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A Company of Destiny
History of Glyconutritionals
Since the beginning of recorded time, history has
validated the importance of the amazing aloe vera plant.
340 B.C.
Dr. Bill McAnalley discovers
first biologically active
polysaccharide from aloe
vera gel (Manapol® and
acemannan). More than
150 patents are granted to
companies and scientists
worldwide on the stabilization
and uses of this discovery.
Alexander the Great
carries aloe vera plants
with him for soldiers
wounded in war.
Acemannan is approved
by the USDA for use as
a vaccine adjuvant in
chickens and licensed
to Solvay Animal
Health, Inc., the world’s
largest manufacturer
of veterinary vaccines.
Mannatech's Discovery of Glyconutrients
has Helped Pioneer the Exciting New
Field of Nutritional Glycobiology.
Mannatech negotiates
exclusive distribution
rights to Manapol and
launches company with
nutrition industry’s first
stabilized aloe vera gel
dietary supplement.
Erythropoietin (a glycoprotein
hormone that controls the
formation of red blood
cells) is discovered.
Hydrogel with polysaccharides
from aloe vera gel (Carrisyn®
Hydrogel Wound Dressing)
goes on the market.
2200 B.C.
Aloe, considered a
divine plant in Nippur
(Mesopotamia), is used
for intestinal health.
Atomic Energy Commission 1988
scientists (Lushbaugh and The term "glycobiology"
Hale) demonstrate for the appears in the Oxford
English Dictionary to
first time the ability of
the merging
Journal of Glycobiology
topical fresh aloe vera gel recognize
of the disciplines of
launched by Oxford
to protect
carbohydrate chemistry University Press.
and biochemistry.
animal's skin.
Glycobiology is the
study of the structure,
biosynthesis and biology of
saccharides (sugar chains,
or glycans) that are widely
distributed in nature.
acemannan rejected
by the FDA as a drug
for humans (no
LD50). —Dr. Bill
McAnalley, A Story
of Discovery (2010).
Injectable polysaccharide
from aloe vera
gel (Acemannan
Immunostimulant™) is
approved by the USDA
for use in cats and dogs.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Harper’s Biochemistry
lists the eight sugars
found in glycoproteins.
BioTechnology magazine
publishes article “Capitalizing on
Carbohydrates.” Carbohydrates are
identified as essential for immune
function. Multinational chemical
and pharmaceutical concerns identify
carbohydrates as forming the next
wave of drug development.
“Like valleys they spread out,
like gardens beside a river, like
aloes planted by the Lord, like
cedars beside the waters.”
Numbers 24:6
Nature magazine article
states cell surface sugars are
necessary for recognition
and immune function.
Dr. McAnalley joins
Mannatech with
focus on new field
of carbohydrate
Study by Berger, et al., in
Metabolism showed that
galactose and mannose were
directly incorporated into human
glycoproteins without first
being converted into glucose.
Authors concluded that specific
dietary sugars could represent
a new class of nutrients.
(October) New Scientist
magazine article, “Sugar
Rush,” emphasizes
glycobiology as the
basis of understanding
immunology, neurology and
developmental biology.
As dietary sugars
Ambrotose product approved
claims expand to include
begin to gain
memory, cognition
acceptance as a “new improved
and visual discrimination as well
class of nutrients,”
as positive prebiotic effects.*
Mannatech is issued
more than 50
Scripps Institute
patents worldwide awarded $34
million from NIH to
for Ambrotose
study glycobiology.
Mannatech files
patents on the world’s
first composition
of glyconutrients
and introduces
Ambrotose® complex.
(July) Scientific American
article, “Sweet Medicine,”
reports on pharma’s big
new strategy for making
better drugs from sugars.
The United States of America
National Academy
of Sciences publish
“Transforming Glycoscience,”
a roadmap for the
integration of glycoscience
as a significant part of
higher-education curriculae
within the next decade.
Definitive proof! Dr. Azita
Alavi and colleagues publish
study in the European
Journal of Clinical Nutrition
showing for the first time
that the oral intake of
Ambrotose powder
can have a
impact on the
status of serum
with no adverse
The Gift of Provision
The Story Behind Mannatech
A Desire to Make a Difference
In 1994, Mannatech founder Sam Caster had one profound desire:
to create a business that would make a real difference in the world.
This visionary new company began to quietly assemble a team
of top scientists. Their goal was to develop advanced, foodbased nutritional technologies that could best address
the growing effects of poor nutrition in the world, and its
impact on our health, our weight and the world’s most
vulnerable children.
Amazing, Disruptive Discoveries
In 1996, Mannatech’s first Chief Science Officer, Bill
McAnalley, PhD, made the discovery of a whole new
category of plant-based nutrients called glyconutrients.
Mannatech formulated the world’s first glyconutrient
product, called Ambrotose® complex. Though this
pioneering discovery was at first questioned, even
ridiculed, by the traditional scientific community,
technology supporting it has since received more than
50 worldwide patents, and it’s now revered as science’s
next frontier. Ambrotose complex, formulated with
the Manapol® aloe vera extract, became Mannatech’s
foundational Real Food Technology® solution for proper
cell-to-cell communication and immune system support.
The Story
Real Food Technology® Solutions
Mannatech’s current CEO and Chief Science Officer, Robert Sinnott, MNS, PhD,
extended Mannatech’s proprietary product base through the formulation of
PhytoMatrix® caplets, the industry’s first vitamin and mineral product produced
from natural and plant-sourced ingredients at standardized, nutritionally effective
levels. This approach quickly led to the development of many new, unique products
based on Real Food Technology solutions. In 2012, Dr. Sinnott blended Mannatech’s
proprietary glyconutrient complex, its proprietary antioxidant composition and
its proprietary real-food vitamin/mineral formulation into a whole-food base. This
new product was named NutriVerus™ powder, and it became a complete Real Food
Technology solution for global health.
