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Phobias Phobias can be innate or learned. Innate phobias include those to thunderstorms, loud noises (vacuum cleaners, gunshots, firecrackers), sudden movements, and men with beards and/or hats. Learned phobias can be to certain people, but may or may not be related to prior abuse. Fear of veterinarians or veterinary hospitals may be innate or learned. Puppy parties at the hospital are a good way to prevent this problem. Some dogs have a phobia to the smell of cooked lamb. Thunderphobia The components of thunderphobia are: Sound of thunder Sight of lightening Drop in barometric pressure Rain Wind Treatment is difficult and involves desensitization and medication. Medication: Serotonin-increasing medication (fluoxetine, amitriptyline sertraline). Give throughout the storm season. Trazodone for PRN use. Try to administer 2 hours before the storm. Alprazolam (like diazepam but longer acting). Give before a storm. Melatonin? Desensitization to thunder: Good quality CD (Through a Dog’s Ear) Position the speaker over the dog’s head. Play at a volume that does NOT cause dog to react. Play the CD until the dog goes into his crate (or other safe place). Turn it off as soon as the dog is in the safe place and reward him with tiny tasty treats for lying quietly. Increase the volume very slowly and repeat many, many times. A lazy solution to thunderphobia is to play the thunder CD whenever the dog eats a meal. To increase the realism during desensitization, use strobe lights to mimic lightening and a hose directed on a window or cookie sheet in the shower to mimic rain. Gadgets Storm Defender Cape Anxiety Wrap Thundershirt – works best Adaptil pheromone collar or diffuser Gunshot Phobia This can be treated with a box inside layers of other boxes. Treatment of Phobias in General Desensitize by rewarding the dog for calm behavior when the stimulus is well below threshold for eliciting the phobic behavior. Increase the strength of stimuli very, very slowly. Repeat 10 times a day at each strength. Should the owner soothe the dog? Only if soothing relaxes the dog. Try not to reward anxious behavior. Play may be more effective in calming the dog than a soothing touch or voice. Flooding, by definition, is the process of repeating stimuli until the dog ceases to respond but is rarely used because the dog may outlast the owner. Obsessive-compulsive Behavior Flank Sucking Flank sucking in Dobermans is the first canine behavior to be related to a specific gene, the Cadherin gene. Magnetic resonance imaging revealed higher total brain and gray matter volumes and lower dorsal anterior cingulate cortex and right anterior insula gray matter densities in the affected dogs. The affected Dobermans also had higher fractional anisotropy in the splenium of the corpus callosum, the degree of which correlated with the severity of the behavioral phenotype. Light Chasing Do not use laser pointers to play with dogs. Lick Granuloma A good example of an OCD that has a medical etiology. Other Examples Tail-chasing bull terriers Digging Rottweilers Circling working dogs (Shepherds and Malinois) Less Clear-cut Examples Behaviors with medical complications Lick granulomas Tail mutilation by cats Behaviors that reflect selected behaviors Ball carrying by many breeds of dog Comfort behaviors Tail, paw, or fabric suckling Associated Genes Several genes are associated with circling, flank sucking, and other OCDs. Four genes have an excess of case-only variation in evolutionarily constrained elements, even after correcting for gene size: ataxin-1 (ATXN1), neuronal cadherin (CDH2), catenin alpha2 (CTNNA2), and plasma glutamate carboxypeptidase (PGCP). CDH2, a neural cadherin, encodes a calcium dependent cell-cell adhesion glycoprotein important for synapse assembly, where it mediates presynaptic to postsynaptic adhesions. CTNNA2 encodes a neuronal-specific catenin protein that links cadherins to the cytoskeleton. ATXN1 encodes a chromatin-binding protein that regulates the Notch pathway, a developmental pathway also active in the adult brain, where it mediates neuronal migration, morphology and synaptic plasticity. All three of these genes are involved in synaptic formation. The fourth gene, PGCP, encodes a poorly characterized plasma glutamate carboxypeptidase. It may be involved in the hydrolysis of N-acetylaspartylglutamate. One might consider glutamate targeting drugs for treatment of OCDs. Differentials Seizure Painful process Especially tail chasing and mutilation Attention seeking Genuine object to dig for or snap at Treatments Tricyclic anti-depressants Selective serotonin reuptake inhibitors Methylphenidate (Ritaline) 5-40 mg/dog BID Circling working dogs Phenobarbital Whirling bull terriers If it is attention-seeking behavior, ignore it!