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INNOVATION
IN THE DEVELOPMENT OF NEW DRUGS
AND CREATIVE SOLUTIONS TO ENSURING
EARLY AND ENHANCED ACCESS
Paul Stoffels, M.D.
Chief Scientific Officer, Johnson & Johnson
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HIV LIFE EXPECTANCY
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HIV TODAY
• The Opportunity:
– More than 20 Antiretroviral Drugs and Combinations
– Diagnostics : CD4, Viral Load, Resistance Testing
• The Challenges:
–
–
–
–
–
Life Long Therapy (30-50 years)
Highly mutable virus leading to resistance
Supply Chain
Logistics
Funding
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WHAT IS NEEDED: INNOVATION
• Innovation in Therapy
• Innovation in Prevention
• Innovation in Implementation
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HIV protease gene diversity matrix
Viral isolates
1
10
20
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| @AIDS_conference
30
40
50
60
70
80
Amino-acid position
90
INNOVATION IN THERAPY
• New Drug Targets – Existing Drug Targets
• Combinations
– Single pill
– New Regimens
• Strategically Designed Regimens
– Efficacy
– Prevent resistance
– Implementation and cost
• Long Acting Formulations
• Treatment Strategies
– Treat to prevent
– Combating resistance
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INNOVATION IN PREVENTION
• Barrier Prevention
• Chemical Prevention
– PrEP
– Vaginal Ring
– Long-Acting Injectables
• Biological Prevention
– Antibodies
• HIV Vaccine—The Holy Grail
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90-90-90 – FOR 50 YEARS
• Strategically deploy the drugs we have for
maximal life expectancy and optimal access
• Green Pill First—Red Pill Next
• Universal Viral Load Testing
• Avoid MDR HIV
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INNOVATION IN ACCESS
• Stratification and Simplification of Drug
Regimens
– Supply
– Logistics
– Deployment
– Cost
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ACCELERATING INNOVATION
FOR IMPACT
Transfer Best Practices
– Drug development focused on 90-90-90
– Accelerate drug / vaccine developments:
• Oncology : 24 months
• Vaccines : Ebola vaccine – 18 months
Every day counts
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#AIDS2016 | @AIDS_conference
30 Million people X 50 years
= 1.5 billion years of life.
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#AIDS2016 | @AIDS_conference