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Diagnostic Evidence Co-operative Leeds An introduction to personalised medicine & health in Leeds Michael Messenger, Deputy Director NIHR DEC Leeds A partnership between the NHS, patients, academia, industry and charities A Vision for Leeds Data storage Data linkage Better Actions, Outcomes & Affordability Healthcare data acquisition Metadata (Quality & Accuracy) Improving Patient-Clinician decision making (> accuracy, tailoring, timing, participation) Effective Communication Analysis and interpretation The Personalised Health & Care Journey Prediction & Prevention Early Diagnosis Disease Screening Prognosis Molecular Phenotyping Treatment benefit / response Monitoring Recovery Death Hospital admission Hospital discharge Disease Free Symptomatic Disease Asymptomatic Disease Acute disease diagnosed Disease response Treatment initiation Shift towards individualised prevention Chronic disease relapse Late sideeffects Translational Gap 1 Translational Gap 2 Centre for Personalised Medicine and Health Establish the evidence base to accelerate PM technologies into routine clinical practice “The Push” New Technology • Drugs • Devices • Diagnostics Early Modelling (Commercial and NHS opportunity) • • • • “The Pull” Clinical Need NHS Academia Industry Stakeholders Precision Medicine Research Infrastructure Patient Cohorts, Biobanks, “Big Data”, Analytical Platforms (e.g. Omics), High Performance Computing Patient Benefit Preclinical & Measurement Validity Safety & Clinical Validity Clinical Efficacy & Utility CostEffectiveness & Market Approval Dissemination& Adoption Economic Value Methodological expertise Health Economics, Health Informatics, Medical Statistics, Metrology, Systems Biology, Quality Management, Artificial Intelligence