A World-Changing Approach
As of early 2013, Mannatech operates in 23 countries around the world. The
company adopted the dynamic business model of social entrepreneurship to link its
international product sales directly to the needs of the world’s most at-risk children.
Through its Give for RealSM program, Mannatech empowers caring individuals all
around the world to join the fight against childhood malnutrition by simply choosing
to nourish themselves with advanced nutrition sourced from real foods. At the same
time, Mannatech offers an unprecedented, purpose-driven business opportunity for
those who choose to champion this cause.
Enjoy the full story behind the beginning
of Mannatech in this video,
Destiny Unfolding.
The Story
Our Mission and Vision
Our mission is to fight global malnutrition by
nourishing the world with Real Food Technology®
supplementation while empowering and rewarding
the lives of those who champion our cause.
Our vision is to impact the global epidemic
of childhood malnutrition by linking five
million consumers of Real Food Technology
supplementation with five million children in need.
Three to five million children
under the age of five die every
year from the devastating
effects of malnutrition.1 That
means every six seconds a
child dies from malnutrition.
That’s 14,000 a day.
The facts are heartbreaking.
Staggering. But not
unbeatable, thanks to
people like you.
"Progress for Children: A Report Card
on Nutrition" UNICEF, May 2006
Find out how you can join in the fight against global malnutrition. Visit today.
Mission and Vision
Science Department
of Real Food Technology® Solutions
“Everything man needs to sustain good
health is provided by God in nature.
The job of science is to find it.”
Mannatech accepted the challenge!
Robert A. Sinnott, MNS, PhD
CEO and Chief Science Officer
• Oversees the overall development and R&D management
of Mannatech’s Real Food Technology products
• Earned Bachelor’s Degree in Biological Sciences, a
Master of Natural Sciences Degree and a PhD from
1987–1995, all from Arizona State University
• Focused on plant medicinal chemistry and plant
biotechnology in graduate training
• Instrumental in establishing the science branch of a
nonprofit educational institution for training economically
disadvantaged students in science-based careers
• Joined Mannatech in 2005
• Instrumental in the creation of Mannatech’s
Real Food Technology approach
Thanks to its dedication to food-based research and
development, Mannatech has become a leader in the Real
Food Revolution.
Mannatech has invested tens of millions of dollars in the research,
development and validation of Real Food Technology solutions.
Working from Mannatech’s in-house laboratories, the company’s
scientists and product development specialists actively explore new
technologies for sourcing and formulating real-food solutions for
consumer health and nutrition.
The company’s Research Group collaborates
with major universities and research
firms around the world to conduct clinical
trials and studies on our
products and ingredients.
Visit for full details.
The World's View
Glycoscience Validation
We hold more than 50 patents in 30 countries for the technology
relating to our Ambrotose complex glyconutrient formulation.
And our patent positions have been repeatedly reaffirmed in
court, most recently in July 2010, when Mannatech won judgments
against seven companies found to be manufacturing and marketing
products that infringed on our patented glyconutrient technology.
Recent Glyconutrient Studies
Dr. John Rollins, a former award-winning U.S. Trademark and
Patent Office official, upon his introduction to glyconutrients,
said, "In the past 23 years ... our group at the U.S. Patent
Office had the opportunity to review the best technology
presented by the world's best scientists. There have been many
significant discoveries, but one stands head and shoulders
above the rest: the discovery of a new category of vital
nutrients called glyconutrients."
The United States of America
October 2012 University of Ghent scientists publish Ambrotose product prebiotic study in the
Antoine van Leeuwenhoek Journal of Microbiology.
February 2012 Review of effects of polysaccharides on brain function is published, Mechanisms that might explain the
cognitive benefits of glyconutrients and other polysaccharides are explored.
September 2011 Study shows Mannatech's Ambrotose complex improves well-being in healthy adults (titled Perceived
changes in well-being following polysaccharide intake in middle-aged adults).
Quality and Standards
Mannatech is committed to meeting customer, regulatory and industry standards by manufacturing
products of the highest quality and value. Our suppliers conduct statistical sampling then follow it
with inspection and testing. No product is ever shipped from Mannatech without the highest level of
assurance that it meets our quality standards.
In 2011, an open-label
dosing study published
in the European Journal of
Clinical Nutrition concluded
for the first time in the
scientific community
that the ingestion of a
standardized blend of
plant polysaccharides
(Ambrotose complex)
can induce significant
changes in cell-surface
glycoprotein structures.
And, there were no
reported adverse events.1
In 2012, a report titled Transforming Glycoscience: a Roadmap for the Future
conducted by the National Academies of Science offered bold support
for the function and importance of glycans (or glyconutrients).
“A suite of tools analagous to those available for studying nucleic
acids and proteins is needed to detect, describe and purify glycans
(glyconutrients) from natural sources, and characterize their
chemical composition and structure.”
Current Good Manufacturing Practices
As a global innovator, we adhere to industry-wide current Good Manufacturing Practices (cGMPs)
established by various U.S. and international regulatory agencies. You can rest assured that our
products are safe, effective and precisely labeled.
NSF Certification—Third-Party Mark of Excellence
A growing number of our health products have been Certified
by NSF International, an independent, third-party organization
that helps ensure that supplements and ingredients are labeled
accurately and contain no adulterants or contaminants.
100% Satisfaction Guarantee
You can trust the science and quality behind our
products. We’re so confident you’ll love our products that
we offer a six-month Satisfaction Guarantee.†
Mannatech guarantees your full satisfaction. If not completely satisfied, contact Customer
Care and return the product within 180 days for a full refund. See for details.
