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Mannatech A Company of Destiny History of Glyconutritionals Since the beginning of recorded time, history has validated the importance of the amazing aloe vera plant. 1983 340 B.C. Dr. Bill McAnalley discovers first biologically active polysaccharide from aloe vera gel (Manapol® and acemannan). More than 150 patents are granted to companies and scientists worldwide on the stabilization and uses of this discovery. Alexander the Great carries aloe vera plants with him for soldiers wounded in war. 1992 Acemannan is approved by the USDA for use as a vaccine adjuvant in chickens and licensed to Solvay Animal Health, Inc., the world’s largest manufacturer of veterinary vaccines. Mannatech's Discovery of Glyconutrients has Helped Pioneer the Exciting New Field of Nutritional Glycobiology. 1994 Mannatech negotiates exclusive distribution rights to Manapol and launches company with nutrition industry’s first stabilized aloe vera gel dietary supplement. 1990 1984 1906 Erythropoietin (a glycoprotein hormone that controls the formation of red blood cells) is discovered. Hydrogel with polysaccharides from aloe vera gel (Carrisyn® Hydrogel Wound Dressing) goes on the market. 2200 B.C. Aloe, considered a divine plant in Nippur (Mesopotamia), is used for intestinal health. 2 Atomic Energy Commission 1988 scientists (Lushbaugh and The term "glycobiology" Hale) demonstrate for the appears in the Oxford English Dictionary to first time the ability of 1990 the merging Journal of Glycobiology topical fresh aloe vera gel recognize of the disciplines of launched by Oxford to protect carbohydrate chemistry University Press. and biochemistry. animal's skin. Glycobiology is the Timeline study of the structure, biosynthesis and biology of saccharides (sugar chains, or glycans) that are widely distributed in nature. Injectable acemannan rejected by the FDA as a drug for humans (no LD50). —Dr. Bill McAnalley, A Story of Discovery (2010). Injectable polysaccharide from aloe vera gel (Acemannan Immunostimulant™) is approved by the USDA for use in cats and dogs. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 1998 Harper’s Biochemistry lists the eight sugars found in glycoproteins. 1993 1991 2002 1996 BioTechnology magazine publishes article “Capitalizing on Carbohydrates.” Carbohydrates are identified as essential for immune function. Multinational chemical and pharmaceutical concerns identify carbohydrates as forming the next wave of drug development. 1953 “Like valleys they spread out, like gardens beside a river, like aloes planted by the Lord, like cedars beside the waters.” Numbers 24:6 1995 Nature magazine article states cell surface sugars are necessary for recognition and immune function. 1995 Dr. McAnalley joins Mannatech with focus on new field of carbohydrate technologies. Study by Berger, et al., in Metabolism showed that galactose and mannose were directly incorporated into human glycoproteins without first being converted into glucose. Authors concluded that specific dietary sugars could represent a new class of nutrients. 1998–2002 2002 (October) New Scientist magazine article, “Sugar Rush,” emphasizes glycobiology as the basis of understanding immunology, neurology and developmental biology. 2002–2010 As dietary sugars Ambrotose product approved claims expand to include begin to gain memory, cognition acceptance as a “new improved and visual discrimination as well class of nutrients,” as positive prebiotic effects.* Mannatech is issued 2001 more than 50 Scripps Institute patents worldwide awarded $34 million from NIH to for Ambrotose study glycobiology. technology. 1996 Mannatech files patents on the world’s first composition of glyconutrients and introduces Ambrotose® complex. (July) Scientific American article, “Sweet Medicine,” reports on pharma’s big new strategy for making better drugs from sugars. The United States of America 2012 National Academy of Sciences publish “Transforming Glycoscience,” a roadmap for the integration of glycoscience as a significant part of higher-education curriculae within the next decade. 2011 Definitive proof! Dr. Azita Alavi and colleagues publish study in the European Journal of Clinical Nutrition showing for the first time that the oral intake of Ambrotose powder can have a significant impact on the glycosylation status of serum glycoproteins with no adverse effects. Timeline 3 The Gift of Provision The Story Behind Mannatech A Desire to Make a Difference In 1994, Mannatech founder Sam Caster had one profound desire: to create a business that would make a real difference in the world. This visionary new company began to quietly assemble a team of top scientists. Their goal was to develop advanced, foodbased nutritional technologies that could best address the growing effects of poor nutrition in the world, and its impact on our health, our weight and the world’s most vulnerable children. Amazing, Disruptive Discoveries In 1996, Mannatech’s first Chief Science Officer, Bill McAnalley, PhD, made the discovery of a whole new category of plant-based nutrients called glyconutrients. Mannatech formulated the world’s first glyconutrient product, called Ambrotose® complex. Though this pioneering discovery was at first questioned, even ridiculed, by the traditional scientific community, technology supporting it has since received more than 50 worldwide patents, and it’s now revered as science’s next frontier. Ambrotose complex, formulated with the Manapol® aloe vera extract, became Mannatech’s foundational Real Food Technology® solution for proper cell-to-cell communication and immune system support. 4 The Story Real Food Technology® Solutions Mannatech’s current CEO and Chief Science Officer, Robert Sinnott, MNS, PhD, extended Mannatech’s proprietary product base through the formulation of PhytoMatrix® caplets, the industry’s first vitamin and mineral product produced from natural and plant-sourced ingredients at standardized, nutritionally effective levels. This approach quickly led to the development of many new, unique products based on Real Food Technology solutions. In 2012, Dr. Sinnott blended Mannatech’s proprietary glyconutrient complex, its proprietary antioxidant composition and its proprietary real-food vitamin/mineral formulation into a whole-food base. This new product was named NutriVerus™ powder, and it became a complete Real Food Technology solution for global health. A World-Changing Approach As of early 2013, Mannatech operates in 23 countries around the world. The company adopted the dynamic business model of social entrepreneurship to link its international product sales directly to the needs of the world’s most at-risk children. Through its Give for RealSM