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Transcript
MAP KINASE (MAPK) SIGNALING PATHWAY Inside cells, the MAPK pathway is a chain of many proteins, including BRAF (made by the BRAF gene), MEK and ERK. Changes to the BRAF gene can result in abnormal signaling in the MAPK pathway and stimulate the growth of melanoma cells. Medicines that target the MAPK pathway aim to slow cancer cell growth. Normal Cell Growth BRAF V600 Mutation and Cancer Cell Growth Growth factors Growth factors RAS RAS BRAF V600 MUTATION BRAF MEK Abnormal signaling MEK ERK ERK Stimulation of cancer cell growth The above, simplified illustration does not depict the complete group of proteins/genes relevant to the MAPK pathway. Novartis Pharma AG CH-4002 Basel Switzerland © Novartis 2015 May 2015 G-MTA-1116036 Novartis Pharmaceuticals Corporation East Hanover, New Jersey 07936-1080
