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What is Holism?
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the person as a whole / the innate ability to heal
individualism / client-centered / terrain theory / meeting halfway
upstream thinking / why? / root causes / mechanisms & processes
elegance / obstacles to cure
docere / empowerment / teaching
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What is Holism?
-
the person as a whole / the innate ability to heal
individualism / client-centered / terrain theory / meeting halfway
upstream thinking / why? / root causes / mechanisms & processes
elegance / obstacles to cure
docere / empowerment / teaching
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“it is much more important to know what sort of person has a disease,
than what sort of disease a person has”
William Osler, MD, Founder, Johns Hopkins Hospital
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Brain Fog to Brain Power
finding the Cognitive
Edge
Maximize your brainpower, memory & speed of thought
Be more creative & think outside the box
Be your absolute best - physically, mentally, emotionally, socially
Climb the corporate ladder, lead a company
Balance work, play & family
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Dr. Jason Marr, Naturopathic Doctor
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Using evidence-based, integrative & functional medicine, I work with
urban professionals to prevent, overcome & address adrenal
dysfunction, optimize body & brain function, so that they can do
what they want to do, and achieve their goals.
@marrmedicine | evokemedicine.com
Know Your Speaker:
Dr. Jason Marr, BScH, ND
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Bachelor of Science degree in Kinesiology w/ Honours
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Honours Thesis: Imagery Training in Elite Athletes
University of Waterloo, Waterloo, ON
St. Francis Xavier University, Antigonish, NS
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Naturopathic Doctor
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Canadian College of Naturopathic Medicine, Toronto, ON
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Evoke Integrative Medicine Ltd.:
Naturopathic Doctor & Director
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Practice focused on:
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Adrenal Dysfunction
Brain Medicine
Sports & Injury Rehabilitation
Corporate Wellness
Competitive & Elite Athletes
Modalities:
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Diet & Lifestyle Counselling
Nutraceutical & Orthomolecular Medicine
Herbal / Botanical Medicine
Acupuncture & Intramuscular Stimulation (IMS)
Low-Level (Cold) Laser Therapy
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Institute of Holistic Nutrition (IHN):
Instructor
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Nutritional Pathology
Applied Endocrinology
Lab Diagnostics in Clinical Practice
Nutritional Fundamentals for Health (NFH),
Genuine Health:
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Medical Consultant
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Proactive vs. Preventive:
Preventive: Doing something to stop something bad from happening
Proactive: Doing something to get maximize/optimize your health
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Outcomes:
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Increased energy, motivation, libido, physical & mental abilities
Improved memory, focus, concentration & speed of thought
Improved creativity & problem solving skills
Increased productivity & opportunity
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Optimizing Brain Function:
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Memory / short-term, long-term
Focus & Concentration / seeing through the crowd
Brain Fog / the haze
Speed of Thought / reaction time
Mood / anxiety, depression
Low Libido / motivation / “burnout” / overtraining
Creativity / foresight / thinking outside the box
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Brain Diseases/Disorders
- Alzheimer’s Disease
- Multiple Sclerosis
- Parkinson’s Disease
- Dementia
- Stroke
- Anxiety, Depression
- Other Mental Disorders
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@DrMarrND | drmarr.com
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Sub-acute & Sub-chronic Conditions
- Adrenal Dysfunction
- (Brain) Fatigue / “Burnout” / Overload
- Declining memory, focus, concentration
- Lowered libido, motivation
- Insomnia
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Your Brain Needs Fuel:
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Oxygen
Glucose
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Your Brain Needs Fuel:
- Oxygen
- Glucose
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Glucose
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Brain Fuel Requires Blood Delivery:
Delivery of oxygen & glucose is dependent on :
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blood flow to the brain
healthy blood (rule out anemia, esp. iron & b12 deficiencies)
ability to minimize physical/physiological/chemical damage to the brain tissues
caused by using oxygen and glucose as energy sources
crossing a healthy blood-brain barrier
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inflammation
oxidative stress & free radicals
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Brain Function Requires Neurotransmitters:
Neurotransmitters are chemicals that transfer messages between
neurons and from neurons to organs and tissues:
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Dopamine / energy, voltage, power, pleasure
Acetylcholine / youth, memory, speed
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GABA / control, calm, rhythm
Serotonin / mood, sleep, rest
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What are the Adrenals?
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Small pyramid-shaped glands
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Sit atop each kidney, mid-lower back/flank
Adrenals secrete:
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Cortisol
Epinephrine (Adrenaline) & Norepinephrine (Noradrenaline)
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Sympathetic Response:
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Fight or Flight:
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The adrenals are designed to provide us with a short, massive boost of energy to
save your life when under stress (car on fire, sabre-toothed tiger).
