Download Marimastat The Application of Anti

To Starve Cancer to Death!
——The Anti-angiogenesis Effects in the Treatment and
Prevention of Breast Cancer
Xiang Boni 10301010102
Common Methods to Deal with Cancers
 Treatment:
chemotherapy, radiotherapy, surgical excision, etc.
Starvation Therapy
 Prevention:
sports, happy mood, nutritional diet, etc.
“Starvation Therapy” in Yu Juan`s Story
How cancer becomes dangerous
Turning Point: Angiogenesis(the formation of new blood vessels)
Years…
Harmless
MicroscopicDeadly
Tumor(0.5𝑚𝑚3 )
Anti-angiogeneic Therapy
• Why Possible?
Tumor blood vessels are:
 abnormal
 poorly constructed
 vulnerable
The Application of Anti-angiogenesis in Breast Cancer
——Clinical Treatment
VEGF(血管内皮生长因子)
 Bevacizumab  VEGF-A ligand
 Receptor tyrosine kinase inhibitors.
SU011248VEGF Receptor
MMP(基质金属蛋白酶)
 Marimastat
The Application of Anti-angiogenesis in Breast Cancer
——Dietary Prevention
Catechins
(儿茶酚)
Lycopene
(番茄红素)
Eat to Starve Cancer!
Genistein
(染料木黄酮)
Flavonoid
(黄酮类)
Resveratrol
(白藜芦醇)
References:
1.William Li, Can we eat to starve cancer? http: //www. ted. com /talks
/william_li.html
2.Reuben S C, Gopalan A, Petit D M, et al. Modulation of angiogenesis by
dietary phytoconstituents in the prevention and intervention of breast
cancer[J]. Mol Nutr Food Res, 2012,56(1):14-29.
3.Li W W, Li V W, Hutnik M, et al. Tumor angiogenesis as a target for dietary
cancer prevention[J]. J Oncol, 2012,2012:879623.
4.Mackey J R, Kerbel R S, Gelmon K A, et al. Controlling angiogenesis in
breast cancer: a systematic review of anti-angiogenic trials[J]. Cancer Treat
Rev, 2012,38(6):673-688.
5.Vona-Davis L, Rose D P. Angiogenesis, adipokines and breast cancer[J].
Cytokine Growth Factor Rev, 2009,20(3):193-201.
6. J. Cebulla, E. Kim, J. Zhang,et al. Multi-scale Imaging of Angiogenesis in a
Breast Cancer Model[J] . Proc. Intl. Soc. Mag. Reson. Med. 19 (2011):758
7. Bryan P. Schneider , Kathy D. Miller. Angiogenesis of Breast Cancer[J]. J
Clin Oncol ,2005,23:1782-1790.