program, Mannatech empowers caring individuals all around the world to join the fight against childhood malnutrition by simply choosing to nourish themselves with advanced nutrition sourced from real foods. At the same time, Mannatech offers an unprecedented, purpose-driven business opportunity for those who choose to champion this cause. Enjoy the full story behind the beginning of Mannatech in this video, Destiny Unfolding. http://bit.ly/11aYMAR The Story 5 Our Mission and Vision Our mission is to fight global malnutrition by nourishing the world with Real Food Technology® supplementation while empowering and rewarding the lives of those who champion our cause. Our vision is to impact the global epidemic of childhood malnutrition by linking five million consumers of Real Food Technology supplementation with five million children in need. Three to five million children under the age of five die every year from the devastating effects of malnutrition.1 That means every six seconds a child dies from malnutrition. That’s 14,000 a day. The facts are heartbreaking. Staggering. But not unbeatable, thanks to people like you. "Progress for Children: A Report Card on Nutrition" UNICEF, May 2006 1 Find out how you can join in the fight against global malnutrition. Visit GiveForReal.com today. 6 Mission and Vision Science Department Pioneers of Real Food Technology® Solutions “Everything man needs to sustain good health is provided by God in nature. The job of science is to find it.” Paracelsus 1493–1541 Mannatech accepted the challenge! Robert A. Sinnott, MNS, PhD CEO and Chief Science Officer • Oversees the overall development and R&D management of Mannatech’s Real Food Technology products • Earned Bachelor’s Degree in Biological Sciences, a Master of Natural Sciences Degree and a PhD from 1987–1995, all from Arizona State University • Focused on plant medicinal chemistry and plant biotechnology in graduate training • Instrumental in establishing the science branch of a nonprofit educational institution for training economically disadvantaged students in science-based careers • Joined Mannatech in 2005 • Instrumental in the creation of Mannatech’s Real Food Technology approach 8 Science Thanks to its dedication to food-based research and development, Mannatech has become a leader in the Real Food Revolution. • • • Mannatech has invested tens of millions of dollars in the research, development and validation of Real Food Technology solutions. Working from Mannatech’s in-house laboratories, the company’s scientists and product development specialists actively explore new technologies for sourcing and formulating real-food solutions for consumer health and nutrition. The company’s Research Group collaborates with major universities and research firms around the world to conduct clinical trials and studies on our products and ingredients. Visit MannatechScience.org for full details. Science 9 The World's View Self-Evidence Glycoscience Validation Patents We hold more than 50 patents in 30 countries for the technology relating to our Ambrotose complex glyconutrient formulation. And our patent positions have been repeatedly reaffirmed in court, most recently in July 2010, when Mannatech won judgments against seven companies found to be manufacturing and marketing products that infringed on our patented glyconutrient technology. Recent Glyconutrient Studies Dr. John Rollins, a former award-winning U.S. Trademark and Patent Office official, upon his introduction to glyconutrients, said, "In the past 23 years ... our group at the U.S. Patent Office had the opportunity to review the best technology presented by the world's best scientists. There have been many significant discoveries, but one stands head and shoulders above the rest: the discovery of a new category of vital nutrients called glyconutrients." The United States of America October 2012 University of Ghent scientists publish Ambrotose product prebiotic study in the Antoine van Leeuwenhoek Journal of Microbiology. February 2012 Review of effects of polysaccharides on brain function is published, Mechanisms that might explain the cognitive benefits of glyconutrients and other polysaccharides are explored. September 2011 Study shows Mannatech's Ambrotose complex improves well-being in healthy adults (titled Perceived changes in well-being following polysaccharide intake in middle-aged adults). Quality and Standards Recent Discoveries Mannatech is committed to meeting customer, regulatory and industry standards by manufacturing products of the highest quality and value. Our suppliers conduct statistical sampling then follow it with inspection and testing. No product is ever shipped from Mannatech without the highest level of assurance that it meets our quality standards. In 2011, an open-label dosing study published in the European Journal of Clinical Nutrition concluded for the first time in the scientific community that the ingestion of a standardized blend of plant polysaccharides (Ambrotose complex) can induce significant changes in cell-surface glycoprotein structures. And, there were no reported adverse events.1 In 2012, a report titled Transforming Glycoscience: a Roadmap for the Future conducted by the National Academies of Science offered bold support for the function and importance of glycans (or glyconutrients). “A suite of tools analagous to those available for studying nucleic acids and proteins is needed to detect, describe and purify glycans (glyconutrients) from natural sources, and characterize their chemical composition and structure.” Current Good Manufacturing Practices As a global innovator, we adhere to industry-wide current Good Manufacturing Practices (cGMPs) established by various U.S. and international regulatory agencies. You can rest assured that our products are safe, effective and precisely labeled. NSF Certification—Third-Party Mark of Excellence A growing number of our health products have been Certified by NSF International, an independent, third-party organization that helps ensure that supplements and ingredients are labeled accurately and contain no adulterants or contaminants. 100% Satisfaction Guarantee You can trust the science and quality behind our products. We’re so confident you’ll love our products that we offer a six-month Satisfaction Guarantee.