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Version 2 (06.05.08) Name: Wormald/Astbury CONDITION Aetiology Predisposing factors NASOLACRIMAL DUCT OBSTRUCTION (NASOLACRIMAL DRAINAGE DYSFUNCTION) (DISORDERS OF THE COMMENTS LACRIMAL DRAINAGE SYSTEM) Congenital - some babies have a persistent membranous obstruction at opening of nasolacrimal duct into nose; unilateral or bilateral Acquired - usually idiopathic (i.e. no established cause) - usually involutional (i.e. age-related change) stenosis (i.e. abnormal narrowing) of nasolacrimal passages - punctal or canalicular stenosis/occlusion - post-infective (chlamydia, herpes simplex/zoster, staphylococcal) - post-cicatricial disease (ocular pemphigoid, StevensJohnson) - post-conjunctivitis medicamentosa (e.g. long term medications.preservatives in glaucoma or tear deficiency) - iatrogenic (eg repeated probing, eyelid surgery) - secondary to ectropion or punctal eversion - mechanical (trauma, tumours, obstruction by foreign matter e.g. lashes, dacryoliths [calcium stones], punctal/canalicular plugs) - infection of canaliculi (canaliculitis) - rarely, due to Actinomyces (streptothrix sp.) – a Gram-positive bacillus - such cases usually unilateral Often with ‘pouting’ punctum (NJA) - local infection (chronic sinusitis, dacryocystitis) Age: congenital in babies, acquired in later life Other factors: see above Version 2 (06.05.08) Name: Wormald/Astbury CONDITION Symptoms Signs NASOLACRIMAL DUCT OBSTRUCTION (NASOLACRIMAL DRAINAGE DYSFUNCTION) (DISORDERS OF THE LACRIMAL DRAINAGE SYSTEM) Epiphora Irritation Blurred vision due to excessive tear meniscus, especially on downgaze, e.g. when reading Congenital - epiphora and sticky discharge - pressure over lacrimal sac may cause reflux of purulent material from puncta Acquired Check puncta for - size (normally 0.5 to 2.0 mm diameter) - apposition to the globe and marginal tear strip - contact with opposite lid on eye closure Differential Congenital diagnosis - congenital glaucoma (acute) - punctal atresia (congenital absence or abnormal narrowing of puncta) Acquired Rule out inflammation or infection (pain, discharge, swelling, redness, mucus reflux on syringing in adults, history of sinusitis) - canaliculitis - chronic mucopurulent conjunctivitis, pouting punctum expresses chalky concretions, redness & tenderness over canaliculi - dacryocystitis – distended tender lacrimal sac Tumour of lacrimal sac or canaliculi (rare) - can produce lacrimal obstruction - swelling at or below inner canthus (± blood in tears) Bell’s palsy (lacrimal pump failure due to orbicularis weakness) Management by Optometrist COMMENTS Overlap here with acute/chronic dacryocystitis (RW) Version 2 (06.05.08) Name: Wormald/Astbury CONDITION Non-pharmacological NASOLACRIMAL DUCT OBSTRUCTION (NASOLACRIMAL DRAINAGE DYSFUNCTION) (DISORDERS OF THE LACRIMAL DRAINAGE SYSTEM) Congenital Diagnostic test Fluorescein disappearance test - a drop of 1% fluorescein should disappear from the tear meniscus in 5-10 minutes (cobalt blue light, room lights off); any longer suggests partial or complete obstruction Therapy - do not syringe or probe - instruct parent in massage. Gentle pressure with finger over common canaliculus, stroking downwards firmly to raise pressure in lacrimal sac and encourage opening of valve. Suggest ten strokes, four times daily - regular cleaning of discharge from lids Acquired Diagnostic tests Lacrimal syringing - instil a drop of topical anaesthetic - gently dilate punctum with punctal dilator - syringe with normal saline via lacrimal cannula - if saline passes into nose (patient swallows and tastes salt) - nasolacrimal system is patent - if there is resistance to the passage of the cannula and reflux from opposed canaliculus - common canaliculus is stenosed - if no saline passes into nose - complete lacrimal duct obstruction Jones fluorescein dye test - significant amount of fluorescein remaining in tear meniscus two minutes or more after instillation indicates restricted drainage - check for appearance of fluorescein in the nose (examine COMMENTS Are we suggesting optoms should do s and p? and indeed Jones tests? (RW) Version 2 (06.05.08) Name: Wormald/Astbury CONDITION Pharmacological NASOLACRIMAL DUCT OBSTRUCTION (NASOLACRIMAL DRAINAGE DYSFUNCTION) (DISORDERS OF THE LACRIMAL DRAINAGE SYSTEM) tissue after nose blow; if fluorescein present, lacrimal system is patent) - place anaesthetic-soaked cotton bud in nose under inferior turbinate (if bud stained with fluorescein after 5 min, lacrimal system is patent) Therapy Punctal dilation - instil a drop of topical anaesthetic - dilate puncta with progressive diameter punctal dilator - take care not to traumatise tissues - periodic repetition may be required Lacrimal lavage (saline syringing) may be effective in cases of - local (discrete) obstruction - subacute inflammation or infection - less likely to be effective: - in stenosis in the elderly - where there is an underlying disease (inflammation, tumour) Congenital Topical broad spectrum antibiotic e.g. chloramphenicol drops (only if clinical evidence of infection) Acquired Topical broad spectrum antibiotic e.g. chloramphenicol drops (only if clinical evidence of infection) For Actinomyces infection, ofloxacin drops (generally in conjunction with curettage of ‘sulphur granules’) Initial management (including drugs) followed by routine referral (B1) COMMENTS Regular massage of sac in babies? (RW) Version 2 (06.05.08) Name: Wormald/Astbury NASOLACRIMAL DUCT OBSTRUCTION (NASOLACRIMAL DRAINAGE DYSFUNCTION) (DISORDERS OF THE CONDITION COMMENTS LACRIMAL DRAINAGE SYSTEM) Possible management by Ophthalmologist Possible management by Ophthalmologist Probing (through puncta, canaliculi, sac, to nasolacrimal duct) - congenital, not until 1 year of age to allow for spontaneous canalisation - in resistant acquired cases has more limited success and risk of aggravation Canalicular curettage - for Actinomyces infection Surgical removal of posterior wall of vertical limb of canaliculus - considered when repeated punctal dilatation ineffective X-ray imaging of radiopaque liquid injected into the lacrimal drainage system (dacryocystogram, DCG) - pinpoints any obstructions and guides surgery Surgery in canalicular or nasolacrimal duct obstruction includes - dacryocystorhinostomy, DCR (communication made between the lacrimal sac and the nose by removing the intervening bone and suturing lacrimal sac to nasal mucosa) - if other measures have failed, insertion of a Lester-Jones tube Is this congenital or acquired? (RW) Is probing contraindicated in all congenital occlusions because of risk of iatrogenic damage (RW) Congenital: (Oxford Centre for Evidence-based Medicine Level of Evidence = 4) Are you referring to cohort studies here? (RW) Mention endolaser as well (NJA) Evidence base