Glycoscience Validation
To see the full
collection of studies
and published
research, visit
Alavi, A., Fraser O, Tarelli E, et al. An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement
on the N-glycosylation profile of serum in healthy subjects. Eur J Clin Nutr 2008; 65: 648–56
Awards and Recognition
A Company of Provision
June 2005–In its June 6, 2005, edition, BusinessWeek magazine ranked Mannatech #6 on its annual
list of Hot Growth Companies.
June 15, 2005–Mannatech was awarded the coveted “Success Award” by the Direct Selling
Association for the unique changes of the company’s compensation plan at this year’s annual DSA
convention held in Orlando, Florida.
March 14, 2006–Mannatech was the 29th fastest-growing public company in the Dallas/Fort Worth
Metroplex, according to the Dallas Business Journal.
March 22, 2006–Nutrition Business Journal awarded global health and wellness provider Mannatech,
Incorporated, a bronze medal in the publication’s annual Business Achievement Awards.
April 16, 2006–The U.S. Department of Commerce recognized global health and wellness leader
Mannatech for its successful entry into the international marketplace.
May 14, 2006–The Dallas Morning News named Mannatech as one of DFW’s Top 200 Publicly Traded
October 18, 2006–Forbes magazine recognized Mannatech as one of the top 10 best small
companies in America.
January 31, 2007–Mannatech received first- and second-place awards for basic science research
indicating bacteria from the human digestive tract can metabolize the complex carbohydrates in the
company’s glyconutritional supplements.
May 30, 2007–Mannatech was recognized by BusinessWeek as the 12th-best “Hot Growth” small
company in America and as the 4th best in average return on capital over three years.
March 14, 2009–Chief Science Officer and Senior Vice President Robert Sinnott, MNS, PhD, was
selected as the vice chairman of the Senior Scientific Advisory Council (SSAC) for the Council for
Responsible Nutrition (CRN).
March 2009–Mannatech was honored by members of the U.S. House of Representatives, the Texas
House of Representatives and the Dallas City Council.
November 24, 2009–Mannatech’s educational website,, received a Web
Health Merit Award for its accuracy, success in reaching its targeted audience and overall quality.
June 2011–CEO and Chief Science Officer Dr. Rob Sinnott featured in Natural Products Insider
magazine article, “Aloe veritas.”
October 2011–Mannatech and Texas Women’s University announce the development of a Nutrition
and Personal Health Coaching Certification Program. Mannatech helps develop course materials.
April 2012–Mannatech presents new study at the 10th Jenner Glycobiology and Medicine
Symposium in the Netherlands.
July 2012–Mannatech presents product research at the 9th Annual International Society of Sports
Nutrition Conference.
April 2013–Dr. Sinnott featured in Nutraceuticals World magazine article, “Open Innovation in
Nutraceuticals & Functional Foods.”
We do all that we can to earn the trust consumers
place in us every time they use a Mannatech product.
Awards & Recognition
A Company of Provision
And Industry’s “Solution”
The Problem We All Face
Industry set out to “improve” food
Many of us are not consuming
enough essential nutrients!
Industry saw an opportunity in our problems.
In the mid-1900s, commercial farming found new ways to grow food faster and bigger.
The nutritional value of many fruits and vegetables
has declined over the last 50 years.1,2
The USDA now recommends that adults consume
3.5–5 cups of fruits and vegetables per day.3
“Nearly the entire U.S. population fails to eat a diet in
line with the dietary guidelines for Americans.”4
Genetically Modified Seeds
90% of all the money Americans spend on food is
used to buy processed food.5
Davis DR, Epp MD, Riordan HD (2004) Changes in USDA Food Composition Data for 43 Garden Crops, 1950 to 1999. Journal of the American
College of Nutrition 23: 669-682.
Mayer A-M (1997) Historical changes in the mineral content of fruits and vegetables. Brit Food J 96: 207-211.
Krebs-Smith, S.M., Guenther, P.M., Subar, A.F., et al. Americans do not meet federal dietary recommendations. J Nutr 2010; 140(10): 1832-8.
Schlosser E. Fast Food Nation: The Dark Side of the All-American Meal. Perennial/Harper Collins: 2001.
Bigger Livestock
Big Profits
Industry has radically changed our
food over the last 50 years.
Then, industry focused on reinventing food by combining highly processed food
ingredients with chemically made sweeteners, colorings, flavorings and preservatives. They are
so poor in nutritional value that one expert refers to them as “edible food-like substances.”6
We are stressed!
Oxidative stress causes free radicals.
Emotional stress
Excessive exercise
Smoking (including second-hand)
Pollan M. In Defense of Food. New York, New York: The Penguin Press, 2008.
Excessive alcohol consumption
Use of pharmaceuticals
Once the public turned to supplements to fill the gap,
industry saw a new opportunity and began marketing
Food preservatives
We live in a toxic environment!
The Problem
Over 75,000 synthetic chemicals
introduced since 1930
Numerous pollutants common
in our air and water
Artificial sweeteners, colorings
and preservatives
Household cleaners, pesticides
and other chemicals
high-dose synthetic vitamin and mineral products. It was cheaper
and more profitable to develop vitamins and minerals from things
like petroleum, coal tar derivatives and crushed up rocks than to
extract them in their natural form, from whole foods.
Every so-called "solution" has
typically presented more problems.
For many of us, while the "solutions"
continue to increase, our health
continues to decline overall.
The Problem
Industry's “Solution”
Easily Identify
Synthetic Vitamins
Synthetically Made Nutritional Alternatives
Synthetic vitamins are chemically produced
and often include nutrients sourced from
petroleum and coal tar derivatives, not food.
They are inexpensive to produce and easy to
standardize at RDI levels.
