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ACUTE APPENDICITIS Roy Phitayakorn, M.D. Christopher Brandt, M.D. Case Western Reserve University School of Medicine Ms. Z. Cope • You are called to see a patient in the Emergency Department, who is a 25 year-old female with a 1 day history of right-lower quadrant abdominal pain. History What other points of the history do you want to know? History, Ms. Cope Consider the Following • Characterization of symptoms • Temporal sequence • Alleviating / Exacerbating factors: • Pertinent PMH, ROS, MEDS. • Relevant family hx. • Associated signs and symptoms History, Patient ZC • Pain started in the middle of the night and woke the patient from sleep. • Noted some indigestion yesterday • Felt nauseated and vomited after pain • Feels urge to have bowel movement, but has been constipated • No significant MED.HX. or SURG HX. • Negative Family HX What is your Differential Diagnosis? Differential Diagnosis Based on History and Presentation • Systemic or infectious conditions • • • • • • • • • Influenza Gastroenteritis Hepatitis Diaphragmatic pleurisy Spinal disease Typhoid Tuberculosis Acute porphyria Diabetic ketoacidosis Differential Diagnosis (cont.) • Intra-abdominal conditions • • • • • • • • Acute Appendicitis Acute Cholecystitis Diverticulitis (Meckel’s) Inflammatory Bowel Disease (Crohn’s) Duodenal Ulcer Intestinal Obstruction Carcinoma of the Cecum Nonspecific adenitis – Possible Yersinia infection Differential Diagnosis (cont.) • Intra-pelvic conditions • • • • • • • • • Salpingitis Pelvic Inflammatory Disease Ectopic Pregnancy Ruptured Corpus Luteum Cyst Ruptured Follicular Cyst (Mittelschmerz) Ruptured Ovarian Cyst Ovarian Torsion Pyelonephritis Ureteral/Renal stone Physical Examination What would you look for? Physical Examination, Patient ZC • Vital Signs: 39o C, HR=75, RR=15, BP=125/75 • Appearance: Patient is lying quietly on bed in fetal position HEENT : No icterus VAGINAL: nontender, no Discharge CV : nl S1S2, no murmurs RECTAL: Guaiac neg, uncomfortable during exam PULM : CTA Bilat. no pain with Neuromuscular: Minimal hyperesthesia above umbilicus inspiration ABD : Moderately tender in RLQ between pubic symphysis and ASIS, involuntary guarding, Neg bowel sounds Would you like to revise your Differential Diagnosis? Would you like to revise your Differential Diagnosis? • • • • • • • Acute appendicits Diverticulitis (Meckel’s) Inflammatory Bowel Disease (Crohn’s) Ovarian pathology Acute cholecystitis Intestinal obstruction Nonspecific adenitis – Possible Yersinia infection Laboratory What would you obtain? Labs ordered CBC Electrolytes LFT’s Amylase /Lipase B-HCG Urinalysis Lab Results, Ms. Cope CBC: 14,500 LFTs : WNL HCG : WNL Electrolytes : WNL Amylase : WNL U/A: WNL Interventions at this point? Interventions at this point? Consider the following • Start IV with Ringers Lactate or similar isotonic crystalloid solution • Administer antibiotics • Admit to the hospital • Go Directly to the OR? • Other? Studies What further studies would you want at this time? Radiologic Studies to Consider Flat/Upright Abdomen CT Scan: Abd/Pelvis CT Scan: Other ? US Abdomen/Pelvis Considering your Differential Diagnosis • What would you expect to see on a flat/upright abdominal series? • What specific abnormalities do you look for on US? What population? • Are there specific CT findings in any of your top 3 diagnoses? Abdominal Film Abdominal X-ray Findings • Non-specific gas pattern • No fecalith • No free air CT Scan Abdomen & Pelvis CT Scan – Results • Acute Appendicitis Thickened dilated appendix Peri-appendiceal fat stranding Scant free fluid • Incidental small left ovarian cyst What is the differential diagnosis at this point? Revised Differential Diagnosis What next? • • • • Additional Imaging? Observation? OR? Other? What next? Discussion of suggested interventions Management • Surgical Options • Pre-operative preparation Laparoscopic Acute Appendicitis Discussion Pathophysiology of the disease process, visceral vs. parietal abdominal pain, laparoscopy vs. open, antibiotic management, appropriate utilization of resources, etc. Discussion Additional teaching points QUESTIONS ?????? Summary Alternative scenarios • Acute Appendicitis with perforation/ Abscess or tumor • IBD • Acute Diverticulitis • Ovarian Cyst / Torsion/ • Perforated Right colon tumor CT Cecal Tumor CT Sigmoid Diverticulitis CT Ovarian Cystic Mass CT Terminal Ileal Crohn’s CT Acute Appendicitis Acknowledgment The preceding educational materials were made available through the ASSOCIATION FOR SURGICAL EDUCATION In order to improve our educational materials we welcome your comments/ suggestions at: [email protected]