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ARTLIFE company introduces a new biologically active complex– “PROBINORM” The Innovative Bio-Technology Micro Flora The micro flora of the person possesses huge biological potential, sufficient for that, to ensure the full protection of the organism and its metabolic support. The structure of microorganisms of a biofilm is constant at healthy people and changes at pathological conditions. In norm microbiocenosis intestines of the person consists on 85-98% from bifid bacteria and lacto bacteria. Infringement of microbiological balance in intestines of the person serves a starting instant not only for progresses diseases of a digestive tract, but also provides the foundation for a various pathology of system character. Function of Micro Flora The normal micro flora carries out a number of the important functions for ability to live and participates in maintenance of a constancy of the internal environment of an organism. Protective Exchange Immune Bifid Bacteria • Actively participate in synthesis of vitamins and amino acids • speeds up digestion of fats, proteins and carbohydrates break down tough cellulose • stimulate synthesis of immunoglobulin's • stimulate the activity of lymphoid apparatus • Reduce permeability of fabric barriers to toxic products of pathogenic organisms Lacto Bacteria • Produce antibacterial substances which assist destruction of pathogenic bacteria • Participate in the processes of digestion • Produce many biologically active substances Factors influencing the change in Micro Flora The frequent and unjustified acceptance of antibacterial drugs Unhealthy Diet Intoxication of various nature Accommodation in environmentally disadvantaged area. Signs of Dysbacteriosis Bowel Disorder/ Loose Motion Flatulence (excessive formation of gas in the gut) Monotonous pain in a stomach (the pulling and holding apart character, usually amplifying in second half of day) A loud rumbling in stomach Почему необходимо поддерживать баланс микрофлоры Appearance of dysbacteriosis during the teenage period: Подросткам • Deviations at formation of reproductive system • Frequent fatigue and decreased performance • In allergic dermatitis treatment • private colds Почему необходимо поддерживать баланс микрофлоры Micro flora is involved in many processes of the female body and substantially defines the hormonal status and genital function of the woman. Женщинам The dysbacteriosis negatively influences on micro biogenesis vaginal that provokes progress of a candidacies and increases susceptibility to infectious diseases of the urinary system. Why is it necessary to maintain the balance of micro flora Normal micro flora balance provides the activation of immunoglobulin's (antibodies). Natural levels of immunoglobulin's (G): Activates collagen synthesis Prevents dehydration of the skin Neutralizes toxins Женщинам Complex “Probinorm” is included in an antigen line of cosmetics«Pro Biocosmetics», increasing the efficiency of its uses. Why is it necessary to maintain the balance of micro flora Middle-aged and older people should regularly take pro biotic complexes, because: With age, the rate of intestinal micro flora is beginning to deteriorate Reduced the protective functions of the micro flora in countering the malignant new growths Decreased ability to metabolize cholesterol Людям старшего возраста Disturbed immune status Accelerated aging processes Improving the micro flora to normal, you will get it within 24 hours: The whole list of vitamins-in total up to 50% daily needed Amino acid, including essential – 70% Enzyme: Digestive – 30% daily needed for person Energy Products– 60% Regulation of enzyme metabolism– to 60-70% Regulation of mineral metabolism– to 60-70% Pro Biotic Pro biotic (from Greek pro bio – far life) - products containing high concentrations of mineral for the body of the living forms of bacteria, that when entering the intestine normalizes its ecosystem and macro flora of the organism as a whole, heal and prevent the development of pathological processes. Complex “Probinorm” produced with the use of innovative biotechnology micro encapsulation of bacteria developed and patented by experts of the Art life company ИННОВАЦИОННАЯ БИОТЕХНОЛОГИЯ Live Bifida bacteria and lacto bacteria bacterium Acid gum Bifida gum Lacto gum Highly tolerant strains bacteria of different type consist in a thin microcapsule, covered with a hard shell of biopolymer substances. Latest research data of the pla with the proven benefits of the combined intake of these bacteria. INNOVATIVE BIOTECHNOLOGY The bacteria are protected from the effects of aggressive environment of the stomach On a way of settling bacteria of intestines are available a serious obstacle - the sour environment of a stomach and alkaline Wednesday of the duodenum. The thin microcapsule covered by a durable envelope from biopolymer substances, protects bacteria from the effects of environmental factors and provides resistance to acidic environment of the stomach contents. Results - 100% populated beneficial bacteria reaches the destination. INNOVATIVE