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Sedation for Dental Procedures Dr Walid Zuabi FCA RCSI Consultant Anesthetist JUH Sedation • Definition: A state of controlled depression of consciousness that allows patients to tolerate unpleasant procedures while maintaining adequate cardiorespiratory function and the ability to respond purposefully to verbal command and/or tactile stimulation. Stages of Sedation Stages of Sedation Aim of Sedation • Achieving anxiolysis and patient cooperation • Drugs and techniques used should render unintended loss of consciousness unlikely - Local anesthesia relief of Pain - Sedation relief of fear and anxiety - General anaesthesia Relief of both pain and anxiety Which patient groups ? • • • • • Dental Anxiety & Phobia. Prolonged traumatic procedures. Medical conditions aggrevated by stress. Patient cooperation. Special needs. Which patient groups ? • Children and young adults • Anxious adults Patient selection • Only ASA I and ASA II groups should undergo dental sedation in a general dental practice (clinic). Risk classification • ASA I : A normal Healthy patient 0.06-0.08% • ASA II : A patient with mild systemic disease 0.27-0.40% • ASA III: A patient with severe systemic disease 1.8 - 4.3% • ASA IV: A patient with severe systemic disease that is a constant threat to life 7.8 - 23% • ASA V: Moribund patient who is not expected to survive without the operation 9.4-51% • ASA VI: A declared brain dead patient whose organs are being removed for donor purposes • “E” For Emergency surgery Consent * Informed, Written Consent regarding the sedation procedure for a course of dental treatment. DRUGS USED 1- Benzodiazepines 2- Neuroleptanalgesia 3- Nitrous Oxide 4- Sedative Anaesthetics ( I.V. Hypnotic drugs) SOAPME Benzodiazepines – Most widely used. – Wide safety Margin. – IV & Oral formulations available. Benzodiazepines Functions 1- Anxiolytic 2- Sedative (hypnosis) sleep promotion 3- Amnesia/ RETROGRADE 4- Central muscle relaxant effect 5- Anticonvulsant Benzodiazepines • Diazepam Oral: 2 mg q 8 hrs for anxiety 10-15 mg for premedication 2 hrs pre-op (in Hospital) • IV or IM. painful on injection Diazemulus (lipid emulsion): painless on injection 5 mg/ml Benzodiazepines Diazepam • • • • • (Continued) Best anxiolytic Poor amnesic Minimal CV depression Long Duration of action ( > 4 hrs) Active metabolite Benzodiazepines Midazolam • Indications: - Conscious sedation - Co-induction of GA Doses: - For pre-op sedation 0.07 – 0.08 mg/kg 1 hr before procedure I.M injection - Individualized dose I.V Benzodiazepines Midazolam • • • • Best amnesic , good hypnotic Some CV depression Readily produces general anesthesia Duration < 2 Hrs Benzodiazepines Temazepam • Only Oral. • Doses : - Insomnia : 10 – 30 mg - Premedication: 10 – 20 mg 2 Hrs Preop • Good Hypnotic • Short duration • May cause dysphoric reactions in young adults Benzodiazepines • Antidote: Flumazenil (Anexate) • • • • • • • • A specific antagonist I.V Essential requirement if Benzodiazepines are used. 0.2 mg IV every 15 seconds Rapid recovery Duration: 15 min Re-sedation if long acting BZD is used Can precipitate withdrawal reaction in habituated patients. Neuroleptanalgesia • Major tranquilizers: chlorpromazine, droperidol & • Opiates: Fentanyl, morphine & Codeine ============================= • Many side effects - Behavioral syndromes: - inhibition of purposeful movement - inhibition of learned behavior - catalepsy: a condition characterized by rigidity of extremities and decreased sensitivity to pain - Alpha adrenergic blockade - Hypothermia - Extra-pyramidal effects - Anti-cholinergic effects Neuroleptanalgesia • Droperidol: - Dose: 5 mg IV - produce marked catalepsis - Inner anxiety - Duration 2 hrs Fentanyl: - Max. dose 1mcg/kg - Potent Narcotic analgesic - potent respiratory depressant - Duration of action 35 min cont. Nitrous Oxide N2O • LAFFING GAS!! LOL!! Nitrous Oxide N2O • LAFFING GAS!! LOL!! Just Say N O! 2 Nitrous Oxide N2O • LAFFING GAS!! LOL!! Nitrous Oxide N2O • LAFFING GAS!! LOL!! Laughing Gas Nitrous Oxide N2O • • • • • • • Inorganic gas/ N2O A strong analgesic High safety margin Can be used in concentrations up to 70% Needs special administration machine Needs a scavenging system Use nasal masks with two-way valve outlets Sedative Anaesthetics - Propofol: - Ultra-short acting - Rapid clear headed recovery - I.V infusion through a syringe pump - titrate dose to desired response - can achieve very well controlled sedation - Very easy to render patient unconscious!! - Should only be given by trained personnel in skills of: - Tracheal intubation - Artificial ventilation - Cardiovascular resuscitation Risks of Sedation • • • • • • Depression of Airway Reflexes Inter-individual variability Interactions with other medications Allergic responses Cardiovascular decompensation Disinhibition reaction Be prepared !! • Patient check up: - A concise medical history and relevant examination and investigation - General practitioner • Assessment for potential airway problems • Informed Consent • NPO Do you need an anaesthetist ? Do you need an anaesthetist present ? Do you need an anaesthetist ? • • • • Possible airway problems Very young / very old Concurrent medical problem Deep sedation ? Monitoring • Pulse Oximeter • BP • ECG • Defibrillator Emergency drugs that should be available (in resuscitation trolley) - Adrenaline - Atropine - Flumazenil - Lignocaine - Naloxone - IVF Recovery and Discharge - Allow patient to recover in a quiet environment - Patient must be supervised until fully recovered - PACU should be equipped with same standards of the procedure room - Discharge after review by qualified practitioner - Written instructions regarding home care - Avoid alcohol, driving, machinery, signing documents in case of a adults. In Europe • England, Ireland & Switzerland were the only two countries in Europe where dental procedures under deep sedation or G/A where carried out outside hospitals i.e. in dental clinics. • Training programs in conscious sedation for dentists are provided in public sector and in certain universities as a prerequisite for licensing . Risk Management • Using only familiar drugs • Only to correctly indicated patients • Comprehensive preoperative assessment • continuous monitoring • Appropriate emergency drugs and equipment • Full documentation • Well trained support personnel • Treating high risk patients in a well equipped setting for their care 48