Download Clostridium botulinum

A. Childress F2013
Modified by DYH
Clostridium botulinum
• Gram positive, rod shaped
bacterium
• Produces neurotoxins that
cause muscular paralysis
• Component in Botox
• Obligate anaerobe
• Forms endospores
• Often found in soil
• Genome size: 3.89 Mb
• Lethal in small amounts
• 8 types of botulism
– Only A, B, and E are forms of
human botulism
http://microbewiki.kenyon.edu/index.php/File:B2201272-Clostridium_botulinum_bacteriaSPL.jpg
http://microbewiki.kenyon.edu/index.php/Clostridium_botulinum_neu2011
A. Childress F2013
Modified by DYH
Pathogenesis of Clostridium botulinum
•
Modes of entry:
– Infant botulism: bacteria colonize early
and release toxin into intestines where
it is absorbed via bloodstream
– Foodborne botulism: ingestion of
exotoxins from a contaminated food
source that contains infectious C.
botulinum spores
– Wound botulism: bacteria contaminates
a wound and secretes the neurotoxin
into the bloodstream
•
Invasion of the neuromuscular
junction by potent neurotoxin
– Neurotoxin (BTX) inhibits the release of
Acetylcholine from the presynaptic
terminals
– Effects the somatic nervous system and
causes paralysis
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