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Tutorial aminoglycosides 1. 2. 3. 4. 5. 6. What are the building blocks (composition) of ribosome? Why drug interaction with rRNA is less specific than with proteins Mention 3 types of tetracyclines obtained from bacterial cell culture Mention 3 types of tetracyclines semisynthesized Why tetracycline molecule is regarded amphoteric? How tetracycline undergo inactivation in aqueous medium (give representative drawing) 7. Why tetracycline is unstable in acidic medium? And how it can be overcomed in molecular design? 8. How the di-methyl amino group at ring A affects the interaction of tetracycline with the ribosome? 9. How many keto-enol systems are available in tetracycline? 10. There are two keto-enol systems in tetracyclines, please point to them in the structure. 11. Why is it prohibited to substitute other than hydrogen at C4a ? 12. Which of the following groups at C4 gives inactive compound (H, OH, CH3)? 13. Why doxycycline is more acid stable than tetracycline? 14. Why doxycycline is taken twice daily while tetracycline is taken 4 times daily? 15. Why the administration of chlortetracycline is causing photoxicity upon explore to sun light? 16. Mention 3 possible sites of metabolism in tetracycline 17. Which mechanism of resistance the bacteria can use to resist tetracycline without undergoing mutations, or inactivation of antibiotic? 18. How bacteria can inactivate tetracycline by TetX 19. Does methacycline is acid stable? 20. Correct the error in the following name of tetracycline (4-dimethylamino1,4,4a,5,5a,6,11,12aoctahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2anthracenecarboxamide 21. Mention name of 2 tetracyclines that are associated with phototoxic effect. 22. Give name for one tetracycline available as prodrug. 23. What is the functional group difference between tetracycline and doxycycline? 24. What is the functional group difference between tetracycline and minocycline? 25. Highlight the functional groups of tetracycline which should not be changed in the newly designed analogues.