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COLITIS & CROHN’S DISEASE Overview: “Colitis” is a generic term that refers to several conditions that involve inflammation of the colon. A proposed insur ed may indicate he/she has colitis when referring to one of the following conditions: Chronic Ulcerative Colitis (CUC), Crohn’s Disease, ischemic colitis, infectious gastroenteritis, Irritable Bowel Syndrome (IBS), or colon spasms. With the exception of CUC and Crohn’s Disease, most of these conditions are of little concern to the life underwriter. Chronic Ulcerative Colitis (CUC) is characterized by recurrent inflammation of the internal surface of the large intestine (colon) and/or rectum. It manifests itself with abdominal pain, bloody diarrhea, fever, anemia, and an overall feeling of weakness. Generally speaking, the smaller and lower the areas of the colon affected, the more mild and easier it is to treat the condition. In severe cases the entire colon becomes inflamed. Various medications are on the market to treat CUC; for the most extreme cases surgery, possibly including removal of the entire colon, may be necessary. CUC several risks to mortality. The inflamed lining of the colon breaks down, causing many ulcers which can hemorrhage (bleed) massively. The colon can emit poisons into the system and lead to critical illness. The colon may also rupture and spill its content into the abdominal cavity (a major catastrophic event). Of more frequent concern is colon cancer, which, over time, is seen in as many as 42% of individuals with a significant and recurrent history of ulcerative colits. The larger the portion of the colon affected, the more frequent the episodes of inflammation, the greater the risk to deve loping colon cancer. Frequent colonoscopies are required in order to rule out any cancer, or to treat it early, if it develops. Crohn’s Disease refers to inflammation of any part of the gastrointestinal tract, from mouth to anus; untreated Crohn‘s Disease attacks increase in frequency with time. The most commonly infected areas include the small and large intestine and parts of the rectum. Crohn’s Disease manifests itself with abdominal pain, chronic bloody diarrhea, weight loss, anorexia and possibly fever. Abnormal blood studies are common due to vitamin deficiency and blood loss. Treatment is similar to that utilized to treat CUC, although surgery is more common. Unlike for CUC, a colectomy (removal of the entire colon) is generally not curative for Crohn’s disease as other tissues are often involved. The mortality risk for Crohn’s Disease is different from that observed for CUC. In Crohn’s Disease, there is an accumulation of inflammatory products in the wall of the intestine, rather than on the internal surface, as is observed with CUC. This accumulation can lead to a complete blockage of the intestine which may require emergency surgery. Another risk is that the inflammatory material in the wall can become infected and lead to bacterial abscess and contamination of the blood, a potentia lly critical condition. Crohn’s Disease can also lead to the development of channels (fistulae) that extend to other organs, suc h as the kidneys, leading to organ damage there. Finally, repeat surgeries to treat Crohn’s disease may lead to malabsorption of certain nutrients (since the intestine may become shortened over time) leading to malnouris hment. Fortunately, the risk of colon cancer in Crohn’s is much smaller than for CUC. Impact on Life Underwriting: Underwriting offers for individuals Chronic Ulcerative Colitis and Crohn’s Disease depend on the time elapsed since first diagnosis, the age of the patient, the location, frequency, duration, and severity of each episode of inflammation, as well as the patient’s response to treatment and the likelihood of significant surgical intervention in the future. Individuals with occasional irritable bowl syndrome (i.e. not “true colitis”) often can obtain standard rates. Low to mode rate table ratings should be expected for many mild and moderate cases of CUC or Crohn’s Disease. Severe cases with significant and frequent episodes of inflammation may lead to a postponement until further treatment. Individuals with any colitis conditio n, but especially those who experience the inflammations frequently, severely, and over significant areas of the gastrointestinal tract for ten or more years are at an increased risk for the development of colon cancer. Frequent medical checkups with cancer screens, will help the underwriter make a more favorable assessment of the condition. Most declines for colitis are seen for individuals with a history of frequent episodes of inflammation over the course of ten to fifteen or more years lacking appropriate recent medical follow up (via colonoscopy). Underwriting any form of intestinal disorder can be positively affected by good nutritional habits, use of vitamin supplements, regular exercise, and good weight control. Normal lab studies documented in APS data, as well as those requested for the insurance exam, will further aid in evaluating the risk favorably. A cover letter should address positive lifestyle habits. We suggest you complete our Search for Underwriting Credits Questionnaire to help us negotiate the lowest possible rates for your client. Thank you. COLITIS & CROHN’S DISEASE QUESTIONNAIRE Agent: Phone: Fax: Proposed Insured Name: ___________________________________ r M rF Date of Birth: ______________________ Face Amount: _____________________ Max. Premium: $__________/year r UL r WL r Term r Survivorship Do you currently smoke cigarettes? r Y r N If no, did you ever smoke: r Never r Quit (Date): ________________________ Do you currently use any other tobacco products (e.g. cigars, pipe, snuff, nicotine patch, Nicorette gum...): r Y r N If Yes, please provide details: ____________________________________________________________________________________ When did you last use any form of tobacco: _____ (Month) _____ (Year) Type used last: ____________________________________ (1) Date of first diagnosis: ______________ Date of most recent episode: ______________ Total Number. of episodes: ______ Number of episodes past six months: ________ Longest duration: _________________________ (days, weeks, months) Number of episodes past five years: _________ Longest duration: _________________________ (days, weeks, months) (2) What condition(s) have been diagnosed? r Irritable Bowl Syndrome r Mucous Colitis r Chronic Proctitis (rectum) r Frequent colon spasms r Spastic Colitis r Chronic Ulcerative Colitis r Frequent diarrhea r Catarrhal Colitis r Crohn’s Disease r Ulcerative Proctitis r Ulcerative Proctosigmoiditis r Other: ________________ (3) Is the proposed insured taking any medications? If yes: Name of Medication (Prescription or Otherwise) Dates used Quantity Taken Frequency Taken (4) Has the proposed insured ever been hospitalized for the condition? If yes, please provide date(s): ________________________ (5) Has surgery been recommended? If yes, when will the surgery be completed? ________________________________________ (6) Has surgery been done? If yes, please list dates and type of surgery(ies): ____________________________________________ (7) Has the proposed insured ever been disabled because of the condition: If yes, dates: __________________________________ (8) Does the proposed insured have any other medical conditions that may affect underwriting? If yes, please provide details: _______________________________________________________________________________________________________ _______________________________________________________________________________________________________ _______________________________________________________________________________________________________