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stress
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anxiety
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worry
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grief
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Real-life Stress:
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Physical / trauma
Psychological / emotional / social
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financial/money/employment
marital/relationship/family
negative attitudes & beliefs, fear, worry, grief
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Real-life Stress:
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Physiological / biochemical
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lack of, or excessive exercise & overexertion, infection
stimulant use, lack of sleep, lack of routine
anemia (iron & b12 insufficiencies)
hypothyroidism
Environmental / Terrain
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nutritional / nutrient inadequacies, caffeine, sugar, simple carbs
food allergies/sensitivities/intolerances
toxins / heavy metals, smoking, drugs, etc.
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The body does not differentiate stresses:
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Stresses are additive & cumulative
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A single event, or repeated events may cause changes in health
The body can become “primed” or “stuck” in a sympathetic state (ie. “overdrive”)
Adrenal “Fatigue” (Adrenal Dysfunction)
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Cortisol is not the devil you think it is…
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Hormones Associated with the Adrenals:
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Cortisol:
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Anti-inflammatory
Increases metabolism of carbohydrates, proteins & fats for energy
Decrease white blood cell action & formation
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(depresses the immune system)
Cortisol has rhythm:
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Stress disrupts cortisol’s diurnal, routine, circadian release
Generally, should be highest around 5-7am, taper throughout the day
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Hormones Associated with the Adrenals:
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Epinephrine & Norepinephrine:
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Increase heart rate
Increase blood pressure
Increase respiration rate (more oxygen)
Shunt blood to peripheral tissues (esp. brain, heart, lungs, muscles)
Shunt blood away from visceral organs, digestive system
Remember: The Brain Needs Fuel!
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Signs & Symptoms of Adrenal Dysregulation:
Syndrome: A collection of
signs & symptoms forming a pattern -You don’t have to have all the signs/
symptoms to “have” adrenal fatigue, nor does any one sign/symptoms define the issue.
Fatigue / low energy / lethargy
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difficulty waking up (unrestful sleep), not really awake until 10am
< around mid-late afternoon (esp. 3-5pm)
> after dinner or 11pm (second wind, delaying bedtime, vicious circle)
Lack of motivation / anhedonia / low libido
Feeling “stuck” / depression / anxiety
Inability to deal with stress / easily surprised / scared or irritable
Poor memory, focus, concentration, creativity & productivity
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Signs & Symptoms of Adrenal Dysregulation:
cont’d:
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Low immunity, poor wound healing or slow recovery from injury
Low blood pressure & orthostatic hypotension
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dizzy/lightheaded/fainting
Increased PMS symptoms/signs
Need use of stimulants (ie. coffee) & Cravings for salt & salty foods
Increased urination, thirst
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Possible Sequelae of Adrenal Fatigue:
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(Reactive) hypoglycemia
Allergies & asthma
Arthritis & autoimmune disorders
Decreased immunity (frequent colds/flus)
Anxiety/depression, alcoholism, mental disorders
Insomnia
Chronic Fatigue Syndrome / Fibromyalgia Syndrome
Type 2 Diabetes Mellitus & Impaired blood sugar regulation
Infertility
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Stages of Adrenal Fatigue
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Stage 1: Normal graded response & return to baseline
Stage 2: “Tired & Wired”, “Overdrive”
Stage 3: “Burnout”, “Overtraining”
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Wellness Options
Boosting brain power & overcoming adrenal dysfunction
please challenge your licensed and experienced healthcare provider
for recommendations on how to choose the best, safest, most
cost-effective supplements & herbs for you as an individual.
natural health products are not always safe,
particularly in combination with some medications and other supplements
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Physiological Mechanisms for Boosting Brain Power:
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Address anemia & ensure optimal nutrient status
Optimize blood health & metabolism, boost blood flow to the brain
Balance & provide stable glucose in the blood
Manage inflammation & oxidative stress
Support neurotransmitter production
Resolve underlying adrenal dysfunction
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Lifestyle First
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The Refuelling Doctrine:
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The secret to maximizing productivity and performance isn’t all about
working harder
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It’s about rest.
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Improvements = Stress + Adaptation
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Routine, routine, routine:
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Wake, eat, exercise, work, sleep
Plan weekly/daily routines
Train your body to know what to expect, and try not to surprise it.
Compartmentalization
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Rest & Relaxation:
Get adequate sleep & Honour your body:
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bodywork, sauna, bubble baths, low intensity exercise
Mini-breaks
15mins horizontal downtime each day
Ensure 2 rest days per week (no exercise)
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Brain Lifestyle Biohacks:
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Exercise / Physical Activity & Deep Breathing
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Exercise drives blood flow to the brain but is also a stress on the body - Balance!
Contrast hydrotherapy
Reframing: The silver lining & finding the positive
Imagery training & Imagery armour
Neuroplasticity exercises - lumosity.com
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Eat good food.
Mostly vegetables.
With adequate protein.
