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PIUS NDE PhD Affiliation: Meharry Medical College Microbiology & Immunology "Cardiovascular and Related Diseases","Infectious and Immunological Diseases" Title: Dr. Rank: Assistant Professor Address: Dept of Microbiology & Immunology Meharry Medical College Nashville, TN 37208 Contact: Email: [email protected] Telephone: 615 327 6997 Narrative Dr. Pius N. Nde is an Assistant Professor in the Department of Microbiology and Immunology at Meharry Medical College. He received his BSc and MSc degrees from the Biochemistry Department of the University of Ibadan, Nigeria and his PhD degree in Molecular Biology from Humboldt-University Berlin, Germany. Subsequently, he completed postdoctoral research training at Meharry Medical College in the laboratory of Dr. Fernando Villalta. Dr. Nde’s overall research interest focuses on “host pathogen interactions, molecular mechanisms of cardiac pathology induced by Trypanosoma cruzi and diagnosis of neglected tropical diseases.” His current SC1 research project entitled “Molecular mechanisms of Trypanosoma cruzi cardiopathogenesis ” is funded by NIAID, http://projectreporter.nih.gov/project_info_description.cfm?aid=9073494. The focus of the grant is to elucidate the molecular mechanisms utilized by T. cruzi to induce a fibrogenic response that can be exploited for the development of molecular intervention strategies. He is also a previous recipient of the SCORE SC2 grant from NIH. Currently, he is a member of ASBMB, American Society of Matrix Biology and American Heart Association. Dr. Nde’s, publications are available in the link: https://www.ncbi.nlm.nih.gov/sites/myncbi/pius.nde.1/bibliography/43068717/public/?sort=date&d irection=ascending Title of Dr. Nde’s RTRN Spotlight presentation is “Molecular mechanisms of cardiac fibrosis induced by Trypanosoma cruzi infection” Original Articles 1. Villalta, F., Dobish, M.C., Nde, P.N., Kleshchenko, Y.Y., Hargrove, T.Y., Johnson, C.A., Waterman, M.R., Johnston, J.N., and Lepesheva.G.I. VNI cures the acute and chronic experimental Chagas disease. The Journal of Infectious Diseases. 2013; 208 (3):504-511. Publications 1. Udoko AN, Johnson CA, Dykan A, Rachakonda G, Villalta F, Mandape SN, Lima MF, PubMed Pratap S, Nde PN. Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0003747. 2. Lepesheva GI, Hargrove TY, Rachakonda G, Wawrzak Z, Pomel S, Cojean S, Nde PN, PubMed Nes WD, Locuson CW, Calcutt MW, Waterman MR, Daniels JS, Loiseau PM, Villalta F. VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis. J Infect Dis. 2015 Nov 1; 212(9):1439-48. 3. Farrow AL, Rachakonda G, Gu L, Krendelchtchikova V, Nde PN, Pratap S, Lima MF, PubMed Villalta F, Matthews QL. Immunization with Hexon Modified Adenoviral Vectors Integrated with gp83 Epitope Provides Protection against Trypanosoma cruzi Infection. PLoS Negl Trop Dis. 2014 Aug; 8(8):e3089. 4. Johnson CA, Rachakonda G, Kleshchenko YY, Nde PN, Madison MN, Pratap S, PubMed Cardenas TC, Taylor C, Lima MF, Villalta F. Cellular response to Trypanosoma cruzi infection induces secretion of defensin a-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection. Infect Immun. 2013 Nov; 81(11):4139-48. 5. Villalta F, Dobish MC, Nde PN, Kleshchenko YY, Hargrove TY, Johnson CA, Waterman PubMed MR, Johnston JN, Lepesheva GI. VNI cures acute and chronic experimental Chagas disease. J Infect Dis. 2013 Aug 1; 208(3):504-11. 