It's estimated that over 95% of all vitamins
sold are synthetically made.1
“Minerals are generally
recovered by mining
ores or from chemical
processes. Tests
have shown that
minerals contained
in [many of ] the most
popular brands of
multivitamins do not
dissolve (they are not
soluble) in the stomach or small intestine. They probably pass
through the body without being absorbed.”2
Ensley BD, Elless MP, Blaylock MJ, Huang JW. Hydroponic cultivation of metal-accumulating plants as a source of mineral nutrient supplements. Metal
Ions in Biology and Medicine 2000;531–3.
Take a look at your current brand of nutritional supplement and
find out if it contains synthetic sources.
Synthetic Vitamins May Include:
Vitamin B2
Vitamin C
Vitamin D
Vitamin E
Vitamin K
Pantothenic acid
Folic acid
Listed on the label as:
Ascorbic acid
dl-alpha tocopheral
Menadione or phytonadione
Calcium D-pantothenate
Pteroylglutamic acid
Any vitamin ending in the following is synthetic: acetate,
hydrochloride, mononitrate, palmitate or succinate.
Inorganic mineral names will usually
end in one of the following:
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Industry's Solution
Industry's Solution
Ancient Wisdom
What Did They Tell Us?
The Design of Life: “I have given you every seed-bearing
plant throughout the earth and all of the fruit trees for
your food.”
Genesis 1:29
Paracelsus and Hippocrates, considered to be the fathers
of pharmacology and medicine, respectively, believed that
having good health was dependent upon proper nutrition.
Over the centuries, technologies have evolved in both food
and medicine, but this principle remains as true today as it
was then. New research is showing us how the human body
functions at the cellular level and how nutrients in their realfood form support these critical functions. Science is now
bringing us full circle to the very foundations of health and
ancient wisdom.
“Everything man needs
to sustain good health
is provided by God
in nature. The job of
science is to find it.”
Ancient Wisdom
Pietro Longhi. The Apothecary—Aloe vera was a
common tool in doctors' offices in the mid 18th century.
Ancient Wisdom
Real Food Technology:
The Solution
Which Plant Would You Want YOUR
Supplements to Come From?
A chemical plant?
Most nutritional solutions today are falling way short of what your body
actually considers to be “good nutrition.” Sure, the label touts all the popular
vitamins, minerals and other trendy nutrients at levels that seem impressive
on the surface. But your body isn’t fooled. Your body is complex, and it’s
looking for more than just a combination of high-dose synthetic nutrients
to feel its best.
Your body
wants nutrition
from real-food
Mannatech recognizes the importance of nutrients from nature. We
introduced Real Food Technology solutions to take a different approach
to nutritional supplementation. Simply put, we use science not to “create”
nutrition, but rather to “capture” nutrition … from nature, of course.
And as far as your body is concerned, this approach makes all
the difference.
Real Food Technology solutions provide standardized and nutritionally
effective levels of vital nutrients from whole-food sources.
The Keys to a Real Food
Technology Approach
Nutritionally effective levels
Whole-food sources
A real plant?
Real Food Technology
Real Food Technology
Real Food Technology Solutions
A Common-Sense
Approach to Optimal Health
Completing the Circle of Care
Consider for a minute your body as an automobile.
Daily support and maintenance is required or
breakdowns occur.
The modern car is designed to run on certain
raw materials.
It requires routine maintenance.
It will usually last about 100,000 miles or so.
The car must have fuel in the tank, oil in the engine, water in the radiator; air in the tires and, of
course, a driver behind the wheel.
The car also must be maintained by changing the oil and filling the gas tank.
There are numerous things that may improve its performance or looks, but these components
are mandatory for it to start and run. If any of the basic components are missing, or the car isn’t
maintained properly, it’s not going to travel very far without breaking down. And a shiny new
paint job or fresh tires won’t help if the basics are not met.
The same concept can be applied to
understanding the human body.
Our bodies were designed to run on very
specific raw materials.
– Communication
– Protection
– Nourishment
System Support
– Endocrine
– Cardiovascular
– Digestive
It All Starts
with the Cells
For optimal wellness, your body needs
ongoing maintenance in such areas as:
Cellular Support
A variety of food-based
nutrients is required to
support healthy cells.
Healthy cells are necessary
to support healthy glands,
organs, tissues, bones,
fluids, blood and skin.
Healthy cells =
Healthy tissue
Healthy tissue =
Healthy organs
Healthy organs =
Healthy systems
Healthy systems =
Healthy bodies
They require routine maintenance.
And they are designed to last about 85 years or so.
Countless things may enhance how we look or feel, but nutrients
are essential. Unless we provide our bodies with these basic
essentials and perform the necessary maintenance, it is very
difficult to sustain good health.
Role of Nutrients
System Support
Body Fitness
– Fat Loss
– Performance
– Recovery
Role of Nutrients
Sweet Language
of Life
Ambrotose® Complex
and Advanced Ambrotose®
The Missing Link
The first standardized blend of
plant-sourced polysaccharides.
More than 50 patents
issued worldwide for this
breakthrough technology.
Of the 200 that naturally occur in nature,
our cells use eight of these sugars like
letters of an alphabet to create cellular
words. The potential information content of
these sugar structures vastly exceeds that of
any class of macromolecules.1
Every living cell on the planet is covered
with a dense and complex array of sugar molecules called glycans. Every molecule, cell or
organism that interacts with a cell must do so through these cell-surface glycans.1
Immune cells read these sugar structures to determine if our cells are healthy, in need of repair
or need to be destroyed.
Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future.
The National Academies Press: 2012.
When Your Cells Talk,
Your Body Listens
When bad cells go undetected, as in degenerative
type functions, research has shown that sugars
are missing from their glycoprotein structures.
