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Title: The motion of change Jill Mathews Headquartered in Bellingham, SPIE is a not for profit international society advancing the science and application of light. (For SPIE, “light” includes all forms of electromagnetic radiation, from radio waves to X and gamma rays.) Members of SPIE work in a wide variety of science and engineering fields where imaging and light are important. Some design and use the equipment to look for planets in remote galaxies; others are making advances at understanding the new world of nanotechnology. A very large number of SPIE members work on medical imaging and research. Much of this work is on improving the detection of cancer, its prevention and its treatment. Breast cancer is the most common type of cancer in women worldwide. About ten percent of women are confronted with breast cancer during their lives, and as many of us know, breast cancer can be most efficiently treated if detected at an early stage. SPIE scientists and engineers are improving imaging technology to locate and identify the tiniest tumors in any kind of breast tissue. Others are finding and improving new ways to use light, to treat the tumors without radical surgery or to find the optimal mix of treatments for individual patients. Much of the equipment used in genetics to unravel an individual’s genetic map is based on light. Perhaps as our understanding of cancer and genetics develops, we will improve prevention. Until then, our improved understanding of how one’s DNA affects susceptibility to cancer or recurrence allows optimization of the treatment. SPIE is proud of what its members continue to do to overcome cancer. “Our goal is to develop a bedside optical technology that physicians can use to optimize tumor response and minimize toxic side effects of chemotherapies. This work is an important step toward developing technologies for individualized breast cancer care.” Bruce Tromberg, Director Beckman Laser Institute and Medical Clinic, Department of Biomedical Engineering, University of California, Irvine, and 2006 SPIE Board Member Some of the images used to create this piece have been used with permission from contributing authors of the book “Recent Advances in Breast Imaging, Mammography, and Computer-Aided Diagnosis of Breast Cancer,” published in 2006, by SPIE. Ruey-Feng Chang, National Chung Cheng Univ., Chiayi, Taiwan Joseph Y. Lo, Duke Univ. Medical Center, Durham, NC USA Rangaraj M. Rangayyan, Department of Electrical and Computer Engineering and Department of Radiology, Univ. of Calgary, Calgary, AB Canada Yajie Sun, Kodak Health Group, Rochester, NY USA Tibor Tot, Central Hospital, Falun, Uppsala Univ. Sweden