6. Nde PN, Lima MF, Johnson CA, Pratap S, Villalta F. Regulation and use of the PubMed extracellular matrix by Trypanosoma cruzi during early infection. Front Immunol. 2012; 3:337. 7. Johnson CA, Kleshchenko YY, Ikejiani AO, Udoko AN, Cardenas TC, Pratap S, PubMed Duquette MA, Lima MF, Lawler J, Villalta F, Nde PN. Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection. PLoS One. 2012; 7(7):e40614. 8. Nde PN, Johnson CA, Pratap S, Cardenas TC, Kleshchenko YY, Furtak VA, Simmons KJ, PubMed Lima MF, Villalta F. Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand. Chem Biodivers. 2010 May; 7(5):1051-64. 9. Cardenas TC, Johnson CA, Pratap S, Nde PN, Furtak V, Kleshchenko YY, Lima MF, PubMed Villalta F. REGULATION of the EXTRACELLULAR MATRIX INTERACTOME by Trypanosoma cruzi. Open Parasitol J. 2010; 4:72-76. 10. Villalta F, Madison MN, Kleshchenko YY, Nde PN, Lima MF. Molecular analysis of PubMed early host cell infection by Trypanosoma cruzi. Front Biosci. 2008; 13:3714-34. 11. Andrews JA, Bligh WJ, Chiodini PL, Bradley JE, Nde PN, Lucius R. The role of a PubMed recombinant hybrid protein based ELISA for the serodiagnosis of Onchocerca volvulus. J Clin Pathol. 2008 Mar; 61(3):347-51. 12. Madison MN, Kleshchenko YY, Nde PN, Simmons KJ, Lima MF, Villalta F. Human PubMed defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction. Infect Immun. 2007 Oct; 75(10):4780-91. 13. Augustine SA, Kleshchenko YY, Nde PN, Pratap S, Ager EA, Burns JM, Lima MF, PubMed Villalta F. Molecular cloning of a Trypanosoma cruzi cell surface casein kinase II substrate, Tc-1, involved in cellular infection. Infect Immun. 2006 Jul; 74(7):3922-9. 14. Simmons KJ, Nde PN, Kleshchenko YY, Lima MF, Villalta F. Stable RNA interference of PubMed host thrombospondin-1 blocks Trypanosoma cruzi infection. FEBS Lett. 2006 Apr 17; 580(9):2365-70. 15. Nde PN, Simmons KJ, Kleshchenko YY, Pratap S, Lima MF, Villalta F. Silencing of the PubMed laminin gamma-1 gene blocks Trypanosoma cruzi infection. Infect Immun. 2006 Mar; 74(3):1643-8. 16. Nde PN, Pogonka T, Bradley JE, Titanji VP, Lucius R. Sensitive and specific PubMed serodiagnosis of onchocerciasis with recombinant hybrid proteins. Am J Trop Med Hyg. 2002 May; 66(5):566-71. 17. Pogonka T, Brattig N, Nde PN, Adam R, Seeber F, Zipfel PF, Titanji VP, Lucius R. PubMed Localization of T and B cell stimulating domains of the immunodominant 33-kDa protein of Onchocerca volvulus (Ov33). Clin Immunol Immunopathol. 1997 Oct; 85(1):56-66. 18. Titanji VP, Nde PN, Ghogoinu SM, Tamo R, Lucius R, Perler F. The roles of IgG and PubMed defined antigens in cytoadherence and cytotoxicity reactions to onchocercal microfilariae. Afr J Health Sci. 1996 May; 3(2):33-6. 19. Zimmerman PA, Steiner LL, Titanji VP, Nde PN, Bradley JE, Pogonka T, Begovich AB. PubMed Three new DPB1 alleles identified in a Bantu-speaking population from central Cameroon. Tissue Antigens. 1996 Apr; 47(4):293-9. 20. Titanji VP, Nde PN, Mbacham WF. Cell-mediated and monoclonal antibody- PubMed dependent killing of Onchocerca volvulus microfilariae. Scand J Immunol Suppl. 1992; 11:57-61. THANK YOU FOR USING THE RTRN RESEARCH COLLABORATION AND PROFESSIONAL NETWORKING SERVICE. RTRN Data Coordinating Center Mississippi e-Center @ Jackson State University 1230 Raymond Road, Box 1800, Jackson, Mississippi 39204 Phone: 601-979-0332, Fax: 601-979-0338, e-mail: [email protected]