Capitalizing on Carbohydrates, 1991
“Removing one sugar [from their cell-surface
structures] turns protective antibodies (repair cells)
into attackers.” The research shows that the mere
destructive autoimmune functions appear to be
lacking “antibodies associated with this (sugar).”
Rockefeller University,
July 4, 2007
Bill McAnalley's A Story of Discovery Ambrotose:
Cellular Suppor t
Ambrotose Products
Support cellular communication*†
Improve cognitive function*†
Improve memory, concentration and attentiveness*†
Improve mood and decrease irritability*†
Support immune system function*†
Support digestive system health*†
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Benefits vary by product.
Real Food Technology Solutions
for Cellular Protection
In part, premature aging is the breakdown of the body’s natural ability to regenerate its
trillions of cells and produce new ones. This repair and renewal process goes on every
second of every day of your life.
It has been postulated that naturally occurring invaders, called “free radicals,” can
damage cells, interfere with their repair and regeneration, and thereby speed up the
aging process.
Ambrotose AO®
Ambrotose AO is a scientifically proven
antioxidant supplement designed to support
optimal health by effectively enhancing
antioxidant protection in the body.*
Sunlight, physical and emotional stress, and environmental toxins are sources of free
radicals that can damage cells and accelerate the aging process.
Research has shown that two Ambrotose AO capsules
can increase overall antioxidant protection in
humans by 37.9%.† That’s more than two and a
half times the ORAC impact of five servings of
fruits and vegetables (serum ORAC results).
Ambrotose AO capsules:
Cells can protect themselves from these environmental factors, but research suggests
that they require the right nutrients, called antioxidants, to provide proper protection.
Certain fat- and water-soluble vitamins, minerals and plant phytochemicals are
antioxidants that can neutralize free radicals and prevent the damage they cause.
It has been postulated that premature aging can start to occur when cells don’t get
enough antioxidant support, and the body cannot keep up with the demands of
damaged cells.
– Help protect against cell damage caused by
physical and oxidative stress (free radicals),
toxins, environmental stress, and poor diet, all
of which can damage cells, tissues, and DNA.*
Antioxidant nutrients are abundant in vine-ripened fruits and vegetables.
– Provide plant-sourced ingredients for
in OSP
antioxidant and immune support.*
Free radicals can attack our cells
as many as 10,000 times a day.
Comparison of serum ORAC values obtained in two separate clinical studies funded by Mannatech.
The right blend of fat- and water-soluble
antioxidants may protect our cells from this attack.
According to a study funded by the USDA,
five daily servings of fruits and vegetables can increase
overall antioxidant protection by 13.9% (serum ORAC
results).1 Ambrotose AO capsules can
increase overall antioxidant protection
in humans by more than two and a half
times that amount. Read the full study
Cao G, Booth SL, Sadowski JA, Prior RL. Increases in human
plasma antioxidant capacity after consumption of controlled
diets high in fruit and vegetables. Am J Clin Nutr 1998;68:1081–7.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Ambrotose AO
Real Food Technology Solutions
for Cellular Nourishment
Your Cells Need Nourishment
Every cell in your body requires a variety of nutrients to help build and support its proper
structure and function.
Your body is building millions of new cells every second.
There are more than 26 essential vitamins and minerals, and multiple trace elements,
that MUST be obtained through your diet.
PhytoMatrix® Caplets
Vitamins and Minerals
Mannatech’s PhytoMatrix
multivitamin/mineral supplement
provides the industry’s first
standardized blend of foodsourced vitamins, minerals and
PhytoMatrix caplets support:
Foods are comprised of synergistic blends of
[essential] nutrients bound together into the
food matrix.
It is the food matrix [blend] that best supports human biological processes.
Jacobs DR, Jr., Tapsell LC. Food, not nutrients, is the fundamental unit in nutrition.
Nutr Rev 2007;65:439-50.
Proprietary Hydroponic Growing
At the heart of our PhytoMatrix product is a patented, hydroponic cultivation
technology that uses the Indian mustard plant nicknamed “nature’s magnet”
for its ability to absorb minerals from the soil. These plants are hydroponically
grown in solution, allowing them to absorb a controlled amount of
concentrated minerals, which are then stored in the plant tissue.
Why is this significant? Because food sources—like Indian mustard—provide
minerals in their most natural form, so they can be readily absorbed
and utilized by the body. The hydroponic process ensures standardized
concentrations of essential minerals that meet minimum requirements
with a daily serving of four tablets. Even fresh fruits and vegetables—
which usually have high concentrations of vitamins—may be low in
essential minerals.
Cell protection with powerful antioxidants*
Heart health with vitamins B6, B12, B3 (niacin), C, and B9
(folic acid)*
Energy production with a full complement of
B vitamins*
Healthy eyesight with vitamins A, C, E, and niacin, plus
the mineral zinc*
in OSP
Immune system function with vitamins A, C, E, B6, and folic acid, plus
minerals zinc, copper and iron*
PhytoBurst® Chews
Essential Nutrition
PhytoBurst® Chews: A Delicious Delivery
Method for Food-Sourced Nutrition
Delicious fruit-flavored chews (lemon and mixed berry)
Great on-the-go bursts of nutrition
Incorporates hyrdroponic technology found in our
PhytoMatrix caplets
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Cellular Health
Value Proposition
NutriVerus™ Powder
Nutrition the Way Your Body Wants It.
NutriVerus features a nutrient-dense, real-food base of stabilized rice bran, organic
fruits and vegetables, antioxidants and glyco- and phytonutrients.
The Ultimate Solution
for Cellular Health
Mannatech’s Core Innovations in One Product
NutriVerus powder delivers the nutrition your body
needs, the way your body wants it. This completely
unique supplement combines natural, food-sourced
vitamins, minerals, glyconutrients and fat- and watersoluble antioxidants in a nutrient-dense, real-food base
of stabilized rice bran and organic fruits and vegetables.
