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INNOVATION IN THE DEVELOPMENT OF NEW DRUGS AND CREATIVE SOLUTIONS TO ENSURING EARLY AND ENHANCED ACCESS Paul Stoffels, M.D. Chief Scientific Officer, Johnson & Johnson #AIDS2016 | @AIDS_conference HIV LIFE EXPECTANCY #AIDS2016 | @AIDS_conference HIV TODAY • The Opportunity: – More than 20 Antiretroviral Drugs and Combinations – Diagnostics : CD4, Viral Load, Resistance Testing • The Challenges: – – – – – Life Long Therapy (30-50 years) Highly mutable virus leading to resistance Supply Chain Logistics Funding #AIDS2016 | @AIDS_conference WHAT IS NEEDED: INNOVATION • Innovation in Therapy • Innovation in Prevention • Innovation in Implementation #AIDS2016 | @AIDS_conference HIV protease gene diversity matrix Viral isolates 1 10 20 #AIDS2016 | @AIDS_conference 30 40 50 60 70 80 Amino-acid position 90 INNOVATION IN THERAPY • New Drug Targets – Existing Drug Targets • Combinations – Single pill – New Regimens • Strategically Designed Regimens – Efficacy – Prevent resistance – Implementation and cost • Long Acting Formulations • Treatment Strategies – Treat to prevent – Combating resistance #AIDS2016 | @AIDS_conference INNOVATION IN PREVENTION • Barrier Prevention • Chemical Prevention – PrEP – Vaginal Ring – Long-Acting Injectables • Biological Prevention – Antibodies • HIV Vaccine—The Holy Grail #AIDS2016 | @AIDS_conference 90-90-90 – FOR 50 YEARS • Strategically deploy the drugs we have for maximal life expectancy and optimal access • Green Pill First—Red Pill Next • Universal Viral Load Testing • Avoid MDR HIV #AIDS2016 | @AIDS_conference INNOVATION IN ACCESS • Stratification and Simplification of Drug Regimens – Supply – Logistics – Deployment – Cost #AIDS2016 | @AIDS_conference ACCELERATING INNOVATION FOR IMPACT Transfer Best Practices – Drug development focused on 90-90-90 – Accelerate drug / vaccine developments: • Oncology : 24 months • Vaccines : Ebola vaccine – 18 months Every day counts #AIDS2016 | @AIDS_conference #AIDS2016 | @AIDS_conference 30 Million people X 50 years = 1.5 billion years of life. #AIDS2016 | @AIDS_conference #AIDS2016 | @AIDS_conference