† Mannatech guarantees your full satisfaction. If not completely satisfied, contact Customer Care and return the product within 180 days for a full refund. See Mannatech.com for details. † 10 Glycoscience Validation To see the full collection of studies and published research, visit MannatechScience.org. Alavi, A., Fraser O, Tarelli E, et al. An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation profile of serum in healthy subjects. Eur J Clin Nutr 2008; 65: 648–56 1 Self-Evidence 11 Awards and Recognition A Company of Provision June 2005–In its June 6, 2005, edition, BusinessWeek magazine ranked Mannatech #6 on its annual list of Hot Growth Companies. June 15, 2005–Mannatech was awarded the coveted “Success Award” by the Direct Selling Association for the unique changes of the company’s compensation plan at this year’s annual DSA convention held in Orlando, Florida. March 14, 2006–Mannatech was the 29th fastest-growing public company in the Dallas/Fort Worth Metroplex, according to the Dallas Business Journal. March 22, 2006–Nutrition Business Journal awarded global health and wellness provider Mannatech, Incorporated, a bronze medal in the publication’s annual Business Achievement Awards. April 16, 2006–The U.S. Department of Commerce recognized global health and wellness leader Mannatech for its successful entry into the international marketplace. May 14, 2006–The Dallas Morning News named Mannatech as one of DFW’s Top 200 Publicly Traded Companies. October 18, 2006–Forbes magazine recognized Mannatech as one of the top 10 best small companies in America. January 31, 2007–Mannatech received first- and second-place awards for basic science research indicating bacteria from the human digestive tract can metabolize the complex carbohydrates in the company’s glyconutritional supplements. May 30, 2007–Mannatech was recognized by BusinessWeek as the 12th-best “Hot Growth” small company in America and as the 4th best in average return on capital over three years. March 14, 2009–Chief Science Officer and Senior Vice President Robert Sinnott, MNS, PhD, was selected as the vice chairman of the Senior Scientific Advisory Council (SSAC) for the Council for Responsible Nutrition (CRN). March 2009–Mannatech was honored by members of the U.S. House of Representatives, the Texas House of Representatives and the Dallas City Council. November 24, 2009–Mannatech’s educational website, MannatechScience.org, received a Web Health Merit Award for its accuracy, success in reaching its targeted audience and overall quality. June 2011–CEO and Chief Science Officer Dr. Rob Sinnott featured in Natural Products Insider magazine article, “Aloe veritas.” October 2011–Mannatech and Texas Women’s University announce the development of a Nutrition and Personal Health Coaching Certification Program. Mannatech helps develop course materials. April 2012–Mannatech presents new study at the 10th Jenner Glycobiology and Medicine Symposium in the Netherlands. July 2012–Mannatech presents product research at the 9th Annual International Society of Sports Nutrition Conference. April 2013–Dr. Sinnott featured in Nutraceuticals World magazine article, “Open Innovation in Nutraceuticals & Functional Foods.” We do all that we can to earn the trust consumers place in us every time they use a Mannatech product. 12 Awards & Recognition A Company of Provision 13 And Industry’s “Solution” The Problem We All Face Industry set out to “improve” food Many of us are not consuming enough essential nutrients! • S TA R V E D • • • Industry saw an opportunity in our problems. In the mid-1900s, commercial farming found new ways to grow food faster and bigger. The nutritional value of many fruits and vegetables has declined over the last 50 years.1,2 + The USDA now recommends that adults consume 3.5–5 cups of fruits and vegetables per day.3 “Nearly the entire U.S. population fails to eat a diet in line with the dietary guidelines for Americans.”4 Genetically Modified Seeds 90% of all the money Americans spend on food is used to buy processed food.5 Davis DR, Epp MD, Riordan HD (2004) Changes in USDA Food Composition Data for 43 Garden Crops, 1950 to 1999. Journal of the American College of Nutrition 23: 669-682. 2 Mayer A-M (1997) Historical changes in the mineral content of fruits and vegetables. Brit Food J 96: 207-211. 3 www.choosemyplate.gov/food-groups/vegetables-amount.html 4 Krebs-Smith, S.M., Guenther, P.M., Subar, A.F., et al. Americans do not meet federal dietary recommendations. J Nutr 2010; 140(10): 1832-8. 5 Schlosser E. Fast Food Nation: The Dark Side of the All-American Meal. Perennial/Harper Collins: 2001. + Bigger Livestock = Pesticides Big Profits Industry has radically changed our food over the last 50 years. 1 Then, industry focused on reinventing food by combining highly processed food ingredients with chemically made sweeteners, colorings, flavorings and preservatives. They are so poor in nutritional value that one expert refers to them as “edible food-like substances.”6 STRESSED We are stressed! Oxidative stress causes free radicals. • • • • • • Emotional stress Excessive exercise Smoking (including second-hand) Pollan M. In Defense of Food. New York, New York: The Penguin Press, 2008. 6 Excessive alcohol consumption Use of pharmaceuticals Once the public turned to supplements to fill the gap, industry saw a new opportunity and began marketing Food preservatives We live in a toxic environment! TOX I C • • • • 14 The Problem Over 75,000 synthetic chemicals introduced since 1930 Numerous pollutants common in our air and water Artificial sweeteners, colorings and preservatives Household cleaners, pesticides and other chemicals high-dose synthetic vitamin and mineral products. It was cheaper and more profitable to develop vitamins and minerals from things like petroleum, coal tar derivatives and crushed up rocks than to extract them in their natural form, from whole foods. Every so-called "solution" has typically presented more problems. For many of us, while the "solutions" continue to increase, our health continues to decline overall. The Problem 15 Industry's “Solution” Easily Identify Synthetic Vitamins Synthetically Made Nutritional Alternatives • • Synthetic vitamins are chemically produced and often include nutrients sourced from petroleum and coal tar derivatives, not food. They are inexpensive to produce and easy to standardize at RDI levels. It's estimated that over 95% of all vitamins sold are synthetically made.1 wwworganicconsumers.org/articles/article_3697.cfm 1 “Minerals are generally recovered by mining ores or from chemical processes. Tests have shown that minerals contained in [many of ] the most popular brands of multivitamins do not dissolve (they are not soluble) in the stomach or small intestine. They probably pass through the body without being absorbed.”2 Ensley BD, Elless MP, Blaylock MJ, Huang JW. Hydroponic cultivation of metal-accumulating plants as a source of mineral nutrient supplements. Metal Ions in Biology and Medicine 2000;531–3. 