The result? Energy-boosting, immune system–supporting
nutrition in an environment just right for nutritional
synergies to occur, increasing the potential interaction of the
individual nutrients.*
Fat- & Water-Soluble
Organic Fruit Blend
Tart Cherry
& Minerals
from Real Food
Real Food Base
from rice bran and organic
fruits and vegetables
Highly Valued Benefits at a Value-Conscious Price
Glyconutrients and food-sourced nutrients for just $2 a day!
Supports cell-to-cell communication through a blend of specific
plant saccharides including glyconutrients*
Offers antioxidant and immune system support*
Supports brain health*
Organic Vegetable Blend
Broccoli Sprouts
Stabilized Rice Bran (SRB) is
one of the most nutrient-dense
food ingredients in the world.
Unlike other grains, it is gluten-free
Vitamin E complex with tocopherols and tocotrienols
More than 100 antioxidants, metabolic cofactors, and trace elements in its food matrix
Naturally rich in B vitamins
High in inositol
Rich in phytosterols
Rich in fatty acids
Good protein source
Good source of potassium, magnesium and phosphorus
Helps protect your cardiovascular system*
Supports healthy digestion*
Helps your body maintain energy levels*
Provides a natural, food-sourced vitamin/mineral complex for maximum absorption*
Suitable for all ages, including kids age four and up
Cellular Health
Learn more about NutriVerus powder
and the Real Food Revolution.
Watch this video.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Cellular Health
Real Food Technology Solutions
for System Support
Mannatech PLUS™
Endocrine System Support
Mannatech PLUS caplets include a
proprietary blend of standardized
plant sterols formulated to support a
well-functioning endocrine system.*
The Endocrine System Is Your
Body’s Command Central.
PLUS caplets:
When functioning well, its glands direct operations by
producing vital hormones that send signals to keep you
ready for anything and help your body stay balanced.
Because this important control center ultimately
influences almost every cell organ and function
of your body, making sure it gets the nutrients it
needs is a must. Mannatech’s PLUS caplets, can help by
keeping this vital system functioning smoothly
in a state of equilibrium.*
Furnish raw materials for endocrine support*
Support breast, bone and colon health as well as the
immune, nervous and cardiovascular systems*
Support prostate health*
Supply essential amino acids to support
natural hormone production*
in OSP
Mannatech’s PLUS caplets don’t contain hormones. Instead, they provide specific nutrients,
including plant sterols to support your glands’ natural function.*
And because we don’t always eat right, we can miss out on important nutrients like plant sterols
and amino acids that help keep our systems functioning well. That’s why Mannatech developed
PLUS caplets—to supply the body with a proprietary blend of specific, standardized nutrients,
including important plant sterols and amino acids that we may not always get on a consistent
basis from diet alone.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Amino acids—the “building blocks” of proteins
Did you know that of the 20 amino acids that we all need to survive, the human body
produces only 10?
We must rely on our diets for the other half, but not all proteins are created equal. Some contain
specific amino acids for hormone production while others do not. And because humans don’t
store amino acids in their bodies, we need a steady supply every day.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Real Food Technology Solutions
for Cardiovascular
with Vitamin D3
Research shows that most people are
deficient in Omega-3 fatty acids
Your body doesn't produce Omega-3
For centuries, people got enough omega-3s through their diets. Not so anymore. Today's diet
trends result in too much omega-6 in our bodies. Even farm-raised fish are often grain fed and
contribute more omega-6 than omega-3.
Although omega-6 is important, it competes with omega-3 for space in our cells. Our current
diets have created a ratio that ranges as high as 30:1 omega-6 to omega-3. This imbalance has
given rise to an unhealthy inflammatory response, which is a key contributor to many of the
health concerns in our diet.
Healthy Heart
Mannatech's Omega-3 with Vitamin D3
is your best choice with:
Over 1,000 mg of highly concentrated EPA and DHA per serving
Pleasant lemon flavor in an easy-to-swallow gel capsule
A Fat Your Body Needs
• Help support cardiovascular and heart health*
• Help support brain health and function*
CardioBALANCE Capsules:
• Vitamin D is essential for calcium absorption*
Learn more about how our Omega-3 with
Vitamin D3 is unique. Watch this video.
830 IU of vitamin D3, a natural and preferred source of vitamin D
For Additional Cardiovascular Support
• Help maintain a healthy immune system and support a healthy inflammatory
response—a key contributor to good health*
Made from molecularly distilled, high-quality fish oils, for
There are good fats and bad, but omega-3 fatty acids are a fat
that you absolutely must have.
• Provide support for healthy triglyceride levels already
within normal levels*
fatty acids
are considered
“essential” because
they are vital to
your health and
your body cannot
produce them.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Provide nourishment for cardiovascular health through
a unique herbal vitamin and amino acid blend.*
Help maintain homocysteine levels that are
already within normal range.*
Include folate as well as L-arginine, which is thought to
increase nitric oxide production—essential in maintaining
blood vessel health—as well as CoQ10, which is often
depleted by cholesterol-lowering drugs.*
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Real Food Technology Solutions
for Digestive System
Did you know that approximately
70% of your immune system is
located in your digestive tract?
Healthy Digestion
Mannatech's GI-ProBalance
slimsticks provide the “right”
bacteria to help maintain the
microbial balance in a healthy
This balance can promote a healthy effect among
the various microflora that live in the human
intestine, thereby supporting optimal digestive
tuned to unleash
the power of
Developed after extensive research on the
digestion and beneficial effects of Ambrotose
powder, GI-ProBalance slimsticks were formulated
to enhance the benefits of Ambrotose products.
