablet, capsule, gum, candy etc... Manufacturing Process Raw material/Mixing -> Extraction -> Concentration -> Purification -> Spray dry -> Packaging ROSE CRYSTA series Anti-Metabolic Syndrome/blood glucose level control RO SE CRYSTA-70 Experimental Data α-Glucosidase Inhibition Polyphenol concentration IC50(50% inhibition conc.) Inhibition (%) no addition=0% [Method] Samples are incubated for 5 minutes at 37 ℃ with p-nitrophenol-α-Dglucopyranoside (NPD) 2.5 mM (concentration at test). After incubation, α-glucosidase (from yeast) was added to 0.005 U/ml at the reaction concentration. After incubation for 15 minutes at 37 ℃, equal volume of 0.2 M sodium carbonate solution was added to stop the reactions. α-glucosidase activities were calculated from the absorbance of each solution at 400 nm. [Results and Discussion] The inhibition activities against α-glucosidase are getting stronger by higher concentration of polyphenol in rose petal extracts. Especially ROSE CRYSTA-70 shows the most strongly inhibition activity. Α-glucosidase is the enzyme to degrade maltose to glucose. Then the producing and increasing of glucose is slow. As a result, glucose absorption will be calm, and ascending of blood glucose level will be mild. Sample concentration (ppm) Blood Glucose Level Control Time (minute) Control Test (560 mg) Blood Glucose (mg/dL) Control Test (100 mg) Blood Glucose (mg/dL) [Method] 7 and 5 healthy persons are tested with 560 mg and 100 mg dose, respectively. Subjects had nothing except water or pale tea after 9 P.M. the days before their tests, and also they did not have their breakfasts. In each test, blood glucose level was measured (0 min.) before eating 200 g of rice. Each subject additionally eats 560 mg or 100 mg of ROSE CRYSTA-70 as a test group, nothing else as a control group. Blood glucose levels were measured at 30 min., 60 min., and 120 min. after finishing eating rice. Time (minute) Anti-Oxidation Activity DPPH-radical elimination activities of ROSE CRYSTA, ROSE CRYSTA-70, and popular anti-oxidant Vitamin C and E were measured. ROSE CRYSTA showed twice or three times stronger activity than Vitamin E, furthermore ROSE CRYSTA-70 have much stronger activity than Vitamin C. DPPH radical elimination activity(%) Vitamin C = 100% [Results and Discussion] The blood glucose levels at 30 min. were different in both 100 mg and 560mg test groups, comparing with that of control groups(* : p<0.05, + : p<0.1). These results indicate that ROSE CRYSTA-70 can prevent against diabetes and metabolic syndrome by preventing rapid glucose level ascending and following ascending insulin level. Insulin is known to stimulate producing fatty acid, and keeping insulin level low have possibility to reduce fat and to lose weight. DPPH radical elimination activity Vitamin C Vitamin E ROSE CRYSTA ROSE CRYSTA-70