2 Take a look at your current brand of nutritional supplement and find out if it contains synthetic sources. Synthetic Vitamins May Include: Vitamin B2 Vitamin C Vitamin D Vitamin E Vitamin K Pantothenic acid Folic acid Listed on the label as: Riboflavin Ascorbic acid Calciferol dl-alpha tocopheral Menadione or phytonadione Calcium D-pantothenate Pteroylglutamic acid Any vitamin ending in the following is synthetic: acetate, hydrochloride, mononitrate, palmitate or succinate. Inorganic mineral names will usually end in one of the following: ascorbate citrate iodide orotate aspartate disulfide lactate oxide carbonate chloride gluconate glycerophosphate malate methionine picolinate sulfate ide for ick Gu and A Qu Vitamin ents lem ating Evalu ral Supp Mine an amin min? r Vita d levelsonoflyvittwo sources: Is You ndardize are there d Real To achieve sta ients, Source How ingred Plantneral d or foods d from extracte s are vitamin in yeast. ulate rced accum and then ly sou cultured es to m Natural ts or are process igest the s from plan ltiple eral soil, pred rix. 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Come trix® ytoMa l Our Ph deliver rea ! ts caple d nutrients ource food-s neral the min/mi a vita efficacy of ation take now quality or plement erica sup source, mineral th Am and in Nor know the sumers ’t even best vitamin s ion con ple don the amount 150 mill st peo eves that labeled s mately y1. But mo ch beli perly unt and pro Approxi ent dail . Mannate led amo dardized perly labe supplemts they take stan s with and pro produc include: vitamin dardized should rced s at stan ally sou mineral tNatur -sourced tPlant USA) ation ent Market inistr Supplem se. Adm (Dietary Drug disea 4/29/09 nities any and & Opportu Food prevent Trends by thecure or Market , ents ated Supplem evalu , treat Dietary nose nitor: not been to diag Datamo 1 Source ded ts have inten men e state is not * Thes product This How Real Is Your Vitamin? Find out with this tear sheet at http://bit.ly/ZC8v0v . THERE IS A BETTER SOLUTION 16 Industry's Solution Industry's Solution 17 Ancient Wisdom What Did They Tell Us? The Design of Life: “I have given you every seed-bearing plant throughout the earth and all of the fruit trees for your food.” Genesis 1:29 Paracelsus and Hippocrates, considered to be the fathers of pharmacology and medicine, respectively, believed that having good health was dependent upon proper nutrition. Over the centuries, technologies have evolved in both food and medicine, but this principle remains as true today as it was then. New research is showing us how the human body functions at the cellular level and how nutrients in their realfood form support these critical functions. Science is now bringing us full circle to the very foundations of health and ancient wisdom. “Everything man needs to sustain good health is provided by God in nature. The job of science is to find it.” Paracelsus 18 Ancient Wisdom Pietro Longhi. The Apothecary—Aloe vera was a common tool in doctors' offices in the mid 18th century. Ancient Wisdom 19 Real Food Technology: The Solution Which Plant Would You Want YOUR Supplements to Come From? A chemical plant? Most nutritional solutions today are falling way short of what your body actually considers to be “good nutrition.” Sure, the label touts all the popular vitamins, minerals and other trendy nutrients at levels that seem impressive on the surface. But your body isn’t fooled. Your body is complex, and it’s looking for more than just a combination of high-dose synthetic nutrients to feel its best. Your body wants nutrition from real-food sources. Mannatech recognizes the importance of nutrients from nature. We introduced Real Food Technology solutions to take a different approach to nutritional supplementation. Simply put, we use science not to “create” nutrition, but rather to “capture” nutrition … from nature, of course. OR And as far as your body is concerned, this approach makes all the difference. Real Food Technology solutions provide standardized and nutritionally effective levels of vital nutrients from whole-food sources. The Keys to a Real Food Technology Approach • • • Standardized Nutritionally effective levels Whole-food sources A real plant? 20 Real Food Technology Real Food Technology 21 Real Food Technology Solutions A Common-Sense Approach to Optimal Health Completing the Circle of Care DRIVER GAS Consider for a minute your body as an automobile. Daily support and maintenance is required or breakdowns occur. OIL WATER AIR • • • The modern car is designed to run on certain raw materials. It requires routine maintenance. It will usually last about 100,000 miles or so. The car must have fuel in the tank, oil in the engine, water in the radiator; air in the tires and, of course, a driver behind the wheel. The car also must be maintained by changing the oil and filling the gas tank. There are numerous things that may improve its performance or looks, but these components are mandatory for it to start and run. If any of the basic components are missing, or the car isn’t maintained properly, it’s not going to travel very far without breaking down. And a shiny new paint job or fresh tires won’t help if the basics are not met. The same concept can be applied to understanding the human body. • • • Our bodies were designed to run on very specific raw materials. Body Systems Organs Tissue Cells IMMUNE CELL Nourish Me – Communication – Protection – Nourishment System Support – Endocrine – Cardiovascular – Digestive Destroy Me Protect Me Regulate Me It All Starts with the Cells For optimal wellness, your body needs ongoing maintenance in such areas as: Cellular Support Repair Me A variety of food-based nutrients is required to support healthy cells. Healthy cells are necessary to support healthy glands, organs, tissues, bones, fluids, blood and skin. Healthy cells = Healthy tissue Healthy tissue = Healthy organs Healthy organs = Healthy systems Healthy systems = Healthy bodies They require routine maintenance. And they are designed to last about 85 years or so. Countless things may enhance how we look or feel, but nutrients are essential. Unless we provide our bodies with these basic essentials and perform the necessary maintenance, it is very difficult to sustain good health. 22 Role of Nutrients System Support Body Fitness – Fat Loss – Performance – Recovery Role of Nutrients 23 Sweet Language of Life Ambrotose® Complex and Advanced Ambrotose® Glyconutrients The Missing Link The first standardized blend of plant-sourced polysaccharides. More than 50 patents issued worldwide for this breakthrough technology. Of the 200 that naturally occur in nature, our cells use eight of these sugars like letters of an alphabet to create cellular words. The potential information content of these sugar structures vastly exceeds that of any class of macromolecules.1 Every living cell on the planet is covered with a dense and complex array of sugar molecules called glycans. Every molecule, cell or organism that interacts with a cell must do so through these cell-surface glycans.1 Immune cells read these sugar structures to determine if our cells are healthy, in need of repair or need to be destroyed. Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012. 1 When Your Cells Talk, Your Body Listens When bad cells go undetected, as in degenerative type functions, research has shown that sugars are missing from their glycoprotein structures. Capitalizing on Carbohydrates, 1991 “Removing one sugar [from their cell-surface structures] turns protective antibodies (repair cells) into attackers.” The research shows that the mere destructive autoimmune functions appear to be lacking “antibodies associated with this (sugar).” Rockefeller University, July 4, 2007 Bill McAnalley's A Story of Discovery Ambrotose: http://bit.ly/11DgiyU 24 Cellular Suppor t Ambrotose Products • • • • • • Support cellular communication*† Improve cognitive function*† Improve memory, concentration and attentiveness*† Improve mood and decrease irritability*† Support immune system function*† Support digestive system health*† *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. † Benefits vary by product. Ambrotose 25 Real Food Technology Solutions for Cellular Protection • • • • • • • In part, premature aging is the breakdown of the body’s natural ability to regenerate its trillions of cells and produce new ones. This repair and renewal process goes on every second of every day of your life. It has been postulated that naturally occurring invaders, called “free radicals,” can damage cells, interfere with their repair and regeneration, and thereby speed up the aging process. Ambrotose AO® Antioxidants Ambrotose AO is a scientifically proven antioxidant supplement designed to support optimal health by effectively enhancing antioxidant protection in the body.* Sunlight, physical and emotional stress, and environmental toxins are sources of free radicals that can damage cells and accelerate the aging process. • Research has shown that two Ambrotose AO capsules can increase overall antioxidant protection in humans by 37.9%.† That’s more than two and a half times the ORAC impact of five servings of fruits and vegetables (serum ORAC results). • Ambrotose AO capsules: Cells can protect themselves from these environmental factors, but research suggests that they require the right nutrients, called antioxidants, to provide proper protection. Certain fat- and water-soluble vitamins, minerals and plant phytochemicals are antioxidants that can neutralize free radicals and prevent the damage they cause. It has been postulated that premature aging can start to occur when cells don’t get enough antioxidant support, and the body cannot keep up with the demands of damaged cells. – Help protect against cell damage caused by physical and oxidative stress (free radicals), toxins, environmental stress, and poor diet, all of which can damage cells, tissues, and DNA.* Antioxidant nutrients are abundant in vine-ripened fruits and vegetables. – Provide plant-sourced ingredients for Included in OSP Packets antioxidant and immune support.* Free radicals can attack our cells as many as 10,000 times a day. Comparison of serum ORAC values obtained in two separate clinical studies funded by Mannatech. † The right blend of fat- and water-soluble antioxidants may protect our cells from this attack. According to a study funded by the USDA, five daily servings of fruits and vegetables can increase overall antioxidant protection by 13.9% (serum ORAC results).1 Ambrotose AO capsules can increase overall antioxidant protection in humans by more than two and a half times that amount. Read the full study at: http://bit.ly/11otcQf Cao G, Booth SL, Sadowski JA, Prior RL. Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. Am J Clin Nutr 1998;68:1081–7. 1 26 Protection *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Ambrotose AO 27 Real Food Technology Solutions for Cellular Nourishment Your Cells Need Nourishment • • • Every cell in your body requires a variety of nutrients to help build and support its proper structure and function. Your body is building millions of new cells every second. There are more than 26 essential vitamins and minerals, and multiple trace elements, that MUST be obtained through your diet. PhytoMatrix® Caplets Vitamins and Minerals Mannatech’s PhytoMatrix multivitamin/mineral supplement provides the industry’s first standardized blend of foodsourced vitamins, minerals and phytonutrients. PhytoMatrix caplets support: Foods are comprised of synergistic blends of [essential] nutrients bound together into the food matrix. It is the food matrix [blend] that best supports human biological processes. Jacobs DR, Jr., Tapsell LC. Food, not nutrients, is the fundamental unit in nutrition. Nutr Rev 2007;65:439-50. Proprietary Hydroponic Growing Technology At the heart of our PhytoMatrix product is a patented, hydroponic cultivation technology that uses the Indian mustard plant nicknamed “nature’s magnet” for its ability to absorb minerals from the soil. These plants are hydroponically grown in solution, allowing them to absorb a controlled amount of concentrated minerals, which are then stored in the plant tissue. Why is this significant? Because food sources—like Indian mustard—provide minerals in their most natural form, so they can be readily absorbed and utilized by the body. The hydroponic process ensures standardized concentrations of essential minerals that meet minimum requirements with a daily serving of four tablets. Even fresh fruits and vegetables— which usually have high concentrations of vitamins—may be low in essential minerals. 28 Nourishment • • Cell protection with powerful antioxidants* • Heart health with vitamins B6, B12, B3 (niacin), C, and B9 (folic acid)* • • Energy production with a full complement of B vitamins* Healthy eyesight with vitamins A, C, E, and niacin, plus the mineral zinc* Included in OSP Packets Immune system function with vitamins A, C, E, B6, and folic acid, plus minerals zinc, copper and iron* PhytoBurst® Chews Essential Nutrition PhytoBurst® Chews: A Delicious Delivery Method for Food-Sourced Nutrition • • Delicious fruit-flavored chews (lemon and mixed berry) • Great on-the-go bursts of nutrition Incorporates hyrdroponic technology found in our PhytoMatrix caplets *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Nourishment 29 Cellular Health Value Proposition NutriVerus™ Powder Nutrition the Way Your Body Wants It. NutriVerus features a nutrient-dense, real-food base of stabilized rice bran, organic fruits and vegetables, antioxidants and glyco- and phytonutrients. The Ultimate Solution for Cellular Health Mannatech’s Core Innovations in One Product NutriVerus powder delivers the nutrition your body needs, the way your body wants it. This completely unique supplement combines natural, food-sourced vitamins, minerals, glyconutrients and fat- and watersoluble antioxidants in a nutrient-dense, real-food base of stabilized rice bran and organic fruits and vegetables. The result? Energy-boosting, immune system–supporting nutrition in an environment just right for nutritional synergies to occur, increasing the potential interaction of the individual nutrients.