The specially formulated probiotic blend breaks
down the polysaccharides in the Ambrotose
products, thereby enhancing the ability of both
exceptional products to support the digestive and
immune systems.*
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
One of the digestive system's most important
functions is to process food and absorb all the
nutrients our cells can use. It also serves as the
first line of defense against harmful bacteria.
Because the digestive system's organs rely on
nutrients from food, the health of the digestive
system depends on the quality of our diet.
So when your
gut is healthy,
it helps your
whole body
stay healthy.
To digest food, the intestines maintain an
environment that includes healthy bacteria
and enzymes.
Probiotics are dietary bacteria that assist in
digestion. Enzymes regulate the speed of metabolism, among other bodily processes.
Probiotic bacteria must be regularly replenished. In the past, they
were found in many common, raw foods. However, preservatives,
pasteurization and other processing have generally eliminated
probiotics from today’s foods. This forces the body to dip into and,
perhaps, deplete its own supply.
Healthy Digestion
Mannatech's GI-Zyme capsules are
formulated to:
Help improve the level of digestion*
Assist in breaking down proteins, fats and carbohydrates*
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
A New Perspective
on Fat Loss
Real Food Technology Solutions
for Sustainable
Fat Loss
We're Dieting More Often
The desire to lose weight is not a new one. But it’s one
that’s received unmatched attention in the past thirty years.
Conventional wisdom tells us that too many calories and too
little exercise are the major contributors to weight gain. So we’ve
tried to address those issues in many creative ways. From exercise
programs and eating plans, to metabolism-enhancing pills, meal
replacements and even surgery, we’ve virtually thrown the kitchen
sink at losing weight.
Don’t be fooled by trendy, synthetic, weight-loss shakes
and plans. Feed your body with the only protein shake that
incorporates a unique glyconutrient blend and a protein mix based
on Real Food Technology solutions.
75 to 100 million Americans diet each year.1
The typical American dieter now makes four weight-loss
attempts per year—the highest number in 15 years.1
The weight-loss industry by the numbers, ABC News, May 8, 2012
We're Spending More Money
The U.S. weight-loss market now exceeds $60 billion.
If you consider that “only” 75 million Americans are trying to lose
weight, that’s $800 per person per year!
16 grams of vegetable-sourced proteins (rice and yellow pea)
Delicious natural vanilla flavor
Glyconutrient blend helps amplify support at the
cellular level*
No soy
No dairy
With ongoing proper diet and exercise.
U.S. Weight Loss Market Worth $60.9 billion, PRWeb, May 9, 2011
We're Gaining More Weight
Even worse, even when we do lose weight, we seem to have
even bigger challenges keeping it off. Many of us lose a few
inches today, only to gain it all back—and even more—
Globally, there are more than 1 billion overweight adults,
and the number is growing.
Don’t Make This Common Weight-Management Mistake!
When shedding pounds, don’t overlook your body’s basic nutritional needs.
Add NutriVerus powder to your weight-management regimen and give your
body the foundational, whole-food nutrients it craves.
OsoLean® Powder
Target Fat Loss, Marketdata research 2013
According to the American Heart Association, 66% of
Americans are overweight and 34% are obese.
Trend spotting 2013,, December 3, 2012
The Answer?
SUSTAINABLE weight management from REAL-FOOD SOURCES.
Fa t L o s s
Retaining lean muscle when burning fat is important in maintaining body
strength and a healthy metabolism. In a clinical study, the key ingredient
in OsoLean powder promoted fat loss and minimized muscle loss when
combined with a proper diet and exercise.*
More than a just typical whey protein product, OsoLean powder incorporates
a proprietary advanced peptide technology that separates and concentrates
specific parts of whey protein, called peptides, to ensure your body receives
the optimal level of fat-loss peptides.*
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Fa t L o s s
Perform Better
Recover Faster
Mannatech’s advanced Weight and Fitness products are natural and formulated with food-sourced
nutrients to help you go the extra mile, and look amazing while doing it.
When taken daily, over time, BounceBack capsules can:
SPORT™ capsules:
Our BounceBack® capsules allow you to stay active and mobile.*
Help maintain existing normal blood sugar levels
and support carbohydrate utilization*
A proprietary blend of herbs and herbal extracts
A plant sterol supplement formulated with a
combination of Ambrotose complex and wild yam
Help reduce muscle pain and stiffness due to
overexertion or physical activity*
Aid the body’s natural recovery process*
Support optimal joint and cartilage health*
Provide immune system support*
Mannatech’s ImmunoSTART® tablets prime your immune system.*
AmbroStart® drink mix is a delicious, orange-flavored,
energy-releasing supplement that:
Delivers nutrients that provide the body with energy*
Includes medium-chain triglycerides that are
readily broken down into short-chain, free-fatty
acids that can be used as fuel for muscles*
Is a good source of fiber
Helps support a healthy immune system*
EM·PACT® citrus-flavored drink mix:
May enhance the body’s ability to use oxygen
during athletic exertion*
May improve athletic endurance*
Includes medium-chain triglycerides (MCTs) that are readily
broken down into short-chain, free-fatty acids that are used
as fuel for muscles*
Has been clinically shown† to enhance cardiorespiratory
fitness and improve endurance*
Mannatech-funded clinical studies.
Per formance
If it’s operating well, your immune system will remove toxins and keep you healthy. But,
everyday stresses, not eating properly and irregular sleep habits can take a heavy toll on your
immune system. These factors may accelerate your use of and need for nutrients. Eventually,
your immune system may encounter difficulty keeping up with the demands placed
upon it, so it’s critical that you give it the right nourishment.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Helps build, support and nurture immune system health*
Engineered with a targeted array of nutrients, including
bovine colostrum and lactoferrin that work to stimulate
and support the body’s natural immune response*
Increases plasma levels of neutrophil precursors—neutrophils are the most
abundant immune cells and form an integral part of the immune system*
Manna-C™ capsules contain natural forms of vitamin C from wild bush plum
and acerola—wild fruits that are considered two of nature’s richest sources of
this vitamin.
