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Download Supplemental Figure 1. Tumor depth staging for esophageal
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Supplemental Figure 1. Tumor depth staging for esophageal neoplasia. There are 4 layers of the esophagus: mucosa, submucosa, muscularis propria, and adventitia. The mucosa is further divided into the epithelium, lamina propria, and muscularis mucosae. Dysplasia is confined to the epithelium. Intramucosal cancer tumors (T1a) invades the lamina propria or muscularis mucosae. Tumors that invade the submucosa is are classified T1b. T2 cancer tumors invades the muscularis propria, T3 tumors invades the adventitia, and T4 tumors invades adjacent structures. (Reproduced with permission from Rubenstein JH, Shaheen NJ. Epidemiology, Diagnosis, and Management of Esophageal Adenocarcinoma. Gastroenterology 2015; May 6. pii: S0016-5085(15)00642-3. doi: 10.1053/j.gastro.2015.04.053. [Epub ahead of print].)