* Fat- & Water-Soluble Antioxidants Glyconutrients Organic Fruit Blend Strawberry Raspberry Blueberry Tart Cherry Pomegranate Cranberry Essential Vitamins & Minerals from Real Food Real Food Base from rice bran and organic fruits and vegetables Highly Valued Benefits at a Value-Conscious Price Glyconutrients and food-sourced nutrients for just $2 a day! Supports cell-to-cell communication through a blend of specific plant saccharides including glyconutrients* Offers antioxidant and immune system support* Supports brain health* Organic Vegetable Blend Broccoli Broccoli Sprouts Tomato Carrot Spinach Kale Stabilized Rice Bran (SRB) is one of the most nutrient-dense food ingredients in the world. • • Unlike other grains, it is gluten-free • • • • • • • Vitamin E complex with tocopherols and tocotrienols More than 100 antioxidants, metabolic cofactors, and trace elements in its food matrix Naturally rich in B vitamins High in inositol Rich in phytosterols Rich in fatty acids Good protein source Good source of potassium, magnesium and phosphorus Helps protect your cardiovascular system* Supports healthy digestion* Helps your body maintain energy levels* Provides a natural, food-sourced vitamin/mineral complex for maximum absorption* http://bit.ly/YzLo7G Suitable for all ages, including kids age four and up 30 Cellular Health Learn more about NutriVerus powder and the Real Food Revolution. Watch this video. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Cellular Health 31 Real Food Technology Solutions for System Support Mannatech PLUS™ Endocrine System Support Mannatech PLUS caplets include a proprietary blend of standardized plant sterols formulated to support a well-functioning endocrine system.* The Endocrine System Is Your Body’s Command Central. PLUS caplets: When functioning well, its glands direct operations by producing vital hormones that send signals to keep you ready for anything and help your body stay balanced. Because this important control center ultimately influences almost every cell organ and function of your body, making sure it gets the nutrients it needs is a must. Mannatech’s PLUS caplets, can help by keeping this vital system functioning smoothly in a state of equilibrium.* • • Furnish raw materials for endocrine support* • Support breast, bone and colon health as well as the immune, nervous and cardiovascular systems* • Support prostate health* Supply essential amino acids to support natural hormone production* Included in OSP Packets Mannatech’s PLUS caplets don’t contain hormones. Instead, they provide specific nutrients, including plant sterols to support your glands’ natural function.* And because we don’t always eat right, we can miss out on important nutrients like plant sterols and amino acids that help keep our systems functioning well. That’s why Mannatech developed PLUS caplets—to supply the body with a proprietary blend of specific, standardized nutrients, including important plant sterols and amino acids that we may not always get on a consistent basis from diet alone. 32 Endocrine *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Amino acids—the “building blocks” of proteins Did you know that of the 20 amino acids that we all need to survive, the human body produces only 10? We must rely on our diets for the other half, but not all proteins are created equal. Some contain specific amino acids for hormone production while others do not. And because humans don’t store amino acids in their bodies, we need a steady supply every day. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Endocrine 33 Real Food Technology Solutions for Cardiovascular Omega-3 with Vitamin D3 Support Research shows that most people are deficient in Omega-3 fatty acids Your body doesn't produce Omega-3 For centuries, people got enough omega-3s through their diets. Not so anymore. Today's diet trends result in too much omega-6 in our bodies. Even farm-raised fish are often grain fed and contribute more omega-6 than omega-3. Although omega-6 is important, it competes with omega-3 for space in our cells. Our current diets have created a ratio that ranges as high as 30:1 omega-6 to omega-3. This imbalance has given rise to an unhealthy inflammatory response, which is a key contributor to many of the health concerns in our diet. Healthy Heart Mannatech's Omega-3 with Vitamin D3 is your best choice with: • • Over 1,000 mg of highly concentrated EPA and DHA per serving • • Pleasant lemon flavor in an easy-to-swallow gel capsule A Fat Your Body Needs • Help support cardiovascular and heart health* • Help support brain health and function* CardioBALANCE Capsules: • Vitamin D is essential for calcium absorption* Learn more about how our Omega-3 with Vitamin D3 is unique. Watch this video. http://bit.ly/110zN2U Cardiovascular 830 IU of vitamin D3, a natural and preferred source of vitamin D For Additional Cardiovascular Support • Help maintain a healthy immune system and support a healthy inflammatory response—a key contributor to good health* 34 Made from molecularly distilled, high-quality fish oils, for ultra-purity CardioBALANCE There are good fats and bad, but omega-3 fatty acids are a fat that you absolutely must have. • Provide support for healthy triglyceride levels already within normal levels* Omega-3 fatty acids are considered “essential” because they are vital to your health and your body cannot produce them. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. • Provide nourishment for cardiovascular health through a unique herbal vitamin and amino acid blend.* • Help maintain homocysteine levels that are already within normal range.* • Include folate as well as L-arginine, which is thought to increase nitric oxide production—essential in maintaining blood vessel health—as well as CoQ10, which is often depleted by cholesterol-lowering drugs.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Cardiovascular 35 Real Food Technology Solutions for Digestive System Support Did you know that approximately 70% of your immune system is located in your digestive tract? GI-ProBalance® • Healthy Digestion • Mannatech's GI-ProBalance slimsticks provide the “right” bacteria to help maintain the microbial balance in a healthy intestine.