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Download Reporting Criteria of Severe fever with thrombocytopenia syndrome
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Reporting Criteria of Severe fever with thrombocytopenia syndrome (SFTS) Note: Severe fever with thrombocytopenia syndrome, defined as below, requires notification starting from 4 March 2013. (1) Definition: Infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV) belonging to genus Phlebovirus in the family Bunyaviridae. (2) Clinical symptoms: The main route of infection is bite by ticks carrying SFTSV. The incubation period is 6-14 days. The main symptoms are fever and gastrointestinal symptoms (nausea, vomiting, abdominal pain, diarrhea, and melena) associated occasionally with headache, myalgia, neurological symptoms, lymphadenopathy and bleeding. The hematological findings consists of thrombopenia (<100,000/mm3), leukopenia (<4,000/mm3) and increase in serum enzymes (AST, ALT, LDH). The case fatality rate is 10-30%. (3) Reporting criteria a) “Patients (confirmed cases)” In compliance with Article 12 paragraph 1 of the Infectious Diseases Control Law, if a physician has examined a patient with clinical findings as described in (2), has suspected SFTS and has made a diagnosis of SFTS based on the results obtained by the laboratory method and specimen as described below, the physician shall notify the case immediately. b) “Asymptomatic infections” In compliance with Article 12 paragraph 1 of the Infectious Diseases Control Law, if a physician has examined an individual without clinical signs or symptoms listed in (2), but has diagnosed that the individual was an SFTSV infection based on the results obtained by the laboratory method and specimen as described below, the physician shall notify the case immediately. c) “Deceased individual whose death was attributed to SFTSV infection” In compliance with Article 12 paragraph 1 of the Infectious Diseases Control Law, if a physician has examined a deceased person with clinical signs and symptoms as described in (2), and, has diagnosed that the death was due to SFTSV infection based on the results obtained by the laboratory methods and specimens as described below, the physician shall notify the case immediately. d) “Deceased individual whose death was suspected to be due to SFTSV infection” In compliance with Article 12 paragraph 1 of the Infectious Diseases Control Law, if a physician has examined a deceased person with clinical signs and symptoms as described in (2) and has suspected that the death was caused by SFTSV infection, the physician shall notify the case immediately. Laboratory method Detection of virus by isolation and identification Detection of viral genome by PCR Detection of antibody by ELISA or fluorescent antibody method (Detection of IgM, or positive conversion or increase in antibody titer in paired serum specimens) Detection of antibody by neutralization test (positive conversion or increase in antibody titer in paired serum specimens) Specimen Blood, throat swab, urine Serum