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SHANDONG UNIVERSITY Post-doc Positions at Shandong University Shandong University (SDU) is one of the oldest universities in China, and is a key university receiving state promotions of both 211 and 985 programs. SDU School of Medicine has developed close research and education collaborations with the Karolinska Institute during last two decades, and has emerged as the institution that produces the highest number of joint publications with KI in China in recent years. SDU is committed to strengthen the collaborations with KI on all levels. In order to promote collaboration between SDU and KI, SDU will recruit 2 postdoctoral fellows who have obtained their doctoral degrees from KI. The postdoctoral fellows will be supported for two years with an annual salary between 200,000 and 300,000 RMB (approximately 209980 SEK and 314970 SEK). We are inviting motivated candidates to conduct research at SDU. The two positions are available and open for applicants immediately. Research Fields of Prospective Postdocs Highly motivated candidates with strong background knowledge of the following four research areas are encouraged to apply. ○ Cancer Study Digestive tract cancer, especially esophageal and gastric cancer, is highly prevalent in the Shandong area, and it is thus an urgent task to gain profound insights into the disease pathogenesis and to provide rationales to develop efficient prevention/treatment strategies. Since 2005, SDU and KI researchers have been working together to study cellular and molecular mechanisms underlying gastric cancer development and progression. Our future projects will be focused on following issues: (i) The role of cancer stem cells in the formation and recurrence of gastric cancer; and (ii) The genetic and epigenetic abnormalities that drive the development and/or progression of esophageal and gastric cancer. ○ Stem Cell Research Familial hemophagocytic lymphohistiocytosis (FHL) is an inherited immune defect with a high mortality, whilst its only known cure, allogeneic hematopoietic stem cell transplantation, fails in 1/3 of the transplanted patients, due to severe graft versus host disease. In the light of recent progresses in inducible pluripotent stem cells (iPSC) and mesenchymal stem cells (MSC) therapies, the researchers from the Stem Cell Research Lab at the Second University Hospital of Shandong University and the Karolinska Institute are teaming up to explore if iPSC and MSC approaches can be developed into safe and useful therapies. They will establish autologous iPSC or MSC cell lines from FHL patients who carry homozygous gene mutations in SHANDONG UNIVERSITY disease-causing genes, correct the gene mutations using homologous recombination and zinc-finger nucleases technology, induce the gene corrected iPSC or MSC differentiation into HSC. They will evaluate of the biological function and therapeutic safety of these HSCs. The research collaboration may develop a novel strategy to treat and cure inherited immune defects. ○ Cardiovascular Research Researchers at the National Key Laboratory of Cardiovascular Remodeling and Function Research at Qilu Hospital of Shandong University conduct a wide range of preclinical and clinical research in cardiovascular diseases (CVD). With the research theme in cardiovascular remodelling, their research work is to dissect the cellular and molecular mechanisms underlying cardiovascular risk factors, such as hyperlipidemia, hypertension, and diabetes mellitus, drived atherosclerotic lesion development. They investigate the mechanisms underlying atherogenesis and plaque stability, including inflammation, endothelial dysfunction, as well as proliferation, apoptosis, and oxidative stress of the vessel wall cells. Much effort has also been made to elucidate atheroprotective mechanisms, such as angiogenesis and regulatory T cell response, and to discover novel strategies for CVD management. The institution has been actively engaged in research collaborations with KI scientists in the research of angiogenesis and CD4 T cell immune responses in atherosclerosis. ○ Health Management and Policy Center for Health Management and Policy (CHMP) and School of Public Health of Shandong University have long-term collaborations in public healthcare research and education with KI’s public health sector. Currently, we are committed to research focusing on global health problems. In collaboration with KI researchers, we Jointly design and apply for international funds for collaborative research on global health problems. We conduct research projects focused on key public healthcare issues, such as the control of chronic diseases and the containment of antimicrobial resistance, including how to achieve rational use of antibiotics. We have also ongoing projects related to the reform of public healthcare system in China. We can offer the opportunities for comparative studies of Chinese and Swedish healthcare system. Requirements 1. A doctoral degree obtained from KI in 2012 or later. 2. SDU strives to enhance the international research environment, where the recruitment of international post-docs is an important part. Hence, the awardees should have their university education as well as their doctoral training from outside China, to ensure a true international exchange of research which is also a requirement by the funding source. 3. The awardee is required to work not less than 20 months at SDU during the two-year contract. SHANDONG UNIVERSITY To Apply Please submit your cover letter, CV including bibliography, copies of your diplomas and certificates via email to: [email protected]. Contacts for further information Nailin Li, doc KI Scientific Coordinator for China Karolinska Institutet Department of Medicine-Solna Clinical Pharmacology Unit, L7:03 Karolinska University Hospital-Solna 171 76 Stockholm, Sweden HU Shuang (Ms.) Program Officer Dept. International Affairs Shandong University Mingde Building, C306 Shanda Nanlu 27 Jinan 250100, China Tel: +46-8-517 739 96 Fax: +46-8-331 343 Email: [email protected] Tel: +86-531-88364854 Fax: +86-531-88565051 Email: [email protected]