Includes classic Ambrotose complex, along with wild bush plum
and acerola fruit extract, both natural sources of vitamin C
Herbal blend with a natural plant source of vitamin C
for the maintenance of good health*
Our Manna-C capsules combine Ambrotose complex plant polysaccharides with
an herbal blend that yields natural sources of vitamin C. This specially formulated
herbal blend includes lemon verbena, sage, peppermint and other herbs.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
Protecting Our Future
Start a Tradition of Good Nutrition
The pursuit of wellness is one that lasts a lifetime. Give your child the
healthy advantages that come from good nutrition early in life.
Many Mannatech products are appropriate for children. Just check the labels
for any possible age and/or directional restrictions. For starters, here are
some products deemed as “favorites” by kids and parents alike.
MannaBears™ Gummies
A tasty alternative to sweets full of refined sugars and other “junk” foods,
MannaBears gummies include a specially formulated glyconutrient blend as
well as 11 dehydrated fruits and vegetables—like broccoli, carrot, cauliflower,
tomato, papaya and pineapple—to help protect cells from free radical damage.*
GI-ProBalance® Probiotic Slimsticks
Since 70% of your child’s immune system is located in the
digestive tract, her body relies on a wide variety of bacteria and
other microorganisms to help keep it running properly, including
probiotics and prebiotics. Kids love the taste of these delicious
slimsticks as much as parents love how they're working.
Recommended for children four years of age and older.
NutriVerus™ Powder
NutriVerus brings real-food glyconutrient and vitamin/mineral
technologies in a nutrient-dense food base of stabilized rice bran and
organic fruits and vegetables. Sprinkle it on your child’s food every day to
help ensure his meals are more nutritious.
Recommended for children four years of age and older.
"This could be the first generation of children in the
United States that lives less than its parents."
Richard Carmona,
former Surgeon General of the United States, 2009
With everything going on in their world, your child’s immune system can
become overloaded quickly. Give them ImmunoSTART tablets every day to
help build, support and nuture immune system health.*
Do not give to children under age 4 without adult supervision.
Skin Care
Healthy Body, Healthy Skin
Creating a Life of Significance
We’ve Got You Covered
Mannatech products not only help you feel your best, our natural,
glyconutrient-infused skin care products help you look great, too.
The Age-Defying Mannatech LIFT™
Skin Care System
Glowing, younger-looking skin is achievable at any age.
Inspired by French technology and formulated with
over 30 botanical ingredients, the Mannatech LIFT skin
care system is paraben-free and can help turn back the
clock to give skin a more natural, youthful appearance.
With just three easy steps—cleanse, treat and
moisturize—plus our Jeunesse 7™ proprietary blend that is known to moisturize,
hydrate and reduce the appearance of fine lines and wrinkles, you can say “bonjour” to youngerlooking skin in no time.
Aging is natural. Looking your age doesn’t have to be. Look as healthy as you
feel with the Mannatech LIFT Skin Care System.
FIRM with Ambrotose® Body Creme
Suitable for all skin types, this rich, botanically based body
creme is a proprietary blend utilizing both science and
nature. Formulated without synthetic colors, it’s also parabenfree and contains no mineral oil to clog pores. It will leave
your whole body feeling refreshed, hydrated and soft.
Emprizone® Gel
Refresh and moisturize dry, itchy skin with hydrating, aloe-based Emprizone
gel. With vitamins A and E, it’s pH-balanced to leave your skin feeling
soft and revitalized after shaving or waxing. It’s also perfect after drying
exposure to the sun and contains no oils or pore-clogging ingredients.
Skin Care
Life of Significance
How You Can Help
One for One
Become a CUSTOMER and help
nourish a child in need.†
As a Member, refer a few
people, earn discounts
on your orders‡ (up to
FREE!) and help nourish
more children.
—Our Goal—
Become a Champion
Help us change the world while
creating a life of significance for
How You Can Help
Linking five million consumers
with five million children in need.
Find out how people just like you are playing
a crucial role in the fight against global
Give for Real donations are generated through monthly
automatic product orders.
4Free Member Discount Program credits are based on
monthly automatic product orders.
Will You Help?
Be the Change You Want to See.
Helping to nourish many of the world’s most vulnerable
children is as easy as simply nourishing yourself. Just
purchase the daily supplements you need, and Mannatech,
through MannaRelief, helps a child in need.
When you do this, MannaRelief will provide a monthly
donation of PhytoBlend™ powder, formulated based
on Real Food Technology solutions—plant- and foodbased nutrition—to help battle malnutrition in
developing countries.
Partner with Mannatech through our
Give for Real program, and be a part of
the change you want to make in the world.
For more information about this important
program, visit today.
A Hope for the Future.
Mannatech, Incorporated
600 S. Royal Lane, Suite 200
Coppell, TX 75019
Item Number: 1275101
Advanced Ambrotose, AmbroStart, Ambrotose, Ambrotose AO, Ambrotose Phyto Formula, BounceBack, CardioBALANCE, Catalyst, EM•PACT, Emprizone, FIRM with Ambrotose, GI-ProBalance, Give for Real and Design,
GI-Zyme, ImmunoSTART, Jeunesse 7, Live for Real, Manapol, MannaBears, Manna-C, Mannatech LIFT, NutriVerus, OsoLean, Phyt•Aloe, PhytoBlend, PhytoBurst, PhytoMatrix, PLUS, Real Food Technology, SPORT, Stylized M
Design and Mannatech are trademarks of Mannatech, Incorporated.