BIOTECHNOLOGY Keep all useful properties of bacteria during transportation to the place of destination The core of the microcapsules is made of natural fibers, which are a breeding ground for bacteria. It keeps biological properties of bacteria for a long period of time, including transportation to the place of their active life activity. INNOVATIVE BIOTECHNOLOGY Vitamins and Pre biotic provide optimal conditions for activation of beneficial bacteria Cysteine PABK В2, В3 Inulin crust artichoke Improving survival rate of microorganisms is the inclusion complex of vitamins and pre biotic substances in dosage, optimized to the needs of microorganisms. INNOVATIVE BIOTECHNOLOGY Papain helps the best survival rate of bacteria and intensify The enzyme papain provides complete digestion in the gut bacteria of settlement period: complete digestive reactions, prevention of stagnation of food residue, improving the quality of nutrient medium of bacteria. STATUS OF THE MICRO FLORA OF THE BEFORE AND AFTER COMPLEX “PROBINORM” Before: After: Microbial balance broken Microbial balance restored STATUS OF THE MICRO FLORA OF THE BEFORE AND AFTER COMPLEX “PROBINORM” Before: After: An active growth of pathogenic flora. Increases the growth of beneficial bacteria. STATUS OF THE MICRO FLORA OF THE BEFORE AND AFTER COMPLEX “PROBINORM” Before: Develops diarrhea and intestinal tissue is dehydrated. After: Water absorbed properly. STATUS OF THE MICRO FLORA OF THE BEFORE AND AFTER COMPLEX “PROBINORM” Before: After: Decreases the number of antibodies that resist pathogenic flora. Immune globulins are synthesized in good quantity. STATUS OF THE MICRO FLORA OF THE BEFORE AND AFTER COMPLEX “PROBINORM” Before: Decreases the number of immune cells, absorbing the pathogenic in micro-organisms. After: Immune cells in tone and fully perform their functions. THE CLINICAL RESEARCH Testing was carried out in the year 2006 on the basis of the Department of internal medicine, the Faculty of advanced training and post-graduate training of specialists Sibgmu (Tomsk). • Head – MD, Prof. Beloborodova E.i. Clinical characteristic study: • 30 volunteers with dysbacteriosis of the 2nd degree (classification Kuvaevoj i.b., Ladozo K.s., 1998) caused by taking antiboitic. • AGE 40,5 + 0,7 Yrs. • Prescription of daisies 3,0 + 0,2 Yr. • Accompanying pathology: a metabolic syndrome (adiposity I-II level, hypertonic illness of II level, hypercholesterolemia) The clinical research BIFIDA Bacteria* Lacto Bacteria* Normal Till complex of “Probinorm” After Complex of “Probinorm” 106-108 104-105 >108 (р <0,05) >108 <106 >108 (р <0,05) * Microbes in 1 g of feces Function of the complex "Probinorm" contributes to the growth of beneficial microorganisms in the intestines, removing obtained as a result of antibiotic treatment, intoxication, stress. The clinical research Total number of E. coli* 107-108 106-108 108 Escherichia coli with weakly expressed enzymatic properties* до 10% 3050% 10% (р <0,05) Hemolyze Escherichia coli* до 10% 5080% 0% (р <0,01) Other conventionallypathogenic Enter bacteria * 104 104-105 106-107 (р <0,05) Function of Probinorm reduces the number of colonies of conditionally pathogenic microorganisms, which are activated when the wrong nutrition, malnutrition, infections of the upper respiratory tract. The clinical research Staphylococcus* 0-1014 105-107 <102 (р <0,05) The germs of proteus* 0-103 104-106 0-102 (р <0,05) Mushrooms of the genus Candia* 0-104 103-104 0 (р<0,01) Clostridium* 0-105 103-105 <102 (р<0,05) Function of Probinorm reduces the number of pathogenic microorganisms in the intestine, assisting the general improvement of an organism: the normal flora of intestines, getting accustomed, completely displaces the fungi, protozoa microorganisms and harmful bacteria. Dynamics concentration of immunoglobulin's A, M, G, under the influence of “Probinorm” Immunoglobulin's А (G/L) М (G/L) G (G/L) 100 0 1,9 + 0,22 Before complex of “Probinorm” After complex of “Probinorm” 1,5 +0,97 2,3 + 0,31 1,7 +0,05* 14,0 + 0,67 12,0 +0,65* * Reliability of the differences before and after treatment (* - p<0,05) The normalization of intestinal micro flora is accompanied by the removal from the body of harmful and Conducts to strengthening immunity of an organism to what normalization of a level of immunoglobulin's А, М & G. The use of particularly effective: After antibiotic therapy and exposure to toxins When digestion dysfunctions, violations of food intake Reduce gastric acidity Chronic diseases of digestive organs Disease of the liver & belier tract В12 and folic acid deficiency anemia Advantages of the complex: • Availability microencapsulated form of bacteria (100% delivery of the localization) Availability of nutrients in conjunction with the bacteria (optimal environment for the formation of life) • The presence of growth factors for bacteria (stimulation of reproduction and the most rapid microbial balance correction) • Availability pelleted papain digestion supporting intraenteric (prevention of microbial colonies from the toxic action of harmful metabolites). Thanks For Attention!