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Chapter 24 The Digestive System Dr Glenn Huff Kaplan University Anatomy and Physiology 2 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. DIGESTIVE SYSTEM • Irregular tube called alimentary canal or gastrointestinal (GI) tract • Food must first be digested, then absorbed, and later metabolized Slide 2 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 3 WALL OF THE DIGESTIVE TRACT • Digestive tract described as tube that extends from mouth to anus • Wall of the digestive tube is formed by four layers of tissue: • • • • Mucosa Submucosa Muscularis Serosa • forming folds called mesenteries Slide 4 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 5 MOUTH • Roof— • hard palate (parts of maxillary and palatine bones) • soft palate, an arch-shaped muscle separating mouth from pharynx; uvula, a downward projection of soft palate • Floor—formed by • tongue • muscles; • papillae, • taste buds, • lingual frenulum, • Typical tooth • Three main parts—crown, neck, and root • Enamel - hardest tissue in body Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 6 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 7 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 8 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 9 Slide 10 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. MOUTH • Types of teeth—incisors, cuspids, bicuspids, and tricuspids • Twenty teeth in temporary set; - cutting first tooth 6 months; - set complete 2 years • Thirty-two teeth in permanent set; 6 years = first permanent tooth; • set complete usually between ages of 17 and 24 years Slide 11 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 12 SALIVARY GLANDS • Parotid glands—largest salivary glands • Submandibular glands— open into mouth on either side of frenulum • Sublingual glands—open into floor of mouth Slide 13 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 14 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. PHARYNX • Subdivided into three anatomical components: • Nasopharynx • Oropharynx • Laryngopharynx Slide 15 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ESOPHAGUS • Connects pharynx to stomach • Dynamic passageway for food Slide 16 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. STOMACH • Size—expands after large meal; about size of large sausage when empty • Food enters stomach through gastroesophageal (cardiac) sphincter • Pyloric sphincter muscle closes opening between pylorus (lower part of stomach) and duodenum Slide 17 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Stomach • Wall - smooth muscle fibers; contractions produce churning movements (peristalsis) • Lining—mucous membrane; microscopic glands that secrete gastric juice and hydrochloric acid into stomach; mucous membrane lies in folds (rugae) when stomach is empty Slide 18 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 19 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. SMALL INTESTINE • Size—about 7 meters (20 feet) long but only 2 cm or so in diameter • Divisions • Duodenum • Jejunum • Ileum Slide 20 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 21 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. SMALL INTESTINE • Wall— smooth muscle fibers • Lining— • mucous membrane; • microscopic glands • villi • (microscopic finger-shaped projections from surface of mucosa into intestinal cavity) • contain blood and lymph capillaries Slide 22 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. LIVER AND GALLBLADDER • Size and location—liver is largest gland; fills upper right section of abdominal cavity and extends over into left side • Secretes bile • Ducts • Hepatic • Cystic • Common bile • Gallbladder • Location—undersurface of the liver • Function—concentrates and stores bile produced in the liver Slide 23 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 24 PANCREAS • Exocrine gland that lies behind stomach • Functions • Pancreatic cells secrete pancreatic juice (most important digestive juice) into pancreatic ducts; main duct empties into duodenum • Pancreatic islets (of Langerhans)— cells not connected with pancreatic ducts; secrete hormones glucagon and insulin into the blood Slide 25 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. LARGE INTESTINE • Divisions • Cecum • Colon—ascending, transverse, descending, and sigmoid • Rectum • Food enters through ileocecal valve; external opening called anus • Wall—contains smooth muscle fibers that contract to produce churning, peristalsis, and defecation • Lining—mucous membrane Slide 26 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 27 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. APPENDIX • Blind tube off cecum • No important digestive functions in humans Slide 28 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. PERITONEUM • Definitions—peritoneum, serous membrane lining abdominal cavity and covering abdominal organs; • parietal layer of peritoneum lines abdominal cavity; • visceral layer of peritoneum covers abdominal organs; • peritoneal space lies between parietal and visceral layers Slide 29 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Peritoneum • Extensions—largest are the mesentery and greater omentum • Mesentery is extension of parietal peritoneum, which attaches most of small intestine to posterior abdominal wall • Greater omentum, or “lace apron,” hangs down from lower edge of stomach and transverse colon over intestines • X-ray studies of the GI tract— radiopaque contrast medium used to help visualize structures in study images Slide 30 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 31 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. DIGESTION • Definition—transforms foods into substances that can be absorbed and used by cells • Mechanical digestion— • chewing (mastication), • swallowing (deglutition), • peristalsis • break food into tiny particles, mix them well with digestive juices, and move them along the digestive tract Slide 32 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Digestion • Chemical digestion—breaks up large food molecules into compounds that have smaller molecules; brought about by digestive enzymes • Enzymes and chemical digestion • Enzymes are specialized protein molecules that act as catalysts • Breakdown process called hydrolysis Slide 33 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 34 DIGESTION • Carbohydrate digestion—mainly in small intestine • Pancreatic amylase—breaks polysaccharides down to disaccharides • Intestinal juice enzymes • Maltase—changes maltose to glucose • Sucrase—changes sucrose to glucose • Lactase—changes lactose to glucose Slide 35 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. DIGESTION • Protein digestion—starts in stomach; completed in small intestine • Gastric juice enzyme pepsin partially digests proteins • Pancreatic enzyme, trypsin, continues digestion of proteins • Intestinal enzymes, peptidases, complete digestion of partially digested proteins and convert them to amino acids • Fat digestion • Bile contains no enzymes but emulsifies fats (breaks fat droplets into very small droplets) • Pancreatic lipase changes emulsified fats to fatty acids and glycerol in small intestine Slide 36 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ABSORPTION • Definition—process by which digested food moves from intestine into blood or lymph • Foods and most water minerals and vitamins are absorbed from small intestine; some water and vitamin K also absorbed from large intestine • Surface area absorption • Structural adaptations increase absorptive surface area • Fractal geometry—study of fragmented geometric irregular shapes such as those Slide 37 in lining of intestine Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Next week: Urinary System, Chapter 26 Lab: Influence of Fluid Intake on Urine Formation - Power Phys Review time! Slide 38 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Which structure prevents food or water from entering the trachea? A. B. C. D. E. Arytenoid cartilage Epiglottis Nasopharynx Thyroid cartilage Paranasal sinus Slide 39 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Which of the following is the primary gas exchange site? A. B. C. D. E. Trachea Bronchiole Nasal sinuses Alveolus Bronchus Slide 40 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. The point where the trachea divides into right and left primary bronchi is a ridge called A. B. C. D. E. Carina Secondary bronchioles Parietal pleura Visceral pleura Diaphragm Slide 41 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Which of the following are cells of the alveoli that produce surfactant? A. B. C. D. E. Type I alveolar cells Type II alveolar cells Type III alveolar cells Surface cells Macrophages Slide 42 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. With which body system does the respiratory system work to regulate the pH of body fluids? A. B. C. D. E. muscular digestive nervous endocrine urinary Slide 43 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Which of the following is the dominant method of carbon dioxide transport? A. B. C. D. Bound to hemoglobin Bound to oxygen Dissolved in plasma as a gas Dissolved in plasma as bicarbonate ions E. Diffusion Slide 44 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. Exhalation begins when A. B. C. D. Inspiratory muscles relax Diaphragm contracts Blood circulation is the lowest Both Inspiratory muscles relax and Diaphragm contracts E. All of these choices Slide 45 Elsevier items and derived items © 2008, 2004 by Mosby, Inc., an affiliate of Elsevier Inc.