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Smoking Cessation Treatment Options that is superior to nicotine replacement in helping smokers stop smoking and in reducing relapse. Zyban® also appears to prevent weight gain and depression associated with smoking cessation. The length of treatment will vary depending on a person’s mood, withdrawal symptoms and the intensity of the craving. The U.S. Food and Drug Administration has approved five medications to help people quit smoking: bupropion SR (brand name Zyban®)—available by prescription nicotine gum—available over-thecounter nicotine inhaler—available by prescription nicotine nasal spray—available by prescription nicotine patch—available by prescription and over-the-counter Using Zyban® in combination with nicotine-replacement therapy is more effective than using nicotine-replacement alone. This dual-medicine approach— utilizing nicotine replacement to block withdrawal symptoms in combination with Zyban® to reduce craving and stabilize mood—is an effective treatment strategy. Zyban® (bupropion) Zyban® is the first non-nicotine treatment All drugs of abuse, including nicotine, cause a dopamine surge and subsequent depletion in the brain’s reward pathway. Zyban® is thought to lessen nicotine craving by blocking dopamine from being recycled too quickly (inhibiting re-uptake), thereby increasing the availability of dopamine along the brain’s reward path. Nicotine-replacement therapy There are several types of over-the-counter nicotine-replacement products, including patches, gum, nasal spray and inhaler. They are all about equally effective; about 28 percent of smokers who use them successfully quit. The key is to find the right approach for you. Some smokers like to play with the inhaler like they would a cigarette. For others, feeling the spray in the back of their throat is rewarding. You may want to consult a health care professional such as your primary care physician who can help you develop a treatment plan. ©1999-2005 University of Florida McKnight Brain Institute Call or visit Achieve Solutions today. www.achievesolutions.net (XXX) XXX-XXX