* • • • This balance can promote a healthy effect among the various microflora that live in the human intestine, thereby supporting optimal digestive function.* Performance tuned to unleash the power of Ambrotose ® 36 Digestive Developed after extensive research on the digestion and beneficial effects of Ambrotose powder, GI-ProBalance slimsticks were formulated to enhance the benefits of Ambrotose products. The specially formulated probiotic blend breaks down the polysaccharides in the Ambrotose products, thereby enhancing the ability of both exceptional products to support the digestive and immune systems.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. One of the digestive system's most important functions is to process food and absorb all the nutrients our cells can use. It also serves as the first line of defense against harmful bacteria. Because the digestive system's organs rely on nutrients from food, the health of the digestive system depends on the quality of our diet. So when your gut is healthy, it helps your whole body stay healthy. To digest food, the intestines maintain an environment that includes healthy bacteria and enzymes. Probiotics are dietary bacteria that assist in digestion. Enzymes regulate the speed of metabolism, among other bodily processes. Probiotic bacteria must be regularly replenished. In the past, they were found in many common, raw foods. However, preservatives, pasteurization and other processing have generally eliminated probiotics from today’s foods. This forces the body to dip into and, perhaps, deplete its own supply. GI-Zyme® Healthy Digestion Mannatech's GI-Zyme capsules are formulated to: • • Help improve the level of digestion* Assist in breaking down proteins, fats and carbohydrates* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Digestive 37 A New Perspective on Fat Loss Real Food Technology Solutions for Sustainable Fat Loss † We're Dieting More Often The desire to lose weight is not a new one. But it’s one that’s received unmatched attention in the past thirty years. Conventional wisdom tells us that too many calories and too little exercise are the major contributors to weight gain. So we’ve tried to address those issues in many creative ways. From exercise programs and eating plans, to metabolism-enhancing pills, meal replacements and even surgery, we’ve virtually thrown the kitchen sink at losing weight. • • Don’t be fooled by trendy, synthetic, weight-loss shakes and plans. Feed your body with the only protein shake that incorporates a unique glyconutrient blend and a protein mix based on Real Food Technology solutions. 75 to 100 million Americans diet each year.1 The typical American dieter now makes four weight-loss attempts per year—the highest number in 15 years.1 The weight-loss industry by the numbers, ABC News, May 8, 2012 1 We're Spending More Money • The U.S. weight-loss market now exceeds $60 billion. • If you consider that “only” 75 million Americans are trying to lose weight, that’s $800 per person per year! 16 grams of vegetable-sourced proteins (rice and yellow pea) • • • • • Delicious natural vanilla flavor Glyconutrient blend helps amplify support at the cellular level* Gluten-free No soy No dairy Vegetarian-friendly With ongoing proper diet and exercise. † U.S. Weight Loss Market Worth $60.9 billion, PRWeb, May 9, 2011 We're Gaining More Weight Even worse, even when we do lose weight, we seem to have even bigger challenges keeping it off. Many of us lose a few inches today, only to gain it all back—and even more— tomorrow. • • • Available Summer 2013 Globally, there are more than 1 billion overweight adults, and the number is growing. Don’t Make This Common Weight-Management Mistake! When shedding pounds, don’t overlook your body’s basic nutritional needs. Add NutriVerus powder to your weight-management regimen and give your body the foundational, whole-food nutrients it craves. OsoLean® Powder Target Fat Loss Worldometers.com, Marketdata research 2013 • According to the American Heart Association, 66% of Americans are overweight and 34% are obese. Trend spotting 2013, Foodnavigator.com, December 3, 2012 The Answer? SUSTAINABLE weight management from REAL-FOOD SOURCES. 38 Fa t L o s s Retaining lean muscle when burning fat is important in maintaining body strength and a healthy metabolism. In a clinical study, the key ingredient in OsoLean powder promoted fat loss and minimized muscle loss when combined with a proper diet and exercise.* More than a just typical whey protein product, OsoLean powder incorporates a proprietary advanced peptide technology that separates and concentrates specific parts of whey protein, called peptides, to ensure your body receives the optimal level of fat-loss peptides.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Fa t L o s s 39 Performance Recovery Perform Better Recover Faster Mannatech’s advanced Weight and Fitness products are natural and formulated with food-sourced nutrients to help you go the extra mile, and look amazing while doing it. • • When taken daily, over time, BounceBack capsules can: • SPORT™ capsules: • Our BounceBack® capsules allow you to stay active and mobile.* • • • Help maintain existing normal blood sugar levels and support carbohydrate utilization* A proprietary blend of herbs and herbal extracts A plant sterol supplement formulated with a combination of Ambrotose complex and wild yam Help reduce muscle pain and stiffness due to overexertion or physical activity* Aid the body’s natural recovery process* Support optimal joint and cartilage health* Provide immune system support* Mannatech’s ImmunoSTART® tablets prime your immune system.* AmbroStart® drink mix is a delicious, orange-flavored, energy-releasing supplement that: • • • • • • Delivers nutrients that provide the body with energy* Includes medium-chain triglycerides that are readily broken down into short-chain, free-fatty acids that can be used as fuel for muscles* Is a good source of fiber Helps support a healthy immune system* • EM·PACT® citrus-flavored drink mix: • • • • May enhance the body’s ability to use oxygen during athletic exertion* May improve athletic endurance* Includes medium-chain triglycerides (MCTs) that are readily broken down into short-chain, free-fatty acids that are used as fuel for muscles* Has been clinically shown† to enhance cardiorespiratory fitness and improve endurance* Mannatech-funded clinical studies. † 40 Per formance If it’s operating well, your immune system will remove toxins and keep you healthy. But, everyday stresses, not eating properly and irregular sleep habits can take a heavy toll on your immune system. These factors may accelerate your use of and need for nutrients. Eventually, your immune system may encounter difficulty keeping up with the demands placed upon it, so it’s critical that you give it the right nourishment. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Helps build, support and nurture immune system health* Engineered with a targeted array of nutrients, including bovine colostrum and lactoferrin that work to stimulate and support the body’s natural immune response* Increases plasma levels of neutrophil precursors—neutrophils are the most abundant immune cells and form an integral part of the immune system* Manna-C™ capsules contain natural forms of vitamin C from wild bush plum and acerola—wild fruits that are considered two of nature’s richest sources of this vitamin. • • Includes classic Ambrotose complex, along with wild bush plum and acerola fruit extract, both natural sources of vitamin C Herbal blend with a natural plant source of vitamin C for the maintenance of good health* Our Manna-C capsules combine Ambrotose complex plant polysaccharides with an herbal blend that yields natural sources of vitamin C. This specially formulated herbal blend includes lemon verbena, sage, peppermint and other herbs. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Recovery 41 Protecting Our Future Kids Start a Tradition of Good Nutrition The pursuit of wellness is one that lasts a lifetime. Give your child the healthy advantages that come from good nutrition early in life. Many Mannatech products are appropriate for children. Just check the labels for any possible age and/or directional restrictions. For starters, here are some products deemed as “favorites” by kids and parents alike. MannaBears™ Gummies A tasty alternative to sweets full of refined sugars and other “junk” foods, MannaBears gummies include a specially formulated glyconutrient blend as well as 11 dehydrated fruits and vegetables—like broccoli, carrot, cauliflower, tomato, papaya and pineapple—to help protect cells from free radical damage.* GI-ProBalance® Probiotic Slimsticks Since 70% of your child’s immune system is located in the digestive tract, her body relies on a wide variety of bacteria and other microorganisms to help keep it running properly, including probiotics and prebiotics. Kids love the taste of these delicious slimsticks as much as parents love how they're working. Recommended for children four years of age and older. NutriVerus™ Powder NutriVerus brings real-food glyconutrient and vitamin/mineral technologies in a nutrient-dense food base of stabilized rice bran and organic fruits and vegetables. Sprinkle it on your child’s food every day to help ensure his meals are more nutritious. Recommended for children four years of age and older. "This could be the first generation of children in the United States that lives less than its parents." Richard Carmona, former Surgeon General of the United States, 2009 ImmunoSTART® With everything going on in their world, your child’s immune system can become overloaded quickly. Give them ImmunoSTART tablets every day to help build, support and nuture immune system health.* Do not give to children under age 4 without adult supervision. 42 Kids Kids 43 Skin Care Healthy Body, Healthy Skin Creating a Life of Significance We’ve Got You Covered Mannatech products not only help you feel your best, our natural, glyconutrient-infused skin care products help you look great, too. The Age-Defying Mannatech LIFT™ Skin Care System Glowing, younger-looking skin is achievable at any age. Inspired by French technology and formulated with over 30 botanical ingredients, the Mannatech LIFT skin care system is paraben-free and can help turn back the clock to give skin a more natural, youthful appearance. With just three easy steps—cleanse, treat and moisturize—plus our Jeunesse 7™ proprietary blend that is known to moisturize, hydrate and reduce the appearance of fine lines and wrinkles, you can say “bonjour” to youngerlooking skin in no time. Aging is natural. Looking your age doesn’t have to be. Look as healthy as you feel with the Mannatech LIFT Skin Care System. FIRM with Ambrotose® Body Creme Suitable for all skin types, this rich, botanically based body creme is a proprietary blend utilizing both science and nature. Formulated without synthetic colors, it’s also parabenfree and contains no mineral oil to clog pores. It will leave your whole body feeling refreshed, hydrated and soft. Emprizone® Gel Refresh and moisturize dry, itchy skin with hydrating, aloe-based Emprizone gel. With vitamins A and E, it’s pH-balanced to leave your skin feeling soft and revitalized after shaving or waxing. It’s also perfect after drying exposure to the sun and contains no oils or pore-clogging ingredients. 44 Skin Care Life of Significance 45 How You Can Help Consume One for One Become a CUSTOMER and help nourish a child in need.† As a Member, refer a few people, earn discounts on your orders‡ (up to FREE!) and help nourish more children. —Our Goal— Share Champion Become a Champion Help us change the world while creating a life of significance for yourself. 46 How You Can Help Linking five million consumers with five million children in need. WILL YOU HELP? Find out how people just like you are playing a crucial role in the fight against global malnutrition. Give for Real donations are generated through monthly automatic product orders. ‡ 4Free Member Discount Program credits are based on monthly automatic product orders. † Will You Help? 47 Be the Change You Want to See. Helping to nourish many of the world’s most vulnerable children is as easy as simply nourishing yourself. Just purchase the daily supplements you need, and Mannatech, through MannaRelief, helps a child in need. When you do this, MannaRelief will provide a monthly donation of PhytoBlend™ powder, formulated based on Real Food Technology solutions—plant- and foodbased nutrition—to help battle malnutrition in developing countries. Partner with Mannatech through our Give for Real program, and be a part of the change you want to make in the world. For more information about this important program, visit GiveForReal.com today. A Hope for the Future. Mannatech, Incorporated 600 S. Royal Lane, Suite 200 Coppell, TX 75019 Mannatech.com 16517.0413 Item Number: 1275101 Advanced Ambrotose, AmbroStart, Ambrotose, Ambrotose AO, Ambrotose Phyto Formula, BounceBack, CardioBALANCE, Catalyst, EM•PACT, Emprizone, FIRM with Ambrotose, GI-ProBalance, Give for Real and Design, GI-Zyme, ImmunoSTART, Jeunesse 7, Live for Real, Manapol, MannaBears, Manna-C, Mannatech LIFT, NutriVerus, OsoLean, Phyt•Aloe, PhytoBlend, PhytoBurst, PhytoMatrix, PLUS, Real Food Technology, SPORT, Stylized M Design and Mannatech are trademarks of Mannatech, Incorporated.