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Diet does not equal nutrition:
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Diet does not equal nutrition:
What you put into your mouth (digestive tract) is still dependent on:
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Digestion
Absorption
Transport
Metabolism
Synergy
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Nutritional Considerations:
Stabilize blood sugar & ensure protein adequacy (0.8 - 1.25g/kg body weight)
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Protein (neurotransmitters require amino acids) & fiber adequacy
Eliminate refined, fast, fried foods (esp. sugar) & simple carbohydrates
Reduce or eliminate grains, especially wheat, limit fruits to 2-3 servings/day
Anti-Inflammatory Diet
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4x more vegetables than everything else ensuring nutrient adequacies
B-Vitamins & Iron-rich foods (rule out anemias) from meat & green leafy veggies
Rule out food sensitivities (and allergies, intolerances)
Essential Fatty Acids (esp. omega-3s) & healthy fats from fish, nuts/seeds, avocados
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Nootropics:
“Smart drugs”
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Enhance memory, cognitive performance and intelligence
Increased memory, focus, motivation, attention
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Nootropics:
Many are stimulants
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eg. Caffeine, Ritalin/Concerta/Adderall
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Nicotine
L-theanine
Phosphatidylserine (esp. with EPA & DHA)
Adaptogenic herbs (Bacopa, Ginsengs, Gingko…)
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Nutraceuticals & Orthomolecular Medicine
B-vitamins:
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B5 as pantathenic acid
B6 as pyridoxyl-5-phosphate and/or pyridoxine HCl
B12 as methylcobalamin
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Fish oils & Essential Fatty Acids:
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2000-3000mg per day of combined EPA & DHA
6:1 or higher ratio of EPA to DHA (but you still want some of both)
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EPA is more anti-inflammatory, functional
DHA is more structural
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Nutraceuticals & Orthomolecular Medicine
Magnesium
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Magnesium (bis)glycinate or taurate
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oxides, and even citrates are more likely to give you loose stools and do not absorb as well
Antioxidants
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Vitamin C +/- Bioflavonoids
N-Acetyl-L-Carnitine (ALCAR)
CoQ10
N-Acetyl-Cysteine (NAC)
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Nutraceuticals & Orthomolecular Medicine
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For calming / cortisol excess:
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GABA
L-Theanine
Phosphatidylserine (PS)
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Support Neurotransmiter Production:
Adequate & Complete Protein:
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Neurotransmitters are derived from amino acids, the building blocks of protein
Vitamin B6 is a cofactor (pyridoxyl-5-phosphate and pyridoxine HCl)
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Tyrosine, phenylalanine, gingko, rhodiola, caffeine/guarana, nicotine (dopamine)
Choline (as GPC), conjugated linoleic acid (CLA), gingko (acetylcholine)
GABA, L-Theanine, Phosphatidylserine, Kava, Passionflower, Scutellaria (GABA)
Melatonin, L-Tryptophan or 5-HTP, St. John’s Wort (serotonin)
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Amino acids including tyrosine, phenylalanine, alpha-GPC, tryptophan etc., are known to cross the
blood brain barrier.
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Support Neurotransmiter Production:
- B6 dependent enzymatic processes:
phenylalanine > tyrosine > dopamine
tryptophan > 5-HTP > serotonin > melatonin
sources of phenylalanine & tryptophan > primarily meat.
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Herbal & Botanical Medicines
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Adaptogens:
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Korean ginseng / Panax Ginseng
Siberian ginseng / Eleutherococcus
Licorice root / Glycyrrhiza glabra
Cordyceps mushroom / Cordyceps sinensis
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Ashwagandha / Withania somnifera
Rhodiola / Rhodiola rosea
Skullcap / Scutellaria lateriflora or baicalensis
Passionflower / Passiflora incarnata
Reishi mushroom
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Herbal & Botanical Medicines
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Blood Supporting & Antioxidant:
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Gingko berries / Gingko biloba
Rosemary / Rosmarinus officinalis
Hawthorne berries / Crataegus oxycanthus
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Individualized Treatment:
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Work with your qualified, licensed and experienced healthcare provider to
tailor you treatment plan to your individual needs and ensure you are doing so
safely given your personal medical history and current terrain.
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Additional Resources:
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The Better Brain Book, David Perlmutter MD
The Edge Effect, Eric Braverman MD
Adrenal Fatigue, The 21st Century Stress Syndrome, James L. Wilson
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Stay Tuned!
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Overloaded - The Refuelling Doctrine, Dr. Jason Marr ND
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Thank You! Questions?
Dr. Jason Marr, BScH, ND
Evoke Integrative Medicine Ltd. / 1030 West Georgia St., Suite 312
evokemedicine.com
I work with urban professionals and athletes to optimize
brain & body and overcome adrenal dysfunction so that
they can do what they want to do
@MarrMedicine
@EvokeIM
facebook.com/DrMarrND
facebook.com/EvokeIM
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